46 results found.

Respiratory Insufficiency Clinical Trial using TOSCA 500 monitor

Baylor Research Institute - Recruiting 18 years to 85 years.
- Pilot Study: Transcutaneous Carbon Dioxide Monitoring Post Cardiac Surgery: Incidence and Severity of Respiratory Insufficiency.
TOSCA 500 monitor

Persistent Atrial Fibrillation, or Longstanding Persistent Atrial Clinical Trial using Synergy Ablation System

AtriCure, Inc. - Recruiting 18 years or older.
- AtriCure Synergy Ablation Lesions for Non-Paroxysmal Forms of Atrial Fibrillation Treatment During Concomitant On-Pump Endo/Epicardial Cardiac Surgery.
Synergy Ablation System

Hemorrhage, or Soft Tissue Bleeding Clinical Trial using EVARRESTT Fibrin Sealant Patch; Standard of Care

Ethicon, Inc. - Recruiting 18 years or older.
- A Non-Investigational Post-Market Trial Using EVARRESTT Fibrin Sealant Patch as an Adjunct to Hemostasis in Soft Tissue Bleeding During Intra-Abdominal, Retroperitoneal, Pelvic and Non-Cardiac Thoracic Surgery.
EVARRESTT Fibrin Sealant Patch; Standard of Care

Postoperative Complications Clinical Trial using Incentive spirometry (IS); Breath Stacking (BS)

Federal University of Sao Paulo - Recruiting 18 years to 80 years.
- Comparison Between Incentive Spirometry and Breath Stacking After Cardiac Surgery.
Incentive spirometry (IS); Breath Stacking (BS)

Acute Kidney Injury Clinical Trial using AC607; Vehicle Only

AlloCure Inc. - Recruiting 21 years or older.
- A Randomized, Multicenter, Double-Blind, Placebo-Controlled Study of AC607 for the Treatment of Acute Kidney Injury in Cardiac Surgery Subjects.
AC607; Vehicle Only

Cardiovascular Diseases, Coronary Disease, Coronary Artery Diseas Clinical Trial using cardiac catheterization; coronary artery bypass graft surgery; percutaneous coronary intervention; Lifestyle; Medication

New York University School of Medicine - Recruiting 21 years or older.
- International Study of Comparative Health Effectiveness With Medical and Invasive Approaches (ISCHEMIA).
cardiac catheterization; coronary artery bypass graft surgery; percutaneous coronary intervention; Lifestyle; Medication

Cardiac Surgery Clinical Trial using NeuroSave device

NeuroSave Inc. - Recruiting 18 years or older.
- Targeted Cerebral Hypothermia During Cardiac Surgery: A Feasibility Trial.
NeuroSave device

General Anesthesia Clinical Trial using Remimazolam; Propofol; Sevoflurane; Remifentanil; Fentanyl; Rocuronium

Paion UK Ltd. - Recruiting 18 years or older.
- A Randomized, Single-blind Phase II Study Evaluating the Efficacy, Safety and Pharmacokinetics of Remimazolam in General Anesthesia in Adult Patients Undergoing Cardiac Surgery, Including Follow-up Sedation in the PACU/ICU.
Remimazolam; Propofol; Sevoflurane; Remifentanil; Fentanyl; Rocuronium

Coronary Artery Disease, Aortic Stenosis, Aortic Insufficiency, M Clinical Trial using cardioPAT cell saver

Rigshospitalet, Denmark - Recruiting 18 years or older.
- CardioPAT Project - Reducing the Need for Allogenic Blood Transfusion After On-pump Cardiac Surgery With Intra- and Postoperative Use of a New Device: a Randomized Trial.
cardioPAT cell saver

Acute Kidney Injury Clinical Trial

University Hospital, Basel, Switzerland - Recruiting 18 years or older.
- Novel Biomarkers (TIMP-2 and IGFBP7) of Tubular Renal Cell Damage for the Prediction of the Cardiac Surgery Associated Acute Kidney Injury (CSA-AKI) - A Feasibility Study.

Acute Kidney Injury, or Cardiac Surgery Clinical Trial using Sodium Bicarbonate; Sodium Chloride

North Shore Long Island Jewish Health System - Recruiting N/A to 21 years.
- Sodium Bicarbonate to Prevent Acute Kidney Injury in Children Undergoing Cardiac Surgery: A Randomized Clinical Trial.
Sodium Bicarbonate; Sodium Chloride

Heart Disease Clinical Trial using Fibrinogen; Saline solution; Prothrombin complex

IRCCS Policlinico S. Donato - Recruiting 18 years or older.
- The ZEroPLASmaTrial (ZEPLAST): a Randomized, Controlled Trial on Transfusion Avoidance in High Transfusion-risk Cardiac Surgery Patients.
Fibrinogen; Saline solution; Prothrombin complex

Disorder; Heart, Functional, Postoperative, Cardiac Surgery Clinical Trial using Restrictive Transfusion Strategy; Liberal transfusion strategy

St. Michael's Hospital, Toronto - Recruiting 18 years or older.
- An International, Multi-centre, Randomized Controlled Trial to Assess Transfusion Thresholds in Patients Undergoing Cardiac Surgery.
Restrictive Transfusion Strategy; Liberal transfusion strategy

Postoperative Pain Clinical Trial using Hydromorphone

University of Erlangen-Nrnberg Medical School - Recruiting 40 years to 85 years.
- Phase 4 Study of Postoperative Pain Therapy With Hydromorphone Using Patient-Controlled Target-Controlled Infusion (TCI-PCA) vs. Patient-Controlled Analgesia (PCA) After Elective Cardiac Surgery.
Hydromorphone

Hypertension, Pulmonary, or Ventricular Dysfunction, Left Clinical Trial using IK-3001

INO Therapeutics - Recruiting N/A to 80 years.
- Examination of Safety and Effectiveness of IK-3001 (Nitric Oxide for Inhalation) in Japanese Subjects With Pulmonary Hypertension Associated With Cardiac Surgery - Multi-Center, Open-Label, Clinical Study.
IK-3001

Cardiopulmonary Bypass, or Altered Heparin Response Clinical Trial using Heparin; ATryn

Massachusetts General Hospital - Recruiting 18 years or older.
- Understanding 'Heparin Resistance' in Cardiac Surgery: Altered Heparin Responsiveness and Its Association With Acute Inflammatory Reactions.
Heparin; ATryn

Heart Disease Clinical Trial using Dexmedetomidine; Placebo

The Cleveland Clinic - Recruiting 18 years to 85 years.
- Ancillary Effects of Dexmedetomidine Sedation After Cardiac Surgery.
Dexmedetomidine; Placebo

Cardiac Surgery, or Erythrocyte Transfusion Clinical Trial using Red blood cell units stored <= 10 days; Red blood cell units stored >= 21 days

New England Research Institutes - Recruiting 12 years or older.
- Red Cell Storage Duration Study.
Red blood cell units stored <= 10 days; Red blood cell units stored >= 21 days

Cardiac Surgery, or Erythrocyte Transfusion Clinical Trial

Duke University - Recruiting 18 years or older.
- Impact of Blood Storage Duration on Physiologic Measures: RECESS Ancillary Physiologic Study (RECAP).

Congenital Heart Disease Clinical Trial using EQUANOX Advance 8004CB sensor

Mayo Clinic - Recruiting N/A to 3 years.
- Does Near Infrared Spectroscopy Predict Low Cardiac Output State in Neonates and Infants Following Cardiac Surgery for Congenital Heart Disease?.
EQUANOX Advance 8004CB sensor

Low Cardiac Output Syndrome Clinical Trial using Levosimendan; placebo

Universit… Vita-Salute San Raffaele - Recruiting 18 years or older.
- Levosimendan to Reduce Mortality in High Risk Cardiac Surgery Patients. A Multicentre Randomized Controlled Trial.
Levosimendan; placebo

Incisional Hernia, or Abdominal Aortic Aneurysm Clinical Trial using PRINCIPLES technique; Conventional group

University of Belgrade - Recruiting N/A or older.
- Prospective Case-control Study on the Incidence of Incisional Hernias at 12 Months After Closure of Midline Laparotomies in Patients Treated for Abdominal Aortic Aneurysm.
PRINCIPLES technique; Conventional group

Cardiac Disease Clinical Trial using Exparel infiltration

Maimonides Medical Center - Recruiting 18 years to 75 years.
- The Use of Exparel for Extended Pain Control in Minimally Invasive Cardiac Surgery.
Exparel infiltration

Poor Glycemic Control Clinical Trial using metformin; Glargine+ metformin; Metformin+glargine+aspart

Emory University - Recruiting 18 years to 80 years.
- Prospective Study Aim to Determine the Efficacy and Safety of a Glargine-based Hospital Discharge Algorithm in Cardiac Surgery Patients With Perioperative Hyperglycemia.
metformin; Glargine+ metformin; Metformin+glargine+aspart

Ventricular Dysfunction Clinical Trial using cardiac surgery for ventricular dysfunction

Rennes University Hospital - Recruiting 18 years or older.
- Hemodynamic Indices Predictive of a Beneficial Response to Fluid Expansion in Case of Hemodynamic Failure After Cardiac Surgery With Altered Preoperative Ejection Fraction (LVEFó45%): Sensibility and Specificity of Respiratory Variations of Pulse Pressure (?PP), Photoplethysmography (?POP), Perfusion Index (PVI), End Expiratory Occlusion Test, and Passive Leg Rising Test, Compared With Fluid Expansion..
cardiac surgery for ventricular dysfunction

Aortic Disease Clinical Trial using epsilon-aminocaproic acid (EACA)

University of Pennsylvania - Recruiting 18 years or older.
- The Effect of Standard vs Aggressive Dosing Regimens for Epsilon-aminocaproic Acid on a Quantifiable Parameter of Fibrinolysis as Measured by Thromboelastography.
epsilon-aminocaproic acid (EACA)

Coronary Heart Disease Clinical Trial using Tetraspan; acetated Ringer`s solution

Haukeland University Hospital - Recruiting 18 years to 80 years.
- Ringer`s Acetat Versus Balanced Hydroxyethyl-starch as Primesolution in the Heart-lung Maschine During Cardio-pulmonary-bypass. Postoperatively Fluid Balance and Cardiac Function.
Tetraspan; acetated Ringer`s solution

Heart; Dysfunction Postoperative, Cardiac Surgery, Genetic Predis Clinical Trial

Brigham and Women's Hospital - Recruiting 20 years to 90 years.
- Identification of Genomic Predictors of Adverse Events After Cardiac Surgery.

Acute Kidney Injury Clinical Trial using THR-184

Thrasos Innovation, Inc. - Recruiting 18 years to 85 years.
- A Multi-Center, Parallel-Group, Randomized, Double Blind, Adaptive Study Investigating the Safety and Efficacy of THR-184 in Patients at Increased Risk of Developing Cardiac Surgery Associated-Acute Kidney Injury (CSA-AKI).
THR-184

Ischaemic Reperfusion Injury Clinical Trial using Remote ischaemic preconditioning (RIPC); Placebo

NHS Greater Glasgow and Clyde - Recruiting N/A to 5 years.
- Effect of Remote Ischaemic Preconditioning in Cardiac Dysfunction and End-organ Injury Following Cardiac Surgery With Cardiopulmonary Bypass in Children..
Remote ischaemic preconditioning (RIPC); Placebo

Shock Clinical Trial using Vasopressin; Norepinephrine

University of Sao Paulo - Recruiting 18 years or older.
- .
Vasopressin; Norepinephrine

Fluid Overload Clinical Trial using furosemide; ethacrynic acid

Bambino Ges— Hospital and Research Institute - Recruiting N/A to 10 years.
- Phase III Study of Furosemide Continuous Infusion Versus Ethacrynic Acid Continuous Infusion in Children Undergoing Cardiac Surgery: Randomized Double Blind Controlled Clinical Trial.
furosemide; ethacrynic acid

Nosocomial Infection Clinical Trial using Glutamine; Maltodextrin

University of Alberta - Recruiting 18 years or older.
- GLutamine Enterally After carDiac Surgery for Inflammation Attenuation and ouTcOme impRovement (GLADIATOR): A Phase II Randomized, Blinded, Placebo-Controlled Trial.
Glutamine; Maltodextrin

Postoperative Pain Clinical Trial using Pregabalin 75mg; pregabalin 150 mg; Placebo

Larissa University Hospital - Recruiting 18 years to 85 years.
- The Effects of Pregabalin on Acute and Chronic Postoperative Pain After Cardiac Surgery.
Pregabalin 75mg; pregabalin 150 mg; Placebo

CABG, or Valve Surgery Clinical Trial using Breathing exercises

Uppsala University - Recruiting 18 years or older.
- Effects of Deep Breathing Exercises Two Months After Cardiac Surgery.
Breathing exercises

Acute Renal Failure, or Acute Kidney Injury Clinical Trial

National Taiwan University Hospital - Recruiting 18 years or older.
- Early Diagnosis of Postoperative Acute Renal Failure - Using Biomarker to Predict the Outcome of Cardiac Surgery Associated Acute Kidney Injury.

Coronary Artery Disease Clinical Trial using Robotic-assisted Coronary Surgical Revascularization; PCI- Drug Eluting Stents

Lawson Health Research Institute - Recruiting 30 years to 85 years.
- Same Procedure Cardiac Hybrid Surgery in a Specialty Built OR-- A Pilot Study.
Robotic-assisted Coronary Surgical Revascularization; PCI- Drug Eluting Stents

Heart; Dysfunction Postoperative, Cardiac Surgery, or Disorder; H Clinical Trial using Isoflurane; Propofol

Sheba Medical Center - Recruiting 18 years or older.
- Influence of Anesthesia on Mechanical Efficiency of Left Ventricle in Patients Undergoing Open Heart Surgery.
Isoflurane; Propofol

Old Myocardial Infarction, Chronic Myocardial Ischemia, or Left V Clinical Trial using bone marrow mononuclear cells injection; placebo intramyocardial injection

Chinese PLA General Hospital - Recruiting 18 years to 75 years.
- A Prospective,Randomized, Placebo-Controlled Study of Intramyocardial Injection of Autologous Bone-Marrow Mononuclear Cells in Patients With Severe, Chronic Ischemic Heart Disease Undergoing Coronary Bypass Surgery.
bone marrow mononuclear cells injection; placebo intramyocardial injection

Aortic Valve Insufficiency, Aortic Valve Stenosis, Mitral Valve I Clinical Trial using antithrombin III

University of Bari - Recruiting 18 years to 80 years.
- Effects of the Administration Of Antithrombin on the Coagulation Status and on the Inflammatory Response in Patients With Low Plasmatic Levels of Antithrombin After Cardiac Surgery.
antithrombin III

Coronary Artery Stenosis, or Coronary Artery Bypass Graft Surgery Clinical Trial using Dexamethasone; Placebo

VU University Medical Center - Recruiting 18 years to 75 years.
- Reduction of the Cardiac Proapoptotic Stress Response by Dexamethasone in Patients Undergoing Coronary Artery Bypass Grafting Surgery.
Dexamethasone; Placebo

Cardiac Surgery Clinical Trial using Red blood cell transfusion

Instituto do Coracao - Recruiting 18 years or older.
- Transfusion Requirements After Cardiac Surgery: a Randomized Controlled Clinical Trial (TRACS STUDY).
Red blood cell transfusion

Surgery Clinical Trial

Medical University of Vienna - Recruiting 19 years to 90 years.
- Is Global Longitudinal Peak Systolic Strain (GLPSS) Derived From Transesophageal Echocardiography a Reliable Measure of Systolic Function? A Multicenter-Study to Compare GLPSS With Ejection Fraction Derived From Biplane Simpson's Method on TTE and TEE in Patients Undergoing Elective Cardiac and Non-Cardiac Surgery.

Pulmonary Hypertension Clinical Trial using Sildenafil (Viagra); Sildenafil; Placebo

St. Michael's Hospital, Toronto - Recruiting 18 years or older.
- A Phase II, Double Blind Randomized Controlled Trial to Determine the Safety and Efficacy of 12.5mg of Oral Sildenafil (Viagra) Compared to Placebo to Decrease Pulmonary Hypertension in Cardiac Patients After Cardiopulmonary Bypass.
Sildenafil (Viagra); Sildenafil; Placebo

Infective Endocarditis Clinical Trial using Cardiac surgery; State-to-the-art treatment

Instituto de Ciencias del Corazon - Recruiting 18 years or older.
- Rationale, Design and Methods for the Early Surgery in Infective Endocarditis Study: a Multicenter, Prospective, Randomized Trial Comparing the State-of-the-Art Therapeutic Strategy Versus Early Surgery Strategy in Infective Endocarditis.
Cardiac surgery; State-to-the-art treatment