Thomas Jefferson University

44 results found.

Pancreaticoduodenectomy Clinical Trial using 3% NaCl Solution; Lactated Ringers Solution

Thomas Jefferson University - Recruiting 18 years or older.
- Prospective Randomized Controlled Trial on the Use of a Restrictive Fluid Regimen With Hypertonic Saline for Patients Undergoing Pancreaticoduodenectomy.
3% NaCl Solution; Lactated Ringers Solution

Stage IV Colorectal Cancer Clinical Trial using Vitamin C

Thomas Jefferson University - Recruiting 18 years or older.
- Phase I/II Study of Intravenous Ascorbic Acid in Combination With Irinotecan Versus Irinotecan Alone for Advanced Colorectal Cancer.
Vitamin C

Pain Clinical Trial using Sternalock Rigid Fixation

Thomas Jefferson University - Recruiting 18 years to 79 years.
- A Prospective Randomized Study of Two Types of Sternal Closure After Open Heart Surgery: Rigid Sternal Fixation vs. Sternal Wire Closure.
Sternalock Rigid Fixation

Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Lymph Clinical Trial using Fludarabine phosphate; Thiotepa; Total body irradiation; Therapeutic allogeneic lymphocytes; Cyclophosphamide; Allogeneic hematopoietic stem cell transplantation (HSCT); Peripheral blood stem cell transplantation; Tacrolimus; Mycophenolate mofetil

Thomas Jefferson University - Recruiting 18 years or older.
- A Two Step Approach to Reduced Intensity Allogeneic Hematopoietic Stem Cell Transplantation for High Risk Hematologic Malignancies.
Fludarabine phosphate; Thiotepa; Total body irradiation; Therapeutic allogeneic lymphocytes; Cyclophosphamide; Allogeneic hematopoietic stem cell transplantation (HSCT); Peripheral blood stem cell transplantation; Tacrolimus; Mycophenolate mofetil

Stage 0/1 Breast Cancer, Post Biopsy, or Pre-surgery Clinical Trial using IV/oral n-acetylcysteine

Thomas Jefferson University - Recruiting 18 years or older.
- Pilot Study of Anti-oxidant Supplementation With N-Acetyl Cysteine in Stage 0/I Breast Cancer.
IV/oral n-acetylcysteine

Onychomycosis Clinical Trial using Pulsed Dye Laser for the treatment of nail fungus

Thomas Jefferson University - Recruiting 18 years to 65 years.
- Pulsed Dye Laser Treatment of Onychomycosis.
Pulsed Dye Laser for the treatment of nail fungus

Mild Cognitive Impairment (MCI) Clinical Trial using Behavioral Activation (BA); Supportive Therapy (ST)

Thomas Jefferson University - Recruiting 65 years or older.
- Preventing Cognitive Decline in African Americans With Mild Cognitive Impairment.
Behavioral Activation (BA); Supportive Therapy (ST)

Non-Hodgkin's Lymphoma Clinical Trial using Bendamustine; Ofatumumab; Carboplatin; Etoposide; CT Scan; PET Scan; Stem Cell Transplant (STC)

Thomas Jefferson University - Recruiting 18 years or older.
- Phase I/II Study of Bendamustine in Combination With Ofatumumab, Carboplatin and Etoposide for Refractory or Relapsed Aggressive B-cell Lymphomas.
Bendamustine; Ofatumumab; Carboplatin; Etoposide; CT Scan; PET Scan; Stem Cell Transplant (STC)

Hyperhydrosis, or Depression Clinical Trial using Glycopyrrolate

Thomas Jefferson University - Recruiting 18 years or older.
- A Pilot Study to Measure and Treat Antidepressant-Induced Excessive Sweating With Glycopyrrolate (AIDES-G).
Glycopyrrolate

Metastatic Hepatocellular Carcinoma, or Advanced Liver Cancer Clinical Trial using Ascorbic Acid + Sorafenib; Sorafenib alone

Thomas Jefferson University - Recruiting 18 years or older.
- Phase I/II Study of Intravenous Ascorbic Acid in Treatment of Metastatic Hepatocellular Carcinoma.
Ascorbic Acid + Sorafenib; Sorafenib alone

Neonatal Abstinence Syndrome Clinical Trial using sublingual buprenorphine; oral morphine

Thomas Jefferson University - Recruiting N/A or older.
- A Randomized, Active-Control, Double-Blind, Double-Dummy Clinical Trial Comparing Sublingual Buprenorphine And Morphine Solution For The Treatment Of Neonatal Opioid Abstinence Syndrome.
sublingual buprenorphine; oral morphine

Stage IV Pancreatic Cancer Clinical Trial using Ascorbic Acid

Thomas Jefferson University - Recruiting 18 years or older.
- Phase II, Open Label Study of Intravenous Ascorbic Acid in Combination With Gemcitabine and Erlotinib in the Treatment of Metastatic Pancreatic Cancer.
Ascorbic Acid

Basal Cell Carcinoma Clinical Trial using Low-Risk BCC Excisional Margins

Thomas Jefferson University - Recruiting N/A or older.
- Long Term Prospective Study Evaluating Effectiveness of Narrow Margins for Low-Risk Facial Basl Cell Carcinomas.
Low-Risk BCC Excisional Margins

Pancreatic Neoplasms, Biliary Tract Neoplasms, Pancreatitis, Chro Clinical Trial using pancreaticojejunostomy

Thomas Jefferson University - Recruiting 18 years or older.
- A Randomized Trial of Two Surgical Techniques for Pancreaticojejunostomy in Patients Undergoing Pancreaticoduodenectomy.
pancreaticojejunostomy

Neonatal Abstinence Syndrome Clinical Trial using oral morphine; sublingual buprenorphine

Thomas Jefferson University - Recruiting N/A or older.
- A Randomized, Open Label Clinical Trial of Buprenorphine in the Treatment of Neonatal Abstinence Syndrome in Infants With In Utero Exposure to Benzodiazepines or Are Breastfeeding.
oral morphine; sublingual buprenorphine

Breast Cancer Clinical Trial using 3D HI and SHI of ultrasound contrast agent

Thomas Jefferson University - Recruiting 18 years or older.
- Quantitative Subharmonic Breast Imaging.
3D HI and SHI of ultrasound contrast agent

Pancreatic Fistula, Distal Pancreatectomy Complications, Falcifor Clinical Trial using Falciform patch and fibrin glue application; standard pancreatic closure

Thomas Jefferson University - Recruiting 18 years or older.
- A Prospective Randomized Comparison of Pancreatic Stump Closure Techniques Utilizing an Autologous Falciform Patch and Fibrin Glue Compared to Standard Closure Following Distal Pancreatectomy With or Without Splenectomy.
Falciform patch and fibrin glue application; standard pancreatic closure

Age-related Macular Degeneration, or Depression Clinical Trial using BA-LVR; ST-LVR

Thomas Jefferson University - Recruiting 65 years or older.
- Low Vision Depression Prevention Trial for Age Related Macular Degeneration.
BA-LVR; ST-LVR

Breast Cancer Clinical Trial

Thomas Jefferson University - Recruiting 18 years or older.
- Tumor Suppressor Status as a Predictor of Chemotherapy Response in Triple Negative Breast Cancer..

Hematologic Malignancy, Leukemia, Acute Lymphoblastic Leukemia, A Clinical Trial using Total Body Irradiation (TBI); Donor Lymphocyte Infusion (DLI); Cyclophosphamide (CY); Tacrolimus; Mycophenolate Mofetil (MMF); Hematopoietic Stem Cell Transplant (HSCT)

Thomas Jefferson University - Recruiting 18 years or older.
- A Two Step Approach to Allogeneic Hematopoietic Stem Cell Transplantation for High-Risk Hematologic Malignancies Using Two Related Donors.
Total Body Irradiation (TBI); Donor Lymphocyte Infusion (DLI); Cyclophosphamide (CY); Tacrolimus; Mycophenolate Mofetil (MMF); Hematopoietic Stem Cell Transplant (HSCT)

Side Effects of Calcineurin Inhibitors, Renal Toxicity, Hepatic F Clinical Trial using Liver biopsy

Thomas Jefferson University - Recruiting 18 years or older.
- Sirolimus Switching From Calcinurin Inhibitors (CNI) 90 - 180 Days After Liver Transplantation.
Liver biopsy

Estrogen Receptor-negative Breast Cancer, HER2-negative Breast Ca Clinical Trial using Paclitaxel; Carboplatin; Doxorubicin; Cyclophosphamide; Veliparib

Thomas Jefferson University - Recruiting 18 years or older.
- An Adaptive, Randomized Phase II Trial to Determine Pathologic Complete Response With the Addition of Carboplatin With and Without Veliparib to Standard Chemotherapy in the Neoadjuvant Treatment of Triple-Negative Breast Cancer.
Paclitaxel; Carboplatin; Doxorubicin; Cyclophosphamide; Veliparib

Ductal Breast Carcinoma in Situ, Invasive Ductal Breast Carcinoma Clinical Trial using Behavioral dietary intervention; Therapeutic conventional surgery; Radiation therapy; Counseling intervention; Quality-of-life assessment

Thomas Jefferson University - Recruiting 18 years or older.
- A Feasibility Pilot Trial Evaluating Caloric Restriction for Oncology Research in Early Stage Breast Cancer Patients.
Behavioral dietary intervention; Therapeutic conventional surgery; Radiation therapy; Counseling intervention; Quality-of-life assessment

Sickle Cell Anemia, Sickle Cell-hemoglobin C Disease, or Sickle C Clinical Trial using Fludarabine; Cytarabine; Cellular Infusions; Total Body Irradiation; Cyclophosphamide; Bortezomib; Rituximab; Plasmapheresis

Thomas Jefferson University - Recruiting 18 years to 45 years.
- Reduced Intensity Allogeneic Hematopoietic Stem Cell Transplantation for Sickle Cell Anemia From HLA Matched or Partially-Matched Related Donors.
Fludarabine; Cytarabine; Cellular Infusions; Total Body Irradiation; Cyclophosphamide; Bortezomib; Rituximab; Plasmapheresis

Anemia, Hematopoietic/Lymphoid Cancer, Lymphopenia, Neutropenia, Clinical Trial using Allogeneic hematopoietic stem cell transplantation; Peripheral blood stem cell transplantation; Management of therapy complications

Thomas Jefferson University - Recruiting 18 years or older.
- Compassionate Use of the CliniMACSr CD34 Reagent System for Patients Requiring a Post Hematopoietic Stem Cell Transplant Boost of Donor Hematopoietic Stem Cells.
Allogeneic hematopoietic stem cell transplantation; Peripheral blood stem cell transplantation; Management of therapy complications

Advanced Hepatocellular Carcinoma, HCC, or Liver Cancer Clinical Trial using PD-0332991

Thomas Jefferson University - Recruiting 18 years or older.
- A Phase II Study of PD-0332991 in Adult Patients With Advanced Hepatocellular Carcinoma.
PD-0332991

Prostate Cancer Clinical Trial using Cabazitaxel; Intensity Modulated Radiation Therapy (IMRT); Anti-Androgen Therapy: Bicalutamide; Luteinizing Hormone-Releasing Hormone (LHRH) Agonist

Thomas Jefferson University - Recruiting 18 years or older.
- Phase I Trial of Weekly Cabazitaxel With Concurrent Intensity Modulated Radiation Therapy and Androgen Deprivation Therapy for the Treatment of Locally Advanced High Risk Adenocarcinoma of the Prostate.
Cabazitaxel; Intensity Modulated Radiation Therapy (IMRT); Anti-Androgen Therapy: Bicalutamide; Luteinizing Hormone-Releasing Hormone (LHRH) Agonist

Pancreatic Cancer Clinical Trial using Alcohol Block

Thomas Jefferson University - Recruiting 18 years or older.
- A Randomized, Controlled Trial of Intraoperative Celiac Plexus Neurolysis for Patients With Operable (Resectable and Unresectable) Pancreatic and Periampullary Cancer.
Alcohol Block

Episodic Migraine Clinical Trial using saline placebo; Ibuprofen

Thomas Jefferson University - Recruiting 18 years to 65 years.
- .
saline placebo; Ibuprofen

Hematologic Malignancy Clinical Trial using Total Body Irradiation (TBI); Donor Lymphocyte Infusion (DLI); Cyclophosphamide; Stem Cell Infusion

Thomas Jefferson University - Recruiting 18 years or older.
- A Two Step Approach to Allogeneic Hematopoietic Stem Cell Transplantation for High-Risk Hematologic Malignancies From One Versus Two HLA Partially-Matched Related Donors.
Total Body Irradiation (TBI); Donor Lymphocyte Infusion (DLI); Cyclophosphamide; Stem Cell Infusion

Hematological Malignancies Clinical Trial using Total Body Irradiation; Cyclophosphamide; Tacrolimus; Mycophenolate mofetil; Fludarabine; Thiotepa; Hematopoietic stem cell transplantation

Thomas Jefferson University - Recruiting 18 years or older.
- Post Transplant Cyclophosphamide for Unrelated and Related Allogeneic Hematopoietic Stem Cell Transplantation for Hematological Malignancies.
Total Body Irradiation; Cyclophosphamide; Tacrolimus; Mycophenolate mofetil; Fludarabine; Thiotepa; Hematopoietic stem cell transplantation

Complete Traumatic Spinal Cord Injury Clinical Trial using Zoledronic acid; normal saline 0.9%

Thomas Jefferson University - Recruiting 18 years to 65 years.
- Zoledronic Acid to Prevent Bone Loss After Acute Spinal Cord Injury.
Zoledronic acid; normal saline 0.9%

Migraine Clinical Trial using STOPAIN topical gel

Thomas Jefferson University - Recruiting 18 years to 65 years.
- A Study to Evaluate the Efficacy and Tolerability of STOPAIN in the Treatment of a Single Migraine Attack.
STOPAIN topical gel

Malignant Neoplasm Clinical Trial using Total-body irradiation; Donor lymphocytes infusion (DLI); Cyclophosphamide; Allogeneic hematopoietic stem cell transplantation (HSCT); Tacrolimus; Mycophenolate mofetil

Thomas Jefferson University - Recruiting 18 years or older.
- A Two Step Approach to Haploidentical Hematopoietic Stem Cell Transplantation for Patients in Remission From HLA Partially-Matched Related Donors-Effect of Maternal Donors on Outcomes.
Total-body irradiation; Donor lymphocytes infusion (DLI); Cyclophosphamide; Allogeneic hematopoietic stem cell transplantation (HSCT); Tacrolimus; Mycophenolate mofetil

Recurrent Melanoma, Stage IV Melanoma, or Tumors Metastatic to Br Clinical Trial using Ipilimumab; Whole-Brain Radiation Therapy (WBRT); Stereotactic Radiosurgery (SRS)

Thomas Jefferson University - Recruiting 18 years or older.
- Phase I Study of Ipilimumab Combined With Whole Brain Radiation Therapy or Radiosurgery for Melanoma Patients With Brain Metastases.
Ipilimumab; Whole-Brain Radiation Therapy (WBRT); Stereotactic Radiosurgery (SRS)

Pain Clinical Trial using intrathecal hydromorphone (IT hydromorphone)

Thomas Jefferson University - Recruiting 18 years or older.
- Intrathecal (IT) Hydromorphone for Cesarean Section (C/S): A Dose Finding Study.
intrathecal hydromorphone (IT hydromorphone)

Pain Clinical Trial using oral acetaminophen; intravenous acetaminophen

Thomas Jefferson University - Recruiting 18 years to 65 years.
- Prospective, Randomized, Double-blind, Placebo-Controlled Study to Compare the Effects of Intravenous Versus Oral Acetaminophen on Postoperative Clinical Outcomes After Ambulatory Lumbar Discectomy.
oral acetaminophen; intravenous acetaminophen

Castrate Resistant Prostate Cancer, Chemotherapy Naive Prostate C Clinical Trial using Pasireotide; Everolimus; Laboratory biomarker analysis

Thomas Jefferson University - Recruiting 18 years or older.
- An Open Label Randomized Phase II Study of SOM230 and Everolimus in Castrate-Resistant, Chemotherapy-Na‹ve Prostate Cancer Patients.
Pasireotide; Everolimus; Laboratory biomarker analysis

Preterm Premature Rupture of Membranes Clinical Trial using indomethacin

Thomas Jefferson University - Recruiting 15 years to 50 years.
- A Double-blinded Randomized Controlled Trial With Indomethacin Versus Placebo in Women With Preterm Premature Rupture of Membranes (PPROM) Between 24 and 32 Weeks Gestation.
indomethacin

Peripheral Artery Disease, or Hypertension Clinical Trial using nebivolol; Metoprolol succinate

Thomas Jefferson University - Recruiting 18 years or older.
- Effect of Nebivolol Compared With Metoprolol in Hypertensive Patients With Peripheral Arterial Disease.
nebivolol; Metoprolol succinate

Shoulder Pain Clinical Trial using interscalene nerve catheter

Thomas Jefferson University - Recruiting 18 years or older.
- Comparison of In-Plane vs. Out-of-Plane Ultrasound-Guided Approach for Interscalene Nerve Catheters: a Prospective, Randomized Trial.
interscalene nerve catheter

Uncontrolled Postoperative Pain Clinical Trial using 0.375% ROPIVACAINE

Thomas Jefferson University - Recruiting 18 years to 40 years.
- Can Post-operative TAP Block Improve Quality of Recovery After C-sections in Patients on Methadone Maintenance Therapy for Opioid Abstinence?.
0.375% ROPIVACAINE

Heart Failure Clinical Trial

Thomas Jefferson University - Recruiting 60 years or older.
- How the Elderly Live With Pain in Heart Failure.

Adult Acute Megakaryoblastic Leukemia (M7), Adult Acute Monoblast Clinical Trial using Sirolimus; Idarubicin; Cytarabine

Thomas Jefferson University - Recruiting 18 years or older.
- A Pilot, Pharmacodynamic Correlate Trial of Sirolimus in Combination With Chemotherapy (Idarubicin, Cytarabine) for the Treatment of Newly Diagnosed Acute Myelogenous Leukemia.
Sirolimus; Idarubicin; Cytarabine