39 results found.

Brain and Central Nervous System Tumors, Cognitive/Functional Eff Clinical Trial using modafinil; placebo

University of South Florida - Recruiting 6 years to 17 years.
- A Phase II Placebo-Controlled Trial of Modafinil to Improve Neurocognitive Deficits in Children Treated for a Primary Brain Tumor.
modafinil; placebo

Glioblastoma, Small Cell Glioblastoma, Giant Cell Glioblastoma, G Clinical Trial using Rindopepimut (CDX-110) with GM-CSF; Temozolomide; KLH

Celldex Therapeutics - Recruiting 18 years or older.
- An International, Randomized, Double-Blind, Controlled Study of Rindopepimut/GM-CSF With Adjuvant Temozolomide in Patients With Newly Diagnosed, Surgically Resected, EGFRvIII-positive Glioblastoma.
Rindopepimut (CDX-110) with GM-CSF; Temozolomide; KLH

Glioblastoma, Small Cell Glioblastoma, Giant Cell Glioblastoma, G Clinical Trial using Bevacizumab; Rindopepimut (CDX-110) with GM-CSF; KLH

Celldex Therapeutics - Recruiting 18 years or older.
- A Phase II Study of Rindopepimut/GM-CSF in Patients With Relapsed EGFRvIII-Positive Glioblastoma.
Bevacizumab; Rindopepimut (CDX-110) with GM-CSF; KLH

Malignant Glioma Clinical Trial using 18F-FMISO; PET without SCS; SCS; PET without/with SCS; Radiotherapy; Temozolomide

Dr. Negrin University Hospital - Recruiting 18 years to 75 years.
- Positron Emission Tomography With Fluoro-misonidazole (PET-FMISO) in High Grade Gliomas: Assessment of Tumor Hypoxia and Effect of Spinal Cord Stimulation.
18F-FMISO; PET without SCS; SCS; PET without/with SCS; Radiotherapy; Temozolomide

Nausea, Vomiting, or Glioma Clinical Trial using Aprepitant; Ondansetron

Duke University - Recruiting 18 years or older.
- A Randomized Open Label Phase II Trial of Aprepitant (Emend) in Combination With Ondansetron Compared to Standard 5HT3 Serotonin Antagonist (Ondansetron) in the Prevention of Acute and Delayed Chemotherapy Induced Nausea and Vomiting (CINV) in Glioma Patients Receiving a Temozolomide Based Regimen.
Aprepitant; Ondansetron

Recurrent Glioblastoma Clinical Trial using Nivolumab; Ipilimumab; Bevacizumab

Bristol-Myers Squibb - Recruiting 18 years or older.
- A Randomized Phase IIb, Open Label Study of Nivolumab or Nivolumab in Combination With Ipilimumab Versus Bevacizumab in Adult Subjects With Recurrent Glioblastoma (GBM).
Nivolumab; Ipilimumab; Bevacizumab

Solid Tumors, Brain Tumors, Sarcoma, Wilm's Tumor, or Rhabdomyosa Clinical Trial using NK cellular therapy; rhIL-15

National Institutes of Health Clinical Center (CC) - Recruiting 2 years to 29 years.
- A Phase I Study of Autologous Activated Natural Killer (NK) Cells +/- rhIL15 in Children and Young Adults With Refractory Solid Tumors.
NK cellular therapy; rhIL-15

Astrocytoma, Central Nervous System Tumor, Glioblastoma, Glioma, Clinical Trial

National Institutes of Health Clinical Center (CC) - Recruiting 1 year or older.
- Evaluation of the Natural History of Patients With Tumors of the Central Nervous System.

Glioma, Glioblastoma, or Brain Tumor, Recurrent Clinical Trial using ANG1005; Bevacizumab

Angiochem Inc - Recruiting 18 years or older.
- A Phase II, Open-Label, Multi-Center Study of ANG1005 in Patients With Recurrent High-Grade Glioma.
ANG1005; Bevacizumab

Brain Tumor Clinical Trial using SVV; CVP

Yonsei University - Recruiting 20 years to 65 years.
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SVV; CVP

Brain Tumor, or Central Nervous System Tumor Clinical Trial using cisplatin; cyclophosphamide; lomustine; vincristine sulfate; radiation therapy

Children's Oncology Group - Recruiting 3 years to 21 years.
- A Study Evaluating Limited Target Volume Boost Irradiation and Reduced Dose Craniospinal Radiotherapy (18.00 Gy) and Chemotherapy in Children With Newly Diagnosed Standard Risk Medulloblastoma: A Phase III Double Randomized Trial.
cisplatin; cyclophosphamide; lomustine; vincristine sulfate; radiation therapy

Radiation Injury, or Brain Tumor Clinical Trial

University of Michigan - Recruiting 18 years or older.
- .

Brain and Central Nervous System Tumors Clinical Trial

St. Jude Children's Research Hospital - Recruiting N/A to 21 years.
- Molecular and Histopathologic Characterization of Atypical Teratoid Rhabdoid Tumors, Choroid Plexus Carcinomas, Ependymomas and Medulloblastoma/PNET of the Pediatric CNS.

Glioblastoma Multiforme, or Gliosarcoma Clinical Trial using AMG 102 with Avastin

Duke University - Recruiting 18 years or older.
- Phase II Study to Evaluate the Efficacy and Safety of AMG 102 and Avastin in Subjects With Recurrent Malignant Glioma.
AMG 102 with Avastin

Brain Cancer Clinical Trial

University of Utah - Recruiting 18 years or older.
- Assessment of Primary and Metastatic Brain Tumor Hypoxia With 18F-Fluoromisonidazole, [18F]Fluoro-2-deoxy-D-glucose (FDG) and [15O]Water (H215O).

Adult Anaplastic Oligodendroglioma, Adult Giant Cell Glioblastoma Clinical Trial using trebananib; placebo; bevacizumab; pharmacological study; laboratory biomarker analysis

National Cancer Institute (NCI) - Recruiting 18 years or older.
- Phase II Double-Blinded Placebo-Controlled Study of Bevacizumab With or Without AMG 386 in Patients With Recurrent Glioblastoma or Gliosarcoma.
trebananib; placebo; bevacizumab; pharmacological study; laboratory biomarker analysis

Brain Cancer Clinical Trial using preoperative fMRI. DTI and DSI with tractography

Memorial Sloan-Kettering Cancer Center - Recruiting 18 years or older.
- Using Functional MRI and Diffusion Tensor Imaging of the Motor and Language Pathways to Optimize Brain Tumor Resection.
preoperative fMRI. DTI and DSI with tractography

Brain Tumor Clinical Trial using everolimus; immunohistochemistry staining method; laboratory biomarker analysis

University of California, San Francisco - Recruiting 18 years or older.
- Phase II Trial of RAD001 in Patients With Recurrent Low Grade Glioma.
everolimus; immunohistochemistry staining method; laboratory biomarker analysis

Tumors Metastatic to Brain, or Unspecified Adult Solid Tumor Clinical Trial using stereotactic radiosurgery; quality-of-life assessment; cognitive assessment

Case Comprehensive Cancer Center - Recruiting 18 years or older.
- Dose Escalation for Larger Brain Metastases: Phase I/II Study.
stereotactic radiosurgery; quality-of-life assessment; cognitive assessment

Brain Tumor Clinical Trial using MRI

University of Texas Southwestern Medical Center - Recruiting 18 years or older.
- High Resolution Magnetic Resonance Imaging in Patients With Brain Tumors.
MRI

Glioblastoma Multiforme, Anaplastic Astrocytoma, Anaplastic Oligo Clinical Trial using Toca 511

Tocagen Inc. - Recruiting 18 years to 80 years.
- A P1 Ascending Dose Trial of the Safety and Tolerability of Toca 511, a Retroviral Replicating Vector, Administered Intravenously Prior to, and Intracranially at the Time of, Subsequent Resection for Recurrent HGG & Followed by Treatment With Extended-Release 5-FC.
Toca 511

Metastatic Cancer Clinical Trial using conventional surgery; intraoperative radiation therapy

National Cancer Institute (NCI) - Recruiting 18 years or older.
- A Phase I/II Study Utilizing the Zeiss INTRABEAM System for the Treatment of a Resected Solitary Brain Metastasis.
conventional surgery; intraoperative radiation therapy

Recurrent Childhood Anaplastic Astrocytoma, Recurrent Childhood A Clinical Trial using oncolytic HSV-1716; dexamethasone; therapeutic conventional surgery; laboratory biomarker analysis

Pediatric Brain Tumor Consortium - Recruiting 16 years to 21 years.
- A Phase I Study of Intratumoral/Peritumoral Herpes Simplex Virus-1 Mutant HSV1716 in Patients With Refractory or Recurrent High Grade Gliomas (HGG).
oncolytic HSV-1716; dexamethasone; therapeutic conventional surgery; laboratory biomarker analysis

Brain Metastases Clinical Trial using Single Fraction Stereotactic Radiosurgery (SRS); Fractionated Whole Brain Radiation Therapy (WBRT); Fractionated Stereotactic Radiation Therapy (FSRT); Magnetic Resonance Imaging (MRI) Assessments

University of Michigan Cancer Center - Recruiting 18 years or older.
- MRI Study of Changes in Blood-Brain/Tumor-Barrier Permeability in Patients With Brain Metastases During and After Radiotherapy.
Single Fraction Stereotactic Radiosurgery (SRS); Fractionated Whole Brain Radiation Therapy (WBRT); Fractionated Stereotactic Radiation Therapy (FSRT); Magnetic Resonance Imaging (MRI) Assessments

Benign Neoplasms, Brain, Brain Cancer, Brain Neoplasms, Benign, B Clinical Trial using 5-ALA (Gliolan)

Emory University - Recruiting 18 years or older.
- WCI1999-11: A Phase II Study of 5-Aminolevulinic Acid (ALA) to Enhance Visualization and Resection of Newly Diagnosed or Recurrent Malignant Gliomas.
5-ALA (Gliolan)

Metastatic Cancer, or Unspecified Adult Solid Tumor, Protocol Spe Clinical Trial using bevacizumab; quality-of-life assessment

Northwestern University - Recruiting 18 years or older.
- A Phase II Trial of Bevacizumab in Patients With Recurrent Solid Tumor Brain Metastases Who Have Failed Whole Brain Radiation Therapy.
bevacizumab; quality-of-life assessment

Malignant Glioma (WHO Grade III or IV) Clinical Trial using CTO and Bevacizumab; CTO alone

Duke University - Recruiting 18 years or older.
- A Phase 1/2 Trial of Carboxyamidotriazole Orotate (CTO) Alone or in Combination With Bevacizumab for Adult Patients With Recurrent Malignant Glioma Post-Bevacizumab Failure.
CTO and Bevacizumab; CTO alone

Brain Tumor, or Malignant Neoplasm of Fourth Ventricle of Brain Clinical Trial using Ommaya Reservoir; Methotrexate; Leucovorin

M.D. Anderson Cancer Center - Recruiting N/A to 22 years.
- Methotrexate Infusion Into the Fourth Ventricle in Children With Malignant Fourth Ventricular Brain Tumors: A Pilot Study.
Ommaya Reservoir; Methotrexate; Leucovorin

Brain Tumor Clinical Trial using Exercise Program

The Hospital for Sick Children - Recruiting 9 years to 14 years.
- The Neuro-protective Effects of Exercise in Children With Brain Tumors.
Exercise Program

Brain Tumor Clinical Trial using Interstitial Laser Therapy

Brigham and Women's Hospital - Recruiting 18 years or older.
- Neurosurgical Use of Interstitial Laser Therapy (ILT).
Interstitial Laser Therapy

Glioma, Brain Cancer, Brain Tumor, Glioblastoma Multiforme, or Hi Clinical Trial using Dendritic Cell Vaccine; Tumor Lysate; Imiquimod; Punch Biopsy of the Skin; Leukapheresis

University of Miami Sylvester Comprehensive Cancer Center - Recruiting 1 year to 30 years.
- A Phase I Study of Dendritic Cell Vaccine Therapy With In Situ Maturation for Pediatric Brain Tumors.
Dendritic Cell Vaccine; Tumor Lysate; Imiquimod; Punch Biopsy of the Skin; Leukapheresis

Brain Tumors Clinical Trial using DC/AAT; DC/AAT-Flu; DC/KLH

Rockefeller University - Recruiting 18 years or older.
- A Phase I Study of Autologous Dendritic Cells Pulsed With Autologous Apoptotic Tumor Cells (DC/AAT) Administered Intradermally to Cancer Patients With Brain Tumors.
DC/AAT; DC/AAT-Flu; DC/KLH

Sarcoma, Neuroblastoma, Wilms Tumor, Leukemia, Lymphoma, or Brain Clinical Trial using Marqibo

Spectrum Pharmaceuticals, Inc - Recruiting 2 years to 20 years.
- Phase I Trial to Evaluate the Safety, Activity and Pharmacokinetics of Marqibo(Registered Trademark) (Vincristine Sulfate Liposomes Injection) in Children and Adolescents With Refractory Cancer.
Marqibo

Brain and Central Nervous System Tumors Clinical Trial using biologic sample preservation procedure

National Cancer Institute (NCI) - Recruiting N/A to 18 years.
- A Children's Oncology Group Protocol for Collecting and Banking Pediatric Brain Tumor Research Specimens.
biologic sample preservation procedure

Brain and Central Nervous System Tumors, Lymphoma, Neuroblastoma, Clinical Trial using crizotinib; pharmacogenomic studies; pharmacological study

National Cancer Institute (NCI) - Recruiting 1 year to 21 years.
- A Phase I/II Study of PF-02341066, an Oral Small Molecule Inhibitor of Anaplastic Lymphoma Kinase (ALK) and c-Met, in Children With Relapsed/Refractory Solid Tumors, Primary CNS Tumors, and Anaplastic Large Cell Lymphoma.
crizotinib; pharmacogenomic studies; pharmacological study

Brain and Central Nervous System Tumors Clinical Trial using cisplatin; cyclophosphamide; etoposide; lomustine; vincristine sulfate

National Cancer Institute (NCI) - Recruiting 3 years to 30 years.
- Study Of Reduced Dose Craniospinal Radiotherapy (1800 cGy) And Chemotherapy In Children With Newly-Diagnosed Standard-Risk Posterior Fossa Primitive Neuro-ectodermal Tumor (PNET/Medulloblastoma).
cisplatin; cyclophosphamide; etoposide; lomustine; vincristine sulfate

Brain Tumors Clinical Trial using MRI

University of Michigan - Recruiting 18 years or older.
- Quantitation of Human Brain Tumor Therapy Response by MR.
MRI

GLIOBLASTOMA MULTIFORME, or Brain Neoplasm Clinical Trial

Washington University School of Medicine - Recruiting 18 years to 70 years.
- BIRN (Biomedical Informatics Research Network)Resources Facilitate the Personalization of Malignant Brain Tumor.

Brain Tumor Clinical Trial using high-dose chemotherapy and autologous stem cell rescue

Samsung Medical Center - Recruiting N/A or older.
- Multicenter Clinical Trial to Evaluate Efficacy of High-dose Chemotherapy With Autologous Stem Cell Rescue for Children With High-risk Brain Tumors.
high-dose chemotherapy and autologous stem cell rescue