National Institutes of Health Clinical Center (CC) - Recruiting 18 years or older. - A Pharmacokinetic/Pharmacodynamic Study With a Phase I Run-In With a PARP Inhibitor (Olaparib) in Combination With Carboplatin for Refractory or Recurrent Women's Cancers.
Gynecologic Oncology Group - Recruiting 18 years or older. - A Phase II Evaluation of ADXS11-001 (NSC 752718, BB-IND#13,712) in the Treatment of Persistent or Recurrent Squamous or Non-Squamous Cell Carcinoma of the Cervix.
live-attenuated Listeria monocytogenes cancer vaccine ADXS11-001; laboratory biomarker analysis
Gynecologic Oncology Group - Recruiting 18 years or older. - Randomized Phase III Clinical Trial of Adjuvant Radiation Versus Chemoradiation in Intermediate Risk, Stage I/IIA Cervical Cancer Treated With Initial Radical Hysterectomy and Pelvic Lymphadenectomy.
Gynecologic Oncology Group - Recruiting 18 years or older. - Glycoprotein and Glycan Profiling in Patients With Locally Advanced Cervical Cancer (Stage IB2, IIA > 4 CM, IIB to IVA) Undergoing Pelvic and Para-Aortic (Abdominal) Lymphadenectomy.
National Cancer Institute (NCI) - Recruiting 18 years or older. - Randomized Phase II Study of Intravenous 3-Aminopyridine-2-carboxaldehyde Thiosemicarbazone (3-AP, Triapiner NSC #663249) Cisplatin-Radiochemotherapy Versus Intravenous Cisplatin-Radiochemotherapy in Women Diagnosed With Stage IB-IVA Cervical Cancer and Stage II-IVA Vaginal Cancer.
Gynecologic Oncology Group - Recruiting 18 years or older. - Evaluation of Physical Function and Quality of Life (QOL) Before and After Non-Radical Surgical Therapy (Extra Fascial Hysterectomy or Cone Biopsy With Pelvic Lymphadenectomy) for Stage IA1 (LVSI+) and IA2-IB1 (=/<2CM) Cervical Cancer.
Sidney Kimmel Comprehensive Cancer Center - Recruiting 18 years or older. - A Phase I Efficacy and Safety Study of HPV16-specific Therapeutic DNA-vaccinia Vaccination in Combination With Topical Imiquimod, in Patients With HPV16+ High Grade Cervical Dysplasia (CIN3).
TA-HPV; pNGVL4a-Sig/E7(detox)/HSP70 DNA vaccine; imiquimod
M.D. Anderson Cancer Center - Recruiting 18 years or older. - Effect of a Beta Andrenergic Blockade Combined With Relaxation/Guided Imagery Audio Intervention on Symptom Distress in Women With Advanced, Recurrent Incurable Cervical Cancer - Feasibility Study.
National Cancer Institute (NCI) - Recruiting 18 years or older. - A Phase 2 Study of Ipilimumab in Women With Metastatic or Recurrent HPV-Related Cervical Carcinoma of Either Squamous Cell or Adenocarcinoma Histologies.
NCIC Clinical Trials Group - Recruiting 18 years or older. - A Randomized Phase III Trial Comparing Radical Hysterectomy and Pelvic Node Dissection vs Simple Hysterectomy and Pelvic Node Dissection in Patients With Low-Risk Early Stage Cervical Cancer.
Massachusetts General Hospital - Recruiting 18 years or older. - Pilot Study of Adjuvant Proton Beam Teletherapy for Post-Hysterectomy Cancers of the Uterus and Cervix With Metastases to Regional Lymph Nodes.
National Cancer Institute (NCI) - Recruiting 18 years or older. - Phase II Randomized Assessing Pelvic Irradiation Combined With Cisplatin Alone or Cisplatin Plus Cetuximab in Patients With Carcinoma of the Cervix Stage IB2, II and III.
University College, London - Recruiting 18 years or older. - A Phase III Multicentre Trial of Weekly Induction Chemotherapy Followed by Standard Chemoradiation Versus Standard Chemoradiation Alone in Patients With Locally Advanced Cervical Cancer.
Queensland Centre for Gynaecological Cancer - Recruiting 18 years or older. - A Phase III Randomized Clinical Trial of Laparoscopic or Robotic Radical Hysterectomy Versus Abdominal Radical Hysterectomy in Patients With Early Stage Cervical Cancer.
Total Abdominal Radical Hysterectomy; Total Laparoscopic or Robotic Radical Hysterectomy
Queen Mary University of London - Recruiting 18 years or older. - A Phase I/II, Multi-centre Dose Escalation Study of Simultaneous Boost Intensity-modulated Radiotherapy for Locally Advanced Cervical Cancer.
Wenzhou Medical University - Recruiting 18 years to 75 years. - Phase III Randomized Trial of Comparing Chemoradiotherapy vs. Radiotherapy Alone in Lymph Node Negative Patients With Early-Stage Cervical Cancer Following Radical Hysterectomy.
Catholic University of the Sacred Heart - Recruiting N/A to 75 years. - Prospective Randomized Trial on Laparoscopic Radical Hysterectomy With Pelvic Lymphadenectomy for the Treatment of Early Stage Cervical Cancer (FIGO Stages IA2-IB1-IIA<2cm) and Advanced Stage Cervical Cancer (FIGO Stages IB2-IIA>2 Cm-IIB) Submitted to NACT With Complete Clinical Response: Thunderbeat Technology Versus Standard Bipolar Electro Surgery.
Thunderbeat technology; Standard bipolar electrosurgery
Chinese Academy of Medical Sciences - Recruiting 18 years to 70 years. - A Single Center, Non-randomized, Open Phase II Clinical Study of Albumin-bound Paclitaxel Plus Nedaplatin in Patients With Advanced, Recurrent Metastatic Cervical Cancer.
Zhejiang University - Recruiting 18 years to 65 years. - Prevaccination Distribution of Cervical Human Papillomavirus (HPV) Types and Their Associations With Invasive Cervical Cancer and Its Precursors in Yangtze River Delta Area, China.
University of Virginia - Recruiting 18 years or older. - An Exploratory Pharmacogenomic Study of Neoadjuvant Cetuximab Followed by Cisplatin, Radiotherapy, and Cetuximab in Women With Newly Diagnosed Locally Advanced or Metastatic Cervical Carcinoma.
National Cancer Institute (NCI) - Recruiting N/A or older. - A Limited Access Phase II Trial of Pemetrexed (Alimta, LY231514) (NSC #698037) in Combination With Cisplatin (NSC #119875) in the Treatment of Advanced, Persistent, or Recurrent Carcinoma of the Cervix.
Medstar Research Institute - Recruiting 9 years to 17 years. - Immunogenicity Of A Prophylactic Quadrivalent Human Papillomavirus (Types 6, 11, 16, And 18) L1 Virus-Like Particle Vaccine In Male And Female Adolescent Transplant Recipients..
Thai Gynecologic Oncology Collaborative Group - Recruiting 18 years to 60 years. - Comparing Standard Concurrent Chemo-radiation to Neoadjuvant Chemotherapy Then Surgery or Radiation in Patients Stage Ib2-early IIb Cervical Carcinoma.
Charite University, Berlin, Germany - Recruiting 18 years to 70 years. - Prospective, Randomised and Multi-centric Therapy Optimisation Study for Examining the Influence of Surgical Staging on the Oncological Results for Patients With Cervix Carcinoma of the FIGO Stages IIB-IV After Chemoradiation.
National Cancer Institute (NCI) - Recruiting 18 years or older. - A Phase I-II Trial of Mild Whole-Body Hyperthermia Combined With Liposomal Doxorubicin/5-Fluorouracil in Patients With Advanced Malignancy.
Julius-Maximilians University - Recruiting 19 years to 90 years. - Vaccination of Patients With Advanced Melanoma, Pancreatic, Colon and Cervical Cancer With HLA-A1, -A2 and -B35 Restricted Survivin Peptides.