City of Hope Medical Center

26 results found.

Kidney Cancer Clinical Trial using gene expression analysis; protein expression analysis; diagnostic laboratory biomarker analysis; immunoenzyme technique; immunohistochemistry staining method

City of Hope Medical Center - Recruiting N/A or older.
- Development of a Blood Test of Anti-IMP3 Autoantibody for the Detection of Renal Cell Carcinoma With Metastasis and Metastatic Potential.
gene expression analysis; protein expression analysis; diagnostic laboratory biomarker analysis; immunoenzyme technique; immunohistochemistry staining method

Estrogen Receptor-negative Breast Cancer, Estrogen Receptor-posit Clinical Trial using zoledronic acid; laboratory biomarker analysis; therapeutic conventional surgery

City of Hope Medical Center - Recruiting N/A or older.
- A Pilot Study of the Impact of a Single Dose of Zoledronic Acid on Biomarkers in Breast Cancer.
zoledronic acid; laboratory biomarker analysis; therapeutic conventional surgery

Breast Cancer, or Stage IV Breast Cancer Clinical Trial using positron emission tomography; copper Cu 64-DOTA-trastuzumab; Biopsy; Immunohistochemistry staining method; laboratory biomarker analysis; mutation analysis

City of Hope Medical Center - Recruiting 18 years or older.
- 64 Cu-DOTA-Trastuzumab Positron Emission Tomography in Women With Advanced HER2 Positive Invasive Breast Cancer.
positron emission tomography; copper Cu 64-DOTA-trastuzumab; Biopsy; Immunohistochemistry staining method; laboratory biomarker analysis; mutation analysis

Type 1 Diabetes Mellitus Clinical Trial using Blood draw

City of Hope Medical Center - Recruiting 18 years or older.
- Detection of Human Beta Cell Death in T1DM by Methylation Specific PCR.
Blood draw

HER2-positive Breast Cancer, Recurrent Breast Cancer, or Stage IV Clinical Trial using pertuzumab; trastuzumab; paclitaxel albumin-stabilized nanoparticle formulation; laboratory biomarker analysis

City of Hope Medical Center - Recruiting 19 years or older.
- Phase II Prospective Open Label Single Arm Study of Pertuzumab, Trastuzumab, and Nab-Paclitaxel in Patients With HER-2 Positive Metastatic Breast Cancer.
pertuzumab; trastuzumab; paclitaxel albumin-stabilized nanoparticle formulation; laboratory biomarker analysis

Recurrent Colon Cancer, Recurrent Rectal Cancer, Stage IVA Colon Clinical Trial using ziv-aflibercept; leucovorin calcium; irinotecan hydrochloride; fluorouracil

City of Hope Medical Center - Recruiting 18 years or older.
- A Prospective Study of Short Infusion of Ziv-Aflibercept in Combination With FOLFIRI in Patients With Metastatic Colorectal Cancer.
ziv-aflibercept; leucovorin calcium; irinotecan hydrochloride; fluorouracil

Malignant Neoplasm, or Psychosocial Effects of Cancer and Its Tre Clinical Trial using psychosocial assessment and care; educational intervention; communication skills training; questionnaire administration

City of Hope Medical Center - Recruiting 18 years to 30 years.
- Pilot Study of Psycho-Educational Group for Young Adults (YA) on Treatment: Impact on Knowledge, Distress, and Satisfaction.
psychosocial assessment and care; educational intervention; communication skills training; questionnaire administration

Recurrent Prostate Cancer, Stage I Prostate Cancer, Stage IIA Pro Clinical Trial using stereotactic body radiation therapy; quality-of-life assessment; laboratory biomarker analysis

City of Hope Medical Center - Recruiting 19 years or older.
- Stereotactic Body Radiation Therapy to the Prostate Fossa: Phase I Dose Escalation Study.
stereotactic body radiation therapy; quality-of-life assessment; laboratory biomarker analysis

Cytomegalovirus Infection, or Healthy, no Evidence of Disease Clinical Trial using multi-CMV epitope modified vaccinia Ankara vaccine; laboratory biomarker analysis

City of Hope Medical Center - Recruiting 18 years to 50 years.
- Phase I Evaluation of a CMV-MVA Triplex Vaccine: Safety and Biologically Effective Dose in Healthy Volunteers With or Without Prior Immunity to CMV and Vaccinia.
multi-CMV epitope modified vaccinia Ankara vaccine; laboratory biomarker analysis

Cancer, Solid Tumor, or Hematologic Malignancy Clinical Trial

City of Hope Medical Center - Recruiting 65 years or older.
- Delivering the Geriatric Assessment Tool to Older Adults With Cancer Using Computer Survey Methodologies: Testing Feasibility, Reliability, and Validity of Research Electronic Data Capture (REDCap) and Support Screen (Touchscreen) Technologies.

Recurrent Renal Cell Cancer, Stage I Renal Cell Cancer, or Stage Clinical Trial using fluorescence imaging; laparoscopic surgery; indocyanine green

City of Hope Medical Center - Recruiting 18 years or older.
- A Prospective Investigation of the Use of the Fluorescence Imaging on the da Vinci Surgical System for Intraoperative Near Infrared Imaging of Renal Cortical Tumors.
fluorescence imaging; laparoscopic surgery; indocyanine green

Adult Spinal Cord Neoplasm, Recurrent Adult Spinal Cord Neoplasm, Clinical Trial using therapeutic conventional surgery; quality-of-life assessment

City of Hope Medical Center - Recruiting 18 years or older.
- Comparison of Minimally Invasive Approaches of Spine Tumor Surgery.
therapeutic conventional surgery; quality-of-life assessment

Adult Grade III Lymphomatoid Granulomatosis, Cutaneous B-cell Non Clinical Trial using autologous CD19CAR-CD28-CD3zeta-EGFRt-expressing Tcm-enriched T cells; autologous hematopoietic stem cell transplantation; laboratory biomarker analysis

City of Hope Medical Center - Recruiting 18 years or older.
- Phase I Study of Cellular Immunotherapy Using Central Memory-Enriched T Cells Lentivirally Transduced to Express a CD19-Specific, CD28-Costimulatory Chimeric Receptor and a Truncated EGFR Following Peripheral Blood Stem Cell Transplantation for Patients With High-Risk Intermediate Grade B-Lineage Non-Hodgkin Lymphoma.
autologous CD19CAR-CD28-CD3zeta-EGFRt-expressing Tcm-enriched T cells; autologous hematopoietic stem cell transplantation; laboratory biomarker analysis

Hematopoietic/Lymphoid Cancer, or Unspecified Adult Solid Tumor, Clinical Trial using questionnaire administration; quality-of-life assessment

City of Hope Medical Center - Recruiting 18 years or older.
- Physical, Emotional and Social Stressors and Their Impact on Quality of Life of Caregivers of Hospitalized Older Adults With Cancer.
questionnaire administration; quality-of-life assessment

Adult Acute Lymphoblastic Leukemia in Remission, Adult Acute Myel Clinical Trial using clofarabine; melphalan; allogeneic hematopoietic stem cell transplantation; laboratory biomarker analysis

City of Hope Medical Center - Recruiting 18 years to 75 years.
- Phase II Study of Clofarabine and High-Dose Melphalan Conditioning Prior to Allogeneic Hematopoietic Cell Transplantation for Myelodysplasia or Acute Leukemia in Remission.
clofarabine; melphalan; allogeneic hematopoietic stem cell transplantation; laboratory biomarker analysis

Breast Cancer Clinical Trial

City of Hope Medical Center - Recruiting 18 years or older.
- Adjuvant Therapy in Older Versus Younger Women With Breast Cancer: Longitudinal Impact of Adjuvant Chemotherapy on Functional Status, Comorbidity and Quality of Life.

Breast Neoplasms, HER2 Protein, Human, or Geriatric Health Servic Clinical Trial using Lapatinib; Trastuzumab; laboratory biomarker analysis; pharmacological study

City of Hope Medical Center - Recruiting 60 years or older.
- Tolerability of the Combination of Lapatinib and Trastuzumab in Adults Age 60 or Older With HER2 Positive Locally Advanced or Metastatic Breast Cancer.
Lapatinib; Trastuzumab; laboratory biomarker analysis; pharmacological study

Cancer Survivor Clinical Trial using carvedilol; placebo; pharmacogenomic studies; laboratory biomarker analysis; quality-of-life assessment; polymorphism analysis; microarray analysis; polymerase chain reaction; enzyme-linked immunosorbent assay; questionnaire administration

City of Hope Medical Center - Recruiting 16 years or older.
- Pharmacologic Reversal of Ventricular Remodeling in Childhood Cancer Survivors at Risk for Congestive Heart Failure (PREVENT-CHF): A Phase IIB Randomized Placebo-Controlled Trial.
carvedilol; placebo; pharmacogenomic studies; laboratory biomarker analysis; quality-of-life assessment; polymorphism analysis; microarray analysis; polymerase chain reaction; enzyme-linked immunosorbent assay; questionnaire administration

Adenocarcinoma of the Lung, Bronchoalveolar Cell Lung Cancer, Lar Clinical Trial using PI3K inhibitor BKM120; pemetrexed disodium; carboplatin; laboratory biomarker analysis; pharmacological study; quality-of-life assessment

City of Hope Medical Center - Recruiting 18 years or older.
- Phase I Trial of BKM120 in Combination With Carboplatin and Pemetrexed in Patients With Advanced Non-Squamous Non-Small Cell Lung Cancer (NSCLC).
PI3K inhibitor BKM120; pemetrexed disodium; carboplatin; laboratory biomarker analysis; pharmacological study; quality-of-life assessment

Adult Supratentorial Primitive Neuroectodermal Tumor (PNET), Ewin Clinical Trial using etoposide; ifosfamide; intensity-modulated radiation therapy; topotecan hydrochloride; busulfan; melphalan; autologous hematopoietic stem cell transplantation; peripheral blood stem cell transplantation; autologous bone marrow transplantation

City of Hope Medical Center - Recruiting 6 Months to 40 years.
- A Pilot Study of Whole-body MRI-guided Intensity Modulated Radiation Therapy Combined With Systemic Chemotherapy Followed by High-Dose Chemotherapy With Busulfan, Melphalan and Topotecan and Stem Cell Rescue in Patients With Poor Risk Ewing's Sarcoma.
etoposide; ifosfamide; intensity-modulated radiation therapy; topotecan hydrochloride; busulfan; melphalan; autologous hematopoietic stem cell transplantation; peripheral blood stem cell transplantation; autologous bone marrow transplantation

Ovarian Cancer, Peritoneal Cavity Cancer, or Unspecified Adult So Clinical Trial using paclitaxel albumin-stabilized nanoparticle formulation; liquid chromatography; mass spectrometry; pharmacological study; laboratory biomarker analysis

City of Hope Medical Center - Recruiting 19 years or older.
- Phase I Trial of Intraperitoneal Nab-Paclitaxel (Abraxane) in the Treatment of Advanced Malignancies Primarily Confined to the Peritoneal Cavity.
paclitaxel albumin-stabilized nanoparticle formulation; liquid chromatography; mass spectrometry; pharmacological study; laboratory biomarker analysis

Perioperative/Postoperative Complications, or Prostate Cancer Clinical Trial using robot-assisted laparoscopic surgery; questionnaire administration; intraoperative complication management/prevention

City of Hope Medical Center - Recruiting 18 years or older.
- A Prospective Randomized Trial of Pelvic Drain Placement Versus no Pelvic Drain Placement After Robotic Assisted Laparoscopic Prostatectomy (RALP) in Patients With Prostate Cancer.
robot-assisted laparoscopic surgery; questionnaire administration; intraoperative complication management/prevention

Breast Cancer Clinical Trial using axillary lymph node dissection; isosulfan blue based lymphatic mapping; quality-of-life assessment; Questionnaire administration

City of Hope Medical Center - Recruiting N/A or older.
- Reducing Extremity Lymphedema Through Axillary Lymphatic Preservation Surgery.
axillary lymph node dissection; isosulfan blue based lymphatic mapping; quality-of-life assessment; Questionnaire administration

Adenocarcinoma of the Prostate, Bone Metastases, Hormone-resistan Clinical Trial using sipuleucel-T; external beam radiation therapy; laboratory biomarker analysis

City of Hope Medical Center - Recruiting 18 years or older.
- Randomized Phase II Trial of Sipuleucel T Immunotherapy Preceded by Sensitizing Radiation Therapy and Sipuleucel-T Alone in Patients With Castrate Resistant Metastatic Prostate Cancer.
sipuleucel-T; external beam radiation therapy; laboratory biomarker analysis

Male Breast Cancer, Recurrent Breast Cancer, or Stage IV Breast C Clinical Trial using paclitaxel albumin-stabilized nanoparticle formulation; questionnaire administration

City of Hope Medical Center - Recruiting 65 years or older.
- Efficacy and Tolerability of Nanoparticle Albumin Bound Paclitaxel (Abraxane) in Patients 65 and Older With Metastatic Breast Cancer.
paclitaxel albumin-stabilized nanoparticle formulation; questionnaire administration

Graft Versus Host Disease, Leukemia, or Lymphoma Clinical Trial using rituximab; fludarabine phosphate; melphalan; sirolimus; tacrolimus; allogeneic hematopoietic stem cell transplantation; indium In 111 ibritumomab tiuxetan; yttrium Y 90 ibritumomab tiuxetan; laboratory biomarker analysis

City of Hope Medical Center - Recruiting 18 years to 69 years.
- A Phase II Study of Allogeneic Hematopoietic Stem Cell Transplant for B-Cell Non-Hodgkin Lymphoma Using Zevalin, Fludarabine and Melphalan.
rituximab; fludarabine phosphate; melphalan; sirolimus; tacrolimus; allogeneic hematopoietic stem cell transplantation; indium In 111 ibritumomab tiuxetan; yttrium Y 90 ibritumomab tiuxetan; laboratory biomarker analysis