300 results found.

Breast Cancer, or Neoplasm Metastasis Clinical Trial using Standard supportive care (packed RBC transfusion); epoetin alfa + packed RBC transfusion

Janssen Research & Development, LLC - Recruiting 18 years or older.
- A Randomized, Open-label, Multicenter, Phase 3 Study of Epoetin Alfa Plus Standard Supportive Care Versus Standard Supportive Care in Anemic Patients With Metastatic Breast Cancer Receiving Standard Chemotherapy.
Standard supportive care (packed RBC transfusion); epoetin alfa + packed RBC transfusion

Metastatic Breast Cancer Clinical Trial using Cisplatin; Metronomic Cyclophosphamide

Centre Jean Perrin - Recruiting 18 years or older.
- .
Cisplatin; Metronomic Cyclophosphamide

Metastatic Breast Cancer Clinical Trial using Palbociclib; Fulvestrant; Placebo

Pfizer - Recruiting 18 years or older.
- Multicenter, Randomized, Double-Blind, Placebo-Controlled, Phase 3 Trial Of Fulvestrant (Faslodex?) With Or Without PD-0332991 (Palbociclib) +/- Goserelin In Women With Hormone Receptor-Positive, HER2-Negative Metastatic Breast Cancer Whose Disease Progressed After Prior Endocrine Therapy.
Palbociclib; Fulvestrant; Placebo

Neutropenia Clinical Trial using HM10460A (45 æg/kg); HM10460A (135 æg/kg); HM10460A (270 æg/kg); Pegfilgrastim 6mg

Spectrum Pharmaceuticals, Inc - Recruiting 18 years or older.
- Phase 2, Open-Label, Dose-Ranging Study of HM10460A or Pegfilgrastim Use for the Management of Neutropenia in Patients With Breast Cancer Who Are Candidates for Adjuvant and Neoadjuvant Chemotherapy With the Docetaxel + Cyclophosphamide (TC) Regimen.
HM10460A (45 æg/kg); HM10460A (135 æg/kg); HM10460A (270 æg/kg); Pegfilgrastim 6mg

Breast Cancer Clinical Trial using physiologic testing; screening questionnaire administration; breast imaging study; radiomammography; study of high risk factors

Case Comprehensive Cancer Center - Recruiting 50 years or older.
- Longitudinal Changes in Mammographic Density and Risk of Breast Cancer.
physiologic testing; screening questionnaire administration; breast imaging study; radiomammography; study of high risk factors

Breast Neoplasms, Ovarian Neoplasms, Colonic Neoplasms, Prostatic Clinical Trial

Memorial Sloan-Kettering Cancer Center - Recruiting N/A or older.
- Ascertainment of Peripheral Blood or Saliva Samples for Genetic Epidemiology Studies of Familial Cancers.

Breast Cancer Clinical Trial

Memorial Sloan-Kettering Cancer Center - Recruiting 18 years or older.
- Clinical Significance of Germline BRCA Mutations.

Breast Cancer Clinical Trial using gene expression analysis; immunohistochemistry staining method; laboratory biomarker analysis

Case Comprehensive Cancer Center - Recruiting N/A or older.
- Assessment of Candidate Protein Expression in Human Breast Cancer Specimens.
gene expression analysis; immunohistochemistry staining method; laboratory biomarker analysis

Women at Increased Risk for Developing Breast Carcinoma Clinical Trial using Mammography (CESM) and MRI

Memorial Sloan-Kettering Cancer Center - Recruiting 21 years or older.
- Comparison of Contrast Enhanced Mammography to Breast MRI in Screening Patients at Increased Risk for Breast Cancer.
Mammography (CESM) and MRI

Breast Cancer Clinical Trial using Aerobic Activity; Dietician Counseling; Yoga; Cognitive Behavior Therapy; Smoking Cessation Counseling; Questionnaires; Saliva Samples; Dietary Assessment; Blood Samples

M.D. Anderson Cancer Center - Recruiting 18 years or older.
- The Role of Lifestyle Factors in Breast Cancer-Related Outcomes.
Aerobic Activity; Dietician Counseling; Yoga; Cognitive Behavior Therapy; Smoking Cessation Counseling; Questionnaires; Saliva Samples; Dietary Assessment; Blood Samples

Breast Cancer Clinical Trial using Nutrition Education; Acupuncture

Mount Sinai School of Medicine - Recruiting 18 years or older.
- Comparison of Weight Loss Among Early Stage Breast Cancer Patients Post Chemotherapy: Nutrition Education in Combination With Weight Loss Acupuncture Vs. Nutrition Education Alone.
Nutrition Education; Acupuncture

Stage IB Breast Cancer, or Stage II Breast Cancer Clinical Trial using regional nodal XRT; chestwall XRT; WBI

National Surgical Adjuvant Breast and Bowel Project (NSABP) - Recruiting 18 years or older.
- A Randomized Phase III Clinical Trial Evaluating Post-Mastectomy Chestwall and Regional Nodal XRT and Post-Lumpectomy Regional Nodal XRT in Patients With Positive Axillary Nodes Before Neoadjuvant Chemotherapy Who Convert to Pathologically Negative Axillary Nodes After Neoadjuvant Chemotherapy.
regional nodal XRT; chestwall XRT; WBI

Breast Neoplasms, or Stomach Neoplasms Clinical Trial using Herceptin; afatinib; trastuzumab

Boehringer Ingelheim - Recruiting 18 years or older.
- Phase I Trial of Afatinib in Combination With 3 Weekly Trastuzumab in Patients With Tumours Overexpressing HER2. Once the MTD of Afatinib With 3 Weekly Trastuzumab Was Established the Safety of This Dose Will be Assessed Also in Combination With Weekly Trastuzumab..
Herceptin; afatinib; trastuzumab

Metastatic Breast Cancer Clinical Trial using Paclitaxel; Bevacizumab; Letrozole; Anastrozole; Exemestane; Fulvestrant; Goserelin; leuprorelin acetate

Japan Breast Cancer Research Group - Recruiting 20 years to 75 years.
- Bevacizumab Plus Paclitaxel Optimization Study With Interventional Maintenance Endocrine Therapy in Advanced or Metastatic ER-positive HER2-negative Breast Cancer -BOOSTER Trial, a Multicenter Randomized Phase II Study-.
Paclitaxel; Bevacizumab; Letrozole; Anastrozole; Exemestane; Fulvestrant; Goserelin; leuprorelin acetate

Mixed Muellerian Cancer, Cervical Cancer, Ovarian Cancer, Breast Clinical Trial using Carboplatin; Olaparib; Treatment Effect

National Institutes of Health Clinical Center (CC) - Recruiting 18 years or older.
- A Pharmacokinetic/Pharmacodynamic Study With a Phase I Run-In With a PARP Inhibitor (Olaparib) in Combination With Carboplatin for Refractory or Recurrent Women's Cancers.
Carboplatin; Olaparib; Treatment Effect

HER2 Positive Metastatic Breast Cancers Clinical Trial using ONT-380; Capecitabine; Trastuzumab

Oncothyreon Inc. - Recruiting 18 years or older.
- A Phase 1b, Open-label Study to Assess the Safety and Tolerability of ONT-380 Combined With Capecitabine and Trastuzumab, Alone and in Combination in HER2+ Metastatic Breast Cancer.
ONT-380; Capecitabine; Trastuzumab

Breast Cancer Clinical Trial using Verbal and Written Instruction; Verbal and Written Plus Simulation

Memorial Sloan-Kettering Cancer Center - Recruiting 19 years or older.
- A Comparison of Strategies for Injection Teaching: Verbal and Written Instruction Versus Verbal and Written Plus Simulation in Patients With Breast Cancer and Their Caregivers.
Verbal and Written Instruction; Verbal and Written Plus Simulation

Breast Cancer, Lobular Carcinoma, or Invasive Breast Cancer Clinical Trial using Tissue specimen

Memorial Sloan-Kettering Cancer Center - Recruiting N/A or older.
- Molecular Genetic Basis of Invasive Breast Cancer Risk Associated With Lobular Carcinoma in Situ.
Tissue specimen

Joint Pain, or Breast Cancer Clinical Trial using Walk with Ease

University of North Carolina, Chapel Hill - Recruiting 21 years or older.
- Physical Activity to Reduce Joint Pain During Aromatase Inhibitor Therapy.
Walk with Ease

Estrogen Receptor-positive Breast Cancer, HER2-negative Breast Ca Clinical Trial using fulvestrant; anastrozole

Alliance for Clinical Trials in Oncology - Recruiting 18 years or older.
- Alternate Approaches for Clinical Stage II or III Estrogen Receptor Positive Breast Cancer Neoadjuvant Treatment (ALTERNATE) in Postmenopausal Women: A Phase III Study.
fulvestrant; anastrozole

Clear Cell Renal Cell Carcinoma, Stage III Renal Cell Cancer, or Clinical Trial using cabozantinib-s-malate; sunitinib malate; laboratory biomarker analysis

National Cancer Institute (NCI) - Recruiting 18 years or older.
- Randomized Phase II Study Comparing Cabozantinib With Commercially Supplied Sunitinib in Patients With Previously Untreated Locally Advanced or Metastatic Renal Cell Carcinoma.
cabozantinib-s-malate; sunitinib malate; laboratory biomarker analysis

Solid Cancers Clinical Trial using letrozole; fulvestrant; GDC-0032

Genentech - Recruiting 18 years or older.
- An Open-Label, Phase I/II, Dose Escalation Study Evaluating the Safety and Tolerability of GDC-0032 in Patients With Locally Advanced or Metastatic Solid Tumors and in Combination With Endocrine Therapy in Patients With Locally Advanced or Metastatic Hormone Receptor-Positive Breast Cancer.
letrozole; fulvestrant; GDC-0032

Breast Cancer Clinical Trial using GDC-0941; placebo; fulvestrant; GDC-0980

Genentech - Recruiting 18 years or older.
- A Phase II, Double-Blind, Placebo Controlled, Randomized Study of GDC-0941 or GDC-0980 With Fulvestrant Versus Fulvestrant in Advanced or Metastatic Breast Cancer in Patients Resistant to Aromatase Inhibitor Therapy.
GDC-0941; placebo; fulvestrant; GDC-0980

Breast Cancer Clinical Trial using GDC-0941; Placebo; paclitaxel

Genentech - Recruiting 18 years or older.
- A Phase II, Randomized Study of Paclitaxel With GDC-0941 Versus Paclitaxel With Placebo in Patients With Locally Recurrent or Metastatic Breast Cancer.
GDC-0941; Placebo; paclitaxel

Breast Cancer Clinical Trial

Genentech - Recruiting 18 years or older.
- An Observational Cohort Study Of Treatment Patterns And Outcomes In Patients With HER2 Positive (Her2+) Metastatic Breast Cancer (SystHERs Registry (Systematic Therapies for HER2+ Metastatic Breast Cancer Study))..

Breast Cancer Clinical Trial using GDC-0032; Docetaxel; Paclitaxel

Genentech - Recruiting 18 years or older.
- A Phase Ib Open-Label, Dose-Escalation Study of the Safety and Pharmacology of GDC-0032 in Combination With Either Docetaxel or Paclitaxel in Patients With HER2-Negative, Locally Advanced or Metastatic Breast Cancer.
GDC-0032; Docetaxel; Paclitaxel

Metastatic Breast Cancer Clinical Trial using PF-05280014; Paclitaxel; Herceptin®

Pfizer - Recruiting 18 years or older.
- A Phase 3 Randomized, Double-Blind Study Of PF-05280014 Plus Paclitaxel Versus Trastuzumab Plus Paclitaxel For The First-Line Treatment Of Patients With HER2-Positive Metastatic Breast Cancer.
PF-05280014; Paclitaxel; Herceptin®

Bone Metabolism Biomarkers, Bone Mineral Density, or Physical Fit Clinical Trial using Vitamin D3; Physical Activity

University of Rochester - Recruiting 18 years or older.
- The Effect of High-Dose Vitamin D and Physical Activity on Bone Health in Breast Cancer Patients Receiving Hormonal Therapy.
Vitamin D3; Physical Activity

Metastatic Breast Cancer Clinical Trial using Anakinra plus Standard of Care

Baylor Research Institute - Recruiting 18 years to 80 years.
- Pilot Safety and Blood Immune Cell Transcriptional Profiling Study of Anakinra Plus the Physician's Chemotherapy Choice in Metastatic Breast Cancer Patients.
Anakinra plus Standard of Care

HER2 Positive Breast Cancers Clinical Trial using ONT-380; T-DM1

Oncothyreon Inc. - Recruiting 18 years or older.
- A Phase 1b, Open-label Study to Assess the Safety and Tolerability of ONT-380 Combined With T-DM1.
ONT-380; T-DM1

Breast Cancer, or Lymphedema Clinical Trial using Supportive care (lymphedema education); Lymphedema Survey; bilateral upper extremities (BUE) measurements

Case Comprehensive Cancer Center - Recruiting 18 years or older.
- Effect of Intensive Education on Breast Cancer Patient's Understanding of Lymphedema.
Supportive care (lymphedema education); Lymphedema Survey; bilateral upper extremities (BUE) measurements

Breast Cancer Clinical Trial using doxorubicin hydrochloride; enalapril maleate

Masonic Cancer Center, University of Minnesota - Recruiting 18 years or older.
- The Effect of Enalapril on Doxorubicin Exposure in Adjuvant Breast Cancer Treatment.
doxorubicin hydrochloride; enalapril maleate

Breast Cancer Clinical Trial using Paclitaxel; BKM120 matching placebo; BKM120

Novartis - Recruiting 18 years or older.
- A Randomized, Double-blind, Placebo Controlled, Phase II/III Study of BKM120 Plus Paclitaxel in Patients With HER2 Negative Inoperable Locally Advanced or Metastatic Breast Cancer, With or Without PI3K Pathway Activation..
Paclitaxel; BKM120 matching placebo; BKM120

Colorectal Cancer, Breast Cancer, Coronary Heart Disease, or Diab Clinical Trial using risk assessment survey; decision support for providers for prevention based on risk

Brigham and Women's Hospital - Recruiting 18 years to 75 years.
- Health Information Technology (HIT) Enhanced Family History Documentation and Management in Primary Care.
risk assessment survey; decision support for providers for prevention based on risk

Advanced Cancer, Metastatic Cancer, Lymphoma, Metastatic Breast C Clinical Trial using LY3023414; Midazolam; Letrozole

Eli Lilly and Company - Recruiting 18 years or older.
- A Phase 1 First-in-Human Dose Study of LY3023414 in Patients With Advanced Cancer.
LY3023414; Midazolam; Letrozole

HER2-positive Breast Cancer, Recurrent Breast Cancer, Stage IA Br Clinical Trial using laboratory biomarker analysis; pharmacological study; questionnaire administration; fluorine F 18-clevudine; positron emission tomography/computed tomography

University of Southern California - Recruiting 18 years or older.
- Development of an In Vivo Cell Proliferation Marker for PET Assessment of Chemotherapeutic Response in Cancer.
laboratory biomarker analysis; pharmacological study; questionnaire administration; fluorine F 18-clevudine; positron emission tomography/computed tomography

Breast Cancer Clinical Trial

University of Kentucky - Recruiting 18 years to 65 years.
- A Pilot Study of Working Women and Breast Cancer.

Metastatic GPNMB Over-expressing Triple Negative Breast Cancer Clinical Trial using CDX-011; Capecitabine

Celldex Therapeutics - Recruiting 18 years or older.
- A Randomized Multicenter Pivotal Study of CDX-011 (CR011-vcMMAE)in Patients With Metastatic, GPNMB Over-Expressing, Triple Negative Breast Cancer. (The METRIC Study).
CDX-011; Capecitabine

Breast Tumor, Breast Cancer, Cancer of the Breast, Estrogen Recep Clinical Trial using nab-Paclitaxel 125 mg/m2 plus carboplatin AUC 2 in triple negative metastatic breast cancer (TNMBC) subjects; Carboplatin AUC 2; gemcitabine 1000 mg

Celgene Corporation - Recruiting 18 years or older.
- A Phase 2/3, Multi-center, Open-label, Randomized Study of Weekly Nab-paclitaxel in Combination With Gemcitabine or Carboplatin, Compared to the Combination of Gemcitabine and Carboplatin, as First-line Treatment in Female Subjects With ER, PgR, and HER2 Negative (Triple Negative) Metastatic Breast Cancer.
nab-Paclitaxel 125 mg/m2 plus carboplatin AUC 2 in triple negative metastatic breast cancer (TNMBC) subjects; Carboplatin AUC 2; gemcitabine 1000 mg

Metastatic Breast Cancer Clinical Trial using Mammaglobin-A DNA vaccine

Washington University School of Medicine - Recruiting 18 years or older.
- A Phase I Clinical Trial to Evaluate the Safety and Immunogenicity of a Mammaglobin-A DNA Vaccine in Breast Cancer Patients With Metastatic Disease.
Mammaglobin-A DNA vaccine

Breast Cancer Clinical Trial using Questionnaires; Yoga Classes

H. Lee Moffitt Cancer Center and Research Institute - Recruiting 18 years or older.
- Evaluating Yoga for Aromatase Inhibitor-associated Joint Pain in Women With Breast Cancer: A Pilot Study.
Questionnaires; Yoga Classes

Breast Cancer Clinical Trial using Capecitabine; Exemestane; Everolimus

Novartis - Recruiting 18 years or older.
- Phase II Study of Everolimus in Combination With Exemestane Versus Everolimus Alone Versus Capecitabine in the Treatment of Postmenopausal Women With ER+Locally Advanced, Recurrent, or Metastatic Breast Cancer After Recurrence or Progression on Prior Letrozole or Anastrozole..
Capecitabine; Exemestane; Everolimus

Breast Cancer Clinical Trial using radiation - no radiation see intervention description; radiation: see intervention description

Maastricht Radiation Oncology - Recruiting N/A or older.
- Radiotherapy After Primary CHEMotherapy for cT1-2cN1M0 Breast Cancer.: a Multicentre Prospective Registration Study..
radiation - no radiation see intervention description; radiation: see intervention description

Ovarian Carcinosarcoma, Recurrent Ovarian Epithelial Cancer, Recu Clinical Trial using paclitaxel; carboplatin; ifosfamide

Gynecologic Oncology Group - Recruiting 18 years or older.
- A Randomized Phase III Trial of Paclitaxel Plus Carboplatin Versus Ifosfamide Plus Paclitaxel in Chemotherapy-Naive Patients With Newly Diagnosed Stage I-IV, Persistent or Recurrent Carcinosarcoma (Mixed Mesodermal Tumors) of the Uterus, Fallopian Tube, Peritoneum or Ovary.
paclitaxel; carboplatin; ifosfamide

Breast Cancer Clinical Trial using Trastuzumab

Northwestern University - Recruiting 18 years or older.
- Phase I/II Dose Escalation Trial to Assess Safety of Intrathecal Trastuzumab for the Treatment of Leptomeningeal Metastases in HER2 Positive Breast Cancer.
Trastuzumab

Breast Cancer Clinical Trial using Accelerated Partial Breast Irradiation (APBI)

M.D. Anderson Cancer Center - Recruiting 18 years or older.
- Assessing the Cosmesis and Toxicity of Partial Breast Irradiation Using Proton Beam Irradiation.
Accelerated Partial Breast Irradiation (APBI)

Breast Cancer Clinical Trial

National Institutes of Health Clinical Center (CC) - Recruiting 18 years or older.
- Study of Pregnancy Hormone Concentrations in Urban and Nomadic Mongolian Women.

Breast Cancer Clinical Trial using Educational DVD 1; Educational DVD 2

Amgen - Recruiting 18 years or older.
- Randomized, Single-blind Study to Estimate the Effect of Patient Education on Reported Bone Pain in Breast Cancer Patients Receiving Chemotherapy and Pegfilgrastim.
Educational DVD 1; Educational DVD 2

Breast Cancer, Colon Cancer, or Lung Cancer Clinical Trial using Walk With Ease Program; Collect Blood, GA and Other Survey Tools

UNC Lineberger Comprehensive Cancer Center - Recruiting 60 years or older.
- Feasibility of an Evidence-based Walking Program in a Sample of Cancer Patients >60 Years of Age Undergoing Cytotoxic Chemotherapy.
Walk With Ease Program; Collect Blood, GA and Other Survey Tools

Oncology, BRCA Mutated, High Grade Serous Ovarian Cancer, or BRCA Clinical Trial using Veliparib

AbbVie - Recruiting 18 years or older.
- A Phase 1 Study to Evaluate the Safety, Pharmacokinetics and Oral Bioavailability of Veliparib Extended Release Formulations in Subjects With Solid Tumors.
Veliparib

Invasive Ductal Carcinoma, or Ductal Carcinoma in Situ Clinical Trial using Intra-operative Radiation Therapy - IORT

Xoft, Inc. - Recruiting 40 years or older.
- A Safety and Efficacy Study of Intra-Operative Radiation Therapy (IORT) Using the Xoftr Axxentr eBxT System at the Time of Breast Conservation Surgery for Early Stage Breast Cancer.
Intra-operative Radiation Therapy - IORT

Ductal Breast Carcinoma in Situ, Estrogen Receptor-negative Breas Clinical Trial using therapeutic conventional surgery; radiation therapy; quality-of-life assessment

Roswell Park Cancer Institute - Recruiting 50 years or older.
- Phase II Trial of Single Fraction Radiation Therapy (SFRT) at Roswell Park Cancer Institute for Select Patients With Early Stage Breast Cancer.
therapeutic conventional surgery; radiation therapy; quality-of-life assessment

Breast Cancer Clinical Trial using MM-302 Monotherapy; MM-302 in combination with trastuzumab; MM-302 in combination with trastuzumab q3w; MM-302 in combination with trastuzumab and cyclophosphamide

Merrimack Pharmaceuticals - Recruiting 18 years or older.
- A Phase 1, Multi-Center, Open-Label, Dose-Escalation, Safety, and Pharmacokinetic Clinical Study of Intravenously Administered MM-302 Monotherapy and in Combination With Trastuzumab With or Without Cyclophosphamide in Patients With Advanced HER2 Positive Breast Cancer.
MM-302 Monotherapy; MM-302 in combination with trastuzumab; MM-302 in combination with trastuzumab q3w; MM-302 in combination with trastuzumab and cyclophosphamide

Breast Cancer Clinical Trial

AstraZeneca - Recruiting N/A or older.
- A Multicenter, Non-interventional, Prospective Study to Collect Efficacy and Safety Data in Chinese Patients Who Have Received Faslodex 250mg Treatment Under the Condition of Actual Usage in Clinical Practice.

Breast Cancer Clinical Trial using Trastuzumab Emtansine; Trastuzumab; Lapatinib; Abraxane; Paclitaxel

The Methodist Hospital System - Recruiting 18 years or older.
- Randomized Open Label Phase II Trial Of Neoadjuvant Trastuzumab Emtansine (Te) In Combination With Lapatinib (L) Follow by Abraxane (A) Compared With Trastuzumab Plus Lapatinib Follow by Paclitaxel In Her 2 Neu Over-Expressed Breast Cancer Patients (TEAL Trial).
Trastuzumab Emtansine; Trastuzumab; Lapatinib; Abraxane; Paclitaxel

Advanced Solid Tumors (Excluding Breast Cancer) Clinical Trial using TAS-102 tablets; TAS-102 oral solution

Taiho Pharma USA, Inc. - Recruiting 18 years or older.
- A Phase 1, Open-label, Randomized, Crossover Study Evaluating the Bioavailability of TAS-102 Tablets Relative to an Oral Solution Containing Equivalent Amounts of FTD and TPI.
TAS-102 tablets; TAS-102 oral solution

Metastatic Breast Cancer Clinical Trial using TDM1; Lapatinib; Abraxane

The Methodist Hospital System - Recruiting 18 years or older.
- Phase Ib Trial of Trastuzumab Emtansine In Combination With Lapatinib Plus Abraxane In Metastatic Her 2 Neu Over-Expressed Breast Cancer Patients.
TDM1; Lapatinib; Abraxane

Breast Cancer Clinical Trial using trastuzumab [Herceptin]

Hoffmann-La Roche - Recruiting 18 years or older.
- A Single Arm Multi-center Study Investigating the at Home Administration of Trastuzumab Subcutaneous Vial for the Treatment of Patients With HER2-positive Early Breast Cancer..
trastuzumab [Herceptin]

Breast Cancer Clinical Trial using pertuzumab; trastuzumab; Aromatase Inhibitor; Induction Chemotherapy

Hoffmann-La Roche - Recruiting 18 years or older.
- A Randomized, Two-arm, Open-label, Multicenter Phase II Trial Assessing the Efficacy and Safety of Pertuzumab Given in Combination With Trastuzumab Plus an Aromatase Inhibitor in First Line Patients With HER2-positive and Hormone Receptor-positive Advanced (Metastatic or Locally Advanced) Breast Cancer..
pertuzumab; trastuzumab; Aromatase Inhibitor; Induction Chemotherapy

Breast Cancer Clinical Trial using Palbociclib; Aromatase Inhibitor (AI)

Dana-Farber Cancer Institute - Recruiting 18 years or older.
- A Phase 2 Pilot Feasibility Study of Palbociclib in Combination With Adjuvant Endocrine Therapy for Hormone Receptor Positive Invasive Breast Cancer.
Palbociclib; Aromatase Inhibitor (AI)

Breast Cancer Clinical Trial using taxane; pertuzumab; trastuzumab [Herceptin]

Hoffmann-La Roche - Recruiting 18 years or older.
- A Multicenter, Open-label, Single-arm Study of a Pertuzumab in Combination With Trastuzumab and a Taxane in First Line Treatment of Patients With HER2- Positive Advanced (Metastatic or Locally Recurrent) Breast Cancer.
taxane; pertuzumab; trastuzumab [Herceptin]

Breast Cancer Clinical Trial using trastuzumab emtansine; trastuzumab

Hoffmann-La Roche - Recruiting 18 years or older.
- A Randomized, Multicenter, Open-Label Phase III Study to Evaluate the Efficacy and Safety of Trastuzumab Emtansine Versus Trastuzumab as Adjuvant Therapy for Patients With HER2-Positive Primary Breast Cancer Who Have Residual Tumor Present Pathologically in the Breast or Axillary Lymph Nodes Following Preoperative Therapy.
trastuzumab emtansine; trastuzumab

Breast Cancer Clinical Trial using trastuzumab emtansine

Hoffmann-La Roche - Recruiting 18 years or older.
- A Phase I, Open Label, Parallel Group, Pharmacokinetic Study of Trastuzumab Emtansine in Patients With HER2-Positive Metastatic Breast Cancer and Normal or Reduced Hepatic Function.
trastuzumab emtansine

Breast Cancer Clinical Trial using trastuzumab [Herceptin]

Hoffmann-La Roche - Recruiting 18 years or older.
- An Open-label, Randomized, Multicenter Phase III Study in Patients With HER2-positive Metastatic Breast Cancer Responding to First Line Treatment With Intravenous Trastuzumab for at Least 3 Years and Investigating Patient Preference for Subcutaneous Trastuzumab.
trastuzumab [Herceptin]

Breast Cancer Clinical Trial using trastuzumab [Herceptin]

Hoffmann-La Roche - Recruiting 18 years or older.
- A PHASE III PROSPECTIVE, TWO-COHORT NON-RANDOMIZED, MULTI-CENTRE, MULTINATIONAL, OPEN LABEL STUDY TO ASSESS THE SAFETY OF ASSISTED- AND SELF-ADMINISTERED SUBCUTANEOUS TRASTUZUMAB AS THERAPY IN PATIENTS WITH OPERABLE HER2-POSITIVE EARLY BREAST CANCER [SafeHer Study].
trastuzumab [Herceptin]

Breast Cancer Clinical Trial using Kadcyla (trastuzumab emtansine)

Hoffmann-La Roche - Recruiting 18 years or older.
- A Two-cohort, Open-label, Multicenter Study of Trastuzumab Emtansine (T-DM1) in HER2-positive Locally Advanced or Metastatic Breast Cancer Patients Who Have Received Prior Anti-HER2 and Chemotherapy-based Treatment..
Kadcyla (trastuzumab emtansine)

Breast Cancer Clinical Trial using trastuzumab emtansine [Kadcyla]; trastuzumab [Herceptin]; pertuzumab [Perjeta]; taxane; anthracycline-based chemotherapy

Hoffmann-La Roche - Recruiting 18 years or older.
- A RANDOMIZED, MULTICENTER, OPEN-LABEL, PHASE III TRIAL COMPARING TRASTUZUMAB PLUS PERTUZUMAB PLUS A TAXANE FOLLOWING ANTHRACYCLINES VERSUS TRASTUZUMAB EMTANSINE PLUS PERTUZUMAB FOLLOWING ANTHRACYCLINES AS ADJUVANT THERAPY IN PATIENTS WITH OPERABLE HER2?POSITIVE PRIMARY BREAST CANCER.
trastuzumab emtansine [Kadcyla]; trastuzumab [Herceptin]; pertuzumab [Perjeta]; taxane; anthracycline-based chemotherapy

Breast Cancer Clinical Trial using Atorvastatin; Placebo

Wake Forest Cancer Center CCOP Research Base - Recruiting 30 years to 80 years.
- Preventing Anthracycline Cardiovascular Toxicity With Statins (PREVENT).
Atorvastatin; Placebo

Solid Tumour,, Breast Cancer,, Metastatic Melanoma,, or Non-small Clinical Trial using F16IL2 in combination with paclitaxel

Philogen S.p.A. - Recruiting 18 years or older.
- Phase Ib/II Study of the Tumour-targeting Human F16IL2 Monoclonal Antibody-cytokine Fusion Protein in Combination With Paclitaxel in Patients With Advanced Solid Tumours.
F16IL2 in combination with paclitaxel

Advanced HER2-positive Breast Cancer or Gastric Cancer Clinical Trial using LJM716; Trastuzumab

Novartis - Recruiting 18 years or older.
- A Multicenter, Open-label, Dose Escalation, Phase I Study of LJM716 Administered Intravenously in Combination With Trastuzumab in Patients With HER2 Overexpressing Metastatic Breast Cancer or Gastric Cancer.
LJM716; Trastuzumab

Breast Cancer Clinical Trial using Arimidex with Faslodex; Arimidex without Faslodex

Baylor Breast Care Center - Recruiting 18 years or older.
- A Phase II Trial of Neoadjuvant Arimidex With or Without Faslodex in Postmenopausal Women With Hormone Receptor Positive Breast Cancer.
Arimidex with Faslodex; Arimidex without Faslodex

Breast Cancer Clinical Trial

Ontario Clinical Oncology Group (OCOG) - Recruiting 60 years or older.
- A Prospective Cohort Study Evaluating Risk of Local Recurrence Following Breast Conserving Surgery and Endocrine Therapy in Low Risk Luminal A Breast Cancer.

Solid Tumors, Triple-Negative Breast Cancer, Non Small Cell Lung Clinical Trial using CB-839

Calithera Biosciences, Inc - Recruiting 18 years or older.
- A Phase 1 Study of the Safety, Pharmacokinetics, and Pharmacodynamics of Escalating Oral Doses of the Glutaminase Inhibitor CB-839 in Patients With Advanced and/or Treatment-Refractory Solid Tumors.
CB-839

Metastatic Breast Cancer Clinical Trial using Fulvestrant; Goserelin; Anastrozole

Hospital Affiliated to Military Medical Science, Beijing - Recruiting 18 years to 60 years.
- The Study of Goserelin Plus Fulvestrant Comparing With Goserelin Plus Anastrozole for Advanced Breast Cancer.
Fulvestrant; Goserelin; Anastrozole

Metastatic Breast Cancer Clinical Trial using Docetaxel

Centro Universitario contra el Cáncer - Recruiting 21 years to 85 years.
- Docetaxel in Patients With Metastatic Breast Cancer Who Have Been Heavily Pretreated, Including Prior Treatment With Paclitaxel or Docetaxel..
Docetaxel

Breast Cancer Clinical Trial using ado -trastuzumab emtansine T-DM1; Bcl-2 inhibitor ABT-737

Ukrainian Antitumor Center - Recruiting 18 years to 80 years.
- A Phase I/II Study of Ado-Trastuzumab Emtansine(T-DM1) + ABT-737 in Treating Patients With HER2(+) Breast Cancer.
ado -trastuzumab emtansine T-DM1; Bcl-2 inhibitor ABT-737

Hormone Receptor Positive Breast Cancer Clinical Trial using faslodex 500mg; arimidex 1mg; faslodex dummy; arimidex dummy

AstraZeneca - Recruiting 18 years or older.
- A Randomised, Double-blind, Parallel-group, Multicentre, Phase III Study to Compare the Efficacy and Tolerability of Fulvestrant (FASLODEX) 500 mg With Anastrozole (ARIMIDEX) 1 mg as Hormonal Treatment for Postmenopausal Women With Hormone Receptor-Positive Locally Advanced or Metastatic Breast Cancer Who Have Not Previously Been Treated With Any Hormonal Therapy..
faslodex 500mg; arimidex 1mg; faslodex dummy; arimidex dummy

FGFR Inhibition, Pharmacokinetics, Biomarkers, or ER+ Breast Canc Clinical Trial using AZD4547; Exemestane; Placebo; Fulvestrant

AstraZeneca - Recruiting 18 years or older.
- A Randomised Double-blind Phase IIa Study (With Combination Safety Run-in) to Assess the Safety and Efficacy of AZD4547 in Combination With Fulvestrant vs. Fulvestrant Alone in ER+ Breast Cancer Patients With FGFR1 Polysomy or Gene Amplification Who Have Progressed Following Treatment With Prior Endocrine Therapy (Adjuvant or First-line Metastatic) (GLOW).
AZD4547; Exemestane; Placebo; Fulvestrant

Carcinoma of Breast, Human Epidermal Growth Factor 2 Negative Car Clinical Trial using niraparib; Physician's choice

Tesaro, Inc. - Recruiting 18 years or older.
- A Phase III, Randomized, Open Label, Multicenter, Controlled Trial of Niraparib Versus Physician's Choice in Previously-treated, Her2 Negative, Germline BRCA Mutation-positive Breast Cancer Patients.
niraparib; Physician's choice

Breast Cancer Clinical Trial using Lapatinib; Herceptin

Dana-Farber Cancer Institute - Recruiting 18 years or older.
- A Phase 2 Study of Lapatinib in Combination With Trastuzumab in Patients With HER2-Positive, Metastatic Breast Cancer.
Lapatinib; Herceptin

Breast Cancer, BIRADS 3, BIRADS 4, or BIRADS 5 Clinical Trial using DCE-MRI and DWI

American College of Radiology Imaging Network - Recruiting 18 years or older.
- A MULTI-CENTER STUDY EVALUATING THE UTILITY OF DIFFUSION WEIGHTED IMAGING FOR DETECTION AND DIAGNOSIS OF BREAST CANCER.
DCE-MRI and DWI

Prostate Cancer Clinical Trial using TAK-700; Bicalutamide

Southwest Oncology Group - Recruiting 18 years or older.
- A Phase III Randomized Trial Comparing Androgen Deprivation Therapy + TAK-700 With Androgen Deprivation Therapy + Bicalutamide in Patients With Newly Diagnosed Metastatic Sensitive Prostate Cancer.
TAK-700; Bicalutamide

Renal Cell Carcinoma, Breast Cancer, Colon Cancer, Lung Cancer, o Clinical Trial using dimethane sulfonate (DMS612, NSC 281612)

National Institutes of Health Clinical Center (CC) - Recruiting 18 years or older.
- A Phase 1, Dose Escalation Study of the Safety, Tolerability and Pharmacokinetics of Intravenous Dimethane Sulfonate (DMS612, NSC 281612) in Advanced Malignancies.
dimethane sulfonate (DMS612, NSC 281612)

Breast Cancer Clinical Trial using VitaBlueT; Placebo; Lovazar

H. Lee Moffitt Cancer Center and Research Institute - Recruiting 45 years to 75 years.
- Pilot Clinical Trial of COGNUTRIN in Breast Cancer Survivors.
VitaBlueT; Placebo; Lovazar

Breast Cancer Clinical Trial using ABP 980; trastuzumab; epirubicin; cyclophosphamide; paclitaxel; Lumpectomy or mastectomy with sentinel node or axillary node dissection

Amgen - Recruiting 18 years or older.
- A Randomized, Double-Blind, Phase 3 Study Evaluating the Efficacy and Safety of ABP 980 Compared With Trastuzumab in Subjects With HER2 Positive Early Breast Cancer.
ABP 980; trastuzumab; epirubicin; cyclophosphamide; paclitaxel; Lumpectomy or mastectomy with sentinel node or axillary node dissection

Advanced Ovarian Cancer, Primary Peritoneal Cancer, Advanced Brea Clinical Trial using BMN 673

National Institutes of Health Clinical Center (CC) - Recruiting 18 years or older.
- Pilot Trial of BMN 673, an Oral PARP Inhibitor, in Patients With Advanced Solid Tumors and Deleterious BRCA Mutations.
BMN 673

Advanced Metastatic Breast Cancer Clinical Trial using AZD2014; Fulvestrant

AstraZeneca - Recruiting 18 years or older.
- A Phase I, Open-label, Multicentre, Study to Assess the Safety, Tolerability, Pharmacokinetics and Preliminary Efficacy of AZD2014 Administered Orally in Combination With Intramuscular (IM) Fulvestrant to Patients With Estrogen Receptor Positive (ER+) Advanced, Metastatic Breast Cancer.
AZD2014; Fulvestrant

Inflammatory Breast Cancer Clinical Trial

National Institutes of Health Clinical Center (CC) - Recruiting 18 years or older.
- A Case-Control Study of Inflammatory Breast Cancer in North Africa.

Breast Cancer, Microbiota, or Estrogens Clinical Trial

National Institutes of Health Clinical Center (CC) - Recruiting 55 years to 69 years.
- BRANCH:Fecal Microbiota Among Participants in a Pre-paid Health Plan.

Breast Cancer Clinical Trial

National Institutes of Health Clinical Center (CC) - Recruiting 18 years or older.
- A Prospective (Cohort) Study to Identify Factors Affecting Morbidity Following the Diagnosis and Treatment of Patients With Breast Cancer: A Multi-Institutional Study Between the National Institutes of Health (NIH) Rehabilitation Medicine Department (RMD) and the Walter Reed National Military Medical Center (WRNMMC) Breast Care Center (BCC).

Breast Cancer, or Ovarian Cancer Clinical Trial using AZ2281; Carboplatin

National Institutes of Health Clinical Center (CC) - Recruiting 18 years or older.
- A Phase I Study With an Expansion Cohort of the PARP Inhibitor AZD2281 Combined With Carboplatin in BRCA1/2 Familial Breast and Ovarian Cancer and Sporadic Triple Negative Breast and Ovarian Cancer.
AZ2281; Carboplatin

Breast Cancer, Breast Neoplasm, Breast Tumor, or Cancer of the Br Clinical Trial using Proton Radiotherapy

Proton Collaborative Group - Recruiting 50 years or older.
- Phase II Protocol of Proton Therapy for Partial Breast Irradiation in Early Stage Breast Cancer.
Proton Radiotherapy

Head and Neck Neoplasms, Lung Neoplasms, Urinary Bladder Neoplasm Clinical Trial using Tetrahydrouridine (THU); [F-18]-5-FLUORO-2'-DEOXYCYTIDINE

National Institutes of Health Clinical Center (CC) - Recruiting 18 years or older.
- Phase 0 Trial of [F-18]-5-Fluoro-2'-Deoxycytidine With Tetrahydrouridine.
Tetrahydrouridine (THU); [F-18]-5-FLUORO-2'-DEOXYCYTIDINE

Breast Cancer, or Colon Cancer Clinical Trial

National Institutes of Health Clinical Center (CC) - Recruiting 21 years or older.
- The NCl Community Cancer Center Program Patients Reported Symptom Surveillance and Disparities Study.

Breast Cancer, Breast Neoplasm, Breast Tumor, or Cancer of the Br Clinical Trial using Proton Radiotherapy

Proton Collaborative Group - Recruiting 18 years or older.
- Phase II Study of Postoperative, Cardiac-Sparing Proton Radiotherapy for Women With Stage III,Loco-Regional, Non-Metastatic Breast Cancer.
Proton Radiotherapy

Breast Cancer Clinical Trial

National Institutes of Health Clinical Center (CC) - Recruiting 10 years to 50 years.
- Epigenetics and Breast Cancer Risk in African American Women.

Breast Cancer, Healthy Volunteer, or Prostate Cancer Clinical Trial

National Institutes of Health Clinical Center (CC) - Recruiting 18 years to 90 years.
- An Exploratory Evaluation of Biomarkers in Blister Fluid in Healthy Volunteers and Irradiated Skin.

Breast Neoplasms Clinical Trial

National Institutes of Health Clinical Center (CC) - Recruiting 18 years to 74 years.
- A Multidisciplinary Study of Breast Cancer in Ghana: Pilot Phase.

Breast Cancer Clinical Trial using 111 Indium CHX-A DTPA-Trastuzumab; 111Indium Trastuzumab

National Institutes of Health Clinical Center (CC) - Recruiting 18 years or older.
- A Phase 0 Trial of (111)Indium CHX-A DTPA Trastuzumab Imaging in Cancer.
111 Indium CHX-A DTPA-Trastuzumab; 111Indium Trastuzumab

Invasive Breast Cancer Clinical Trial using Eucerin; Mometasone Furoate 0.1%

Memorial Sloan-Kettering Cancer Center - Recruiting 18 years or older.
- Mometasone Furoate 0.1% Versus Eucerin on Moderate to Severe Skin Toxicities in Breast Cancer Patients Receiving Postmastectomy Radiation:A Randomized Trial, Double Blind Trial.
Eucerin; Mometasone Furoate 0.1%

Metastatic Cancers Other Than Melanoma That Express ESO Antigen, Clinical Trial using Anti-NY ESO-1 mTCR PBL; Aldesleukin; Cyclophosphamide; Fludarabine

National Institutes of Health Clinical Center (CC) - Recruiting 18 years to 66 years.
- Phase II Study of Metastatic Cancer That Expresses NY-ESO-1 Using Lymphodepleting Conditioning Followed by Infusion of Anti-NY ESO-1 Murine TCR-Gene Engineered Lymphocytes.
Anti-NY ESO-1 mTCR PBL; Aldesleukin; Cyclophosphamide; Fludarabine

Local Advanced or Metastatic Postmenopausal Breast Cancer Clinical Trial

AstraZeneca - Recruiting N/A or older.
- LINE: Treatment Patterns in postmenopausaL Women With Hormone Receptor Positive Breast Cancer.

Ductal Breast Carcinoma in Situ, Invasive Ductal Breast Carcinoma Clinical Trial using Behavioral dietary intervention; Therapeutic conventional surgery; Radiation therapy; Counseling intervention; Quality-of-life assessment

Thomas Jefferson University - Recruiting 18 years or older.
- A Feasibility Pilot Trial Evaluating Caloric Restriction for Oncology Research in Early Stage Breast Cancer Patients.
Behavioral dietary intervention; Therapeutic conventional surgery; Radiation therapy; Counseling intervention; Quality-of-life assessment

Metastatic Breast Cancer Clinical Trial using Paclitaxel; Reolysin

NCIC Clinical Trials Group - Recruiting 18 years or older.
- A Randomized Phase II Study of Reolysin For Patients Receiving Standard Weekly Paclitaxel Therapy as Therapy For Advanced/Metastatic Breast Cancer.
Paclitaxel; Reolysin

Periodontal Disease, or Quality of Life Clinical Trial

University of Michigan - Recruiting N/A or older.
- Oral Health in Breast Cancer Survivors on Aromatase Inhibitors.

Breast Cancer Clinical Trial

West Pomeranian Cancer Center - Recruiting 18 years to 70 years.
- Circulating microRNAs as a Novel Biomarker of Early Cardiotoxicity in Breast Cancer Patients Treated With Anthracyclines.

Breast Neoplasms, or Breast Cancer Clinical Trial using Taxane; Taxotere; Abraxane; Ixabepilone

The Methodist Hospital System - Recruiting 18 years or older.
- Phase II Study of The Efficacy And Safety of Chloroquine (C) in CombinAtion With Taxane or Taxane-like (T) Chemo Agents in The Treatment of Patients With Advanced or Metastatic Breast Cancer Who Have Failed Anthracycline Chemo Base Therapy..
Taxane; Taxotere; Abraxane; Ixabepilone

Breast Neoplasms, BRCA 1 Gene Mutation, or BRCA 2 Gene Mutation Clinical Trial using BMN 673; Physician's-Choice

BioMarin Pharmaceutical - Recruiting 18 years or older.
- A Phase 3, Open-Label, Randomized, Parallel, 2-Arm, Multi-Center Study of BMN 673 Versus Physician's Choice in Germline BRCA Mutation Subjects With Locally Advanced and/or Metastatic Breast Cancer, Who Have Received No More Than 2 Prior Chemotherapy Regimens for Metastatic Disease.
BMN 673; Physician's-Choice

Breast Cancer Clinical Trial using Anthracycline based chemotherapy; taxane-based chemotherapy

The Methodist Hospital System - Recruiting 18 years or older.
- Prospective Study To Validate The Predictive Value Of Mammostrat Score, DDR Score And TLE3 Gene When A Taxane-Based Chemo Agents Or Anthracycline-Based Chemo Agent Is Used In The Neo-Adjuvant Setting.
Anthracycline based chemotherapy; taxane-based chemotherapy

Breast Cancer Clinical Trial using 3D mammography (Tomosynthesis); Ultrasound

University of Genova - Recruiting 18 years or older.
- Tomosynthesis (TS) Versus Ultrasonography (US) in Screening Women With Dense Breast.
3D mammography (Tomosynthesis); Ultrasound

Breast Cancer, or Triple Negative Breast Cancer Clinical Trial using Everolimus

The Methodist Hospital System - Recruiting 18 years or older.
- Neoadjuvant Phase II Study Of Everolimus Plus Cisplatin In Triple Negative Breast Cancer Patients With Residual Disease After Standard Chemotherapy.
Everolimus

Metastatic Breast Cancer With Intracranial Metastases Clinical Trial using cabazitaxel; lapatinib

SCRI Development Innovations, LLC - Recruiting 18 years or older.
- Phase II Study With Lead-in Safety Cohort of Cabazitaxel Plus Lapatinib as Therapy for HER2-Positive Metastatic Breast Cancer Patients With Intracranial Metastases.
cabazitaxel; lapatinib

Breast Cancer Clinical Trial using dynamic contrast-enhanced ultrasound imaging; shear wave elastography

University of Southern California - Recruiting 18 years or older.
- Real Time Contrast Enhanced Ultrasound and Ultrasound-Based Elastography: Novel Techniques in Assessment of Treatment Response to Neoadjuvant Chemotherapy for Breast Cancer.
dynamic contrast-enhanced ultrasound imaging; shear wave elastography

Breast Cancer Clinical Trial

Hoffmann-La Roche - Recruiting 18 years or older.
- Program for Assessment of Capecitabine (Xeloda) Plus Docetaxel First-line Therapies in HER2-negative Metastatic Breast Cancer (XEBRA Study).

Breast Cancer Clinical Trial using Taxane chemotherapy; Perjeta (pertuzumab); Herceptin (trastuzumab)

Hoffmann-La Roche - Recruiting 18 years or older.
- An Open-label, Multicentre, Phase IIIb Study With Intravenous Administration of Pertuzumab, Subcutaneous Trastuzumab, and a Taxane in Patients With HER2-positive Metastatic Breast Cancer.
Taxane chemotherapy; Perjeta (pertuzumab); Herceptin (trastuzumab)

Breast Cancer Clinical Trial

Stockholm South General Hospital - Recruiting 18 years or older.
- Sentinel Node Biopsy Before and/or After Neoadjuvant Chemotherapy in Breast Cancer.

Breast Cancer Clinical Trial using Pamidronate; Zoledronic acid; placebo

Ottawa Hospital Research Institute - Recruiting 18 years or older.
- A Randomized, Double-blind, Placebo-controlled, Phase IV Trial Evaluating the Palliative Benefit of Either Continuing Pamidronate or Switching to Second-line Zoledronic Acid in Breast Cancer Patients With High-risk Bone Metastases..
Pamidronate; Zoledronic acid; placebo

Emesis Clinical Trial using Dexamethasone, Ondansetron, Aprepitant; Arm A: Standard Anti-emetic regimen

Ottawa Hospital Research Institute - Recruiting 19 years or older.
- A Randomized, Phase IV Trial of Individualized Care Versus Standard Care, in the Prevention of Chemotherapy Induced Nausea and Vomiting in Breast Cancer Patients. The EPIC Study.
Dexamethasone, Ondansetron, Aprepitant; Arm A: Standard Anti-emetic regimen

Metastatic Breast Cancer Clinical Trial using eribulin mesylate; Trastuzumab

SCRI Development Innovations, LLC - Recruiting 18 years or older.
- Phase II Trial of Eribulin in Patients Who Do Not Achieve Pathologic Complete Response (pCR) Following Neoadjuvant Chemotherapy.
eribulin mesylate; Trastuzumab

Breast Cancer Clinical Trial using pertuzumab; placebo; trastuzumab [Herceptin]; Chemotherapy

Hoffmann-La Roche - Recruiting 18 years or older.
- A Randomized Multicenter, Double-blind, Placebo-controlled Comparison of Chemotherapy Plus Trastuzumab Plus Placebo Versus Chemotherapy Plus Trastuzumab Plus Pertuzumab as Adjuvant Therapy in Patients With Operable HER2-positive Primary Breast Cancer.
pertuzumab; placebo; trastuzumab [Herceptin]; Chemotherapy

Breast Cancer, Pain, Postoperative, BRCA1 Mutation, BRCA2 Mutatio Clinical Trial using Botulinum Toxin Type A; Sodium Chloride Solution

Mayo Clinic - Recruiting 18 years or older.
- Botulinum Toxin A in Tissue Expander Breast Reconstruction: A Double-Blinded Randomized Controlled Trial.
Botulinum Toxin Type A; Sodium Chloride Solution

Advanced Castrate-resistant Prostate Cancer (CRPC);, Squamous Non Clinical Trial using AZD8186

AstraZeneca - Recruiting 18 years or older.
- A Phase I, Open-label, Multicentre Study to Assess the Safety, Tolerability, Pharmacokinetics and Preliminary Anti-tumour Activity of Ascending Doses of AZD8186 in Patients With Advanced Castrate-resistant Prostate Cancer (CRPC), Squamous Non-Small Cell Lung Cancer (sqNSCLC), Triple Negative Breast Cancer (TNBC) and Patients With Known PTEN-deficient Advanced Solid Malignancies, With Expansion to Assess the Pharmacodynamic Activity of AZD8186 Within Prospectively-validated PTEN Deficient Tumours.
AZD8186

Locally Advanced Breast Cancer Clinical Trial using Neoadjuvant Chemotherapy with Docetaxel

Yonsei University - Recruiting 20 years to 70 years.
- .
Neoadjuvant Chemotherapy with Docetaxel

Breast Cancer, Colorectal Cancer, Gastric Cancer, Malignant Melan Clinical Trial

Hoffmann-La Roche - Recruiting 18 years or older.
- OCCURRENCE RATE OF COLON CANCER, BREAST CANCER, GASTRIC CANCER AND MALIGNANT MELANOMA IN TURKEY & DIAGNOSIS AND TREATMENT CHARACTERISTICS.

Breast Cancer Clinical Trial using interviews with a psychologist; Questionnaires

Centre Oscar Lambret - Recruiting 18 years to 65 years.
- Early Individualized Psychosocial Assets to Facilitate the Return to Employment of Women With Breast Cancer.
interviews with a psychologist; Questionnaires

Neoplasms, Breast Clinical Trial using lapatinib; trastuzumab; Aromatase inhibitor

GlaxoSmithKline - Recruiting 18 years or older.
- A Phase III Trial to Compare the Safety and Efficacy of Lapatinib Plus Trastuzumab Plus an Aromatase Inhibitor (AI) vs. Trastuzumab Plus an AI vs. Lapatinib Plus an AI as 1st- or 2nd- Line Therapy in Postmenopausal Subjects With Hormone Receptor+, HER2+ Metastatic Breast Cancer (MBC) Who Received Prior Trastuzumab and Endocrine Therapies.
lapatinib; trastuzumab; Aromatase inhibitor

Breast Cancer Metastatic Clinical Trial using PF-03084014; Docetaxel

Pfizer - Recruiting 18 years or older.
- Phase 1B Study Of Docetaxel + PF-03084014 In Metastatic Or Locally Recurrent/Advanced Triple Negative Breast Cancer.
PF-03084014; Docetaxel

Breast Cancer, or Gastric Cancer Clinical Trial using Trastuzumab + NK cells

National University Hospital, Singapore - Recruiting 21 years or older.
- Phase I/II Study of Expanded, Activated Autologous Natural Killer Cell Infusions With Trastuzumab for Patients With HER2+ Breast and Gastric Cancer.
Trastuzumab + NK cells

Advanced Solid Malignancy, Safety and Tolerability, Pharmacokinet Clinical Trial using AZD5363

AstraZeneca - Recruiting 18 years or older.
- A Phase I, Open-Label, Multicentre Study to Assess the Safety, Tolerability, Pharmacokinetics and Preliminary Anti-tumour Activity of Ascending Doses of AZD5363 Under Adaptable Dosing Schedules in Patients With Advanced Solid Malignancies..
AZD5363

Breast Neoplasms Clinical Trial using Neratinib

Washington University School of Medicine - Recruiting 18 years or older.
- A Phase II Study of Neratinib in Metastatic HER2 Non-amplified But HER2 Mutant Breast Cancer.
Neratinib

Fallopian Tube, Primary Peritoneal Cancer, or Solid Tumors (eg Br Clinical Trial using ABT-767

AbbVie - Recruiting 18 years or older.
- A Phase 1 Study of ABT-767 in BRCA1 or BRCA2 Mutation Carriers With Advanced Solid Tumors and in Subjects With High Grade Serous Ovarian, Fallopian Tube, or Primary Peritoneal Cancer.
ABT-767

Breast Cancer Clinical Trial using AIM materials and assessments

Memorial Sloan-Kettering Cancer Center - Recruiting 18 years or older.
- Attention and Interpretation Modification (AIM) for Fear of Breast Cancer Recurrence: An Intervention Development Study.
AIM materials and assessments

Metastatic Castration-resistant Prostate Cancer, or Metastatic Br Clinical Trial using Abiraterone acetate

Janssen Research & Development, LLC - Recruiting N/A or older.
- A Phase 3b Multicenter, Open-label Abiraterone Acetate Long-term Safety Study.
Abiraterone acetate

Breast Cancer, or Tobacco Dependence Clinical Trial using placebo; varenicline

Memorial Sloan-Kettering Cancer Center - Recruiting 18 years or older.
- Treatment of Tobacco Dependence in Breast Cancer Patients: A Randomized Trial of Varenicline (Chantix).
placebo; varenicline

Breast Neoplasms, BRCA 1 Gene Mutation, or BRCA 2 Gene Mutation Clinical Trial using BMN 673

BioMarin Pharmaceutical - Recruiting 18 years or older.
- A Phase 2, 2-Stage, 2-Cohort Study of BMN 673 in Locally Advanced and/or Metastatic Breast Cancer Patients With BRCA Mutation.
BMN 673

Breast Cancer Clinical Trial using questionaire, blood or saliva sample

Memorial Sloan-Kettering Cancer Center - Recruiting 18 years to 54 years.
- Genome-Wide Association Study of Radiation Exposure and Bilateral Breast Cancer.
questionaire, blood or saliva sample

Breast Cancer Clinical Trial using BRCA testing and questionnaire assessments

Memorial Sloan-Kettering Cancer Center - Recruiting 18 years to 50 years.
- Understanding Decision Making Processes for Undergoing Genetic Testing Among Women With Newly Diagnosed Breast Cancer.
BRCA testing and questionnaire assessments

Breast Cancer Clinical Trial using microarray analysis; breast biopsy

Georgetown University - Recruiting 18 years or older.
- Pilot Study for Analysis of Tumor Gene Expression by DNA Microarray Analysis in Patients Undergoing Breast Cancer Surgery or Core Biopsy Sampling.
microarray analysis; breast biopsy

Breast Cancer, or Hereditary Breast/Ovarian Cancer (brca1, brca2) Clinical Trial using counseling intervention; educational intervention; survey administration; psychosocial assessment and care; supportive care

Georgetown University - Recruiting 8 years or older.
- Parent Communication Study II - Randomized Controlled Trial of Decision Support vs. Education for Parent Communication of BRCA 1/2 Cancer Genetic Test Results to Children.
counseling intervention; educational intervention; survey administration; psychosocial assessment and care; supportive care

Breast Cancer, Cardiac Toxicity, or Cardiovascular Complications Clinical Trial using trastuzumab; doxorubicin hydrochloride; polymorphism analysis; laboratory biomarker analysis; questionnaire administration; assessment of therapy complications; magnetic resonance imaging

Vanderbilt University - Recruiting 18 years to 85 years.
- Predicting Adverse Cardiac Events in Breast Cancer Therapy (PACE in Breast Cancer).
trastuzumab; doxorubicin hydrochloride; polymorphism analysis; laboratory biomarker analysis; questionnaire administration; assessment of therapy complications; magnetic resonance imaging

Breast Cancer Clinical Trial using survey web-based or telephone interview

Memorial Sloan-Kettering Cancer Center - Recruiting 18 years to 64 years.
- Breast Cancer and the Workforce: Ethnic Differences in the Impact of Breast Cancer on Employment Status, Financial Situation, and Quality of Life (BCW).
survey web-based or telephone interview

Breast Cancer Clinical Trial using HER-2 pulsed Dendritic Cell Vaccine

University of Pennsylvania - Recruiting 18 years or older.
- Pilot Phase I HER-2 Pulsed DC Vaccine to Prevent Recurrence for Patients With HER-2 Driven High Risk Invasive Breast Cancer.
HER-2 pulsed Dendritic Cell Vaccine

Breast Cancer Clinical Trial using Herceptin

National Guard Health Affairs - Recruiting 18 years to 80 years.
- .
Herceptin

Male Breast Cancer, Recurrent Breast Cancer, or Stage IV Breast C Clinical Trial using eribulin mesylate; laboratory biomarker analysis

University of Washington - Recruiting 18 years or older.
- Phase II Trial of Metronomic Eribulin (Halaven) In Pretreated Metastatic Breast Cancer (MBC).
eribulin mesylate; laboratory biomarker analysis

Breast Cancer Prevention Clinical Trial using Metformin; Placebo

University of Arizona - Recruiting 30 years to 45 years.
- Phase II Study of Metformin for Reduction of Obesity-Associated Breast Cancer Risk.
Metformin; Placebo

Breast Neoplasm, or Metastasis Clinical Trial using Eribulina

Medica Scientia Innovation Research - Recruiting 18 years or older.
- A Phase IIa Prospective, Multicenter, Open and Not Controlled of the Efficacy and Tolerability on the First Line Treatment With Eribulin as a Unic Agent on Patients With HER2 Negative Metastatic Breast Cancer Previously Treated With Taxanes.
Eribulina

Breast Cancer Clinical Trial using Nab-Paclitaxel

Barwon Health - Recruiting 18 years or older.
- Tailored Neoadjuvant Epirubicin and Cyclophosphamide (EC) and Nanoparticle Albumin Bound (Nab) Paclitaxel for Newly Diagnosed Breast Cancer.
Nab-Paclitaxel

Breast Cancer Clinical Trial using carboplatin and paclitaxel and or without trastuzumab

Guangdong General Hospital - Recruiting 18 years or older.
- A Pilot Study of Dose-dense (Biweekly) Carboplatin Plus Paclitaxel With or Without Trastuzumab as Neoadjuvant Treatment for Breast Cancer.
carboplatin and paclitaxel and or without trastuzumab

Breast Cancer Clinical Trial using HER-2 pulsed Dendritic Cell Vaccine

University of Pennsylvania - Recruiting 18 years or older.
- Pilot Phase I HER-2 Pulsed DC Vaccine to Prevent Recurrence for Patients With HER-2 Driven High Risk Invasive Breast Cancer Post Neoadjuvant Chemotherapy.
HER-2 pulsed Dendritic Cell Vaccine

Breast Cancer, or DCIS Clinical Trial using HER-2 Pulsed Dendritic cell Vaccine

University of Pennsylvania - Recruiting 18 years or older.
- A Randomized Trial of HER-2/Neu Pulsed DC1 Vaccine for Patients With DCIS.
HER-2 Pulsed Dendritic cell Vaccine

Breast Neoplasms Clinical Trial using Aromasin (exemestane)

Pfizer - Recruiting 18 years or older.
- A Prospective Non-Interventional Study Of China Early Invasive Breast Cancer Patients Receiving Adjuvant Therapy With Aromasinr.
Aromasin (exemestane)

Breast Cancer Clinical Trial using Trastuzumab, Anthracycline; Trastuzumab, anthracycline

Peking Union Medical College Hospital - Recruiting 18 years to 60 years.
- Safety and Efficacy Evaluation of Trastuzumab Administered Concurrently or Sequentially to Anthracycline-containing Adjuvant Regimen for Breast Cancer.
Trastuzumab, Anthracycline; Trastuzumab, anthracycline

HER2-positive, Newly Diagnosed, Primary Breast Cancer, Neoadjuvan Clinical Trial using BKM120; Trastuzumab; Paclitaxel; Placebo

Novartis - Recruiting 18 years or older.
- NeoPHOEBE: Pi3k Inhibition in Her2 OverExpressing Breast cancEr: A Phase II, Randomized, Parallel Cohort, Two Stage, Double-blind, Placebo-controlled Study of Neoadjuvant Trastuzumab Versus Trastuzumab + BKM120 in Combination With Weekly Paclitaxel in HER2-positive, PIK3CA Wild-type and PIK3CA Mutant Primary Breast Cancer.
BKM120; Trastuzumab; Paclitaxel; Placebo

Breast Cancer Survivors Clinical Trial using Aspirin; Omega 3 FFA

The University of Texas Health Science Center at San Antonio - Recruiting 18 years or older.
- A Phase 0, Investigator Initiated Study, Evaluating the Impact of COX2 Inhibition on Human Sera Biomarkers From Obese Subjects.
Aspirin; Omega 3 FFA

Metastatic Breast Cancer Clinical Trial using fresolimumab (GC1008); Radiation Therapy

New York University School of Medicine - Recruiting 18 years or older.
- Fresolimumab and Radiotherapy in Metastatic Breast Cancer.
fresolimumab (GC1008); Radiation Therapy

Gestational Trophoblastic Tumor, Hydatidiform Mole, Low Risk Meta Clinical Trial using leucovorin calcium; dactinomycin; methotrexate; quality-of-life assessment

Gynecologic Oncology Group - Recruiting 18 years or older.
- A Phase III Randomized Trial of Pulse Actinomycin-D Versus Multi-Day Methotrexate for the Treatment of Low-Risk Gestational Trophoblastic Neoplasia.
leucovorin calcium; dactinomycin; methotrexate; quality-of-life assessment

Breast Cancer Clinical Trial using trastuzumab [Herceptin]; taxane; anthracycline

Hoffmann-La Roche - Recruiting 18 years or older.
- NATIONAL PHASE IIIB PROSPECTIVE, TWO-COHORT NON-RANDOMIZED, MULTI-CENTRE, OPEN LABEL STUDY TO ASSESS THE SAFETY OF SUBCUTANEOUS TRASTUZUMAB AND MOLECULAR BIOMARKERS IN PATIENTS WITH EARLY AND LOCALLY ADVANCED HER2-POSITIVE BREAST CANCER.
trastuzumab [Herceptin]; taxane; anthracycline

Estrogen Receptor-negative Breast Cancer, HER2-negative Breast Ca Clinical Trial using veliparib; pegylated liposomal doxorubicin hydrochloride; pharmacological study; laboratory biomarker analysis

National Cancer Institute (NCI) - Recruiting 18 years or older.
- Phase I Study of ABT-888, PARP Inhibitor, and Pegylated Liposomal Doxorubicin (PLD) in Recurrent Gynecologic Cancer and Breast Cancer.
veliparib; pegylated liposomal doxorubicin hydrochloride; pharmacological study; laboratory biomarker analysis

Estrogen Receptor-negative Breast Cancer, Estrogen Receptor-posit Clinical Trial using zoledronic acid; laboratory biomarker analysis; therapeutic conventional surgery

City of Hope Medical Center - Recruiting N/A or older.
- A Pilot Study of the Impact of a Single Dose of Zoledronic Acid on Biomarkers in Breast Cancer.
zoledronic acid; laboratory biomarker analysis; therapeutic conventional surgery

Breast Cancer Clinical Trial using trastuzumab [Herceptin]; paclitaxel; docetaxel; carboplatin; chemotherapy

Hoffmann-La Roche - Recruiting 18 years or older.
- AN OPEN-LABEL, MULTINATIONAL, MULTICENTER, PHASE IIIB STUDY WITH SUBCUTANEOUS ADMINISTRATION OF TRASTUZUMAB IN PATIENTS WITH HER2-POSITIVE EARLY BREAST CANCER TO EVALUATE PATIENT SATISFACTION.
trastuzumab [Herceptin]; paclitaxel; docetaxel; carboplatin; chemotherapy

Ductal Breast Carcinoma in Situ, Lobular Breast Carcinoma in Situ Clinical Trial using docosahexaenoic acid; placebo; laboratory biomarker analysis

National Cancer Institute (NCI) - Recruiting 18 years or older.
- A Multicenter Phase II Study of Docosahexaenoic Acid (DHA) in Patients With a History of Breast Cancer, Premalignant Lesions, or Benign Breast Disease.
docosahexaenoic acid; placebo; laboratory biomarker analysis

Breast Cancer, HER-2 Positive Breast Cancer, or Triple Negative B Clinical Trial using ganetespib

Synta Pharmaceuticals Corp. - Recruiting 18 years or older.
- An Open Label Multicenter Phase 2 Window of Opportunity Study Evaluating Ganetespib(STA-9090) Monotherapy in Women With Previously Untreated Metastatic HER2 Positive or Triple Negative Breast Cancer.
ganetespib

Breast Cancer Clinical Trial using Photon; 3D-Proton/Conventional plan or 3D-proton only

University of Florida - Recruiting 18 years or older.
- Proton Therapy for Peripheral Lymph Nodes in Breast Cancer.
Photon; 3D-Proton/Conventional plan or 3D-proton only

Breast Cancer, Breast Cancer in Young Women, or Breast Cancer in Clinical Trial using Targeted; Enhanced Tailored

University of Michigan - Recruiting 20 years to 64 years.
- Interventions to Increase Screening Utilization by Breast Cancer Survivors and Their High Risk Female Relatives: Using Cancer Surveillance and the Michigan Genomics Academic-Practice Partnership.
Targeted; Enhanced Tailored

Estrogen Receptor Negative Breast Cancer, Human Epidermal Growth Clinical Trial using cisplatin; laboratory biomarker analysis; pharmacological study; dynamic contrast-enhanced MRI, diffusion-weighted MRI & chemical exchange saturation transfer MRI; GDC -0941

Vanderbilt-Ingram Cancer Center - Recruiting 18 years or older.
- A Phase Ib/II Trial of GDC-0941 (a PI3K Inhibitor) in Combination With Cisplatin in Patients With Androgen Receptor Negative Triple Negative Metastatic Breast Cancer.
cisplatin; laboratory biomarker analysis; pharmacological study; dynamic contrast-enhanced MRI, diffusion-weighted MRI & chemical exchange saturation transfer MRI; GDC -0941

BRCA1 Mutation Carrier, BRCA2 Mutation Carrier, Recurrent Breast Clinical Trial using veliparib; carboplatin; laboratory biomarker analysis

National Cancer Institute (NCI) - Recruiting 18 years or older.
- Phase II Trial of Single Agent ABT-888 With Post-Progression Therapy of ABT-888 in Combination With Carboplatin in Patients With Stage IV BRCA-associated Breast Cancer.
veliparib; carboplatin; laboratory biomarker analysis

Breast Cancer Clinical Trial using One-stage dermal matrix/implant procedure; Two-stage tissue expander/implant procedure

University Health Network, Toronto - Recruiting 18 years to 75 years.
- Acellular Dermal Matrix in One-Stage Breast Reconstruction: A RCT.
One-stage dermal matrix/implant procedure; Two-stage tissue expander/implant procedure

Breast Cancer Clinical Trial using Trastuzumab; Pertuzumab; Paclitaxel; Doxorubicin; Cyclophosphamide; Mastectomy; Radiation Therapy

Dana-Farber Cancer Institute - Recruiting 18 years or older.
- Phase II Trial of Paclitaxel Combined With Trastuzumab and Pertuzumab as Pre-Operative Therapy for Inflammatory Breast Cancer.
Trastuzumab; Pertuzumab; Paclitaxel; Doxorubicin; Cyclophosphamide; Mastectomy; Radiation Therapy

Male Breast Cancer, Recurrent Breast Cancer, or Stage IV Breast C Clinical Trial using paclitaxel albumin-stabilized nanoparticle formulation; questionnaire administration

City of Hope Medical Center - Recruiting 65 years or older.
- Efficacy and Tolerability of Nanoparticle Albumin Bound Paclitaxel (Abraxane) in Patients 65 and Older With Metastatic Breast Cancer.
paclitaxel albumin-stabilized nanoparticle formulation; questionnaire administration

Breast Cancer Clinical Trial using palliative surgery; therapeutic conventional surgery; palliative radiation therapy; radiation therapy

Eastern Cooperative Oncology Group - Recruiting 18 years or older.
- A Randomized Phase III Trial of the Value of Early Local Therapy for the Intact Primary Tumor in Patients With Metastatic Breast Cancer.
palliative surgery; therapeutic conventional surgery; palliative radiation therapy; radiation therapy

Breast Cancer Clinical Trial using TPI 287; Dexamethasone; Benadryl; Ranitidine

M.D. Anderson Cancer Center - Recruiting 18 years or older.
- A Phase II Open-Label Study of TPI 287 in Patients With Breast Cancer Metastatic to the Brain.
TPI 287; Dexamethasone; Benadryl; Ranitidine

Estrogen Receptor-positive Breast Cancer, Musculoskeletal Complic Clinical Trial using anastrozole; questionnaire administration; laboratory biomarker analysis; pharmacogenomic studies

Eastern Cooperative Oncology Group - Recruiting 18 years or older.
- A Cohort Study to Evaluate Genetic Predictors of Aromatase Inhibitor Musculoskeletal Symptoms (AIMSS).
anastrozole; questionnaire administration; laboratory biomarker analysis; pharmacogenomic studies

HER2-positive Metastatic Breast Cancer Clinical Trial using Trastuzumab; Pertuzumab; Paclitaxel; Vinorelbine; T-DM1

Swiss Group for Clinical Cancer Research - Recruiting 18 years or older.
- A Randomized Phase II Trial of Pertuzumab in Combination With Trastuzumab With or Without Chemotherapy, Both Followed by T-DM1 in Case of Progression, in Patients With HER2-positive Metastatic Breast Cancer.
Trastuzumab; Pertuzumab; Paclitaxel; Vinorelbine; T-DM1

Lung Cancer, Esophageal Cancer, Mesothelioma, Gastrointestinal Ne Clinical Trial using Mithramycin

National Institutes of Health Clinical Center (CC) - Recruiting 18 years or older.
- Phase II Evaluation of Mithramycin, an Inhibitor of Cancer Stem Cell Signaling, in Patients With Malignancies Involving Lungs, Esophagus, Pleura, or Mediastinum.
Mithramycin

Breast Cancer Clinical Trial using BKM120

Dana-Farber Cancer Institute - Recruiting 18 years or older.
- A Phase II Trial of BKM120 in Patients With Triple Negative Metastatic Breast Cancer.
BKM120

Breast Cancer Clinical Trial using Ruxolitinib

Dana-Farber Cancer Institute - Recruiting 18 years or older.
- Phase II Study of Ruxolitinib (INCB018424) in Patients With PSTAT3+ Breast Cancer.
Ruxolitinib

Breast Cancer, or Prostate Cancer Clinical Trial

Centre Val d'Aurelle - Paul Lamarque - Recruiting 18 years to 80 years.
- Multicenter Prospective Evaluation of a Predictive Test of Late Toxicities After Radiotherapy by the Rate of Radiation Induced CD8 T-Lymphocyte Apoptosis: Application to Breast and Prostate Cancers..

Breast Cancer Survivor Clinical Trial using manualized group intervention; standardized, manualized group intervention

Memorial Sloan-Kettering Cancer Center - Recruiting 18 years or older.
- Development of Group Interventions for Breast Cancer Survivors.
manualized group intervention; standardized, manualized group intervention

Ovarian Cancer, or Breast Cancer Clinical Trial using BKM120 and Olaparib

Dana-Farber Cancer Institute - Recruiting 18 years or older.
- Phase I Study of the Oral PI3kinase Inhibitor BKM120 and the Oral PARP Inhibitor Olaparib in Patients With Recurrent Triple Negative Breast Cancer or Recurrent High Grade Serous Ovarian Cancer.
BKM120 and Olaparib

Recurrent Breast Cancer, or Metastatic Breast Cancer Clinical Trial using Ruxolitinib; Paclitaxel

Dana-Farber Cancer Institute - Recruiting 18 years or older.
- Phase II Study of Combination Ruxolitinib (INCB018242) With Preoperative Chemotherapy for Triple Negative Inflammatory Breast Cancer Following Completion of a Phase I Combination Study in Recurrent/Metastatic Breast Cancer.
Ruxolitinib; Paclitaxel

Breast Neoplasms Clinical Trial using Vinorelbine 25 mg/m2 weekly; Afatinib 40mg once daily (OD); Paclitaxel 80 mg/m2 weekly

Boehringer Ingelheim Pharmaceuticals - Recruiting 18 years or older.
- LUX-Breast 2; An Open Label, Phase II Trial of Afatinib (BIBW 2992) in Patients With Metastatic HER2-overexpressing Breast Cancer Failing HER2-targeted Treatment in the Neoadjuvant and/or Adjuvant Treatment Setting.
Vinorelbine 25 mg/m2 weekly; Afatinib 40mg once daily (OD); Paclitaxel 80 mg/m2 weekly

Oral Contraceptive Clinical Trial using Oral Contraceptive: Ortho-Novumr 1/35; Oral Contraceptive: Ovconr 35; Oral Contraceptive: Microgestin Fer 1/20

University of Southern California - Recruiting 18 years to 35 years.
- The Effects of Dose and Formulation of Oral Contraceptives (OCs) on Breast-Cell Proliferation: Can the Chemopreventive Effects of OCs on Endometrial and Ovarian Cancer be Extended to Breast Cancer?.
Oral Contraceptive: Ortho-Novumr 1/35; Oral Contraceptive: Ovconr 35; Oral Contraceptive: Microgestin Fer 1/20

Advanced or Metastatic Breast Cancer,, or ER+ve Advanced or Metas Clinical Trial using AZD5363 when combined with weekly paclitaxel.; AZD5363when combined with weekly paclitaxel.; A placebo in combination with weekly paclitaxel.

AstraZeneca - Recruiting 18 years or older.
- A Phase I/II Study of AZD5363 Combined With Paclitaxel in Patients With Advanced or Metastatic Breast Cancer. Comprising a Safety Run-In and a Placebo-controlled Randomised Expansion in ER+ve Patients Stratified by PIK3CA Mutation Status..
AZD5363 when combined with weekly paclitaxel.; AZD5363when combined with weekly paclitaxel.; A placebo in combination with weekly paclitaxel.

Breast Cancer, or Surgery Clinical Trial using SLN detection +/- complementary axillary lymphadenectomy

Institut Cancerologie de l'Ouest - Recruiting 18 years to 65 years.
- Multicentric, National, Prospective, Comparative, Non Randomized Study, Assessing Medico-economic Impact of Three Strategies of Sentinel Lymph Node Analysis in Immediately Operable Breast Cancer.
SLN detection +/- complementary axillary lymphadenectomy

Carcinoma Clinical Trial

Onkovis GmbH - Recruiting N/A or older.
- Open, Multicenter Observational Study of Paclitaxel Utilized in Mono- or Combination Therapy for the Treatment of Breast Cancer, Non-small Cell Lung Cancer and Ovarial Cancer..

Triple Negative Breast Cancer Clinical Trial using Cisplatin; Paclitaxel; Pre- and Post-chemotherapy clinical diagnostic tissue

Dana-Farber Cancer Institute - Recruiting 18 years or older.
- A Randomized Phase II Study of Preoperative Cisplatin Versus Paclitaxel in Patients With Triple Negative Breast Cancer Without Germline BRCA Mutations: Evaluating the Homologous Recombination Deficiency (HRD) Biomarker.
Cisplatin; Paclitaxel; Pre- and Post-chemotherapy clinical diagnostic tissue

Breast Cancer, or Alopecia Clinical Trial using PAXMAN Orbis Scalp Cooler; Control No treatment to prevent hair loss

Baylor Breast Care Center - Recruiting 18 years or older.
- Scalp Cooling for Alopecia Prevention (SCALP).
PAXMAN Orbis Scalp Cooler; Control No treatment to prevent hair loss

Neoplasms Clinical Trial using bevacizumab plus docetaxel

Tampere University Hospital - Recruiting 18 years or older.
- Single Arm Study of the Combination of Biweekly Avastin and Docetaxel as the First Line Treatment for Patients With Metastatic Breast Cancer.
bevacizumab plus docetaxel

Stage I Breast Cancer, Stage II Breast Cancer, Stage IIIA Breast Clinical Trial using questionnaire administration; quality-of-life assessment; management of therapy complications; exercise intervention

University of Southern California - Recruiting 18 years or older.
- Combined Exercise Program for Early Breast Cancer Survivors.
questionnaire administration; quality-of-life assessment; management of therapy complications; exercise intervention

Carcinoma Clinical Trial

Onkovis GmbH - Recruiting N/A or older.
- Open, Multicenter Observational Study of Docetaxel Utilized in Mono- or Combination Therapy for Treatment of Breast Cancer, NSCLC, Prostate Carcinoma, Adenocarcinoma of Stomach and Advanced Squamous Cell Carcinoma of Head/Neck Region..

Stage I Breast Carcinoma, or Stage II Breast Carcinoma Clinical Trial using intra-operative MRI

Dana-Farber Cancer Institute - Recruiting 18 years to 75 years.
- A Pilot Study to Evaluate Image-guided Breast Conserving Surgery in the Advanced Multimodality Image Guided Operating Suite (AMIGO).
intra-operative MRI

Breast Cancer Clinical Trial using MAB HER 2 (HERCEPTIN)

Memorial Sloan-Kettering Cancer Center - Recruiting 18 years or older.
- Xenogeneic HER2/Neu DNA Immunization for Patients With Metastatic and High Risk Breast Cancer: A Phase I Study to Assess Safety and Immunogenicity.
MAB HER 2 (HERCEPTIN)

Melanoma, Breast Neoplasms, Lobular Carcinoma, Triple-negative Br Clinical Trial using LGK974

Novartis - Recruiting 18 years or older.
- A Phase I, Open-label, Dose Escalation Study of Oral LGK974 in Patients With Malignancies Dependent on Wnt Ligands.
LGK974

Anxiety, Depression, Adverse Effects, or Health Behavior Clinical Trial using Screening-based nurse navigation

Danish Cancer Society - Recruiting 18 years or older.
- Optimized Rehabilitation: A Randomized Study of Systematic Monitorering and Management of Breast Cancer Patients' Symptoms.
Screening-based nurse navigation

Women With Estrogen Receptor Positive Breast Cancer Taking Aromat Clinical Trial using Arm A Directed exercise program; Observation

Christiana Care Health Services - Recruiting 40 years or older.
- Pilot Study for the Effect of Exercise Intervention in Breast Cancer Patients With Arthralgias Receiving Aromatase Inhibitors.
Arm A Directed exercise program; Observation

Breast Cancer Clinical Trial using Fluorestradiol (FES); PET/CT Imaging

Memorial Sloan-Kettering Cancer Center - Recruiting 18 years or older.
- Fluorestradiol (FES) PET/CT for Imaging Estrogen Receptor Status.
Fluorestradiol (FES); PET/CT Imaging

Breast Cancer Clinical Trial using Ultrasonography

Seoul National University Hospital - Recruiting 30 years or older.
- Multicenter Prospective Study to Evaluate the Value of Combined Elastography and Color Doppler Ultrasonography for Breast Screening With Ultrasound.
Ultrasonography

Stage 0/1 Breast Cancer, Post Biopsy, or Pre-surgery Clinical Trial using IV/oral n-acetylcysteine

Thomas Jefferson University - Recruiting 18 years or older.
- Pilot Study of Anti-oxidant Supplementation With N-Acetyl Cysteine in Stage 0/I Breast Cancer.
IV/oral n-acetylcysteine

Breast Cancer Clinical Trial using immediate implant breast reconstruction

Centre Val d'Aurelle - Paul Lamarque - Recruiting 18 years or older.
- Immediate Implant Breast Reconstruction for Patients With Mastectomy Ans Post op‚rative Chest Wall Radiotherapy.
immediate implant breast reconstruction

Advanced Breast Cancer Clinical Trial

Dartmouth-Hitchcock Medical Center - Recruiting 18 years or older.
- Developing Plasma DNA as a Surrogate for Tumor Biopsy to Identify Tumor Genetic Alterations in Patients With Advanced Breast Cancer.

Breast Neoplasm Clinical Trial

Medica Scientia Innovation Research - Recruiting 18 years or older.
- Observational, Retrospective and Multicenter Study to Evaluate the Clinical Benefit of Trastuzumab in Combination With Lapatinib in Metastatic Breast Cancer HER2 Positive Patients Who Has Been Previously Treated With Trastuzumab and/or Lapatinib.

Breast Cancer Clinical Trial using 3D HI and SHI of ultrasound contrast agent

Thomas Jefferson University - Recruiting 18 years or older.
- Quantitative Subharmonic Breast Imaging.
3D HI and SHI of ultrasound contrast agent

Breast Cancer Clinical Trial

Thomas Jefferson University - Recruiting 18 years or older.
- Tumor Suppressor Status as a Predictor of Chemotherapy Response in Triple Negative Breast Cancer..

Early Stage Breast Cancer Clinical Trial using Melatonin; Vitamin D; Placebo (melatonin); Placebo (vitamin D)

Juravinski Cancer Center - Recruiting 18 years or older.
- Anti-proliferative Effects of Vitamin D and Melatonin in Breast Cancer.
Melatonin; Vitamin D; Placebo (melatonin); Placebo (vitamin D)

Breast Cancer Clinical Trial using trastuzumab [Herceptin]; paclitaxel; docetaxel

Hoffmann-La Roche - Recruiting 18 years or older.
- A Multicenter, Single Arm, Open-Label PhIV Study to Investigate the Effect of First-Line Herceptin (Trastuzumab) in Combination With a Taxane in Patients With Metastatic Breast Cancer Who Relapsed After Receiving (Neo)Adjuvant Herceptin for HER2-Positive Early Breast Cancer.
trastuzumab [Herceptin]; paclitaxel; docetaxel

Recurrent Melanoma, Stage IIIB Melanoma, Stage IIIC Melanoma, or Clinical Trial using ipilimumab; recombinant interferon alfa-2b; quality-of-life assessment

National Cancer Institute (NCI) - Recruiting 18 years or older.
- A Phase III Randomized Study of Adjuvant Ipilimumab Anti-CTLA4 Therapy Versus High-Dose Interferon a-2b for Resected High-Risk Melanoma.
ipilimumab; recombinant interferon alfa-2b; quality-of-life assessment

Cancer of the Breast Clinical Trial using Axillary Reverse Mapping

University of Arkansas - Recruiting 18 years or older.
- ARM: Axillary Reverse Mapping.
Axillary Reverse Mapping

Breast Cancer Clinical Trial using Pegylated liposomal doxorubicin

University of Arizona - Recruiting 18 years or older.
- A Single Arm Phase II Trial to Assess Association of BRCA1 Protein Expression With Overall Response Rate in Patients With Metastatic Breast Cancer on Pegylated Liposomal Doxorubicin.
Pegylated liposomal doxorubicin

Male Breast Cancer, Recurrent Melanoma, Stage IV Breast Cancer, S Clinical Trial using propranolol hydrochloride; Correlative Studies

Ohio State University Comprehensive Cancer Center - Recruiting 18 years or older.
- A Pilot Study of Beta-Blockers in Patients With Advanced Cancer.
propranolol hydrochloride; Correlative Studies

Breast Cancer Clinical Trial using Carboplatin; 3D-RT or IMRT

New York University School of Medicine - Recruiting 18 years or older.
- Phase I-II Study of Concurrent Adjuvant Systemic Therapy and Accelerated Radiotherapy (Over 3 Weeks).
Carboplatin; 3D-RT or IMRT

Colorectal Cancer Clinical Trial using Cetuximab; Neratinib

National Surgical Adjuvant Breast and Bowel Project (NSABP) - Recruiting 18 years or older.
- A Phase I/II Dose-Escalation Study Evaluating the Combination of Neratinib and Cetuximab in Patients With 'Quadruple Wild-Type' (KRAS/NRAS/BRAF/PIK3CA Wild-Type) Metastatic Colorectal Cancer Resistant to Cetuximab.
Cetuximab; Neratinib

Colorectal Cancer Clinical Trial

National Surgical Adjuvant Breast and Bowel Project (NSABP) - Recruiting 18 years or older.
- NSABP Patient Registry and Biospecimen Profiling Repository.

Male Breast Cancer, Recurrent Breast Cancer, Recurrent Fallopian Clinical Trial using mifepristone; carboplatin; gemcitabine hydrochloride; laboratory biomarker analysis; pharmacological study

University of Chicago - Recruiting 18 years or older.
- Carboplatin, Gemcitabine, and Mifepristone for Advanced Breast Cancer and Recurrent or Persistent Epithelial Ovarian Cancer.
mifepristone; carboplatin; gemcitabine hydrochloride; laboratory biomarker analysis; pharmacological study

Advanced or Metastatic Solid Tumors, or Advanced or Metastatic Br Clinical Trial using Azacitidine (Vidaza); Nab-paclitaxel (Abraxane)

University of Utah - Recruiting 18 years or older.
- A Phase I/II Clinical Trial of the Hypomethylating Agent Azacitidine (Vidaza) With the Nanoparticle Albumin Bound Paclitaxel (Abraxane) in the Treatment of Patients With Advanced or Metastatic Solid Tumors and Breast Cancer.
Azacitidine (Vidaza); Nab-paclitaxel (Abraxane)

Primary Breast Cancer, or Recurrent/Metastatic Breast Cancer Clinical Trial

ICORG- All Ireland Cooperative Oncology Research Group - Recruiting 18 years or older.
- Breast Cancer Proteomics and Molecular Heterogeneity.

Breast Cancer, HER2 Positive Breast Cancer, or HER2 Negative Brea Clinical Trial using Biomarker Analysis

ICORG- All Ireland Cooperative Oncology Research Group - Recruiting 18 years or older.
- Exosomal and Free Extracellular RNAs and Proteins as Predictive Biomarkers for HER2 Therapies in Breast Cancer.
Biomarker Analysis

Neoplasms, Breast Clinical Trial using GSK Biologicals' recombinant WT1 Antigen-Specific Cancer Immunotherapeutic (ASCI) GSK2302024A; Placebo

GlaxoSmithKline - Recruiting 18 years or older.
- Study of GSK2302024A Antigen-Specific Cancer Immunotherapeutic Combined With Standard Neoadjuvant Treatment in Patients With WT1-positive Primary Invasive Breast Cancer.
GSK Biologicals' recombinant WT1 Antigen-Specific Cancer Immunotherapeutic (ASCI) GSK2302024A; Placebo

Stage I Chronic Lymphocytic Leukemia, Stage II Chronic Lymphocyti Clinical Trial using ibrutinib; rituximab; bendamustine hydrochloride; laboratory biomarker analysis; quality-of-life assessment

National Cancer Institute (NCI) - Recruiting 65 years or older.
- A Randomized Phase III Study of Bendamustine Plus Rituximab Versus Ibrutinib Plus Rituximab Versus Ibrutinib Alone in Untreated Older Patients (ò 65 Years of Age) With Chronic Lymphocytic Leukemia (CLL).
ibrutinib; rituximab; bendamustine hydrochloride; laboratory biomarker analysis; quality-of-life assessment

HER2-positive Breast Cancer, or TNM Stage II-IV Breast Cancer Clinical Trial

ICORG- All Ireland Cooperative Oncology Research Group - Recruiting N/A or older.
- CharactHer: A Study of the Molecular and Cytogenetic Characteristics of HER2-positive Breast Cancers to Predict Durable Complete Response After Chemotherapy and Trastuzumab.

Breast Cancer, Newly Diagnosed Breast Cancer, or Recurrent Breast Clinical Trial

ICORG- All Ireland Cooperative Oncology Research Group - Recruiting 18 years or older.
- Circulating miRNAs: Novel Breast Cancer Biomarkers and Their Use for Guiding and Monitoring Response to Chemotherapy.

Her2 Positive Metastatic Breast Cancer Clinical Trial using non-pegylated liposomal doxorubicon (MyocetT); Lapatinib (TyverbT)

ICORG- All Ireland Cooperative Oncology Research Group - Recruiting 18 years or older.
- A Phase I/II Study of Lapatinib Plus Myocet TM in Patients With HER2+ve Metastatic Breast Cancer Following Disease Progression During, or After, Treatment With Trastuzumab and Taxanes.
non-pegylated liposomal doxorubicon (MyocetT); Lapatinib (TyverbT)

Breast Cancer Clinical Trial using Eribulin; Carboplatin

H. Lee Moffitt Cancer Center and Research Institute - Recruiting 18 years or older.
- A Phase I Dose Escalation Study of Eribulin in Combination With Weekly Carboplatin for the Treatment of Metastatic Breast Cancer.
Eribulin; Carboplatin

Breast Cancer, Brain Cancer, Gastrointestinal Cancers, Genitourin Clinical Trial using IGF-Methotrexate

University of Illinois at Chicago - Recruiting 18 years or older.
- STM-02: Phase I Study of IGF-Methotrexate Conjugate in the Treatment of Advanced Tumors Expressing IGF-1R.
IGF-Methotrexate

Breast Cancer, Colorectal Cancer, Lung Cancer, Melanoma (Skin), o Clinical Trial

ICORG- All Ireland Cooperative Oncology Research Group - Recruiting N/A or older.
- Collaborative Project on Potential Serum Markers for Malignant Melanoma, Metastatic Breast, Advanced Lung Pancreatic Carcinoma and Colorectal Cancer.

HER2-positive Breast Cancer, Recurrent Breast Cancer, or Stage IV Clinical Trial using pertuzumab; trastuzumab; paclitaxel albumin-stabilized nanoparticle formulation; laboratory biomarker analysis

City of Hope Medical Center - Recruiting 19 years or older.
- Phase II Prospective Open Label Single Arm Study of Pertuzumab, Trastuzumab, and Nab-Paclitaxel in Patients With HER-2 Positive Metastatic Breast Cancer.
pertuzumab; trastuzumab; paclitaxel albumin-stabilized nanoparticle formulation; laboratory biomarker analysis

Prostatic Neoplasms, Breast Neoplasms, Colorectal Neoplasms, Mela Clinical Trial using Interactive Voice Response (IVR) Reminders

Michigan State University - Recruiting 21 years or older.
- Improving Adherence to Oral Cancer Agents and Self Care of Symptoms Using an IVR.
Interactive Voice Response (IVR) Reminders

Breast Cancer Clinical Trial using Paclitaxel + LCL161; paclitaxel

Novartis - Recruiting 18 years or older.
- A Phase II Multi-center, Open-label, Neoadjuvant, Randomized Study of Weekly Paclitaxel With or Without LCL161 in Patients With Triple Negative Breast Cancer.
Paclitaxel + LCL161; paclitaxel

Breast Cancer Clinical Trial using BYL719; BKM120; Placebo

Novartis - Recruiting 18 years or older.
- A Phase II Randomized, Double-blind Placebo Controlled, Study of Letrozole With or Without BYL719 or Buparlisib, for the Neoadjuvant Treatment of Postmenopausal Women With Hormone Receptor-positive HER2-negative Breast Cancer.
BYL719; BKM120; Placebo

Breast Cancer Clinical Trial using axillary lymph node dissection; isosulfan blue based lymphatic mapping; quality-of-life assessment; Questionnaire administration

City of Hope Medical Center - Recruiting N/A or older.
- Reducing Extremity Lymphedema Through Axillary Lymphatic Preservation Surgery.
axillary lymph node dissection; isosulfan blue based lymphatic mapping; quality-of-life assessment; Questionnaire administration

Malignant Tumor Clinical Trial using Novilase Interstitial Laser Therapy

Novian Health Inc. - Recruiting 18 years to 80 years.
- A Multicenter 'Ablate and Resect' Study of Novilaser Interstitial Laser Therapy for the Ablation of Small Breast Cancers.
Novilase Interstitial Laser Therapy

Breast Cancer Clinical Trial using trastuzumab [Herceptin]; Chemotherapy

Hoffmann-La Roche - Recruiting 18 years or older.
- An Open Label, Randomised Phase II Study Assessing Quality of Life Associated With Subcutaneous Trastuzumab Injected Into the Thigh or Upper Arm in Patients With HER2-positive Early Breast Cancer.
trastuzumab [Herceptin]; Chemotherapy

Breast Cancer Clinical Trial

Hoffmann-La Roche - Recruiting 18 years or older.
- CLINICAL PRACTICE SURVEILLANCE OF THE USE OF HERCEPTIN SUBCUTANEOUS IN PATIENTS WITH HER2-POSITIVE EARLY BREAST CANCER (HerSCin).

Breast Cancer Clinical Trial

Hoffmann-La Roche - Recruiting 18 years or older.
- Breast Cancer Care (BRECC) Registry - Development of a Breast Cancer Registry to Determine the Magnitude of Breast Cancer and Current Clinical Care Patterns in Kenya.

Breast Cancer, Prostate Cancer, Lung Cancer, Lymphoma Cancer, or Clinical Trial using group intervention and questionnaires; individual phone intervention and questionnaires

Memorial Sloan-Kettering Cancer Center - Recruiting 70 years or older.
- Pilot of a Geriatric Group Psychoeducational Intervention for Elderly Patients With Cancer.
group intervention and questionnaires; individual phone intervention and questionnaires

Weight Clinical Trial using Diet and exercise

Baptist Health South Florida - Recruiting 18 years to 89 years.
- A Study of Lifestyle Intervention in Overweight or Obese Women With Early Stage Breast Cancer.
Diet and exercise

HER2-positive Breast Cancer, Inflammatory Breast Cancer, Male Bre Clinical Trial using entinostat; lapatinib ditosylate; trastuzumab; laboratory biomarker analysis

National Cancer Institute (NCI) - Recruiting 18 years or older.
- Phase I and Phase I Trastuzumab Cohort Study of Entinostat, Lapatinib and Trastuzumab in Patients With HER2-Positive Metastatic Breast Cancer in Whom Trastuzumab Has Failed.
entinostat; lapatinib ditosylate; trastuzumab; laboratory biomarker analysis

Prostate Cancer, Salivary Gland Cancer, Endometrial Cancer, Squam Clinical Trial using OPB-111001

Otsuka Novel Products GmbH - Recruiting 18 years or older.
- A Two-part Phase 1/2a, Open-label, Dose Escalation Study to Evaluate the Tolerability and Preliminary Antitumour Activity of OPB-111001 in Patients With Advanced Cancers That Are Poorly Responsive to Standard Anticancer Treatment.
OPB-111001

Breast Cancer, or HER2 Positive Clinical Trial using PTC+Pertuzumab; FEC-T+Pertuzumab

The Netherlands Cancer Institute - Recruiting 18 years or older.
- Optimizing Neoadjuvant Systemic Treatment for HER2 Positive Breast Cancer - the TRAIN-2 Study.
PTC+Pertuzumab; FEC-T+Pertuzumab

Estrogen Receptor-positive Breast Cancer, HER2-positive Breast Ca Clinical Trial using docetaxel; carboplatin; trastuzumab; pertuzumab; goserelin acetate; therapeutic conventional surgery; whole breast irradiation; quality-of-life assessment; laboratory biomarker analysis; aromatase inhibition therapy

National Cancer Institute (NCI) - Recruiting 18 years or older.
- A Randomized Phase III Trial Evaluating Pathologic Complete Response Rates in Patients With Hormone Receptor-Positive, HER2-Positive, Large Operable and Locally Advanced Breast Cancer Treated With Neoadjuvant Therapy of Docetaxel, Carboplatin, Trastuzumab, and Pertuzumab (TCHP) With or Without Estrogen Deprivation.
docetaxel; carboplatin; trastuzumab; pertuzumab; goserelin acetate; therapeutic conventional surgery; whole breast irradiation; quality-of-life assessment; laboratory biomarker analysis; aromatase inhibition therapy

Breast Cancer Clinical Trial

European Organisation for Research and Treatment of Cancer - EORTC - Recruiting 18 years or older.
- Clinical and Biological Characterization of Male Breast Cancer: an International EORTC, BIG, TBCRC and NABCG Intergroup Study..

Metastatic Gastrointestinal Carcinoid Tumor, Pulmonary Carcinoid Clinical Trial using pazopanib hydrochloride; placebo; quality-of-life assessment; laboratory biomarker analysis

National Cancer Institute (NCI) - Recruiting 18 years or older.
- Prospective Randomized Phase II Trial of Pazopanib (NSC # 737754, IND 75648) Versus Placebo in Patients With Progressive Carcinoid Tumors.
pazopanib hydrochloride; placebo; quality-of-life assessment; laboratory biomarker analysis

Fatigue, or Breast Cancer Clinical Trial

Faculdade de Medicina do ABC - Recruiting 18 years to 80 years.
- Biomarkers of Fatigue Related to Adjuvant Chemotherapy for Breast Cancer: Evaluation of Plasma and Lymphocyte Expression..

Untreated Human Epidermal Growth Factor Receptor-2(HER2)Positive Clinical Trial using Blood test

Gustave Roussy, Cancer Campus, Grand Paris - Recruiting 18 years or older.
- Identification of Early Markers of Response and Resistance to Trastuzumab in Patients With Localized Human Epidermal Growth Factor Receptor-2(HER-2)-Positive Breast Cancer Candidates for Breast Conserving Surgery.
Blood test

Breast Cancer, or Unspecified Adult Solid Tumor, Protocol Specifi Clinical Trial using positron emission tomography/computed tomography; fludeoxyglucose F 18; PET/MRI; gadopentetate dimeglumine; questionnaire administration

Case Comprehensive Cancer Center - Recruiting 18 years or older.
- Positron Mammographic Imaging (PMI).
positron emission tomography/computed tomography; fludeoxyglucose F 18; PET/MRI; gadopentetate dimeglumine; questionnaire administration

Advanced, Metastatic Breast Cancer Clinical Trial using LEE011; Letrozole; Letrozole Placebo

Novartis - Recruiting N/A or older.
- A Randomized Double-blind, Placebo-controlled Study of LEE011 in Combination With Letrozole for the Treatment of Postmenopausal Women With Hormone Receptor Positive, HER2 Negative, Advanced Breast Cancer Who Received no Prior Therapy for Advanced Disease.
LEE011; Letrozole; Letrozole Placebo

Breast Cancer Clinical Trial using beauty care

Gustave Roussy, Cancer Campus, Grand Paris - Recruiting 18 years or older.
- Evaluation of Beauty Care Before Chemotherapy in Women With Breast Cancer.
beauty care

Early Breast Cancer Clinical Trial using LEE011; Letrozole

Novartis - Recruiting 18 years or older.
- A Randomized Pre-surgical Pharmacodynamics Study to Assess the Biological Activity of LEE011 Plus Letrozole Versus Single Agent Letrozole in Primary Breast Cancer.
LEE011; Letrozole

Breast Cancer Clinical Trial using Interview; Blood and Tissue Collection

M.D. Anderson Cancer Center - Recruiting 18 years or older.
- Inflammatory Breast Cancer (IBC) Registry.
Interview; Blood and Tissue Collection

Estrogen Receptor-positive Breast Cancer, HER2-negative Breast Ca Clinical Trial using systemic chemotherapy; tamoxifen citrate; anastrozole; exemestane; letrozole

National Cancer Institute (NCI) - Recruiting 18 years or older.
- A PHASE III, RANDOMIZED CLINICAL TRIAL OF STANDARD ADJUVANT ENDOCRINE THERAPY +/-CHEMOTHERAPY IN PATIENTS WITH 1-3 POSITIVE NODES, HORMONE RECEPTOR-POSITIVE AND HER2-NEGATIVE BREAST CANCER WITH RECURRENCE SCORE (RS) OF 25 OR LESS. RXPONDER: A CLINICAL TRIAL RX FOR POSITIVE NODE, ENDOCRINE RESPONSIVE BREAST CANCER.
systemic chemotherapy; tamoxifen citrate; anastrozole; exemestane; letrozole

Female Breast Cancer Clinical Trial

National Guard Health Affairs - Recruiting 40 years or older.
- Breast Cancer in Young Women: Is it Different?.

Breast Cancer, Cancer Survivor, Cognitive/Functional Effects, or Clinical Trial using cognitive intervention; questionnaire administration; quality-of-life assessment; blood-oxygen-level-dependent functional magnetic resonance imaging; memory intervention

University of Washington - Recruiting 21 years to 90 years.
- Behavioral and Neural Indices of Cognitive Rehabilitation in Women's Cancer: A Pilot Study..
cognitive intervention; questionnaire administration; quality-of-life assessment; blood-oxygen-level-dependent functional magnetic resonance imaging; memory intervention

Breast Cancer, Colon Cancer, or Bladder Cancer Clinical Trial using Glycosylated Recombinant Human Interleukin-7; Diphtheria-Tetanus Vaccine; Polio Vaccine; Pneumaococcal Vaccine; Hepatitis A Vaccine; Hepatitis B Vaccine; Influenza Vaccine; PhiX 174

National Institutes of Health Clinical Center (CC) - Recruiting 60 years or older.
- A Multicenter Phase II Study of Enhancement of Immune Reconstitution and Vaccine Responses With Administration of Glyco-Recombinant Human IL-7 in Older Subjects Following Chemotherapy.
Glycosylated Recombinant Human Interleukin-7; Diphtheria-Tetanus Vaccine; Polio Vaccine; Pneumaococcal Vaccine; Hepatitis A Vaccine; Hepatitis B Vaccine; Influenza Vaccine; PhiX 174

Breast Neoplasms, or Ovarian Neoplasms Clinical Trial

National Institutes of Health Clinical Center (CC) - Recruiting 18 years or older.
- Clinical, Genetic, Behavioral, Laboratory and Epidemiologic Characterization of Individuals and Families at High Risk of Breast/Ovarian Cancer.

Gastro-intestinal Cancer, Lung Cancer, Head and Neck Cancer, or B Clinical Trial using Instructed to read patient education pamphlets

Sunnybrook Health Sciences Centre - Recruiting 18 years or older.
- The Impact of a Patient Education Intervention on Knowledge, Self-efficacy, Symptom Burden, Health Related Quality of Life and Satisfaction With the Experience of Care for Oncology Ambulatory Patients Post Completion of the Edmonton Screening Assessment System.
Instructed to read patient education pamphlets

Cancer, Melanoma, Breast Cancer, Head and Neck Cancer, or Lymphom Clinical Trial using LTX-315

Lytix Biopharma AS - Recruiting 18 years or older.
- A Phase I, Open-label, Multi-centre, Multi-dose, Dose Escalation Study of LTX-315 in Patients With Transdermally Accessible Tumours.
LTX-315

Hormone Receptor-Positive Breast, Gynecologic, Desmoid, or Hormon Clinical Trial using z-Endoxifen; [(18)F] Fluoroestradiol

National Institutes of Health Clinical Center (CC) - Recruiting 18 years or older.
- Phase I Trial of Z-Endoxifen in Adults With Refractory Hormone Receptor-Positive Breast Cancer, Desmoid Tumors, Gynecologic Tumors, or Other Hormone Receptor-Positive Solid Tumors.
z-Endoxifen; [(18)F] Fluoroestradiol

Breast Cancer Clinical Trial using Clinical data

National University Hospital, Singapore - Recruiting 21 years or older.
- .
Clinical data

Breast Cancer Clinical Trial using Radiation Therapy

New York University School of Medicine - Recruiting 18 years or older.
- Prospective Trial of Two Prone Breast Radiotherapy Techniques With Randomization to Concurrent Versus Weekly Boost.
Radiation Therapy

Breast Cancer Clinical Trial

National University Hospital, Singapore - Recruiting 18 years or older.
- .

HER2-negative Und Hormone-receptor Positive Metastatic Breast Can Clinical Trial using Everolimus in combination with standard endocrine therapy

University of Ulm - Recruiting 18 years or older.
- DETECT IV - A Multicenter Single Arm Phase II Study to Investigate the Clinical Efficacy of Everolimus in Combination With Endocrine Therapy in Postmenopausal Patients With Hormone-receptor Positive, HER2-negative Metastatic Breast Cancer and Persisting HER2-negative Circulating Tumor Cells..
Everolimus in combination with standard endocrine therapy

Breast Neoplasms Clinical Trial using Trastuzumab; pertuzumab; lapatinib

UNC Lineberger Comprehensive Cancer Center - Recruiting 18 years or older.
- Defining the HER2 Positive (+) Breast Cancer Kinome Response to Trastuzumab, Pertuzumab, Combination Trastuzumab +Pertuzumab, or Combination Trastuzumab + Lapatinib.
Trastuzumab; pertuzumab; lapatinib

Adenocarcinoma of the Gastroesophageal Junction, Esophageal Cance Clinical Trial using FOLFOX regimen; docetaxel; fluorouracil; irinotecan hydrochloride; leucovorin calcium; oxaliplatin

Southwest Oncology Group - Recruiting 18 years or older.
- A Randomized Phase II Pilot Study Prospectively Evaluating Treatment for Patients Based on ERCC1(Excision Repair Cross-Complementing 1) for Advanced/Metastatic Esophageal, Gastric or Gastroesophageal Junction (GEJ) Cancer.
FOLFOX regimen; docetaxel; fluorouracil; irinotecan hydrochloride; leucovorin calcium; oxaliplatin

Quality of Life Clinical Trial using Exercise Intervention

Universidad Politecnica de Madrid - Recruiting 18 years to 80 years.
- Integrative Exercise and Life Style Intervention Increase Leisure Time Activity in Breast Cancer Patients..
Exercise Intervention

HER-2 Positive Breast Cancer Clinical Trial using Everolimus; Vinorelbine; Trastuzumab

UNC Lineberger Comprehensive Cancer Center - Recruiting 21 years or older.
- A Phase II Study Evaluating The Efficacy And Tolerability Of Everolimus (RAD001) In Combination With Trastuzumab And Vinorelbine In The Treatment Of Progressive HER2-Positive Breast Cancer Brain Metastases.
Everolimus; Vinorelbine; Trastuzumab

Male Breast Cancer, Neurotoxicity, Peripheral Neuropathy, Stage I Clinical Trial using laboratory biomarker analysis; questionnaire administration

Fox Chase Cancer Center - Recruiting 18 years or older.
- Assessing Heavy Metal Contributions to Neurotoxicity in Breast Cancer Patients Undergoing Adjuvant or Neoadjuvant Chemotherapy.
laboratory biomarker analysis; questionnaire administration

Breast Cancer Clinical Trial using biologic sample preservation procedure; laboratory biomarker analysis; biopsy

UNC Lineberger Comprehensive Cancer Center - Recruiting 18 years or older.
- Correlation of Molecular Markers With Response to Therapy and Breast Cancer Behavior.
biologic sample preservation procedure; laboratory biomarker analysis; biopsy

HER2-positive Metastatic Breast Cancer Clinical Trial using Trastuzumab; Paclitaxel

Biocad - Recruiting 18 years to 70 years.
- International Multicenter Randomized Double Blind Phase III Clinical Trial Comparing Safety and Efficacy of BCD-022 (CJSC BIOCAD, Russia) Used With Paclitaxel to Herceptinr (F. Hoffmann-La Roche Ltd, Switzerland) Used With Paclitaxel in the First-line Treatment of HER2-positive Metastatic Breast Cancer Patients.
Trastuzumab; Paclitaxel

Estrogen Receptor-positive Breast Cancer, Stage I Breast Cancer, Clinical Trial using tamoxifen citrate; polymerase chain reaction; pharmacological study; gene expression analysis; immunohistochemistry staining method; pharmacogenomic studies; matrix-assisted laser desorption/ionization time of flight mass spectrometry; polymorphism analysis; therapeutic conventional surgery; nucleic acid sequencing; protein analysis

Roswell Park Cancer Institute - Recruiting 18 years or older.
- Pilot Study to Analyze a Novel Mechanism Underlying Response to Tamoxifen Therapy in Breast Cancer Patients.
tamoxifen citrate; polymerase chain reaction; pharmacological study; gene expression analysis; immunohistochemistry staining method; pharmacogenomic studies; matrix-assisted laser desorption/ionization time of flight mass spectrometry; polymorphism analysis; therapeutic conventional surgery; nucleic acid sequencing; protein analysis

Pain Clinical Trial using Doxycycline

Ottawa Hospital Research Institute - Recruiting 19 years or older.
- A Phase 2 Trial Exploring the Clinical and Correlative Effects of Combining Doxycycline With Bone-Targeted Therapy in Patients With Metastatic Breast Cancer.
Doxycycline

Breast Cancer Clinical Trial using Vitamin D3; Placebo

Ottawa Hospital Research Institute - Recruiting 18 years or older.
- A Phase 2 Randomized, Double-blind, Window of Opportunity Trial Evaluating Clinical and Correlative Effects of Vitamin D in Patients With Breast Cancer. The ICARUS Trial.
Vitamin D3; Placebo

Breast Cancer Clinical Trial using MammaPrint 70-gene expression profile; BluePrint 80 gene expression profile

Agendia - Recruiting 18 years to 90 years.
- Prospective Neo-adjuvant REGISTRY Trial Linking MammaPrint, Subtyping and Treatment Response: Neoadjuvant Breast Registry - Symphony Trial (NBRST) (Pronounced 'in Breast').
MammaPrint 70-gene expression profile; BluePrint 80 gene expression profile

Anxiety Disorder, Depression, Ductal Breast Carcinoma in Situ, Lo Clinical Trial using educational intervention; counseling intervention; psychosocial support for caregiver; questionnaire administration; laboratory biomarker analysis

University of Washington - Recruiting N/A or older.
- Psychoeducation for Spouses/Partners of Women With Breast Cancer.
educational intervention; counseling intervention; psychosocial support for caregiver; questionnaire administration; laboratory biomarker analysis

Breast Cancer, Ovarian Cancer, Colon Cancer, Lung Cancer, Gastric Clinical Trial using Veliparib (ABT-888); Placebo

AbbVie - Recruiting 18 years or older.
- A Randomized, Placebo-Controlled Crossover Study to Evaluate the Effect of Veliparib (ABT-888) on Cardiac Repolarization in Subjects With Relapsed or Refractory Solid Tumors.
Veliparib (ABT-888); Placebo

Breast Cancer, or Endometrial Cancer Clinical Trial using HLA vaginal gel (HyaloGYNr),; questionnaires

Memorial Sloan-Kettering Cancer Center - Recruiting 18 years or older.
- A Single-Arm Clinical Trial Investigating the Feasibility of a Non-Hormonal Vaginal Moisturizer in Hormone-Receptor Positive Postmenopausal Cancer Survivors Experiencing Estrogen Deprivation Symptoms.
HLA vaginal gel (HyaloGYNr),; questionnaires

Breast Cancer Clinical Trial

University of Kansas - Recruiting 30 years to 65 years.
- High Risk Breast Clinic: Protocol for Women at Increased Risk for Developing Breast Cancer.

Breast Cancer Clinical Trial using allogeneic GM-CSF-secreting breast cancer vaccine; trastuzumab; cyclophosphamide

Sidney Kimmel Comprehensive Cancer Center - Recruiting 18 years or older.
- A Randomized, Open-Label Comparative Study of Combination Therapy With Cyclophosphamide and an Allogeneic GM-CSF-secreting Breast Tumor Vaccine With or Without Trastuzumab for the Treatment of Metastatic Breast Cancer That Does NOT Over-express HER-2/Neu.
allogeneic GM-CSF-secreting breast cancer vaccine; trastuzumab; cyclophosphamide

Triple Negative Breast Cancer Clinical Trial using Veliparib; Carboplatin; Paclitaxel; Doxorubicin; Cyclophosphamide

AbbVie - Recruiting 18 years or older.
- A Randomized, Placebo-Controlled, Double-Blind, Phase 3 Study Evaluating Safety and Efficacy of the Addition of Veliparib Plus Carboplatin Versus the Addition of Carboplatin to Standard Neoadjuvant Chemotherapy Versus Standard Neoadjuvant Chemotherapy in Subjects With Early Stage Triple Negative Breast Cancer (TNBC).
Veliparib; Carboplatin; Paclitaxel; Doxorubicin; Cyclophosphamide

Breast Cancer Clinical Trial using Enzalutamide; exemestane; Placebo (for enzalutamide)

Medivation, Inc. - Recruiting 18 years or older.
- A Phase 2, Randomized, Double-Blind, Placebo-Controlled, Multicenter Study of Efficacy and Safety of Enzalutamide in Combination With Exemestane in Patients With Advanced Breast Cancer That Is Estrogen or Progesterone Receptor-Positive and HER2-Normal.
Enzalutamide; exemestane; Placebo (for enzalutamide)

Estrogen Receptor-negative Breast Cancer, HER2-negative Breast Ca Clinical Trial using Paclitaxel; Carboplatin; Doxorubicin; Cyclophosphamide; Veliparib

Thomas Jefferson University - Recruiting 18 years or older.
- An Adaptive, Randomized Phase II Trial to Determine Pathologic Complete Response With the Addition of Carboplatin With and Without Veliparib to Standard Chemotherapy in the Neoadjuvant Treatment of Triple-Negative Breast Cancer.
Paclitaxel; Carboplatin; Doxorubicin; Cyclophosphamide; Veliparib

Breast Cancer Clinical Trial using Indocyanine Green

Jules Bordet Institute - Recruiting 18 years or older.
- Study of the (Intravenously Injected) Indocyanine Green Distribution in Tumour Bearing Breasts and in Axillary Pieces of Dissection of Patients Who Have Received Neoadjuvant Therapy for Histologically Proven Mammary Cancer.
Indocyanine Green

Breast Neoplasms Clinical Trial

Medical University of Graz - Recruiting 18 years to 80 years.
- Prospective Validation of Genomic Signatures to Predict Treatment Response in the Axillary Nodes After Neoadjuvant Chemotherapy in Patients With HER2-negative Breast Cancer.

Advanced, Androgen Receptor Positive Triple Negative Breast Cance Clinical Trial using Enzalutamide

Medivation, Inc. - Recruiting 18 years or older.
- A Phase 2, Single Arm, Open Label, Multicenter Study of the Clinical Activity and Safety of Enzalutamide in Patients With Advanced, Androgen Receptor Positive, Triple Negative Breast Cancer.
Enzalutamide

Breast Cancer Clinical Trial using Indocyanine Green

Jules Bordet Institute - Recruiting 18 years or older.
- Evaluation of Near- InfraRed Imaging of ICG in Comparison With the Lymphoscintigraphic Technique Using Intramammary and Peritumoral Injection of 99mTc-HSA-Nanocolloids for the SLN Detection in BC Patients..
Indocyanine Green

Breast Cancer, Gastric Cancer Clinical Trial using trastuzumab emtansine; capecitabine

Hoffmann-La Roche - Recruiting 18 years or older.
- PHASE I FOLLOWED BY PHASE II STUDY OF THE COMBINATION OF TRASTUZUMAB EMTANSINE (T-DM1) AND CAPECITABINE IN HER2-POSITIVE METASTATIC BREAST CANCER AND HER2-POSITIVE LOCALLY ADVANCED OR METASTATIC GASTRIC CANCER PATIENTS.
trastuzumab emtansine; capecitabine

Metastatic Breast Cancer, or Carcinomatous Meningitis Clinical Trial using Trastuzumab

Institut Curie - Recruiting 18 years or older.
- Phase 1-2 Study of Safety and Efficacy of Intrathecal Trastuzumab Administration in Metastatic HER2 Positive Breast Cancer Patients Developing Carcinomatous Meningitis.
Trastuzumab

Metastatic Breast Cancer Clinical Trial using Fulvestrant; Everolimus; Placebo (for Everolimus)

PrECOG, LLC. - Recruiting 18 years or older.
- Randomized, Double-Blind, Placebo-Controlled Phase II Trial of Fulvestrant (Faslodex) Plus Everolimus in Post-Menopausal Patients With Hormone-Receptor Positive Metastatic Breast Cancer Resistant to Aromatase Inhibitor Therapy.
Fulvestrant; Everolimus; Placebo (for Everolimus)

Breast Cancer, or Stage IV Breast Cancer Clinical Trial using positron emission tomography; copper Cu 64-DOTA-trastuzumab; Biopsy; Immunohistochemistry staining method; laboratory biomarker analysis; mutation analysis

City of Hope Medical Center - Recruiting 18 years or older.
- 64 Cu-DOTA-Trastuzumab Positron Emission Tomography in Women With Advanced HER2 Positive Invasive Breast Cancer.
positron emission tomography; copper Cu 64-DOTA-trastuzumab; Biopsy; Immunohistochemistry staining method; laboratory biomarker analysis; mutation analysis

Estrogen Receptor-negative Breast Cancer, HER2-negative Breast Ca Clinical Trial using veliparib; cisplatin; vinorelbine tartrate; laboratory biomarker analysis; pharmacological study

University of Washington - Recruiting 18 years or older.
- Phase I Study of ABT-888 in Combination With Cisplatin and Vinorelbine for Patients With Advanced Triple Negative Breast Cancer and/or BRCA-Mutation Associated Breast Cancer.
veliparib; cisplatin; vinorelbine tartrate; laboratory biomarker analysis; pharmacological study

Metastatic Breast Cancer Clinical Trial using Veliparib; Temozolomide; Carboplatin; Paclitaxel; Placebo

AbbVie - Recruiting 18 years or older.
- A Randomized, Phase 2 Study of the Efficacy and Tolerability of Veliparib in Combination With Temozolomide or Veliparib in Combination With Carboplatin and Paclitaxel Versus Placebo Plus Carboplatin and Paclitaxel in Subjects With BRCA1 or BRCA2 Mutation and Metastatic Breast Cancer.
Veliparib; Temozolomide; Carboplatin; Paclitaxel; Placebo

Breast Cancer Clinical Trial using Cone Beam CT

University Health Network, Toronto - Recruiting 18 years or older.
- Automating the Breast Radiation Therapy Process to Improve Efficiency.
Cone Beam CT