19 results found.

Childhood Mixed Glioma, Untreated Childhood Anaplastic Astrocytom Clinical Trial using veliparib; temozolomide; 3-dimensional conformal radiation therapy; intensity-modulated radiation therapy; pharmacological study; laboratory biomarker analysis

National Cancer Institute (NCI) - Recruiting N/A to 21 years.
- A Phase I/II Study of ABT-888, an Oral Poly(ADP-ribose) Polymerase Inhibitor, and Concurrent Radiation Therapy, Followed by ABT-888 and Temozolomide, in Children With Newly Diagnosed Diffuse Pontine Gliomas (DIPG).
veliparib; temozolomide; 3-dimensional conformal radiation therapy; intensity-modulated radiation therapy; pharmacological study; laboratory biomarker analysis

Untreated Childhood Anaplastic Astrocytoma, Untreated Childhood A Clinical Trial using WEE1 inhibitor MK-1775; radiation therapy; pharmacological study; laboratory biomarker analysis

National Cancer Institute (NCI) - Recruiting 37 Months to 21 years.
- A Phase 1 Study of MK-1775 Concurrent With Local Radiation Therapy for the Treatment of Newly Diagnosed Children With Diffuse Intrinsic Pontine Gliomas.
WEE1 inhibitor MK-1775; radiation therapy; pharmacological study; laboratory biomarker analysis

Glioblastoma, Anaplastic Astrocytoma, Anaplastic Oligodendrogliom Clinical Trial using Toca 511; 5-FC

Tocagen Inc. - Recruiting 18 years or older.
- A Phase 1 Ascending Dose Trial of the Safety and Tolerability of Toca 511 in Patients With Recurrent High Grade Glioma.
Toca 511; 5-FC

Diffuse Intrinsic Pontine Glioma, Anaplastic Astrocytoma, or High Clinical Trial using Lenalidomide; Radiation Therapy

National Institutes of Health Clinical Center (CC) - Recruiting 1 year to 21 years.
- A Phase I Trial of Lenalidomide and Radiotherapy in Children With Diffuse Intrinsic Pontine Gliomas and High-grade Gliomas.
Lenalidomide; Radiation Therapy

Adult Anaplastic Astrocytoma, Adult Anaplastic Oligodendroglioma, Clinical Trial using DEC-205-NY-ESO-1 fusion protein vaccine; sirolimus; laboratory biomarker analysis

Roswell Park Cancer Institute - Recruiting 18 years or older.
- A Phase I Clinical Trial of mTOR Inhibition With Rapamycin for Enhancing Intranodal Dendritic Cell Vaccine Induced Anti-tumor Immunity in Patients With NY-ESO-1 Expressing Solid Tumors.
DEC-205-NY-ESO-1 fusion protein vaccine; sirolimus; laboratory biomarker analysis

Adult Anaplastic Astrocytoma, Adult Anaplastic Oligodendroglioma, Clinical Trial using Montanide ISA-51/survivin peptide vaccine; sargramostim; laboratory biomarker analysis

Roswell Park Cancer Institute - Recruiting 18 years or older.
- Phase I Study of Safety, Tolerability and Immunological Effects of SVN53-67/M57-KLH in Patients With Survivin-Positive Malignant Gliomas.
Montanide ISA-51/survivin peptide vaccine; sargramostim; laboratory biomarker analysis

Adult Anaplastic Astrocytoma, Adult Anaplastic Ependymoma, Adult Clinical Trial using 3-Tesla magnetic resonance imaging; CEST-MRI; DW-MRI; DCE-MRI; DSC-MRI; IV administration of gadolinium-containing contrast agent

Vanderbilt-Ingram Cancer Center - Recruiting 18 years or older.
- Early Detection of Glioma Treatment Response Using MRI-Based Biomarkers.
3-Tesla magnetic resonance imaging; CEST-MRI; DW-MRI; DCE-MRI; DSC-MRI; IV administration of gadolinium-containing contrast agent

Acoustic Schwannoma, Adult Anaplastic Astrocytoma, Adult Anaplast Clinical Trial using fluorine F 18 fluorodopa; positron emission tomography; computed tomography; diffusion-weighted magnetic resonance imaging; perfusion-weighted magnetic resonance imaging; therapeutic conventional surgery; biopsy; laboratory biomarker analysis

Mayo Clinic - Recruiting 7 years or older.
- Evaluating the Impact of 18F-DOPA-PET on Neurosurgical Planning for Gliomas.
fluorine F 18 fluorodopa; positron emission tomography; computed tomography; diffusion-weighted magnetic resonance imaging; perfusion-weighted magnetic resonance imaging; therapeutic conventional surgery; biopsy; laboratory biomarker analysis

Glioblastoma, Malignant Glioma, Brain Tumors, or Anaplastic Astro Clinical Trial using Stem Cell Radiotherapy (ScRT) and Temozolomide

Beth Israel Medical Center - Recruiting 18 years to 70 years.
- STRONG Trial - Stem Cell Radiotherapy (ScRT) and Temozolomide for Newly Diagnosed High-grade Glioma (HGG): A Prospective, Phase I/II Trial.
Stem Cell Radiotherapy (ScRT) and Temozolomide

Glioblastoma Multiforme, Anaplastic Astrocytoma, Anaplastic Oligo Clinical Trial using Toca 511

Tocagen Inc. - Recruiting 18 years to 80 years.
- A P1 Ascending Dose Trial of the Safety and Tolerability of Toca 511, a Retroviral Replicating Vector, Administered Intravenously Prior to, and Intracranially at the Time of, Subsequent Resection for Recurrent HGG & Followed by Treatment With Extended-Release 5-FC.
Toca 511

Adult Anaplastic Astrocytoma, Adult Anaplastic Oligodendroglioma, Clinical Trial using anti-endoglin monoclonal antibody TRC105; bevacizumab; laboratory biomarker analysis; pharmacological study

National Cancer Institute (NCI) - Recruiting 18 years or older.
- Phase I/Comparative Randomized Phase II Trial of TRC105 Plus Bevacizumab Versus Bevacizumab in Bevacizumab-Na‹ve Patients With Recurrent Glioblastoma Multiforme.
anti-endoglin monoclonal antibody TRC105; bevacizumab; laboratory biomarker analysis; pharmacological study

Recurrent Childhood Anaplastic Astrocytoma, Recurrent Childhood A Clinical Trial using oncolytic HSV-1716; dexamethasone; therapeutic conventional surgery; laboratory biomarker analysis

Pediatric Brain Tumor Consortium - Recruiting 16 years to 21 years.
- A Phase I Study of Intratumoral/Peritumoral Herpes Simplex Virus-1 Mutant HSV1716 in Patients With Refractory or Recurrent High Grade Gliomas (HGG).
oncolytic HSV-1716; dexamethasone; therapeutic conventional surgery; laboratory biomarker analysis

Adult Anaplastic Astrocytoma, Adult Anaplastic Ependymoma, Adult Clinical Trial using Temozolomide; hypofractionated radiation therapy; bevacizumab; questionnaire administration

Northwestern University - Recruiting 18 years or older.
- A Phase II Study of the Efficacy of Hypofractionated Radiation Therapy With Bevacizumab and Temozolomide Followed by Maintenance Temozolomide and Bevacizumab for Recurrent High-Grade Gliomas.
Temozolomide; hypofractionated radiation therapy; bevacizumab; questionnaire administration

Adult Anaplastic Astrocytoma, Adult Anaplastic Oligodendroglioma, Clinical Trial using vorinostat; stereotactic body radiation therapy; laboratory biomarker analysis; pharmacological study; therapeutic conventional surgery

National Cancer Institute (NCI) - Recruiting 18 years or older.
- High-Dose Vorinostat With Radiation Therapy in the Treatment of Recurrent Glioma.
vorinostat; stereotactic body radiation therapy; laboratory biomarker analysis; pharmacological study; therapeutic conventional surgery

Malignant Glioma, Glioblastoma Multiforme, Anaplastic Astrocytoma Clinical Trial using Dendritic Cell Vaccine; Tumor Lysate; Imiquimod; Leukapheresis

University of Miami Sylvester Comprehensive Cancer Center - Recruiting 13 years or older.
- Dendritic Cell Vaccine For Malignant Glioma and Glioblastoma Multiforme in Adult and Pediatric Subjects.
Dendritic Cell Vaccine; Tumor Lysate; Imiquimod; Leukapheresis

Glioblastoma Multiforme, or Anaplastic Astrocytoma Clinical Trial using Super-Selective Intraarterial Intracranial Infusion of BEVACIZUMAB

Weill Medical College of Cornell University - Recruiting 18 years or older.
- Phase I Trial of Super-Selective Intraarterial Intracranial Infusion of Avastin (Bevacizumab) For Treatment of Relapsed/Refractory Glioblastoma Multiforme and Anaplastic Astrocytoma.
Super-Selective Intraarterial Intracranial Infusion of BEVACIZUMAB

Glioblastoma Multiforme, or Anaplastic Astrocytoma Clinical Trial using Bevacizumab and Carboplatin

Weill Medical College of Cornell University - Recruiting 18 years or older.
- Phase I/II Trial Of Repeated Super-selective Intraarterial Cerebral Infusion Of Bevacizumab Plus Carboplatin For Treatment Of Relapsed/Refractory Glioblastoma Multiforme And Anaplastic Astrocytoma.
Bevacizumab and Carboplatin

Glioblastoma Multiforme/Anaplastic Astrocytoma Clinical Trial using temozolomide; radiation therapy; stereotactic radiotherapy

Ohio State University Comprehensive Cancer Center - Recruiting 18 years or older.
- A Phase I Trial of Hypofraction Radiotherapy + Temozolomide in the Treatment of Patients With Glioblastoma Multiforme and Anaplastic Astrocytoma of the Brain.
temozolomide; radiation therapy; stereotactic radiotherapy

Brain and Central Nervous System Tumors Clinical Trial using antineoplaston A10; antineoplaston AS2-1

National Cancer Institute (NCI) - Recruiting 18 years or older.
- Phase II Study of Antineoplastons A10 and AS2-1 in Adult Patients With Anaplastic Astrocytoma.
antineoplaston A10; antineoplaston AS2-1