96 results found.

Leukemia, Lymphoblastic, Acute Clinical Trial using Geriatric assessment adapted therapy; Stem cells autotransplantation

Gruppo Italiano Malattie EMatologiche dell'Adulto - Recruiting 60 years or older.
- 'Geriatric Assessment Adapted' Therapy for Ph- ALL Elderly Patients. GIMEMA Protocol LAL1104. EudraCT Code 2005-002156-17.
Geriatric assessment adapted therapy; Stem cells autotransplantation

Relapsed/Refractory Philadelphia Positive B-precursor Acute Lymph Clinical Trial using Blinatumomab

Amgen - Recruiting 18 years or older.
- A Phase 2 Single Arm, Multicenter Trial to Evaluate the Efficacy of the BiTE Antibody Blinatumomab in Adult Subjects With Relapsed/Refractory Philadelphia Positive B-precursor Acute Lymphoblastic Leukemia (Alcantara Study).
Blinatumomab

B-cell Childhood Acute Lymphoblastic Leukemia, Peripheral T-cell Clinical Trial using dexamethasone; mitoxantrone hydrochloride; temsirolimus; vincristine sulfate; pegaspargase; methotrexate; laboratory biomarker analysis; pharmacological study

National Cancer Institute (NCI) - Recruiting 1 year to 21 years.
- A Phase 1 Study of Temsirolimus in Combination With Intensive Re-Induction Therapy for Children With Relapsed Acute Lymphoblastic Leukemia and Non-Hodgkin Lymphoma.
dexamethasone; mitoxantrone hydrochloride; temsirolimus; vincristine sulfate; pegaspargase; methotrexate; laboratory biomarker analysis; pharmacological study

Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, Burkitt Lym Clinical Trial using CPX-351

Children's Hospital Medical Center, Cincinnati - Recruiting 12 Months to 30 years.
- A Phase I/Pilot Study of CPX-351 for Children, Adolescents and Young Adults With Recurrent or Refractory Hematologic Malignancies.
CPX-351

Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia, or Myelodys Clinical Trial using Allopurinol; Keppra; Busulfan; Cyclophosphamide; Cyclosporine A; Mycophenolate mofetil; Allogeneic hematopoietic stem cell transplant; Filgrastim; antithymocyte globulin

Masonic Cancer Center, University of Minnesota - Recruiting N/A to 44 years.
- Busulfan and Cyclophosphamide Followed By Allogeneic Hematopoietic Cell Transplantation In Patients With Hematological Malignancies.
Allopurinol; Keppra; Busulfan; Cyclophosphamide; Cyclosporine A; Mycophenolate mofetil; Allogeneic hematopoietic stem cell transplant; Filgrastim; antithymocyte globulin

Osteonecrosis, Acute Lymphoblastic Leukaemia, or Lymphoblastic Ly Clinical Trial

Heinrich-Heine University, Duesseldorf - Recruiting 10 years to 18 years.
- Part I: Incidence, Clinical Course and Significance of MRI for Early Diagnosis of Osteonecrosis in Children and Adolescents With Acute Lymphoblastic Leukemia (ALL) or Lymphoblastic Lymphoma (LBL) Part II: Susceptibility for Aseptic Osteonecroses in Children and Adolescents With Chemotherapy for ALL or LBL.

Relapsed B-Cell Acute Lymphoblastic Leukemia Clinical Trial using leukapheresis or collection of PBMCs; cyclophosphamide; modified T cells

Memorial Sloan-Kettering Cancer Center - Recruiting N/A to 26 years.
- A Phase I Trial of Autologous T-Lymphocytes Genetically Targeted to the B-Cell Specific Antigen CD19 in Pediatric and Young Adult Patients With Relapsed B-Cell Acute Lymphoblastic Leukemia.
leukapheresis or collection of PBMCs; cyclophosphamide; modified T cells

Adult Acute Lymphoblastic Leukemia Clinical Trial using Vincristine Sulfate Liposome; Vincristine Sulfate

Nanjing Luye Sike Pharmaceutical Co.,Ltd. - Recruiting 18 years to 65 years.
- Phase III Study of Vincristine Sulfate Liposome Or Vincristine Sulfate For Injection Combined Chemotherapy as Initial Induction Regimen In Adults Acute Lymphoblastic Leukemia.
Vincristine Sulfate Liposome; Vincristine Sulfate

Leukemia Clinical Trial using Daunorubicin; Vincristine; Prednisone; PEG-Asparaginase; Methotrexate; 6-MP (6-Mercaptopurine); Cyclophosphamide; Cytarabine; Leucovorin; Dexamethasone

Memorial Sloan-Kettering Cancer Center - Recruiting 18 years to 60 years.
- A Novel 'Pediatric-Inspired' Regimen With Reduced Myelosuppressive Drugs for Adults (Aged 18-60) With Newly Diagnosed Ph Negative Acute Lymphoblastic Leukemia.
Daunorubicin; Vincristine; Prednisone; PEG-Asparaginase; Methotrexate; 6-MP (6-Mercaptopurine); Cyclophosphamide; Cytarabine; Leucovorin; Dexamethasone

Acute Myeloid Leukemia With Multilineage Dysplasia Following Myel Clinical Trial using fludarabine phosphate; cyclophosphamide; total-body irradiation; iodine I 131 monoclonal antibody BC8; allogeneic bone marrow transplantation; tacrolimus; mycophenolate mofetil

Fred Hutchinson Cancer Research Center - Recruiting 18 years or older.
- Hematopoietic Bone Marrow Transplantation for Patients With High-Risk Acute Myeloid Leukemia (AML), Acute Lymphoblastic Leukemia (ALL), or Myelodysplastic Syndrome (MDS) Using Related HLA-Mismatched Donors: A Trial Using Radiolabeled Anti-CD45 Antibody Combined With Immunosuppression Before and After Transplantation.
fludarabine phosphate; cyclophosphamide; total-body irradiation; iodine I 131 monoclonal antibody BC8; allogeneic bone marrow transplantation; tacrolimus; mycophenolate mofetil

Acute Lymphoblastic Leukemia Clinical Trial using VDCLD regimen

Changzhou Jinyuan Pharmaceutical Manufacturing Co., Ltd. - Recruiting 14 years to 60 years.
- Pegylated Liposomal Doxorubicin-contained Versus Daunorubicin-contained VDCLD Regimen in Previously Untreated Adult Patients With Acute Lymphoblastic Leukemia: Complete Remission Rates and Changes of Leukemia Stem Cells.
VDCLD regimen

B-cell Childhood Acute Lymphoblastic Leukemia, Cognitive/Function Clinical Trial using cognitive assessment; psychosocial assessment and care; diffusion tensor imaging; laboratory biomarker analysis; pharmacological study

Children's Oncology Group - Recruiting 1 year to 17 years.
- A Study of Neurocognitive Function in Children Treated for ALL.
cognitive assessment; psychosocial assessment and care; diffusion tensor imaging; laboratory biomarker analysis; pharmacological study

Adult Acute Lymphoblastic Leukemia in Remission, Adult Nasal Type Clinical Trial using dasatinib; pharmacological study

National Cancer Institute (NCI) - Recruiting 18 years or older.
- Phase I Pharmacokinetic Study of Dasatinib (BMS-354825) (NSC-732517; IND-73969) in Patients With Advanced Malignancies and Varying Levels of Liver Dysfunction.
dasatinib; pharmacological study

Adult Subjects With Relapsed/Refractory B-precursor Acute Lymphob Clinical Trial using Blinatumomab; Standard of Care Chemotherapy

Amgen - Recruiting 18 years or older.
- A Phase 3, Randomized, Open Label Study Investigating the Efficacy of the BiTE Antibody Blinatumomab Versus Standard of Care Chemotherapy in Adult Subjects With Relapsed/Refractory B-precursor Acute Lymphoblastic Leukemia (ALL) (TOWER Study).
Blinatumomab; Standard of Care Chemotherapy

Childhood Acute Lymphoblastic Leukemia Clinical Trial using PEG-L-asparaginase ind; PEG-L-asparaginase cons; E.coli L-asparaginase; High-dose Methotrexate; Low-dose Methotrexate; Triple intrathecal therapy; Cranial irradiation; Daunorubicin

Federal Research Institute of Pediatric Hematology, Oncology and Immunology - Recruiting 1 year to 18 years.
- Moscow-Berlin 2008 Multicenter Randomised Study for Treatment of Acute Lymphoblastic Leukemia in Children and Adolescents.
PEG-L-asparaginase ind; PEG-L-asparaginase cons; E.coli L-asparaginase; High-dose Methotrexate; Low-dose Methotrexate; Triple intrathecal therapy; Cranial irradiation; Daunorubicin

Leukemia, Myeloid, Acute, Leukemia, Lymphoblastic, Acute, or Leuk Clinical Trial using Allogeneic Lymphocytes; Fludarabine; Cyclophosphamide; Methylprednisolone; Cyclosporine

National Institutes of Health Clinical Center (CC) - Recruiting 8 years to 75 years.
- Mismatched Donor Lymphocyte Infusions for Relapsed Disease Following Allogeneic Stem Cell Transplantation.
Allogeneic Lymphocytes; Fludarabine; Cyclophosphamide; Methylprednisolone; Cyclosporine

Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities, Adul Clinical Trial using pretargeted radioimmunotherapy; cyclosporine; mycophenolate mofetil; total-body irradiation; nonmyeloablative allogeneic hematopoietic stem cell transplantation; peripheral blood stem cell transplantation; fludarabine phosphate; pharmacological study

Fred Hutchinson Cancer Research Center - Recruiting 18 years or older.
- Hematopoietic Cell Transplantation for Patients With High-Risk Acute Myeloid Leukemia (AML), Acute Lymphoblastic Leukemia (ALL), or Myelodysplastic Syndrome (MDS) Using Radiolabeled DOTA-Biotin Pretargeted by BC8 Antibody-Streptavidin Conjugate.
pretargeted radioimmunotherapy; cyclosporine; mycophenolate mofetil; total-body irradiation; nonmyeloablative allogeneic hematopoietic stem cell transplantation; peripheral blood stem cell transplantation; fludarabine phosphate; pharmacological study

Adult Nasal Type Extranodal NK/T-cell Lymphoma, Anaplastic Large Clinical Trial using yttrium Y 90 anti-CD45 monoclonal antibody BC8; carmustine; etoposide; cytarabine; melphalan; peripheral blood stem cell transplantation; autologous hematopoietic stem cell transplantation; laboratory biomarker analysis

Fred Hutchinson Cancer Research Center - Recruiting 18 years or older.
- A Phase I/II Study Evaluating Escalating Doses of 90Y-BC8-DOTA (Anti-CD45) Antibody Followed by BEAM Chemotherapy and Autologous Stem Cell Transplantation for High-Risk Lymphoid Malignancies.
yttrium Y 90 anti-CD45 monoclonal antibody BC8; carmustine; etoposide; cytarabine; melphalan; peripheral blood stem cell transplantation; autologous hematopoietic stem cell transplantation; laboratory biomarker analysis

Acute Lymphoblastic Leukemia, Acute Myelogenous Leukemia, Lymphob Clinical Trial using Clofarabine; Mitoxantrone

New York Medical College - Recruiting N/A to 30 years.
- A Pilot Study of Mitoxantrone in Combination With Clofarabine (MITCL) in Children, Adolescents and Young Adults (CAYA) With Refractory/Relapsed Acute Leukemia or High Grade Non-Hodgkin Lymphoma.
Clofarabine; Mitoxantrone

Lymphoblastic Leukemia, Acute T-cell, or Precursor T-Cell Lymphob Clinical Trial using BMS-906024; Dexamethasone

Bristol-Myers Squibb - Recruiting 18 years or older.
- Phase 1 Ascending Multiple-Dose Study to Evaluate the Safety, Pharmacokinetics (PK) and Pharmacodynamics (PD) of BMS-906024 in Subjects With Relapsed/Refractory T-cell Acute Lymphoblastic Leukemia or T-cell Lymphoblastic Lymphoma.
BMS-906024; Dexamethasone

B-cell Childhood Acute Lymphoblastic Leukemia, Philadelphia Chrom Clinical Trial using doxorubicin hydrochloride; cytarabine; vincristine sulfate; dexamethasone; pegaspargase; methotrexate; mercaptopurine tablet; leucovorin calcium; cyclophosphamide; thioguanine; quality-of-life assessment; questionnaire administration; laboratory biomarker analysis

Children's Oncology Group - Recruiting 1 year to 30 years.
- Treatment of Patients With Newly Diagnosed Standard Risk B-Precursor Acute Lymphoblastic Leukemia (ALL).
doxorubicin hydrochloride; cytarabine; vincristine sulfate; dexamethasone; pegaspargase; methotrexate; mercaptopurine tablet; leucovorin calcium; cyclophosphamide; thioguanine; quality-of-life assessment; questionnaire administration; laboratory biomarker analysis

Leukemia Clinical Trial using compliance monitoring; telephone-based intervention; mercaptopurine; computer-assisted intervention; counseling intervention; questionnaire administration; study of socioeconomic and demographic variables; standard follow-up care

Children's Oncology Group - Recruiting 6 Months to 25 years.
- A Comprehensive Approach to Improve Medication Adherence in Pediatric ALL.
compliance monitoring; telephone-based intervention; mercaptopurine; computer-assisted intervention; counseling intervention; questionnaire administration; study of socioeconomic and demographic variables; standard follow-up care

Acute Undifferentiated Leukemia, Atypical Chronic Myeloid Leukemi Clinical Trial using cytology specimen collection procedure

Children's Oncology Group - Recruiting N/A to 30 years.
- A Children's Oncology Group Protocol for Collecting and Banking Pediatric Research Specimens Including Rare Pediatric Tumors.
cytology specimen collection procedure

Acute Myeloid Leukemia, or Acute Lymphoblastic Leukemia Clinical Trial using WT1 peptide vaccine

Memorial Sloan-Kettering Cancer Center - Recruiting 18 years or older.
- Phase II Trial of a WT-1 Analog Peptide Vaccine in Patients in Complete Remission (CR) From Acute Myeloid Leukemia (AML) or Acute Lymphoblastic Leukemia (ALL).
WT1 peptide vaccine

Childhood Acute Lymphoblastic Leukemia in Remission, Childhood Ac Clinical Trial using supersaturated calcium phosphate rinse; placebo; questionnaire administration; quality-of-life assessment

Children's Oncology Group - Recruiting 4 years to 21 years.
- A Randomized Double Blinded Trial of Topical Caphosol to Prevent Oral Mucositis in Children Undergoing Hematopoietic Stem Cell Transplantation.
supersaturated calcium phosphate rinse; placebo; questionnaire administration; quality-of-life assessment

Accelerated Phase Chronic Myelogenous Leukemia, Acute Myeloid Leu Clinical Trial using ex vivo-expanded cord blood progenitor cell infusion; umbilical cord blood transplantation; double-unit umbilical cord blood transplantation; fludarabine phosphate; cyclophosphamide; total-body irradiation; cyclosporine; mycophenolate mofetil; laboratory biomarker analysis

Fred Hutchinson Cancer Research Center - Recruiting 6 Months to 45 years.
- Multi-center, Open-label Randomized Study of Single or Double Myeloablative Cord Blood Transplantation With or Without Infusion of Off-The-shelf ex Vivo Expanded Cryopreserved Cord Blood Progenitor Cells in Patients With Hematologic Malignancies.
ex vivo-expanded cord blood progenitor cell infusion; umbilical cord blood transplantation; double-unit umbilical cord blood transplantation; fludarabine phosphate; cyclophosphamide; total-body irradiation; cyclosporine; mycophenolate mofetil; laboratory biomarker analysis

Untreated Adult Acute Lymphoblastic Leukemia, or Untreated Childh Clinical Trial using laboratory biomarker analysis

Children's Oncology Group - Recruiting N/A to 30 years.
- Classification of Newly Diagnosed Acute Lymphoblastic Leukemia (ALL).
laboratory biomarker analysis

Acute Lymphoblastic Leukemia, Acute Myelocytic Leukemia, Chronic Clinical Trial using clofarabine; cytarabine; busulfan; Plerixafor; cyclophosphamide; antithymocyte globulin (rabbit); stem cells; Tacrolimus; mycophenolate mofetil

St. Jude Children's Research Hospital - Recruiting N/A to 21 years.
- T-Cell Replete Haploidentical Donor Hematopoietic Stem Cell Plus Natural Killer (NK) Cell Transplantation in Patients With Hematologic Malignancies Relapsed or Refractory Despite Previous Allogeneic Transplant.
clofarabine; cytarabine; busulfan; Plerixafor; cyclophosphamide; antithymocyte globulin (rabbit); stem cells; Tacrolimus; mycophenolate mofetil

Neurocognitive Impairment, or Acute Lymphoblastic Leukemia Clinical Trial using Neurocognitive and behavioral evaluation

St. Jude Children's Research Hospital - Recruiting 8 years or older.
- Risk of Psychopathology and Neurocognitive Impairment in Leukemia Survivors.
Neurocognitive and behavioral evaluation

Chronic Myeloid Leukemia (CML), Acute Myelogenous Leukemia (AML); Clinical Trial using CliniMACS CD34+ Reagent System; Thiotepa; Cyclophosphamide; Alemtuzumab; Tacrolimus; Melphalan; Busulfan; Fludarabine

Columbia University - Recruiting N/A to 22 years.
- CD34+ Stem Cell Selection for Patients Receiving a Matched or Partially Matched Family or Unrelated Adult Donor Allogeneic Stem Cell Transplant for Malignant Disease.
CliniMACS CD34+ Reagent System; Thiotepa; Cyclophosphamide; Alemtuzumab; Tacrolimus; Melphalan; Busulfan; Fludarabine

Chronic Kidney Disease, Acute Myeloid Leukemia (AML), Acute Lymph Clinical Trial using Haploidentical Bone Marrow/Kidney

Massachusetts General Hospital - Recruiting 18 years to 70 years.
- Combined Haploidentical Reduced Intensity Bone Marrow and Kidney Transplantation for Patients With Chronic Kidney Disease and Advanced Hematological Disorders.
Haploidentical Bone Marrow/Kidney

Adult Acute Lymphoblastic Leukemia in Remission, Adult Acute Myel Clinical Trial using Hedgehog inhibitor PF-04449913

University of Colorado, Denver - Recruiting 18 years or older.
- A Phase 2 Study of PF-04449913 for the Treatment of Acute Leukemia Patients With High Risk of Post-Allogeneic Stem Cell Transplantation Relapse.
Hedgehog inhibitor PF-04449913

Leukemia Clinical Trial using Moxetumomab Pasudotox

M.D. Anderson Cancer Center - Recruiting 18 years or older.
- Phase I/II Study of Moxetumomab Pasudotox in Patients With Relapsed and/or Refractory Acute Lymphoblastic Leukemia (ALL).
Moxetumomab Pasudotox

B-cell Acute Lymphoblastic Leukemia Clinical Trial using anti-CD19 redirected NK cells

National University Health System, Singapore - Recruiting 6 Months to 80 years.
- Pilot Study of Redirected Haploidentical Natural Killer Cell Infusions for B-Lineage Acute Lymphoblastic Leukemia.
anti-CD19 redirected NK cells

Leukemia Clinical Trial using Cyclophosphamide; Mesna; Doxorubicin; Vincristine; Dexamethasone; Ofatumumab; Methotrexate; Cytarabine

M.D. Anderson Cancer Center - Recruiting N/A or older.
- Phase II Study of the Hyper - CVAD Regimen in Combination With Ofatumumab as Frontline Therapy for Patients With CD-20 Positive Acute Lymphoblastic Leukemia.
Cyclophosphamide; Mesna; Doxorubicin; Vincristine; Dexamethasone; Ofatumumab; Methotrexate; Cytarabine

Adult Acute Lymphoblastic Leukemia in Remission, Adult Grade III Clinical Trial using plerixafor; filgrastim; etoposide; leukapheresis

Case Comprehensive Cancer Center - Recruiting 18 years to 78 years.
- A Study of Hematopoietic Stem Cell Supermobilization in Patients With Non-Hodgkin Lymphoma.
plerixafor; filgrastim; etoposide; leukapheresis

B-cell Childhood Acute Lymphoblastic Leukemia, Childhood Diffuse Clinical Trial using rituximab; prednisone; etoposide; doxorubicin hydrochloride; cytarabine; vincristine sulfate; cyclophosphamide; methotrexate; methylprednisolone; leucovorin calcium; therapeutic hydrocortisone

Children's Oncology Group - Recruiting N/A to 18 years.
- Intergroup Trial for Children or Adolescents With B-Cell NHL or B-AL: Evaluation of Rituximab Efficacy and Safety in High Risk Patients.
rituximab; prednisone; etoposide; doxorubicin hydrochloride; cytarabine; vincristine sulfate; cyclophosphamide; methotrexate; methylprednisolone; leucovorin calcium; therapeutic hydrocortisone

Leukemia, or Acute Lymphoblastic Leukemia Clinical Trial using gene-modified T cells targeted to B-ALL tumor cells

Memorial Sloan-Kettering Cancer Center - Recruiting 18 years or older.
- A Phase I Trial of Precursor B Cell Acute Lymphoblastic Leukemia (B-ALL) Treated With Autologous T Cells Genetically Targeted to the B Cell Specific Antigen CD19.
gene-modified T cells targeted to B-ALL tumor cells

Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Lymph Clinical Trial using Fludarabine phosphate; Thiotepa; Total body irradiation; Therapeutic allogeneic lymphocytes; Cyclophosphamide; Allogeneic hematopoietic stem cell transplantation (HSCT); Peripheral blood stem cell transplantation; Tacrolimus; Mycophenolate mofetil

Thomas Jefferson University - Recruiting 18 years or older.
- A Two Step Approach to Reduced Intensity Allogeneic Hematopoietic Stem Cell Transplantation for High Risk Hematologic Malignancies.
Fludarabine phosphate; Thiotepa; Total body irradiation; Therapeutic allogeneic lymphocytes; Cyclophosphamide; Allogeneic hematopoietic stem cell transplantation (HSCT); Peripheral blood stem cell transplantation; Tacrolimus; Mycophenolate mofetil

Hematologic Malignancy, Leukemia, Acute Lymphoblastic Leukemia, A Clinical Trial using Total Body Irradiation (TBI); Donor Lymphocyte Infusion (DLI); Cyclophosphamide (CY); Tacrolimus; Mycophenolate Mofetil (MMF); Hematopoietic Stem Cell Transplant (HSCT)

Thomas Jefferson University - Recruiting 18 years or older.
- A Two Step Approach to Allogeneic Hematopoietic Stem Cell Transplantation for High-Risk Hematologic Malignancies Using Two Related Donors.
Total Body Irradiation (TBI); Donor Lymphocyte Infusion (DLI); Cyclophosphamide (CY); Tacrolimus; Mycophenolate Mofetil (MMF); Hematopoietic Stem Cell Transplant (HSCT)

Acute Lymphoblastic Leukemia Clinical Trial using Everolimus; Prednisone; Vincristine; PEG-Asparaginase; Doxorubicin; Dexrazoxane

Dana-Farber Cancer Institute - Recruiting 18 Months to 21 years.
- A Feasibility Trial of Everolimus (RAD001),an mTOR Inhibitor, Given in Combination With Multiagent Re-Induction Chemotherapy in Pediatric Patients With Relapsed Acute Lymphoblastic Leukemia (ALL).
Everolimus; Prednisone; Vincristine; PEG-Asparaginase; Doxorubicin; Dexrazoxane

Relapsed Lymphoblastic Leukemia, Relapsed Lymphoblastic Lymphoma, Clinical Trial using Sirolimus

Children's Hospital Medical Center, Cincinnati - Recruiting N/A to 30 years.
- Pilot Study Of Sirolimus Plus Multiagent Chemotherapy For Relapsed/Refractory Acute Lymphoblastic Leukemia/Lymphoma.
Sirolimus

Acute Myelogenous Leukemia (AML) in 1st or Subsequent Remission, Clinical Trial using POL6326; Leukapheresis; PBSC Transplant

Polyphor Ltd. - Recruiting 18 years to 75 years.
- A Phase I/II Study Evaluating the Safety and Efficacy of Intravenous POL6326 for the Mobilization and Transplantation of HLA-Matched Sibling Donor Hematopoietic Stem Cells in Patients With Advanced Hematological Malignancies.
POL6326; Leukapheresis; PBSC Transplant

Acute Lymphoblastic Leukemia, Acute Myelogenous Leukemia, or Lymp Clinical Trial using BPX-501 and AP1903

Bellicum Pharmaceuticals - Recruiting 18 years to 65 years.
- A Phase 1/2 Dose Escalation Study Evaluating Safety and Feasibility of BPX-501 T Cells After Partially Mismatched, Related, T Cell-Depleted HSCT (Hematopoietic Stem Cell Transplant).
BPX-501 and AP1903

Leukemia, Pediatric Clinical Trial using Dasatinib

Bristol-Myers Squibb - Recruiting 1 year to 17 years.
- A Phase 2 Multi-Center, Historically Controlled Study of Dasatinib Added to Standard Chemotherapy in Pediatric Patients With Newly Diagnosed Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia.
Dasatinib

GVHD (Acute or Chronic), Acute Myeloid or Lymphoblastic Leukemia Clinical Trial using milatuzumab

Immunomedics, Inc. - Recruiting 18 years or older.
- A Phase I Study of Milatuzumab (hLL1) for Prevention of Acute Graft Versus Host Disease Following Reduced-Intensity Conditioning Allogeneic Stem Cell Transplant in Patients With Hematologic Malignancies.
milatuzumab

Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, Myelodyspla Clinical Trial using EPZ-5676

Epizyme, Inc. - Recruiting 18 years or older.
- A Phase 1, Open-Label, Dose-Escalation & Expanded Cohort, Continuous IV Infusion, Multi-center Study of the Safety, Tolerability,PK & PD of EPZ-5676 in Treatment Relapsed/Refractory Patients With Leukemias Involving Translocation of the MLL Gene at 11q23 or Advanced Hematologic Malignancies.
EPZ-5676

Acute Lymphocytic Leukemia, or Adult Lymphoblastic Lymphoma Clinical Trial using DNR; VCR; PEG-asp; CTX; Prednisone; Liposomal AraC; MTX; LCV; AraC; Etoposide; Dasatinib; Rituximab; Hydrocortisone

University of California, San Diego - Recruiting 18 years to 60 years.
- A Phase II Study of Punctual, Cyclic, and Intensive Chemotherapy With Liposomal Cytarabine (Depocytr) CNS Prophylaxis for Adults With Acute Lymphoblastic Leukemia and Lymphoblastic Lymphoma.
DNR; VCR; PEG-asp; CTX; Prednisone; Liposomal AraC; MTX; LCV; AraC; Etoposide; Dasatinib; Rituximab; Hydrocortisone

Acute Lymphoblastic Leukemia Clinical Trial

Amgen - Recruiting 15 years or older.
- A Retrospective Analysis of Hematological Relapse Free Survival and Overall Survival in Adult Patients With Philadelphia-Negative B-Precursor Acute Lymphoblastic Leukemia in Complete Hematological Remission With Minimal Residual Disease.

Adult Acute Lymphoblastic Leukemia in Remission, Adult Acute Myel Clinical Trial using clofarabine; melphalan; allogeneic hematopoietic stem cell transplantation; laboratory biomarker analysis

City of Hope Medical Center - Recruiting 18 years to 75 years.
- Phase II Study of Clofarabine and High-Dose Melphalan Conditioning Prior to Allogeneic Hematopoietic Cell Transplantation for Myelodysplasia or Acute Leukemia in Remission.
clofarabine; melphalan; allogeneic hematopoietic stem cell transplantation; laboratory biomarker analysis

Chronic Myelogenous Leukemia, Acute Myelogenous Leukemia, Acute L Clinical Trial

National Institutes of Health Clinical Center (CC) - Recruiting N/A or older.
- Relapsed Hematologic Malignancy After Allogeneic Hematopoietic Stem Cell Transplantation: Screening, Disease Characterization and Natural History.

MDS (Myelodysplastic Syndrome), Myeloproliferative Disorder, Lymp Clinical Trial using Graft Manipulation (CD34+ Selection)

National Institutes of Health Clinical Center (CC) - Recruiting 2 years to 80 years.
- Peripheral Blood Stem Cell Allotransplantation For Hematological Malignancies Using Ex Vivo CD34 Selection - a Platform For Adoptive Cellular Therapies.
Graft Manipulation (CD34+ Selection)

Lymphoblastic Leukemia, or Lymphoblastic Lymphoma Clinical Trial using Daunorubicin; Vincristine; PEG-asparaginase; Intrathecal Methotrexate; Cyclophosphamide; Cytarabine; Mercaptopurine; Methotrexate; Doxorubicin; Thioguanine

M.D. Anderson Cancer Center - Recruiting 12 years to 40 years.
- Augmented Berlin-Frankfurt-Munster Therapy for Adolescents/Young Adults With Acute Lymphoblastic Leukemia or Lymphoblastic Lymphoma.
Daunorubicin; Vincristine; PEG-asparaginase; Intrathecal Methotrexate; Cyclophosphamide; Cytarabine; Mercaptopurine; Methotrexate; Doxorubicin; Thioguanine

Leukemia, Lymphoma, Allogeneic Haematopoietic Stem Cell Transplan Clinical Trial using Busulfan; Clofarabine; Thymoglobulin; Stem Cell Transplant

M.D. Anderson Cancer Center - Recruiting N/A to 65 years.
- Busulfan Plus Clofarabine Followed by Allogeneic Hematopoietic Stem Cell Transplantation for Patients With Acute Lymphoblastic Leukemia or Lymphoma, or Biphenotypic Leukemia.
Busulfan; Clofarabine; Thymoglobulin; Stem Cell Transplant

Acute Lymphobkastic Leukemia Clinical Trial using Vincristine; Daunorubicin; Prednisone; L-asparaginase; Ciclophosphamide; Metotrexate; ARA-C; Hidrocortisone; Mercaptopurine; VP-16; Dexametasone

PETHEMA Foundation - Recruiting 15 years or older.
- Pethema LAL-RI/2008: Treatment for Patients With Standard Risk Acute.
Vincristine; Daunorubicin; Prednisone; L-asparaginase; Ciclophosphamide; Metotrexate; ARA-C; Hidrocortisone; Mercaptopurine; VP-16; Dexametasone

Acute Lymphoblastic Leukemia Clinical Trial using inotuzumab ozogamicin; FLAG (fludarabine, cytarabine and G-CSF); HIDAC (high dose cytarabine); cytarabine and mitoxantrone

Pfizer - Recruiting 18 years or older.
- An Open-Label, Randomized Phase 3 Study Of Inotuzumab Ozogamicin Compared To A Defined Investigator's Choice In Adult Patients With Relapsed Or Refractory CD22-Positive Acute Lymphoblastic Leukemia (ALL).
inotuzumab ozogamicin; FLAG (fludarabine, cytarabine and G-CSF); HIDAC (high dose cytarabine); cytarabine and mitoxantrone

Acute Lymphocytic Leukaemia Clinical Trial using SAR3419

Sanofi - Recruiting 16 years or older.
- Phase II Two Stage Finding Run-in Study of SAR3419, An Anti-CD19 Antibody-Maytansine Conjugate, Administered as a Single Agent by Intravenous Infusion in Patients With Relapsed or Refractory Acute Lymphoblastic Leukemia.
SAR3419

Patients With B Cell ALL, Relapsed or Refractory, With no Availab Clinical Trial using CART-19 cells

Abramson Cancer Center of the University of Pennsylvania - Recruiting 18 years or older.
- PHASE II STUDY OF REDIRECTED AUTOLOGOUS T CELLS ENGINEERED TO CONTAIN ANTI-CD19 ATTACHED TO TCR AND 4-1BB SIGNALING DOMAINS IN PATIENTS WITH CHEMOTHERAPY RESISTANT OR REFRACTORY ACUTE LYMPHOBLASTIC LEUKEMIA.
CART-19 cells

B-cell Adult Acute Lymphoblastic Leukemia, Philadelphia Chromosom Clinical Trial using cytarabine; daunorubicin hydrochloride; vincristine sulfate; dexamethasone; methotrexate; pegaspargase; cyclophosphamide; mercaptopurine tablet; blinatumomab; etoposide; prednisone; allogeneic hematopoietic stem cell transplantation; laboratory biomarker analysis

National Cancer Institute (NCI) - Recruiting 35 years to 70 years.
- A Phase III Randomized Trial of Blinatumomab for Newly Diagnosed BCR-ABL-Negative B Lineage Acute Lymphoblastic Leukemia in Adults.
cytarabine; daunorubicin hydrochloride; vincristine sulfate; dexamethasone; methotrexate; pegaspargase; cyclophosphamide; mercaptopurine tablet; blinatumomab; etoposide; prednisone; allogeneic hematopoietic stem cell transplantation; laboratory biomarker analysis

Leukemia, Acute Lymphoblastic, Precursor B-Cell Lymphoblastic Leu Clinical Trial using Diagnosed as ALL

Asan Medical Center - Recruiting 15 years or older.
- Prospective Observational Cohort Registry for Patients With Acute Lymphoblastic Leukemia at Asan Medical Center.
Diagnosed as ALL

Acute Lymphoblastic Leukemia, or Philadelphia Chromosome Clinical Trial using Standard chemotherapy + Imatinib

Rennes University Hospital - Recruiting 1 year to 18 years.
- An Open-label, Phase II Study to Explore the Safety and Efficacy of Imatinib With Chemotherapy in Pediatric Patients With Ph+ / BCR-ABL+ Acute Lymphoblastic Leukemia (Ph+ALL).
Standard chemotherapy + Imatinib

Leukemia Clinical Trial using Rituximab; Imatinib; Cyclophosphamide; Doxorubicin; Mesna; VSLI; Solu-Medrol; Methotrexate; Ara-C; G-CSF; Pegfilgrastim; Dexamethasone

M.D. Anderson Cancer Center - Recruiting 18 years or older.
- Hyper-CVAD With Liposomal Vincristine (Hyper-CMAD) in Acute Lymphoblastic Leukemia.
Rituximab; Imatinib; Cyclophosphamide; Doxorubicin; Mesna; VSLI; Solu-Medrol; Methotrexate; Ara-C; G-CSF; Pegfilgrastim; Dexamethasone

Accelerated Phase Chronic Myelogenous Leukemia, Blastic Phase Chr Clinical Trial using total-body irradiation; thiotepa; fludarabine phosphate; allogeneic hematopoietic stem cell transplantation; T cell-depleted hematopoietic stem cell transplantation; peripheral blood stem cell transplantation; tacrolimus; methotrexate; laboratory biomarker analysis

Fred Hutchinson Cancer Research Center - Recruiting N/A to 21 years.
- A Phase II Study of Selective Depletion of CD45RA+ T Cells From Allogeneic Peripheral Blood Stem Cell Grafts for the Prevention of GVHD in Children.
total-body irradiation; thiotepa; fludarabine phosphate; allogeneic hematopoietic stem cell transplantation; T cell-depleted hematopoietic stem cell transplantation; peripheral blood stem cell transplantation; tacrolimus; methotrexate; laboratory biomarker analysis

For Donors:, Related Donors Donating PBSC to a Family Member, For Clinical Trial using Plerixafor

Center for International Blood and Marrow Transplant Research - Recruiting 18 years to 65 years.
- A Phase II Study Evaluating the Safety and Efficacy of Subcutaneous Plerixafor for the Mobilization and Transplantation of HLA-Matched Sibling Donor Hematopoietic Stem Cells in Recipients With Hematological Malignancies.
Plerixafor

Acute Lymphoblastic Leukemia, Non Hodgkins Lymphoma, Myelodysplas Clinical Trial using Ara-C; Cyclophosphamide; Campath-1H; Total Body Irradiation; Stem Cell Infusion

Baylor College of Medicine - Recruiting N/A to 55 years.
- CD-34 Selection for Ex-vivo T-Cell Depletion of Mobilized Peripheral Blood Stem Cells for Recipients of HLA Haploidentical Related Donor Stem Cell Grafts Receiving Intensive Conditioning.
Ara-C; Cyclophosphamide; Campath-1H; Total Body Irradiation; Stem Cell Infusion

Acute Lymphoblastic Leukemia Clinical Trial using Metformin; Vincristine; Dexamethasone; PEG-asparaginase; Doxorubicin; Intrathecal chemotherapy

H. Lee Moffitt Cancer Center and Research Institute - Recruiting 1 year to 30 years.
- A Phase I Window, Dose Escalating and Safety Trial of Metformin in Combination With Induction Chemotherapy in Relapsed Refractory Acute Lymphoblastic Leukemia: Metformin With Induction Chemotherapy of Vincristine, Dexamethasone, Doxorubicin, and PEG-asparaginase (VPLD).
Metformin; Vincristine; Dexamethasone; PEG-asparaginase; Doxorubicin; Intrathecal chemotherapy

Acute Lymphoblastic Leukemia, or Non-Hodgkin's Lymphoma Clinical Trial using CAT-8015 (Moxetumomab Pasudotox)

MedImmune LLC - Recruiting 6 Months to 25 years.
- A Phase 1, Multicenter, Dose Escalation Study of CAT-8015 in Children, Adolescents and Young Adults With Refractory CD22+ Acute Lymphoblastic Leukemia (ALL) or Non-Hodgkin's Lymphoma (NHL).
CAT-8015 (Moxetumomab Pasudotox)

Acute Lymphoblastic Leukemia Clinical Trial using vINCRISTINE; Dexamethasone; Methotrexate; Cytosine arabinoside

PETHEMA Foundation - Recruiting 55 years or older.
- Treatment Protocol For All Fragile Patients Ph' Negative Over 55 Years.
vINCRISTINE; Dexamethasone; Methotrexate; Cytosine arabinoside

Acute Lymphoblastic Leukemia Clinical Trial using Prednisone; Vincristine; Daunorubicin; L-Asparaginase; Cyclophosphamide; Methotrexate; Cytosine Arabinoside; Mercaptopurine; VP-16

PETHEMA Foundation - Recruiting N/A to 15 years.
- LAL-BR/2001: Study Treatment to Low Risk ALL.
Prednisone; Vincristine; Daunorubicin; L-Asparaginase; Cyclophosphamide; Methotrexate; Cytosine Arabinoside; Mercaptopurine; VP-16

Acute Lymphocytic Leukemia Clinical Trial using Biological/Genetically Modified T cells

Memorial Sloan-Kettering Cancer Center - Recruiting N/A to 19 years.
- A Phase I Dose Escalation Trial Using In Vitro Expanded Allogeneic Epstein-Barr Virus Specific Cytotoxic T-Lymphocytes (EBV-CTLs) Genetically Targeted to the B-Cell Specific Antigen CD19 Positive Residual Or Relapsed Acute Lymphoblastic Leukemia After Allogeneic Hematopoietic Progenitor Cell Transplantation.
Biological/Genetically Modified T cells

Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Lymph Clinical Trial using pentostatin; therapeutic allogeneic lymphocytes; mycophenolate mofetil; cyclosporine

Fred Hutchinson Cancer Research Center - Recruiting N/A or older.
- Pentostatin and Donor Lymphocyte Infusion for Low Donor T-Cell Chimerism After Hematopoietic Cell Transplantation - A Multi-Center Trial.
pentostatin; therapeutic allogeneic lymphocytes; mycophenolate mofetil; cyclosporine

Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Lymph Clinical Trial using leukapheresis; allogeneic hematopoietic stem cell transplantation; autologous hematopoietic stem cell transplantation; peripheral blood stem cell transplantation; laboratory biomarker analysis; DNA analysis; RNA analysis; flow cytometry; reverse transcriptase-polymerase chain reaction; nucleic acid sequencing; protein expression analysis

Fred Hutchinson Cancer Research Center - Recruiting N/A to 75 years.
- Human Immunodeficiency Virus (HIV)-Specific Immune Reconstitution After Hematopoietic Cell Transplant for Treatment of Hematologic Malignancy in Patients Infected With HIV.
leukapheresis; allogeneic hematopoietic stem cell transplantation; autologous hematopoietic stem cell transplantation; peripheral blood stem cell transplantation; laboratory biomarker analysis; DNA analysis; RNA analysis; flow cytometry; reverse transcriptase-polymerase chain reaction; nucleic acid sequencing; protein expression analysis

Contiguous Stage II Adult Lymphoblastic Lymphoma, Noncontiguous S Clinical Trial using doxorubicin hydrochloride; cytarabine; daunorubicin hydrochloride; prednisone; pegaspargase; methotrexate; leucovorin calcium; cyclophosphamide; mercaptopurine; nelarabine; asparaginase; dexamethasone; thioguanine; vincristine sulfate; radiation therapy; laboratory biomarker analysis

National Cancer Institute (NCI) - Recruiting 1 year to 30 years.
- Intensified Methotrexate, Nelarabine (Compound 506U78; IND #52611) and Augmented BFM Therapy for Children and Young Adults With Newly Diagnosed T-Cell Acute Lymphoblastic Leukemia (ALL) or T-cell Lymphoblastic Lymphoma.
doxorubicin hydrochloride; cytarabine; daunorubicin hydrochloride; prednisone; pegaspargase; methotrexate; leucovorin calcium; cyclophosphamide; mercaptopurine; nelarabine; asparaginase; dexamethasone; thioguanine; vincristine sulfate; radiation therapy; laboratory biomarker analysis

Leukemia, Lymphoblastic, Acute, Philadelphia-Positive Clinical Trial using dasatinib

Grupo Espanol de trasplantes hematopoyeticos y terapia celular - Recruiting 18 years or older.
- Multicenter, Non-randomized Phase II Pilot Study to Assess the Efficacy and Safety of Dasatinib After Allogeneic Stem Cell Transplantation in Patients With de Novo Philadelphia Positive (Bcr-abl +) Acute Lymphoblastic Leukemia.
dasatinib

Hematological Malignancies, Acute Lymphoblastic Leukemia (ALL), A Clinical Trial using NiCordr

Gamida Cell ltd - Recruiting 18 years to 65 years.
- Allogeneic Stem Cell Transplantation of NiCordr, Umbilical Cord Blood-derived Ex Vivo Expanded Stem and Progenitor Cells, in Adult Patients With Hematological Malignancies.
NiCordr

Precursor Cell Lymphoblastic Leukemia-Lymphoma Clinical Trial using G-CSF; Ifosfamide; Etoposide; Dexamethasone; Mesna

Washington University School of Medicine - Recruiting 18 years or older.
- A Pilot Study of G-CSF to Disrupt the Bone Marrow Microenvironment in Relapsed or Refractory Acute Lymphoblastic Leukemia.
G-CSF; Ifosfamide; Etoposide; Dexamethasone; Mesna

Leukemia Clinical Trial using PEG-L-asparaginase; cyclophosphamide; cytarabine; daunorubicin hydrochloride; dexamethasone; doxorubicin hydrochloride; etoposide; ifosfamide; mercaptopurine; methotrexate; prednisone; thioguanine; vincristine sulfate; vindesine; daunoxome; fludarabine; Radiation Therapy

University of Schleswig-Holstein - Recruiting 1 year to 18 years.
- International Collaborative Treatment Protocol For Children And Adolescents With Acute Lymphoblastic Leukemia.
PEG-L-asparaginase; cyclophosphamide; cytarabine; daunorubicin hydrochloride; dexamethasone; doxorubicin hydrochloride; etoposide; ifosfamide; mercaptopurine; methotrexate; prednisone; thioguanine; vincristine sulfate; vindesine; daunoxome; fludarabine; Radiation Therapy

Leukemia, Acute Myeloid, Leukemia, Lymphoblastic,Acute, or Myelod Clinical Trial using brentuximab vedotin

Washington University School of Medicine - Recruiting 18 years to 65 years.
- A Pilot Study of Brentuximab Vedotin in the Prevention of Graft-Versus-Host Disease (GVHD) After Mismatched Unrelated Allogeneic Stem Cell Transplantation.
brentuximab vedotin

Acute Lymphoblastic Leukemia Clinical Trial using donor-derived EBV-specific cytotoxic T-cells (EBV-CTL) transduced with the retroviral vector SFGalpha-CD19-CD3zeta; Irradiated donor-derived Lymphoblastoid Cell Line

University College, London - Recruiting N/A to 18 years.
- Immunotherapy With CD19? Gene-modified EBV-specific CTLs After Stem Cell Transplant in Children With High-risk Acute Lymphoblastic Leukaemia.
donor-derived EBV-specific cytotoxic T-cells (EBV-CTL) transduced with the retroviral vector SFGalpha-CD19-CD3zeta; Irradiated donor-derived Lymphoblastoid Cell Line

Acute Lymphoblastic Leukemia Clinical Trial using MOR00208 (formerly Xmab5574)

MorphoSys AG - Recruiting 16 years or older.
- A Phase IIa, Single-arm, Open-label Study of MOR00208, a Humanized Fc-Engineered Anti-CD19 Antibody, in Patients With Relapsed/Refractory B-cell Acute Lymphoblastic Leukemia (B-ALL).
MOR00208 (formerly Xmab5574)

Acute Lymphoblastic Leukemia, or 6-mercaptopurine Therapy Clinical Trial using Xaluprine; Puri-Nethol

Rigshospitalet, Denmark - Recruiting N/A to 18 years.
- Plasma Kinetics of Tablet and Liquid Formulations of 6-mercaptopurine in Childhood Acute Lymphoblastic Leukemia..
Xaluprine; Puri-Nethol

Acute Myeloid Leukemia, or Acute Lymphoblastic Leukemia Clinical Trial using midostaurin

Novartis - Recruiting 3 Months to 18 years.
- A Phase I/II, Open-label, Dose-escalating Study to Evaluate the Safety, Tolerability and Pharmacokinetics of Twice Daily Oral Midostaurin and to Evaluate the Preliminary Clinical and Pharmacodynamic Response in Pediatric Patients With Relapsed or Refractory Leukemia.
midostaurin

Precursor Cell Lymphoblastic Leukemia-Lymphoma Clinical Trial using Rituximab+mVPDL

Asan Medical Center - Recruiting 15 years or older.
- Phase 2 Study Evaluating the Efficacy of Rituximab Plus Modified VPDL for Newly Diagnosed CD20-Positive Philadelphia-Negative Adult Acute Lymphoblastic Leukemia.
Rituximab+mVPDL

Acute Lymphoblastic Leukemia, Precursor B-Cell Lymphoblastic Leuk Clinical Trial using Decitabine; Vorinostat; Vincristine; Dexamethasone; Mitoxantrone; Pegaspargase; Methotrexate

Therapeutic Advances in Childhood Leukemia Consortium - Recruiting 1 year to 21 years.
- A Pilot Study of Decitabine and Vorinostat With Chemotherapy for Relapsed ALL.
Decitabine; Vorinostat; Vincristine; Dexamethasone; Mitoxantrone; Pegaspargase; Methotrexate

B-cell Adult Acute Lymphoblastic Leukemia, or Acute Lymphoblastic Clinical Trial using Combotox; Cytarabine

Montefiore Medical Center - Recruiting 18 years or older.
- A Phase 1 Study of the Deglycosylated Ricin A Chain-containing Combined Anti-CD19 and Anti-CD22 Immunotoxin Combotox in Combination With High-dose Cytarabine in Adult Relapsed or Refractory B-lineage Acute Lymphoblastic Leukemia.
Combotox; Cytarabine

Leukemia, or Lymphoma Clinical Trial using biologic sample preservation procedure

National Cancer Institute (NCI) - Recruiting N/A to 30 years.
- A Children's Oncology Group Protocol for Collecting and Banking Relapsed Acute Lymphoblastic Leukemia Research Specimens.
biologic sample preservation procedure

Acute Lymphoblastic Leukemia Clinical Trial using PEG Asparaginase at six weeks interval; PEG Asparaginase at two weeks interval

Rigshospitalet, Denmark - Recruiting 1 year to 45 years.
- NOPHO Treatment Protocol for Children (1.0 - 17.9 Years of Age) and Young Adults(18.0-45.0 Years) With Acute Lymphoblastic Leukemia. Intermittent Versus Continuous PEG-asparaginase for Asparagine Depletion.
PEG Asparaginase at six weeks interval; PEG Asparaginase at two weeks interval

Acute Myelogenous Leukemia, Acute Lymphoblastic Leukemia, or Non- Clinical Trial using Fenretinide; Cytarabine; Methotrexate

South Plains Oncology Consortium - Recruiting N/A to 21 years.
- A Phase I Study of Intravenous (Emulsion) Fenretinide (4-HPR, NSC 374551) in Children With Recurrent or Resistant Acute Lymphoblastic Leukemia (ALL), Acute Myelogenous Leukemia (AML), and Non-Hodgkin's Lymphoma (NHL) IND #70,058'.
Fenretinide; Cytarabine; Methotrexate

Leukemia Clinical Trial using amsacrine; clofarabine; cyclophosphamide; cytarabine; daunorubicin hydrochloride; dexamethasone; doxorubicin hydrochloride; etoposide phosphate; mercaptopurine; methotrexate; methylprednisolone; pegaspargase; thioguanine; vincristine sulfate; whole-brain radiation therapy

Universit„tsklinikum Hamburg-Eppendorf - Recruiting 1 year to 17 years.
- A Randomized Multi-Center Treatment Study (COALL 08-09) to Improve the Survival of Children With Acute Lymphoblastic Leukemia on Behalf of the German Society of Pediatric Hematology and Oncology.
amsacrine; clofarabine; cyclophosphamide; cytarabine; daunorubicin hydrochloride; dexamethasone; doxorubicin hydrochloride; etoposide phosphate; mercaptopurine; methotrexate; methylprednisolone; pegaspargase; thioguanine; vincristine sulfate; whole-brain radiation therapy

Burkitt Lymphoma, or B-Cell Acute Lymphoblastic Leukemia Clinical Trial using Chemotherapy-Rituximab combination

Northern Italy Leukemia Group - Recruiting 15 years or older.
- Multicentre Study to Optimize Therapy of Burkitt's Leukemia (B-ALL) and Non-Hodgkin Lymphoma.
Chemotherapy-Rituximab combination

Acute Lymphoblastic Leukemia, or Adult Clinical Trial

University of Bologna - Recruiting 18 years or older.
- High Resolution Genome Wide-Copy Number Profiling and Pharmacogenomic Analysis in Acute Lymphoblastic Leukemia by Single Nucleotide Polymorphism (SNP) Arrays.

Acute Lymphoblastic Leukemia, or Non-Hodgkin's Lymphoma Clinical Trial using Rituximab

University of Bologna - Recruiting 18 years or older.
- Intensification Therapy of Mature B-ALL, Burkitt and Burkitt Like and Other High Grade Non-Hodgkin's Lymphoma in Adults.
Rituximab

Acute Lymphoblastic Leukemia Clinical Trial using Hematopoietic stem cell transplantation

Universit„tsklinikum Hamburg-Eppendorf - Recruiting 18 years to 65 years.
- Allogeneic Stem Cell Transplantation With Treosulfan, VP-16 and Cyclophosphamide for Patients With Acute Lymphoblastic Leukemia (ALL) Not Eligible for TBI-Containing Conditioning Regimen: A Phase II-Study.
Hematopoietic stem cell transplantation

Acute Myeloid Leukemia, or Acute Lymphoblastic Leukemia Clinical Trial using ATG FRESENIUS (Anti-Lymphocyte-Globulin)

Universit„tsklinikum Hamburg-Eppendorf - Recruiting 18 years to 65 years.
- Prophylaxis of Chronic Graft-Versus-Host Disease (cGvHD) With or Without Anti-T-Lymphocyte-Globulin (ATG Fresenius) Prior Allogeneic Peripheral Stem Cell Transplantation From HLA-Identical Siblings After Myeloablative Conditioning in Patients With Acute Leukemia: A Randomized Phase III-Study.
ATG FRESENIUS (Anti-Lymphocyte-Globulin)

Adult Acute Lymphocytic Leukemia Clinical Trial using Cyclophosphamide; Dexamethasone; Vincristine; daunorubicin; Asparaginase; Methotrexate; Cytarabine; Mercaptopurine; G-CSF; Vindesine; VP16; Prednisolone; Adriamycin; Thioguanine; VM26; CNS irradiation; Mediastinal Irradiation; Stem cell transplantation; Idarubicin; Fludarabine; Cladribine

Johann Wolfgang Goethe University Hospitals - Recruiting 15 years to 65 years.
- German Multicenter Study for Treatment Optimisation in Acute Lymphoblastic Leukemia in Adults and Adolescents Above 15 Years (Amend 3) (GMALL 07/2003).
Cyclophosphamide; Dexamethasone; Vincristine; daunorubicin; Asparaginase; Methotrexate; Cytarabine; Mercaptopurine; G-CSF; Vindesine; VP16; Prednisolone; Adriamycin; Thioguanine; VM26; CNS irradiation; Mediastinal Irradiation; Stem cell transplantation; Idarubicin; Fludarabine; Cladribine

Acute Lymphoblastic Leukemia Clinical Trial

National Institute of Cancerolog¡a - Recruiting 18 years or older.
- Prevention of Thiopurines Related Toxicity Through the Determination by DHPLC TPMT Polymorphisms in Patients With ALL..