72 results found.

Brain and Central Nervous System Tumors, Cognitive/Functional Eff Clinical Trial using modafinil; placebo

University of South Florida - Recruiting 6 years to 17 years.
- A Phase II Placebo-Controlled Trial of Modafinil to Improve Neurocognitive Deficits in Children Treated for a Primary Brain Tumor.
modafinil; placebo

Childhood Mixed Glioma, Untreated Childhood Anaplastic Astrocytom Clinical Trial using veliparib; temozolomide; 3-dimensional conformal radiation therapy; intensity-modulated radiation therapy; pharmacological study; laboratory biomarker analysis

National Cancer Institute (NCI) - Recruiting N/A to 21 years.
- A Phase I/II Study of ABT-888, an Oral Poly(ADP-ribose) Polymerase Inhibitor, and Concurrent Radiation Therapy, Followed by ABT-888 and Temozolomide, in Children With Newly Diagnosed Diffuse Pontine Gliomas (DIPG).
veliparib; temozolomide; 3-dimensional conformal radiation therapy; intensity-modulated radiation therapy; pharmacological study; laboratory biomarker analysis

Brain Cancer Clinical Trial using Vorinostat; Bevacizumab

M.D. Anderson Cancer Center - Recruiting 18 years or older.
- Phase I/II Adaptive Randomized Trial of Bevacizumab Versus Bevacizumab Plus Vorinostat in Adults With Recurrent Glioblastoma.
Vorinostat; Bevacizumab

Glioblastoma, or Recurrent Metastatic Cancer to the Brain Clinical Trial using ExAblate 4000

InSightec - Recruiting 18 years to 70 years.
- A Feasibility Study to Evaluate the Safety and Feasibility of Transcranial MRI-Guided Focused Ultrasound Surgery in the Treatment of Brain Lesions.
ExAblate 4000

Glioma, or Metastatic Brain Cancer Clinical Trial using ExAblate Transcranial System

InSightec - Recruiting 18 years to 75 years.
- A Study to Evaluate the Safety and Feasibility of Transcranial MRI-Guided Focused Ultrasound Surgery in the Treatment of Brain Tumors.
ExAblate Transcranial System

Untreated Childhood Anaplastic Astrocytoma, Untreated Childhood A Clinical Trial using WEE1 inhibitor MK-1775; radiation therapy; pharmacological study; laboratory biomarker analysis

National Cancer Institute (NCI) - Recruiting 37 Months to 21 years.
- A Phase 1 Study of MK-1775 Concurrent With Local Radiation Therapy for the Treatment of Newly Diagnosed Children With Diffuse Intrinsic Pontine Gliomas.
WEE1 inhibitor MK-1775; radiation therapy; pharmacological study; laboratory biomarker analysis

Brain and Central Nervous System Tumors, Intraocular Melanoma, Lu Clinical Trial using DNA analysis; immunologic technique; pharmacological study; iodine I 131 monoclonal antibody 3F8; 131I-3F8

Memorial Sloan-Kettering Cancer Center - Recruiting N/A or older.
- Phase II Study of Intrathecal I-3F8 in Patients With GD2-Expressing Central Nervous System and Leptomeningeal Neoplasms.
DNA analysis; immunologic technique; pharmacological study; iodine I 131 monoclonal antibody 3F8; 131I-3F8

B-cell Childhood Acute Lymphoblastic Leukemia, Cognitive/Function Clinical Trial using cognitive assessment; psychosocial assessment and care; diffusion tensor imaging; laboratory biomarker analysis; pharmacological study

Children's Oncology Group - Recruiting 1 year to 17 years.
- A Study of Neurocognitive Function in Children Treated for ALL.
cognitive assessment; psychosocial assessment and care; diffusion tensor imaging; laboratory biomarker analysis; pharmacological study

Malignant Glioma, Glioblastoma, or Brain Cancer Clinical Trial using Anti-EGFRvIII CAR (PG13-139-CD8-CD28BBZ (F10) transduced PBL; Aldesleukin; Fludarabine; Cyclophosphamide

National Institutes of Health Clinical Center (CC) - Recruiting 18 years to 66 years.
- A Phase I/II Study of the Safety and Feasibility of Administering T Cells Expressing Anti-EGFRvIII Chimeric Antigen Receptor to Patients With Malignant Gliomas Expressing EGFRvIII.
Anti-EGFRvIII CAR (PG13-139-CD8-CD28BBZ (F10) transduced PBL; Aldesleukin; Fludarabine; Cyclophosphamide

Brain Neoplasms, or Central Nervous System Neoplasms Clinical Trial using Everolimus; Sorafenib

M.D. Anderson Cancer Center - Recruiting 18 years or older.
- A Phase I-II Trial Everolimus and Sorafenib in Patients With Recurrent High-Grade Gliomas.
Everolimus; Sorafenib

Pediatric Cancer, Leukemia, Sarcoma, or Brain Tumors Clinical Trial

National Institutes of Health Clinical Center (CC) - Recruiting N/A to 18 years.
- Protocol for the Enrollment on the Official COG Registry, The Childhood Cancer Research Network (CCRN) Children s Oncology Group.

Ewing's Sarcoma/Soft Tissue Sarcoma, Neuroblastoma, or Brain Tumo Clinical Trial using plerixafor

Sanofi - Recruiting 1 year to 18 years.
- A Phase 1/2 Combined Dose Ranging and Randomized, Open-label, Comparative Study of the Efficacy and Safety of Plerixafor in Addition to Standard Regimens for Mobilization of Haematopoietic Stem Cells Into Peripheral Blood, and Subsequent Collection by Apheresis, Versus Standard Mobilization Regimens Alone in Pediatric Patients, Aged 1 to <18 Years, With Solid Tumours Eligible for Autologous Transplants..
plerixafor

Brain Metastasis, or Cancer Clinical Trial

National Institutes of Health Clinical Center (CC) - Recruiting 18 years to 90 years.
- A Pilot Study to Evaluate Neuropsychological Outcome Measures and Their Relationship With Prognosis in Patients Receiving Radiation Therapy for Brain Metastases.

Brain Metastases Clinical Trial using 18F-FCH PET Scan

Memorial Sloan-Kettering Cancer Center - Recruiting 21 years or older.
- 18F-Fluorocholine (18F-FCho) to Distinguish Necrosis From Recurrence in Brain Metastases.
18F-FCH PET Scan

Melanoma Clinical Trial using SRS; WBRT; Cognitive Function Tests; Questionnaires

M.D. Anderson Cancer Center - Recruiting 18 years or older.
- A Prospective Randomized Phase III Trial to Compare Local Control and Neurocognitive Preservation After Initial Treatment With Stereotactic Radiosurgery (SRS) Versus Whole Brain Radiation Therapy (WBRT) for Patients With >3 Brain Metastases From Melanoma.
SRS; WBRT; Cognitive Function Tests; Questionnaires

Breast Cancer Clinical Trial using TPI 287; Dexamethasone; Benadryl; Ranitidine

M.D. Anderson Cancer Center - Recruiting 18 years or older.
- A Phase II Open-Label Study of TPI 287 in Patients With Breast Cancer Metastatic to the Brain.
TPI 287; Dexamethasone; Benadryl; Ranitidine

Brain Cancer, or Cancer Clinical Trial using Bone marrow specimen banking

Stanford University - Recruiting N/A to 21 years.
- Consent for Obtaining Additional Bone Marrow Specimens at the Time of a Diagnostic Bone Marrow Procedure.
Bone marrow specimen banking

Neuroblastoma, Medulloblastoma, Brain Tumors, or Rare Tumors Clinical Trial using Guided Therapy- Pediatric Gene Analysis Platform

Spectrum Health Hospitals - Recruiting 13 Months or older.
- A Feasibility Trial Using Molecular-Guided Therapy for the Treatment of Patients With Relapsed and Refractory Childhood Cancer.
Guided Therapy- Pediatric Gene Analysis Platform

Brain Cancer Clinical Trial using Diffusion kurtosis imaging (DKI)

Memorial Sloan-Kettering Cancer Center - Recruiting 18 years or older.
- Assessment of Early Response by Diffusion Kurtosis Imaging in Patients With Brain Metastasis.
Diffusion kurtosis imaging (DKI)

Brain Cancer Clinical Trial

University of Utah - Recruiting 18 years or older.
- Assessment of Primary and Metastatic Brain Tumor Hypoxia With 18F-Fluoromisonidazole, [18F]Fluoro-2-deoxy-D-glucose (FDG) and [15O]Water (H215O).

Cancer Liver, Cancer Brain, Cancer Head &Neck, or Cancer Pelvis Clinical Trial using MRI Group

University of Michigan Cancer Center - Recruiting 18 years or older.
- Optimization of MRI for Radiation Therapy.
MRI Group

Breast Cancer, Brain Cancer, Gastrointestinal Cancers, Genitourin Clinical Trial using IGF-Methotrexate

University of Illinois at Chicago - Recruiting 18 years or older.
- STM-02: Phase I Study of IGF-Methotrexate Conjugate in the Treatment of Advanced Tumors Expressing IGF-1R.
IGF-Methotrexate

Adult Anaplastic Oligodendroglioma, Adult Giant Cell Glioblastoma Clinical Trial using trebananib; placebo; bevacizumab; pharmacological study; laboratory biomarker analysis

National Cancer Institute (NCI) - Recruiting 18 years or older.
- Phase II Double-Blinded Placebo-Controlled Study of Bevacizumab With or Without AMG 386 in Patients With Recurrent Glioblastoma or Gliosarcoma.
trebananib; placebo; bevacizumab; pharmacological study; laboratory biomarker analysis

Brain Cancer Clinical Trial using preoperative fMRI. DTI and DSI with tractography

Memorial Sloan-Kettering Cancer Center - Recruiting 18 years or older.
- Using Functional MRI and Diffusion Tensor Imaging of the Motor and Language Pathways to Optimize Brain Tumor Resection.
preoperative fMRI. DTI and DSI with tractography

Brain and Central Nervous System Tumors Clinical Trial using mibefradil dihydrochloride; temozolomide; 3'-deoxy-3'-[18F]fluorothymidine; pharmacological study

Sidney Kimmel Comprehensive Cancer Center - Recruiting 18 years or older.
- A Phase I Open Label Safety Study to Evaluate the Pharmacokinetic Profile and Tolerance of Mibefradil Dose Finding in Subjects With Recurrent High-Grade Glioma Undergoing Standard, Repeated Temozolomide Treatment.
mibefradil dihydrochloride; temozolomide; 3'-deoxy-3'-[18F]fluorothymidine; pharmacological study

Tumors Metastatic to Brain, or Unspecified Adult Solid Tumor Clinical Trial using stereotactic radiosurgery; quality-of-life assessment; cognitive assessment

Case Comprehensive Cancer Center - Recruiting 18 years or older.
- Dose Escalation for Larger Brain Metastases: Phase I/II Study.
stereotactic radiosurgery; quality-of-life assessment; cognitive assessment

Tumors Metastatic to Brain Clinical Trial using radiosurgery; therapeutic conventional surgery; quality-of-life assessment

Case Comprehensive Cancer Center - Recruiting 18 years or older.
- Neoadjuvant Radiosurgery for Resectable Brain Metastases: Phase I/II Study.
radiosurgery; therapeutic conventional surgery; quality-of-life assessment

HER-2 Positive Breast Cancer Clinical Trial using Everolimus; Vinorelbine; Trastuzumab

UNC Lineberger Comprehensive Cancer Center - Recruiting 21 years or older.
- A Phase II Study Evaluating The Efficacy And Tolerability Of Everolimus (RAD001) In Combination With Trastuzumab And Vinorelbine In The Treatment Of Progressive HER2-Positive Breast Cancer Brain Metastases.
Everolimus; Vinorelbine; Trastuzumab

Metastatic Cancer Clinical Trial using conventional surgery; intraoperative radiation therapy

National Cancer Institute (NCI) - Recruiting 18 years or older.
- A Phase I/II Study Utilizing the Zeiss INTRABEAM System for the Treatment of a Resected Solitary Brain Metastasis.
conventional surgery; intraoperative radiation therapy

Brain and Central Nervous System Tumors Clinical Trial using carboplatin; tamoxifen citrate; temozolomide; adjuvant therapy; radiation therapy

National Cancer Institute (NCI) - Recruiting 18 years or older.
- A Phase II Pilot Trial of Radiation Therapy With Concurrent and Adjuvant Temozolomide, Tamoxifen and Carboplatin (T2C) in the Treatment of Patients With Primary Central Nervous System Malignant Gliomas.
carboplatin; tamoxifen citrate; temozolomide; adjuvant therapy; radiation therapy

Brain Metastases Clinical Trial using Single Fraction Stereotactic Radiosurgery (SRS); Fractionated Whole Brain Radiation Therapy (WBRT); Fractionated Stereotactic Radiation Therapy (FSRT); Magnetic Resonance Imaging (MRI) Assessments

University of Michigan Cancer Center - Recruiting 18 years or older.
- MRI Study of Changes in Blood-Brain/Tumor-Barrier Permeability in Patients With Brain Metastases During and After Radiotherapy.
Single Fraction Stereotactic Radiosurgery (SRS); Fractionated Whole Brain Radiation Therapy (WBRT); Fractionated Stereotactic Radiation Therapy (FSRT); Magnetic Resonance Imaging (MRI) Assessments

Brain Metastases From Non-small Cell Lung Cancer Clinical Trial using Veliparib; Placebo

AbbVie - Recruiting 18 years or older.
- A Randomized, Double-Blind, Phase 2, Dose-Ranging Study to Evaluate the Safety and Efficacy of Veliparib and Whole Brain Radiation Therapy Versus Placebo and Whole Brain Radiation Therapy in Subjects With Brain Metastases From Non-Small Cell Lung Cancer.
Veliparib; Placebo

Brain Cancer Clinical Trial using Lacosamide; Placebo

M.D. Anderson Cancer Center - Recruiting 18 years or older.
- Randomized, Double-Blind, Placebo-Controlled Trial of Lacosamide for Seizure Prophylaxis in Patients With High-Grade Gliomas.
Lacosamide; Placebo

Brain Metastases, Lung Cancer, Breast Cancer, Melanoma, or Malign Clinical Trial using 2B3-101; Trastuzumab; 2B3-101 60 mg/m2 every 4 weeks; 2B3-101 50 mg/m2 every 3 weeks

to-BBB technologies B.V. - Recruiting 18 years or older.
- An Open-label, Phase I/IIa, Dose Escalating Study of 2B3-101 in Patients With Solid Tumors and Brain Metastases or Recurrent Malignant Glioma..
2B3-101; Trastuzumab; 2B3-101 60 mg/m2 every 4 weeks; 2B3-101 50 mg/m2 every 3 weeks

Brain and Central Nervous System Tumors, Neuroblastoma, or Sarcom Clinical Trial using iodine I 131 monoclonal antibody 8H9

Memorial Sloan-Kettering Cancer Center - Recruiting N/A or older.
- Phase I Study Of Intrathecal Radioimmunotherapy Using I-8H9 For Central Nervous System/Leptomeningeal Neoplasms.
iodine I 131 monoclonal antibody 8H9

Tumors Metastatic to Brain Clinical Trial using sorafenib tosylate; stereotactic radiosurgery; laboratory biomarker analysis

Vanderbilt-Ingram Cancer Center - Recruiting 18 years or older.
- A Phase I Trial of Sorafenib and Stereotactic Radiosurgery for Patients With 1-4 Brain Metastases.
sorafenib tosylate; stereotactic radiosurgery; laboratory biomarker analysis

Childhood High-grade Cerebellar Astrocytoma, Childhood High-grade Clinical Trial using vorinostat; bevacizumab; temozolomide

National Cancer Institute (NCI) - Recruiting 3 years to 21 years.
- A Randomized Phase II/III Study of Vorinostat (IND# 71976) and Local Irradiation OR Temozolomide and Local Irradiation OR Bevacizumab (IND# 7921) and Local Irradiation Followed by Maintenance Bevacizumab and Temozolomide in Children With Newly Diagnosed High-Grade Gliomas.
vorinostat; bevacizumab; temozolomide

Benign Neoplasms, Brain, Brain Cancer, Brain Neoplasms, Benign, B Clinical Trial using 5-ALA (Gliolan)

Emory University - Recruiting 18 years or older.
- WCI1999-11: A Phase II Study of 5-Aminolevulinic Acid (ALA) to Enhance Visualization and Resection of Newly Diagnosed or Recurrent Malignant Gliomas.
5-ALA (Gliolan)

Brain Metastases From Breast Cancer Clinical Trial using PET/CT Imaging

Abramson Cancer Center of the University of Pennsylvania - Recruiting 18 years or older.
- F18 EF5 PET/CT Imaging in Patients With Brain Metastases From Breast Cancer.
PET/CT Imaging

Metastatic Cancer, or Unspecified Adult Solid Tumor, Protocol Spe Clinical Trial using bevacizumab; quality-of-life assessment

Northwestern University - Recruiting 18 years or older.
- A Phase II Trial of Bevacizumab in Patients With Recurrent Solid Tumor Brain Metastases Who Have Failed Whole Brain Radiation Therapy.
bevacizumab; quality-of-life assessment

Adrenal Cortical Cancer, Brain Cancer, Breast Cancer, CNS Cancer, Clinical Trial using Proton-decoupled 31P MRS at 1.5T; 1H Spectroscopy at 1.5T and 3T

Memorial Sloan-Kettering Cancer Center - Recruiting 18 years or older.
- Spectroscopy With Surface Coils and Decoupling.
Proton-decoupled 31P MRS at 1.5T; 1H Spectroscopy at 1.5T and 3T

Brain Tumor, or Malignant Neoplasm of Fourth Ventricle of Brain Clinical Trial using Ommaya Reservoir; Methotrexate; Leucovorin

M.D. Anderson Cancer Center - Recruiting N/A to 22 years.
- Methotrexate Infusion Into the Fourth Ventricle in Children With Malignant Fourth Ventricular Brain Tumors: A Pilot Study.
Ommaya Reservoir; Methotrexate; Leucovorin

Brain Cancer Clinical Trial using Temozolomide; Memantine; Mefloquine; Metformin

M.D. Anderson Cancer Center - Recruiting 18 years or older.
- A Phase I lead-in to a 2x2x2 Factorial Trial of Dose Dense Temozolomide, Memantine, Mefloquine, and Metformin As Post-Radiation Adjuvant Therapy of Glioblastoma Multiforme.
Temozolomide; Memantine; Mefloquine; Metformin

Brain Metastasis Clinical Trial using Trental; Vitamin E

University of Cincinnati - Recruiting 18 years or older.
- A Phase II Trial to Evaluate the Use of Trental and Vitamin E for Prophylaxis of Radiation Necrosis.
Trental; Vitamin E

Brain Disease Clinical Trial using Stereotactic Radiosurgery (SRS); MRI

M.D. Anderson Cancer Center - Recruiting 3 years or older.
- Efficacy of Post-Surgical Stereotactic Radiosurgery for Metastatic Brain Disease: A Randomized Trial.
Stereotactic Radiosurgery (SRS); MRI

Brain and Central Nervous System Tumors Clinical Trial using olaparib; temozolomide; gene expression analysis; protein expression analysis; laboratory biomarker analysis; pharmacological study; diffusion-weighted magnetic resonance imaging; dynamic contrast-enhanced magnetic resonance imaging; therapeutic conventional surgery

Cancer Research UK - Recruiting 18 years to 70 years.
- A Cancer Research UK Phase I Trial of Olaparib (AZD2281), an Oral PARP Inhibitor, in Combination With Extended Low-Dose Oral Temozolomide in Patients With Relapsed Glioblastoma.
olaparib; temozolomide; gene expression analysis; protein expression analysis; laboratory biomarker analysis; pharmacological study; diffusion-weighted magnetic resonance imaging; dynamic contrast-enhanced magnetic resonance imaging; therapeutic conventional surgery

Breast Cancer, or Brain Metastasis Clinical Trial using Radiation therapy Brain metastasis in breast cancer

Institut Paoli-Calmettes - Recruiting 18 years or older.
- Double-blind Randomized Multicenter Phase III Study Evaluation of the Efficacy of Hippocampal Avoidance on the Cognitive Toxicity of Whole-brain Radiation Therapy After Surgical Resection of Single Brain Metastasis of Breast Cancer..
Radiation therapy Brain metastasis in breast cancer

Brain and Central Nervous System Tumors, Chronic Myeloproliferati Clinical Trial using 3'-deoxy-3'-[18F]fluorothymidine

Barbara Ann Karmanos Cancer Institute - Recruiting 18 years or older.
- Use of [F-18] FLT for Imaging With Positron Emission Tomography (PET).
3'-deoxy-3'-[18F]fluorothymidine

Non-small-cell Lung Cancer Clinical Trial using Icotinib+WBRT

Zhejiang Beta Pharma Inc. - Recruiting 18 years to 75 years.
- A Single Center, Open Label, Multicenter Study to Determine the Safety and Efficacy of Icotinib in Combination With Whole Brain Radiation Therapy For NSCLC Patients With Brain Metastases.
Icotinib+WBRT

Glioma, Brain Cancer, Brain Tumor, Glioblastoma Multiforme, or Hi Clinical Trial using Dendritic Cell Vaccine; Tumor Lysate; Imiquimod; Punch Biopsy of the Skin; Leukapheresis

University of Miami Sylvester Comprehensive Cancer Center - Recruiting 1 year to 30 years.
- A Phase I Study of Dendritic Cell Vaccine Therapy With In Situ Maturation for Pediatric Brain Tumors.
Dendritic Cell Vaccine; Tumor Lysate; Imiquimod; Punch Biopsy of the Skin; Leukapheresis

Brain and Central Nervous System Tumors Clinical Trial using hydroxyurea; imatinib mesylate

National Cancer Institute (NCI) - Recruiting 18 years to 75 years.
- IMATINIB Plus Hydroxyurea in the Treatment of Recurrent or Progressive Meningiomas: a Randomized Phase II Study.
hydroxyurea; imatinib mesylate

Primary Central Nervous System Lymphoma, Brain and Central Nervou Clinical Trial using Rituxan; Carboplatin; Methotrexate; Sodium thiosulfate; Neupogen; Neulasta; Leucovorin

OHSU Knight Cancer Institute - Recruiting 18 years to 75 years.
- A Phase I/II Study of Patient With Newly Diagnosed Primary Central Nervous System Lymphoma Treated With Methotrexate/BBBD, and Adding Rituximab (an Anti CD-20 Antibody) and Carboplatin, to the Treatment Regimen.
Rituxan; Carboplatin; Methotrexate; Sodium thiosulfate; Neupogen; Neulasta; Leucovorin

Brain Tumors Clinical Trial using DC/AAT; DC/AAT-Flu; DC/KLH

Rockefeller University - Recruiting 18 years or older.
- A Phase I Study of Autologous Dendritic Cells Pulsed With Autologous Apoptotic Tumor Cells (DC/AAT) Administered Intradermally to Cancer Patients With Brain Tumors.
DC/AAT; DC/AAT-Flu; DC/KLH

Malignancy, Glioma, or Radiotherapy Clinical Trial using Photon treatment plans; Proton Treatment Plans; Neurocognitive evaluation; Advanced MRI imaging

Abramson Cancer Center of the University of Pennsylvania - Recruiting 18 years or older.
- Detection of Vascular and Neuronal Changes Following Proton and/or Photon Radiotherapy in Patients Receiving Skull Base and/or Brain Radiation.
Photon treatment plans; Proton Treatment Plans; Neurocognitive evaluation; Advanced MRI imaging

Brain and Central Nervous System Tumors Clinical Trial using dasatinib; temozolomide; placebo

National Cancer Institute (NCI) - Recruiting 18 years or older.
- Phase I/Randomized Phase II Trial of Either Dasatinib or Placebo Combined With Standard Chemo-Radiotherapy for Newly Diagnosed Glioblastoma Multiforme (GBM).
dasatinib; temozolomide; placebo

Sarcoma, Neuroblastoma, Wilms Tumor, Leukemia, Lymphoma, or Brain Clinical Trial using Marqibo

Spectrum Pharmaceuticals, Inc - Recruiting 2 years to 20 years.
- Phase I Trial to Evaluate the Safety, Activity and Pharmacokinetics of Marqibo(Registered Trademark) (Vincristine Sulfate Liposomes Injection) in Children and Adolescents With Refractory Cancer.
Marqibo

Brain and Central Nervous System Tumors Clinical Trial using biologic sample preservation procedure

National Cancer Institute (NCI) - Recruiting N/A to 18 years.
- A Children's Oncology Group Protocol for Collecting and Banking Pediatric Brain Tumor Research Specimens.
biologic sample preservation procedure

Brain Metastasis, or Non Small Cell Lung Cancer Clinical Trial using whole brain radiation(WBI); Icotinib

Guangdong Association of Clinical Trials - Recruiting 18 years to 75 years.
- Phase III Study of Icotinib Treat the Patient With Brain Metastasis EGFR-mutant Non Small Cell Lung Cancer Comparing With Whole Brain Radiotherapy.
whole brain radiation(WBI); Icotinib

Brain and Central Nervous System Tumors, Lymphoma, Neuroblastoma, Clinical Trial using crizotinib; pharmacogenomic studies; pharmacological study

National Cancer Institute (NCI) - Recruiting 1 year to 21 years.
- A Phase I/II Study of PF-02341066, an Oral Small Molecule Inhibitor of Anaplastic Lymphoma Kinase (ALK) and c-Met, in Children With Relapsed/Refractory Solid Tumors, Primary CNS Tumors, and Anaplastic Large Cell Lymphoma.
crizotinib; pharmacogenomic studies; pharmacological study

Cognitive/Functional Effects, Fallopian Tube Cancer, Ovarian Canc Clinical Trial using systemic chemotherapy; questionnaire administration; assessment of therapy complications; cognitive assessment; quality-of-life assessment

National Cancer Institute (NCI) - Recruiting 18 years or older.
- A Prospective Study of Cognitive Function During Chemotherapy for Front-Line Treatment of Ovarian, Primary Peritoneal or Fallopian Tube Cancer.
systemic chemotherapy; questionnaire administration; assessment of therapy complications; cognitive assessment; quality-of-life assessment

Glioblastoma Multiforme/Anaplastic Astrocytoma Clinical Trial using temozolomide; radiation therapy; stereotactic radiotherapy

Ohio State University Comprehensive Cancer Center - Recruiting 18 years or older.
- A Phase I Trial of Hypofraction Radiotherapy + Temozolomide in the Treatment of Patients With Glioblastoma Multiforme and Anaplastic Astrocytoma of the Brain.
temozolomide; radiation therapy; stereotactic radiotherapy

Brain and Central Nervous System Tumors Clinical Trial using cisplatin; cyclophosphamide; etoposide; lomustine; vincristine sulfate

National Cancer Institute (NCI) - Recruiting 3 years to 30 years.
- Study Of Reduced Dose Craniospinal Radiotherapy (1800 cGy) And Chemotherapy In Children With Newly-Diagnosed Standard-Risk Posterior Fossa Primitive Neuro-ectodermal Tumor (PNET/Medulloblastoma).
cisplatin; cyclophosphamide; etoposide; lomustine; vincristine sulfate

Brain and Central Nervous System Tumors Clinical Trial using temozolomide; DNA methylation analysis; laboratory biomarker analysis; adjuvant therapy; quality-of-life assessment; radiation therapy

National Cancer Institute (NCI) - Recruiting 18 years or older.
- Phase III Trial on Concurrent and Adjuvant Temozolomide Chemotherapy in Non-1p/19q Deleted Anaplastic Glioma. The CATNON Intergroup Trial..
temozolomide; DNA methylation analysis; laboratory biomarker analysis; adjuvant therapy; quality-of-life assessment; radiation therapy

Nonsmall Cell Lung Cancer Clinical Trial using Radiosurgery; Observation

Samsung Medical Center - Recruiting 18 years or older.
- Randomized Phase III Trial of Stereotactic Radiosurgery (SRS) Versus Observation for Patients With Asymptomatic Cerebral Oligo-metastases in Non-small Cell Lung Cancer (NSCLC).
Radiosurgery; Observation

Kidney Cancer, or Metastatic Cancer Clinical Trial using sunitinib malate

National Cancer Institute (NCI) - Recruiting 18 years or older.
- Phase II Study, Multicenter, Open-label, Evaluating Efficacy of Treatment With Sutentr (Sunitinib) in Patients With Previously Untreated or Recurrent Brain Metastases Originating From Renal Cancer.
sunitinib malate

Breast Cancer, or Metastatic Cancer Clinical Trial using temozolomide; radiation therapy

National Cancer Institute (NCI) - Recruiting 18 years or older.
- Phase II Randomized Multicenter Study Comparing Brain Radiation in Combination With Temozolomide or Radiation Alone in Patients With Brain Metastases From Breast Cancer.
temozolomide; radiation therapy

Neuroblastoma, Brain Tumors, or Solid Tumors Clinical Trial using Temozolomide/Hycamtin (Topotecan)

Gustave Roussy, Cancer Campus, Grand Paris - Recruiting 6 Months to 20 years.
- Phase 2 Single- Arm Studies of Temozolomide in Combination With Topotecan in Refractory and Relapsed Neuroblastoma and Other Paediatric Solid Tumours.
Temozolomide/Hycamtin (Topotecan)

Brain and Central Nervous System Tumors Clinical Trial using antineoplaston A10; antineoplaston AS2-1

National Cancer Institute (NCI) - Recruiting 18 years or older.
- Phase II Study of Antineoplastons A10 and AS2-1 in Adult Patients With Anaplastic Astrocytoma.
antineoplaston A10; antineoplaston AS2-1

Brain and Central Nervous System Tumors Clinical Trial using antineoplaston A10; antineoplaston AS2-1

National Cancer Institute (NCI) - Recruiting 18 years or older.
- Phase II Study of Antineoplastons A10 and AS2-1 in Adult Patients With Primary Malignant Brain Tumors.
antineoplaston A10; antineoplaston AS2-1

Brain and Central Nervous System Tumors Clinical Trial using adjuvant therapy; radiation therapy

National Cancer Institute (NCI) - Recruiting 18 years to 70 years.
- Adjuvant Postoperative High-Dose Radiotherapy for Atypical and Malignant Meningioma: a Phase-II and Observation Study.
adjuvant therapy; radiation therapy

Medulloblastoma, Brain Tumors, or Neuroectodermal Tumors, Primiti Clinical Trial using Etoposide, carboplatin, melphalan, cisplatin, thiotepa

Gustave Roussy, Cancer Campus, Grand Paris - Recruiting N/A to 10 years.
- Treatment Protocol for High-Risk PNET Brain Tumors in Children With Surgery, Sequential Chemotherapy, Conventional and High-Dose With Peripheral Blood Stem Cell Transplantation and Radiation Therapy.
Etoposide, carboplatin, melphalan, cisplatin, thiotepa