26 results found.

Recurrent Melanoma, Stage IV Melanoma, or Tumors Metastatic to Br Clinical Trial using Ipilimumab; Whole-Brain Radiation Therapy (WBRT); Stereotactic Radiosurgery (SRS)

Thomas Jefferson University - Recruiting 18 years or older.
- Phase I Study of Ipilimumab Combined With Whole Brain Radiation Therapy or Radiosurgery for Melanoma Patients With Brain Metastases.
Ipilimumab; Whole-Brain Radiation Therapy (WBRT); Stereotactic Radiosurgery (SRS)

Brain Metastases Clinical Trial using Stereotactic Radiosurgery

University of Alabama at Birmingham - Recruiting 19 years or older.
- RAD 1002: Phase I Dose Escalation/De-escalation Study of Pre-operative Stereotactic Radiosurgery for Brain Metastases.
Stereotactic Radiosurgery

Brain Metastasis, or Cancer Clinical Trial

National Institutes of Health Clinical Center (CC) - Recruiting 18 years to 90 years.
- A Pilot Study to Evaluate Neuropsychological Outcome Measures and Their Relationship With Prognosis in Patients Receiving Radiation Therapy for Brain Metastases.

Brain Metastases Clinical Trial using 18F-FCH PET Scan

Memorial Sloan-Kettering Cancer Center - Recruiting 21 years or older.
- 18F-Fluorocholine (18F-FCho) to Distinguish Necrosis From Recurrence in Brain Metastases.
18F-FCH PET Scan

Melanoma Clinical Trial using SRS; WBRT; Cognitive Function Tests; Questionnaires

M.D. Anderson Cancer Center - Recruiting 18 years or older.
- A Prospective Randomized Phase III Trial to Compare Local Control and Neurocognitive Preservation After Initial Treatment With Stereotactic Radiosurgery (SRS) Versus Whole Brain Radiation Therapy (WBRT) for Patients With >3 Brain Metastases From Melanoma.
SRS; WBRT; Cognitive Function Tests; Questionnaires

Brain Metastases Clinical Trial using Hyperbaric oxygen given at 2.4 ATA for 30 minutes immediately prior to SRS - HBOT for 30 minutes - SRS without prior HBO

Dartmouth-Hitchcock Medical Center - Recruiting 18 years to 80 years.
- A Proof-of-principle Study of Hyperbaric Oxygen as a Radiosensitizer Prior to Stereotactic Radiosurgery for Brain Metastases.
Hyperbaric oxygen given at 2.4 ATA for 30 minutes immediately prior to SRS - HBOT for 30 minutes - SRS without prior HBO

Lung Adenocarcinoma, or Brain Metastases Clinical Trial using erlotinib; pemetrexed; cisplatin

Guangzhou Medical University - Recruiting 18 years or older.
- Phase 2 Study of Erlotinib Plus Pemetrexed/Cisplatin Treating Lung Adenocarcinoma With Brain Metastases.
erlotinib; pemetrexed; cisplatin

Tumors Metastatic to Brain, or Unspecified Adult Solid Tumor Clinical Trial using stereotactic radiosurgery; quality-of-life assessment; cognitive assessment

Case Comprehensive Cancer Center - Recruiting 18 years or older.
- Dose Escalation for Larger Brain Metastases: Phase I/II Study.
stereotactic radiosurgery; quality-of-life assessment; cognitive assessment

Tumors Metastatic to Brain Clinical Trial using radiosurgery; therapeutic conventional surgery; quality-of-life assessment

Case Comprehensive Cancer Center - Recruiting 18 years or older.
- Neoadjuvant Radiosurgery for Resectable Brain Metastases: Phase I/II Study.
radiosurgery; therapeutic conventional surgery; quality-of-life assessment

HER-2 Positive Breast Cancer Clinical Trial using Everolimus; Vinorelbine; Trastuzumab

UNC Lineberger Comprehensive Cancer Center - Recruiting 21 years or older.
- A Phase II Study Evaluating The Efficacy And Tolerability Of Everolimus (RAD001) In Combination With Trastuzumab And Vinorelbine In The Treatment Of Progressive HER2-Positive Breast Cancer Brain Metastases.
Everolimus; Vinorelbine; Trastuzumab

Brain Metastases Clinical Trial using Single Fraction Stereotactic Radiosurgery (SRS); Fractionated Whole Brain Radiation Therapy (WBRT); Fractionated Stereotactic Radiation Therapy (FSRT); Magnetic Resonance Imaging (MRI) Assessments

University of Michigan Cancer Center - Recruiting 18 years or older.
- MRI Study of Changes in Blood-Brain/Tumor-Barrier Permeability in Patients With Brain Metastases During and After Radiotherapy.
Single Fraction Stereotactic Radiosurgery (SRS); Fractionated Whole Brain Radiation Therapy (WBRT); Fractionated Stereotactic Radiation Therapy (FSRT); Magnetic Resonance Imaging (MRI) Assessments

Brain Metastases From Non-small Cell Lung Cancer Clinical Trial using Veliparib; Placebo

AbbVie - Recruiting 18 years or older.
- A Randomized, Double-Blind, Phase 2, Dose-Ranging Study to Evaluate the Safety and Efficacy of Veliparib and Whole Brain Radiation Therapy Versus Placebo and Whole Brain Radiation Therapy in Subjects With Brain Metastases From Non-Small Cell Lung Cancer.
Veliparib; Placebo

Brain Metastases Clinical Trial using Sunitinib

University Health Network, Toronto - Recruiting 18 years or older.
- A Phase I Study of Stereotactic Radiosurgery Concurrent With Sunitinib in Patients With Brain Metastases.
Sunitinib

Brain Metastases Clinical Trial using Hypofractionated stereotactic radiotherapy

University Health Network, Toronto - Recruiting 18 years or older.
- Hypofractionated Stereotactic Radiotherapy (HF-SRT) for Large-Volume Brain Metastases.
Hypofractionated stereotactic radiotherapy

Brain Metastases, Lung Cancer, Breast Cancer, Melanoma, or Malign Clinical Trial using 2B3-101; Trastuzumab; 2B3-101 60 mg/m2 every 4 weeks; 2B3-101 50 mg/m2 every 3 weeks

to-BBB technologies B.V. - Recruiting 18 years or older.
- An Open-label, Phase I/IIa, Dose Escalating Study of 2B3-101 in Patients With Solid Tumors and Brain Metastases or Recurrent Malignant Glioma..
2B3-101; Trastuzumab; 2B3-101 60 mg/m2 every 4 weeks; 2B3-101 50 mg/m2 every 3 weeks

Tumors Metastatic to Brain Clinical Trial using sorafenib tosylate; stereotactic radiosurgery; laboratory biomarker analysis

Vanderbilt-Ingram Cancer Center - Recruiting 18 years or older.
- A Phase I Trial of Sorafenib and Stereotactic Radiosurgery for Patients With 1-4 Brain Metastases.
sorafenib tosylate; stereotactic radiosurgery; laboratory biomarker analysis

Brain Metastases From Breast Cancer Clinical Trial using PET/CT Imaging

Abramson Cancer Center of the University of Pennsylvania - Recruiting 18 years or older.
- F18 EF5 PET/CT Imaging in Patients With Brain Metastases From Breast Cancer.
PET/CT Imaging

Metastatic Cancer, or Unspecified Adult Solid Tumor, Protocol Spe Clinical Trial using bevacizumab; quality-of-life assessment

Northwestern University - Recruiting 18 years or older.
- A Phase II Trial of Bevacizumab in Patients With Recurrent Solid Tumor Brain Metastases Who Have Failed Whole Brain Radiation Therapy.
bevacizumab; quality-of-life assessment

Non-small-cell Lung Cancer Clinical Trial using Icotinib+WBRT

Zhejiang Beta Pharma Inc. - Recruiting 18 years to 75 years.
- A Single Center, Open Label, Multicenter Study to Determine the Safety and Efficacy of Icotinib in Combination With Whole Brain Radiation Therapy For NSCLC Patients With Brain Metastases.
Icotinib+WBRT

Central Nervous System (CNS) Metastases, or Brain Metastases Clinical Trial using Topotecan; Temozolomide

The Methodist Hospital System - Recruiting 18 years to 79 years.
- Phase II Trial of Chemotherapy With Temozolomide in Combination With Topotecan for Central Nervous System (CNS) Metastasis of Solid Tumors.
Topotecan; Temozolomide

Brain Metastases Clinical Trial using 6MV-X ray; Endostar

Jiangsu Simcere Pharmaceutical Co., Ltd. - Recruiting 18 years to 75 years.
- Phase II Study of Continuous Endostar Infusion Combined With Radiotherapy for the Treatment of Patients With Brain Metastases.
6MV-X ray; Endostar

Brain Metastases Clinical Trial using Radiation combined with iniparib (BSI-201)

Centre Val d'Aurelle - Paul Lamarque - Recruiting 18 years or older.
- A Phase I Trial Evaluating Concurrent Whole Brain Radiotherapy and Iniparib (BSI-201) in Multiple Non Operable Brain Metastases.
Radiation combined with iniparib (BSI-201)

Nonsmall Cell Lung Cancer Clinical Trial using Radiosurgery; Observation

Samsung Medical Center - Recruiting 18 years or older.
- Randomized Phase III Trial of Stereotactic Radiosurgery (SRS) Versus Observation for Patients With Asymptomatic Cerebral Oligo-metastases in Non-small Cell Lung Cancer (NSCLC).
Radiosurgery; Observation

Kidney Cancer, or Metastatic Cancer Clinical Trial using sunitinib malate

National Cancer Institute (NCI) - Recruiting 18 years or older.
- Phase II Study, Multicenter, Open-label, Evaluating Efficacy of Treatment With Sutentr (Sunitinib) in Patients With Previously Untreated or Recurrent Brain Metastases Originating From Renal Cancer.
sunitinib malate

Breast Cancer, or Metastatic Cancer Clinical Trial using temozolomide; radiation therapy

National Cancer Institute (NCI) - Recruiting 18 years or older.
- Phase II Randomized Multicenter Study Comparing Brain Radiation in Combination With Temozolomide or Radiation Alone in Patients With Brain Metastases From Breast Cancer.
temozolomide; radiation therapy