Yale University

57 results found.

De Novo Autoimmune Hepatitis Clinical Trial using Pediatric transplant subject with d-AIH; Pediatric transplant subject with acute rejection; Pediatric transplant subject with chronic rejection; Adult non-transplant patients with auto-immune hepatitis; Adult non-transplant subjects with chronic hepatitis C virus; Pediatric control subjects

Yale University - Recruiting 3 Months to 50 years.
- De Novo Autoimmune Hepatitis in Pediatric Liver Transplantation.
Pediatric transplant subject with d-AIH; Pediatric transplant subject with acute rejection; Pediatric transplant subject with chronic rejection; Adult non-transplant patients with auto-immune hepatitis; Adult non-transplant subjects with chronic hepatitis C virus; Pediatric control subjects

Hypoglycemia Clinical Trial using Norepinephrine Transporter (NET) ligand

Yale University - Recruiting 18 years to 55 years.
- Evaluation of the Effect of Hypoglycemia on the Noradrenergic System With PET and a Highly Selective Norepinephrine Transporter Ligand.
Norepinephrine Transporter (NET) ligand

Opiate Dependence Clinical Trial using Vivitrol; Naltrexone (oral); BDRC; Medical Management

Yale University - Recruiting 18 years to 65 years.
- Naltrexone and Behavioral Drug and HIV Risk Reduction Counseling in Russia.
Vivitrol; Naltrexone (oral); BDRC; Medical Management

Opiate Dependence Clinical Trial using Behavioral Drug and HIV Risk Reduction Counseling; Educational Counseling; Treatment as Usual

Yale University - Recruiting 20 years to 65 years.
- Behavioral Drug and HIV Risk Reduction Counseling With MMT in China.
Behavioral Drug and HIV Risk Reduction Counseling; Educational Counseling; Treatment as Usual

Bacteriuria Clinical Trial using 2 cranberry capsules; Placebo

Yale University - Recruiting 65 years or older.
- A Randomized, Controlled Trial of Cranberry Capsules for UTI Prevention in Nursing Home Residents.
2 cranberry capsules; Placebo

Healthy Clinical Trial using Intravenous Ethanol; Intravenous Nicotine; Intravenous Placebo

Yale University - Recruiting 21 years to 50 years.
- A Laboratory Study on the Interactive Effects of IV Ethanol and IV Nicotine on Subjective Effects and Cognition.
Intravenous Ethanol; Intravenous Nicotine; Intravenous Placebo

Smoking Cessation Clinical Trial using Active Comparator App/Training; Experimental App/Training

Yale University - Recruiting 18 years to 65 years.
- .
Active Comparator App/Training; Experimental App/Training

Alcoholism Clinical Trial using mecamylamine

Yale University - Recruiting 18 years to 60 years.
- Treatment With Mecamylamine in Smoking and Non-smoking Alcohol Dependent Patients.
mecamylamine

Post-traumatic Stress Disorder, or Alcohol Dependence Clinical Trial using stress

Yale University - Recruiting 21 years to 65 years.
- Stress Reactivity in Veterans Receiving Pharmacological Treatment for Post-traumatic Stress Disorder (PTSD) and Alcohol Dependence.
stress

Parenting Capacities of Substance Abusing Mothers Clinical Trial using Mentalization-Based Therapy for Substance Abusing Mothers; Parent Education

Yale University - Recruiting 21 years to 45 years.
- Fostering Mothers' Emotionally-Responsive Parenting.
Mentalization-Based Therapy for Substance Abusing Mothers; Parent Education

Acinar Cell Adenocarcinoma of the Pancreas, Duct Cell Adenocarcin Clinical Trial using oxaliplatin; leucovorin calcium; irinotecan hydrochloride; fluorouracil; therapeutic conventional surgery; laboratory biomarker analysis

Yale University - Recruiting 18 years or older.
- Phase II Study of Peri-Operative Modified Folfirinox in Localized Pancreatic Cancer.
oxaliplatin; leucovorin calcium; irinotecan hydrochloride; fluorouracil; therapeutic conventional surgery; laboratory biomarker analysis

Alcohol Dependence, or Stress Disorders, Post-Traumatic Clinical Trial using Prazosin

Yale University - Recruiting 21 years to 65 years.
- The Use of Prazosin for Treatment of Patients With Alcohol Dependence (AD) and Post Traumatic Stress Disorder (PTSD)..
Prazosin

Mental Illness Clinical Trial using Mentalization based therapy

Yale University - Recruiting 18 years to 65 years.
- Feasibility Study of a Mentalization-based Parenting Program for Female Caregivers Involved in Mental Health Services..
Mentalization based therapy

Depression Clinical Trial using Ketamine

Yale University - Recruiting 21 years to 65 years.
- Examining The Effect Of Ketamine On Glutamate/Glutamine Cycling.
Ketamine

Chronic Diseases, or Obesity Clinical Trial using DISTRICT WELLNESS COMMITTEE; NUTRITIONAL QUALITY OF FOODS AND BEVERAGES ON CAMPUS; HEALTH PROMOTION AND MARKETING; OPPORTUNITIES FOR PHYSICAL ACTIVITY

Yale University - Recruiting 9 years to 14 years.
- School Wellness Policy: RCT to Implement & Evaluate Impact on Childhood Obesity.
DISTRICT WELLNESS COMMITTEE; NUTRITIONAL QUALITY OF FOODS AND BEVERAGES ON CAMPUS; HEALTH PROMOTION AND MARKETING; OPPORTUNITIES FOR PHYSICAL ACTIVITY

Metastatic Pancreatic Cancer, or Pancreatic Cancer Clinical Trial using Folfirinox

Yale University - Recruiting 18 years or older.
- Phase II Study of Modified FOLFIRINOX in Advanced Pancreatic Cancer.
Folfirinox

Toxic Epidermal Necrolysis, or Stevens-Johnson Syndrome Clinical Trial using Palifermin

Yale University - Recruiting 18 years or older.
- Palifermin Treatment of Toxic Epidermal Necrolysis.
Palifermin

Depression Clinical Trial using Riluzole; placebo

Yale University - Recruiting 18 years to 65 years.
- Efficacy and Tolerability of Riluzole in Treatment Resistant Depression.
Riluzole; placebo

Type 1 Diabetes Clinical Trial using ePID closed loop system; InsuPatch

Yale University - Recruiting 12 years to 40 years.
- Effect of the Insupatch on Automated Closed-loop Glucose Control in Type 1 Diabetes.
ePID closed loop system; InsuPatch

Chronic Pain, Opioid Addiction, or Symptomatic Hypogonadism Clinical Trial using Testosterone replacement; Waitlist control

Yale University - Recruiting 18 years to 50 years.
- Testosterone Replacement for Male Opioid Agonist Maintained Patients.
Testosterone replacement; Waitlist control

Obesity, or Binge Eating Clinical Trial using Sibutramine; Placebo; Self-help CBT + Sibutramine; Self-help CBT + Placebo

Yale University - Recruiting 18 years to 60 years.
- Treatment of Binge Eating in Obese Patients in Primary Care.
Sibutramine; Placebo; Self-help CBT + Sibutramine; Self-help CBT + Placebo

Alcohol Dependence Clinical Trial using Prazosin; placebo

Yale University - Recruiting 18 years to 55 years.
- Prazosin to Reduce Stress-Induced Alcohol/Drug Craving and Relapse.
Prazosin; placebo

COMT Gene Polymorphism Clinical Trial using delta 9 tetrahydrocannabinol

Yale University - Recruiting 18 years to 55 years.
- Pharmacogenetics of Cannabinoid Response.
delta 9 tetrahydrocannabinol

Pancreatitis Clinical Trial using Indomethacin; Placebo suspension

Yale University - Recruiting 18 years or older.
- A Prospective, Multicenter, Randomized, Double-Blind Controlled Study to Determine Whether a Single Dose of Intraduodenal Indomethacin Can Decrease the Incidence and Severity of Post-ERCP Pancreatitis.
Indomethacin; Placebo suspension

Graft Versus Host Disease, Leukemia, or Myelodysplastic Syndromes Clinical Trial using Fludarabine Phosphate; Tacrolimus; Thiotepa; Total-Body Irradiation (TBI); Magnetic Affinity Cell Sorting; Peripheral Blood Stem Cell Transplantation; Allogeneic Hematopoietic Stem Cell Transplantation; T Cell-Depleted Hematopoietic Stem Cell Transplantation

Yale University - Recruiting 14 years to 55 years.
- A Multi-center Phase II Study of Selective Depletion of CD45RA+ T Cells From Allogeneic Peripheral Blood Stem Cell Grafts for the Prevention of GVHD.
Fludarabine Phosphate; Tacrolimus; Thiotepa; Total-Body Irradiation (TBI); Magnetic Affinity Cell Sorting; Peripheral Blood Stem Cell Transplantation; Allogeneic Hematopoietic Stem Cell Transplantation; T Cell-Depleted Hematopoietic Stem Cell Transplantation

Polycystic Ovarian Syndrome Clinical Trial using Endometrin (progesterone 100mg vaginal inserts); Metformin

Yale University - Recruiting 18 years to 42 years.
- Endometrial Effects of Metformin Action in Women With Polycystic Ovarian Syndrome (PCOS).
Endometrin (progesterone 100mg vaginal inserts); Metformin

Hyperglycemia Clinical Trial

Yale University - Recruiting 18 years or older.
- Continuous Glucose Monitoring in Critically Ill Surgical Patients.

Substance Abuse, Substance Dependence, or Cognitive Impairment Clinical Trial using Cognitive Training + Work Therapy; Work Therapy

Yale University - Recruiting 18 years or older.
- Cognitive Remediation and Work Therapy in the Initial Phase of Substance Abuse Treatment.
Cognitive Training + Work Therapy; Work Therapy

Chronic Lymphocytic Leukemia Clinical Trial using Maintenance lenalidomide

Yale University - Recruiting 18 years to 90 years.
- Maintenance Therapy With Lenalidomide Following Bendamustine and Rituximab Induction Therapy for Chronic Lymphocytic Leukemia.
Maintenance lenalidomide

Behavioral Problems, Cognitive Problems, or Motor Development Clinical Trial

Yale University - Recruiting 4 years to 65 years.
- Yale Pink and Blue Kids: Effects of in Utero Exposure to Nicotine and Selective Serotonin Reuptake Inhibitors in 4-8 Year Old Children.

COPD Clinical Trial using Transcutaneous Electrical Muscle Stimulation (TCEMS)

Yale University - Recruiting N/A to 75 years.
- Rehabilitation of Patients With COPD Using Electrical Muscle Stimulation.
Transcutaneous Electrical Muscle Stimulation (TCEMS)

Cannabis, or Psychotic Disorders Clinical Trial using THC; Placebo

Yale University - Recruiting 21 years to 35 years.
- Cannabinoids and Cerebellar-Motor Functioning.
THC; Placebo

Type 1 Diabetes Clinical Trial using Exenatide

Yale University - Recruiting 18 years to 56 years.
- A Pilot Study to Determine the Effects of a Single Dose of Exenatide (Byetta r) on the Acute Metabolic Responses to a Mixed Meal or Intravenous Glucose Tolerance Test in Patients With Type 1 Diabetes.
Exenatide

Type 1 Diabetes Clinical Trial using ePID closed loop system; liraglutide

Yale University - Recruiting 18 years to 40 years.
- Effect of Liraglutide on Automated Closed-loop Glucose Control in Type 1 Diabetes.
ePID closed loop system; liraglutide

Hypertension, Substance Abuse, Asthma, or Depression Clinical Trial

Yale University - Recruiting 18 years or older.
- Transitions Clinic Network: Linking High-Risk Medicaid Patients From Prison to Community Primary Care.

Bipolar Depression Clinical Trial using ceftriaxone; Saline solution

Yale University - Recruiting 18 years to 65 years.
- Modulation of Glutamatergic Neurotransmission in the Treatment of Bipolar Depression.
ceftriaxone; Saline solution

Acute Myocardial Infarction Clinical Trial

Yale University - Recruiting 18 years or older.
- Measurement of Matrix Metalloproteinase Activation Post Myocardial Infarction.

Schizophrenia, or Schizoaffective Disorder Clinical Trial using Cannabidiol; Placebo

Yale University - Recruiting 18 years to 65 years.
- Cannabinoid Receptor Antagonist Treatment of Cognitive Dysfunction in Schizophrenia.
Cannabidiol; Placebo

Biological Clock Dysfunction, or Optic Nerve Hypoplasia Clinical Trial using Melatonin; Placebo Comparator

Yale University - Recruiting 2 years to 10 years.
- Identification and Treatment of Biological Clock Dysfunction in Optic Nerve Hypoplasia.
Melatonin; Placebo Comparator

Nicotine Dependence Clinical Trial using Cognitive Behavioural Therapy; Contingency Management; Nicotine Transdermal Patch

Yale University - Recruiting 14 years to 19 years.
- Contingency Management for Smoking Cessation in Adolescent Smokers - Phase IV, Enhancing a High School Based Smoking Cessation Program.
Cognitive Behavioural Therapy; Contingency Management; Nicotine Transdermal Patch

HIV, AIDS, Opioid Dependence, or Drug Dependence Clinical Trial using Depot Naltrexone

Yale University - Recruiting 18 years or older.
- Naltrexone for Opioid Dependent Released Human Immunodeficiency Virus Positive (HIV+) Criminal Justice Populations.
Depot Naltrexone

Chronic Stress Clinical Trial

Yale University - Recruiting 18 years to 50 years.
- The Role of Stress in Self-Control, Coping and Emotion Regulation.

Alcohol Drinking Clinical Trial using Naltrexone

Yale University - Recruiting 21 years to 50 years.
- Kappa-PET Imaging and Naltrexone in Alcohol Drinking Behaviors.
Naltrexone

Cystic Fibrosis Clinical Trial

Yale University - Recruiting 3 Months to 4 years.
- Microbiome Acquisition and Progression of Inflammation and Airway Disease in Infants and Children With Cystic Fibrosis.

Cocaine Dependence, or Impulsivity Clinical Trial using cocaine hydrochloride; methylphenidate

Yale University - Recruiting 18 years to 50 years.
- Impulsivity and Stimulant Administration.
cocaine hydrochloride; methylphenidate

Cancer, Cardiovascular Disease, Diabetes, or Non Communicable Chr Clinical Trial

Yale University - Recruiting 40 years or older.
- Eastern Caribbean Health Outcomes Research Network (ECHORN).

Glioblastoma Multiforme Clinical Trial using dynamic contrast enhanced magnetic resonance imaging

Yale University - Recruiting 18 years to 80 years.
- Early Detection of Glioblastoma Multiforme (GBM) Treatment Responses Using Multiple Magnetic Resonance Modalities.
dynamic contrast enhanced magnetic resonance imaging

Alcoholism Clinical Trial using THC; Placebo

Yale University - Recruiting 18 years to 30 years.
- Cannabinoid Receptor Function & Alcoholism: Effects of ë-9-THC.
THC; Placebo

Advanced Breast Cancer Clinical Trial using Vorinostat

Yale University - Recruiting 18 years or older.
- A Dose-Escalating and Phase II Clinical Trial of the Histone Deacetylase (HDAC) Inhibitor Vorinostat (Suberoylanilide Hydroxamic Acid, SAHA, ZolinzaTM) in Combination With Capecitabine (XelodaTM) Using a New Weekly Dose Regimen for Advanced Breast Cancer.
Vorinostat

Cocaine Dependence Clinical Trial using Galantamine; placebo

Yale University - Recruiting 18 years to 50 years.
- Galantamine to Enhance Cognitive Behavioral Therapy for Cocaine Abuse With Methadone Maintained Individuals.
Galantamine; placebo

Adenoma Clinical Trial using nurse observation during colonoscope withdrawal

Yale University - Recruiting 30 years or older.
- The Impact of Active Nurse Participation on Adenoma Detection During Routine Colonoscopy.
nurse observation during colonoscope withdrawal

Kidney; Complications, Allograft Clinical Trial using eculizumab

Yale University - Recruiting 18 years to 65 years.
- Eculizumab Therapy for Chronic Complement-Mediated Injury in Kidney Transplantation: A Randomized, Open-Label, Pilot Intervention Trial.
eculizumab

Diabetes Mellitus, Type 1 Clinical Trial

Yale University - Recruiting 10 years to 37 years.
- ITN0127AI Autoimmunity-blocking Antibody for Tolerance in Recently Diagnosed Type 1 Diabetes (AbATE) Follow-Up Study.

Psychosis, or Schizophrenia Clinical Trial using Early Detection (ED); Usual Detection

Yale University - Recruiting 16 years to 35 years.
- STEP-ED: Reducing Duration of Untreated Psychosis and Its Impact in the U.S..
Early Detection (ED); Usual Detection

Obsessive-Compulsive Disorder Clinical Trial using N-Acetylcysteine; Placebo

Yale University - Recruiting 8 years to 17 years.
- Double-Blind, Placebo-Controlled Trial of N-acetylcysteine (NAC) for the Treatment of Pediatric Obsessive-Compulsive Disorder.
N-Acetylcysteine; Placebo

Alcoholism, Alcohol Abuse, Smoking, or Alcohol Drinking Clinical Trial using Varenicline

Yale University - Recruiting 18 years to 70 years.
- 1/2-Multi-site Study: Varenicline Treatment of Alcohol Dependent Smokers.
Varenicline

Tourette Disorder, or Tourette Syndrome Clinical Trial using placebo; extended-release guanfacine (Intuniv)

Yale University - Recruiting 6 years to 17 years.
- Guanfacine in Children With Tic Disorders: A Multi-site Study.
placebo; extended-release guanfacine (Intuniv)