229 results found.

Type 2 Diabetes Mellitus Clinical Trial using MK-3102; Placebo to MK-3102; Glipizide; Placebo to glipizide; Insulin

Merck Sharp & Dohme Corp. - Recruiting 30 years or older.
- A Phase III, Multicenter, Randomized, Double-blind Study to Evaluate the Efficacy and Safety of MK-3102 Versus Placebo in Subjects With Type 2 Diabetes Mellitus With Moderate or Severe Chronic Kidney Disease or Kidney Failure on Dialysis Who Have Inadequate Glycemic Control.
MK-3102; Placebo to MK-3102; Glipizide; Placebo to glipizide; Insulin

Chronic Obstructive Pulmonary Disease Clinical Trial using Inspiratory muscle training

University Hospital, Brest - Recruiting 18 years or older.
- Effects of Inspiratory Muscle Training (IMT) on Dyspnea in COPD During Pulmonary Rehabilitation: Randomized Controlled Trial.
Inspiratory muscle training

Chronic Obstructive Pulmonary Disease, Cardiovascular Disease, or Clinical Trial

Lund University - Recruiting 35 years to 80 years.
- Biomarkers of Early Chronic Obstructive Pulmonary Disease (COPD) and Cardiovascular Diseases in Smokers/Ex-Smokers Attending Primary Care - Longitudinal Study.

Pulmonary Disease, Chronic Obstructive Clinical Trial using placebo; ipratropium bromide

Boehringer Ingelheim - Recruiting 50 years to 75 years.
- Peri-operative Intervention With Nebulized Ipratropium Bromide in Chinese Patients With Chronic Obstructive Pulmonary Disease (COPD): a Randomized, Double-blind, Placebo-controlled, Parallel-group, Multi-centre Trial..
placebo; ipratropium bromide

Pulmonary Disease, Chronic Obstructive Clinical Trial using tiotropium; placebo; olodaterol

Boehringer Ingelheim - Recruiting 40 years or older.
- A Randomised, Double-blind, Placebo- and Active-controlled Parallel Group Study to Assess the Efficacy of 12 Weeks of Once Daily Treatment of Two Doses of Orally Inhaled Tiotropium + Olodaterol Fixed Dose Combination (Delivered by the Respimat Inhaler) in Patients With Moderate to Severe Chronic Obstructive Pulmonary Disease (COPD).
tiotropium; placebo; olodaterol

Pulmonary Disease, Chronic Obstructive Clinical Trial using olodaterol; tiotropium; placebo

Boehringer Ingelheim - Recruiting 40 years or older.
- A Randomised, Double-blind, Placebo- and Active-controlled Parallel Group Study to Assess the Efficacy of 12 Weeks of Once Daily Treatment of Two Doses of Orally Inhaled Tiotropium+ Olodaterol Fixed Dose Combination (Delivered by the Respimat Inhaler) in Patients With Moderate to Severe Chronic Obstructive Pulmonary Disease (COPD).
olodaterol; tiotropium; placebo

Pulmonary Disease, Chronic Obstructive Clinical Trial using olodaterol; tiotropium; Placebo

Boehringer Ingelheim - Recruiting 40 years or older.
- A Randomised, Placebo-controlled, Double-blind, Single Dose, Cross-over Study to Evaluate the Efficacy and Safety of Orally Inhaled Tiotropium + Olodaterol as Both a Fixed Dose Combination and a Free Combination (Both Delivered by the Respimatr Inhaler) in Patients With Chronic Obstructive Pulmonary Disease (COPD).
olodaterol; tiotropium; Placebo

Pulmonary Disease, Chronic Obstructive Clinical Trial using Placebo to BI 113608 high dose b.i.d.; Placebo to BI 113608 low dose b.i.d.; BI 113608 high dose b.i.d.; Placebo to BI 113608 medium dose b.i.d.; BI 113608 low dose b.i.d.; BI 113608 medium dose b.i.d.

Boehringer Ingelheim - Recruiting 40 years to 80 years.
- Randomized, Placebo-controlled, Double-blind Within Dose Groups, Multiple Rising-dose Study to Evaluate Safety, Tolerability, and PK of Oral BI 113608 Administered as Tablets Twice Daily Over 4 Weeks in Patients With COPD Associated With Chronic Bronchitis.
Placebo to BI 113608 high dose b.i.d.; Placebo to BI 113608 low dose b.i.d.; BI 113608 high dose b.i.d.; Placebo to BI 113608 medium dose b.i.d.; BI 113608 low dose b.i.d.; BI 113608 medium dose b.i.d.

Pulmonary Disease, Chronic Obstructive Clinical Trial using Combivent Respimat via ventilator adapter

Boehringer Ingelheim - Recruiting 40 years or older.
- Open Label, Non-randomised, 1-day Trial to Characterize the Performance of an Adapter Device Designed to Permit Use of the Respimatr Inhaler Device With Patients Requiring Mechanical Ventilation..
Combivent Respimat via ventilator adapter

Pulmonary Disease, Chronic Obstructive Clinical Trial using Tiotropium Bromide 2.5 æg; Indacterol 300 æg; Tiotropium Bromide 18 æg; Indacterol 150 æg

Boehringer Ingelheim - Recruiting 40 years or older.
- Post-Marketing Observational Study of the Impact of Adherence to Treatment With Once-Daily Administered Long-Acting Bronchodilators (LABAs / LAMAs) on Patients Health Related Quality of Life in COPD Patients.
Tiotropium Bromide 2.5 æg; Indacterol 300 æg; Tiotropium Bromide 18 æg; Indacterol 150 æg

Management of Anemia in Chronic Kidney Disease Patients Not on Di Clinical Trial using Darbepoetin alfa

Amgen - Recruiting 18 years or older.
- Strategies Using Darbepoetin Alfa to Avoid Transfusions in Chronic Kidney Disease.
Darbepoetin alfa

Pulmonary Disease, Chronic Obstructive Clinical Trial using Group1:Spirivar Respimatr; Group2:Hirobrizr/Oslifr/Onbrezr Breezhalerr

Boehringer Ingelheim - Recruiting 18 years or older.
- Cross-sectional Study to Assess the Handling , Patient Satisfaction, and Preference for Inhalation Devices in Patients With Chronic Obstructive Pulmonary Disease (COPD)..
Group1:Spirivar Respimatr; Group2:Hirobrizr/Oslifr/Onbrezr Breezhalerr

Secondary Hyperparathyroidism; Chronic Kidney Disease Clinical Trial using AMG 416; cinacalcet

Amgen - Recruiting 18 years to 85 years.
- A Multicenter, Multiple-dose, Two-arm, Active-controlled, Double-blind, Double-dummy Study to Compare the Therapeutic Efficacy and Safety of Oral Doses of Cinacalcet HCl With Intravenous Doses of AMG 416 in Hemodialysis Subjects With Secondary Hyperparathyroidism.
AMG 416; cinacalcet

Hyperparathyroidism, Secondary Clinical Trial using AMG 416

Amgen - Recruiting 18 years or older.
- A Multicenter Single-arm Extension Study to Describe the Long-term Efficacy and Safety of AMG 416 in the Treatment of Secondary Hyperparathyroidism in Subjects With Chronic Kidney Disease on Hemodialysis.
AMG 416

Pulmonary Disease, Chronic Obstructive Clinical Trial using fluticasone propionate; salmeterol; placebo; tiotropium; olodaterol

Boehringer Ingelheim - Recruiting 40 years or older.
- Randomized, Double-blind, Double-dummy, Active-controlled, 4 Period Complete Cross-over Study to Compare the Effect on Lung Function of 6 Weeks Once Daily Treatment With Orally Inhaled Tiotropium+Olodaterol Fixed Dose Combination Delivered by the Respimatr Inhaler vs. 6 Weeks Twice Daily Treatment With Fluticasone Propionate+Salmeterol Fixed Dose Combination Delivered by the Accuhalerr in Patients With Chronic Obstructive Pulmonary Disease (COPD).
fluticasone propionate; salmeterol; placebo; tiotropium; olodaterol

Chronic Obstructive Pulmonary Disease (COPD) With Cachexia Clinical Trial using Placebo; BYM338

Novartis - Recruiting 40 years to 80 years.
- A Randomized, Double Blind, Placebo Controlled, Multi-centre Study to Asses the Pharmacodynamics, Pharmacokinetics, Safety and Tolerability of BYM338 in Chronic Obstructive Pulmonary Disease Patients With Cachexia.
Placebo; BYM338

Ischemia, Phantom Limb Pain, Vascular Disease, or Chronic Pain Clinical Trial using Sciatic catheter; Stump catheter

University of British Columbia - Recruiting 16 years to 90 years.
- Ultrasound Guided Sciatic Perineural Catheter vs Surgically Placed Sciatic Stump Catheter for Below Knee Amputations: Is There A Difference in Patient Outcomes.
Sciatic catheter; Stump catheter

COPD Clinical Trial using Ergometer Training; Motivation

Institut fr Pneumologie Hagen Ambrock eV - Recruiting 18 years to 80 years.
- German: Effekte Eines Telemonitorisch berwachten Ergometertrainings Bei Patienten Mit Einer COPD Nach Exazerbation: Eine Prospektiv Randomisierte Studie.
Ergometer Training; Motivation

Anemia, or Kidney Failure, Chronic Clinical Trial using Sotatercept

Celgene Corporation - Recruiting 18 years or older.
- A Phase 2 Multicenter, Randomized, Open-Label , Multiple-Dose Study of Intravenous and Subcutaneous Administration of Sotatercept (ACE-011) in Subjects With End-Stage Kidney Disease on Hemodialysis Switched From Erythropoiesis Stimulating Agents With Staggered Dose Group Escalation in Part 1 Followed by a Parallel Group, Active Controlled Study of Selected Dose(s) and Regimen(s) in Part 2: To Evaluate the Pharmacokinetics, Safety, Tolerability, Efficacy, Dosing Regimen, and Pharmacodynamics of Sotatercept.
Sotatercept

COPD Clinical Trial using Hydrolyzed casein protein; Hydrolyzed casein protein + carbohydrates; Hydrolyzed casein protein + leucine; Hydrolyzed casein protein + carbohydrates + leucine

Texas A&M University - Recruiting 45 years or older.
- Casein Protein and Leucine Supplementation to Induce Anabolism in COPD Patients and Healthy Elderly.
Hydrolyzed casein protein; Hydrolyzed casein protein + carbohydrates; Hydrolyzed casein protein + leucine; Hydrolyzed casein protein + carbohydrates + leucine

Chagas Disease Clinical Trial using Nifurtimox (BAYa2502) (4 x 30 mg tablet); Nifurtimox (BAYa2502) (slurry of 4 x 30 mg tablets in tap water); Nifurtimox (BAYa2502) (120 mg tablet)

Bayer - Recruiting 18 years to 45 years.
- Open Label, Randomized, Single Dose Cross-over Study to Assess Bioequivalence Between Single 120 mg Nifurtimox Tablet and Four 30 mg Nifurtimox Tablets Administered Orally, Following High Calorie/High Fat Meal to Adult Male and Female Patients Suffering From Chronic Chagas' Disease and to Determine the Pharmacokinetics of Nifurtimox Tablets Administered Orally, in a Form of Aqueous Slurry.
Nifurtimox (BAYa2502) (4 x 30 mg tablet); Nifurtimox (BAYa2502) (slurry of 4 x 30 mg tablets in tap water); Nifurtimox (BAYa2502) (120 mg tablet)

Chronic Kidney Disease Clinical Trial using Structured Exercise

Department of Veterans Affairs - Recruiting 18 years or older.
- Structured Exercise in Obese Diabetic Patients With Chronic Kidney Disease.
Structured Exercise

Chronic Kidney Disease, or Acute Kidney Injury Clinical Trial using 75 mg / 6 mL VFIT

FAST BioMedical - Recruiting 19 years to 75 years.
- A Single-Center Prospective Study Evaluating the FAST Measured Glomerular Filtration Rate (mGFR) TestT in Adults With Preserved Kidney Function and Impaired Kidney Function With Comparison to Iohexol Clearance Methods.
75 mg / 6 mL VFIT

Heart Failure Clinical Trial using BAY94-8862; Eplerenone; Placebo

Bayer - Recruiting 18 years or older.
- A Randomized, Double-blind, Double-dummy, Multi-center Study to Assess Safety and Efficacy of BAY94-8862 in Japanese Subjects With Emergency Presentation at the Hospital Because of Worsening Chronic Heart Failure With Left Ventricular Systolic Dysfunction and Either Type 2 Diabetes Mellitus With or Without Chronic Kidney Disease or Moderate Chronic Kidney Disease Alone Versus Eplerenone.
BAY94-8862; Eplerenone; Placebo

Hypertension, or Chronic Kidney Disease Clinical Trial using Valsartan

Novartis - Recruiting 6 years to 17 years.
- A Multicenter, Open-label, 18 Month Study to Evaluate the Long-term Safety and Tolerability of Valsartan in Children 6 to 17 Years of Age With Hypertension and With or Without Chronic Kidney Disease.
Valsartan

Chronic Kidney Disease Clinical Trial using No intervention

Janssen Inc. - Recruiting 18 years or older.
- A Prospective, Observational, Randomized Comparative Study of Case Managed Versus Non-case Managed Initiation of Hemodialysis.
No intervention

COPD Clinical Trial using ASM-024; Placebo

Asmacure Lt‚e - Recruiting 40 years or older.
- A Randomized, Double-blind, Placebo-controlled, Two-Way Crossover Study to Evaluate the Safety, Tolerability and Clinical Activity of ASM-024 Administered by Dry Power Inhalation to Patients With GOLD 2 (Moderate) or GOLD 3 (Severe) Chronic Obstructive Pulmonary Disease (COPD).
ASM-024; Placebo

Chronic Obstructive Pulmonary Disease Clinical Trial using Home mechanical ventilation

Fundaci¢ Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau - Recruiting N/A to 80 years.
- Home Mechanical Ventilation in Patients With Chronic Obstructive Pulmonary Disease (COPD) Who Develop Nocturnal Hypercapnic Response Associated to Oxygen Therapy.
Home mechanical ventilation

Kidney Disease, Kidney Transplantation, or Kidney Failure, Chroni Clinical Trial

National Institutes of Health Clinical Center (CC) - Recruiting 18 years or older.
- Role of Donor Genetics and Recipient Genetics in Kidney Transplant Outcomes.

Chronic Granulomatous Disease, Healthy, Immunologic Disease, Leuk Clinical Trial

National Institutes of Health Clinical Center (CC) - Recruiting 2 years to 65 years.
- Recruitment and Apheresis Collection of Peripheral Blood Hematopoietic Stem Cells.

Liver Disease Clinical Trial

National Institutes of Health Clinical Center (CC) - Recruiting 18 years or older.
- The Physiology of Fatigue in Patients With Chronic Liver Disease.

Bronchiolitis Obliterans, Chronic Graft Versus Host Disease, Leuk Clinical Trial using Montelukast sodium; Flow cytometry; Laboratory biomarker analysis; Quality-of-life assessment

National Institutes of Health Clinical Center (CC) - Recruiting 6 years to 80 years.
- Multi-Institutional Prospective Phase II Study of Montelukast for the Treatment of Bronchiolitis Obliterans Following Allogeneic or Autologous Stem Cell Transplantation in Children and Adults.
Montelukast sodium; Flow cytometry; Laboratory biomarker analysis; Quality-of-life assessment

Chronic Disease, Healthy, Lyme Arthritis, Lyme Disease, or Multip Clinical Trial

National Institutes of Health Clinical Center (CC) - Recruiting 13 years or older.
- A Comprehensive Clinical, Microbiological and Immunological Assessment of Patients With Suspected Chronic Lyme Infection and Selected Control Populations.

Chronic Granulomatous Disease (CGD), Atherosclerosis, Immune Defi Clinical Trial

National Institutes of Health Clinical Center (CC) - Recruiting 18 years or older.
- Non-Invasive Assessment of Atherosclerosis in Patients With CGD and Other Disorders of the Immune System.

Graft vs Host Disease Clinical Trial using Autologous Serum Eye Drops

National Institutes of Health Clinical Center (CC) - Recruiting 18 years or older.
- A Randomized, Controlled, Double-Masked, Clinical Trial of Autologous Serum Eye Drops for Severe Ocular Chronic Graft-versus-Host Disease (GVHD) in Hematopoietic Stem Cell Transplant (HSCT) Patients.
Autologous Serum Eye Drops

Chronic Granulomatous Disease Clinical Trial using Phagocyte Oxidase Subunit Transduced CD34 Hematopoietic Stem Cells

National Institutes of Health Clinical Center (CC) - Recruiting 3 years to 55 years.
- Autologous Transplantation of Genetically Modified Cells for the Treatment of X-Linked Chronic Granulomatous Disease.
Phagocyte Oxidase Subunit Transduced CD34 Hematopoietic Stem Cells

Leukemia, Myeloid, Acute, Leukemia, Lymphoblastic, Acute, or Leuk Clinical Trial using Allogeneic Lymphocytes; Fludarabine; Cyclophosphamide; Methylprednisolone; Cyclosporine

National Institutes of Health Clinical Center (CC) - Recruiting 8 years to 75 years.
- Mismatched Donor Lymphocyte Infusions for Relapsed Disease Following Allogeneic Stem Cell Transplantation.
Allogeneic Lymphocytes; Fludarabine; Cyclophosphamide; Methylprednisolone; Cyclosporine

IFN-Gamma Therapy, CGD Gene Mutation, CGD Response to IFNg, Chron Clinical Trial using IFN-gamma

National Institutes of Health Clinical Center (CC) - Recruiting N/A or older.
- Assessment of the Biochemical Response to Interferon-Gamma in Subjects With Specific Gene Mutation in Chronic Granulomatous Disease.
IFN-gamma

Lung Cancer, Tuberculosis, Bronchiectasis, Pneumonia, Acute Bronc Clinical Trial using Chest X-ray; computed tomography of the chest; Bronchoscopy

University of Milan - Recruiting 18 years or older.
- Multicenter, Prospective, Observational Study on Epidemiology and Diagnosis of Haemoptysis.
Chest X-ray; computed tomography of the chest; Bronchoscopy

Anemia, or Chronic Kidney Disease Clinical Trial using AKB-6548; Placebo

Akebia Therapeutics - Recruiting 18 years to 82 years.
- Phase 2b Randomized, Double-Blind, Placebo-Controlled Study to Assess the Pharmacodynamic Response, Safety, and Tolerability to 20 Weeks of Oral Dosing of AKB-6548 in Subjects With Anemia Secondary to Chronic Kidney Disease (CKD), GFR Categories G3a-G5 (Stages 3, 4, AND 5) (Pre-Dialysis).
AKB-6548; Placebo

Chronic Obstructive Pulmonary Disease Clinical Trial using Levofloxacin 500mg

University of Monastir - Recruiting 18 years or older.
- Evaluation of Two Strategies of Antibiotic Treatment With Levofloxacin in Acute Exacerbation of Chronic Obstructive Pulmonary Disease: Short Treatment-versus Treatment Guided by Markers of Inflammation.
Levofloxacin 500mg

Chronic Obstructive Pulmonary Disease Clinical Trial using High flow therapy

Institut fr Pneumologie Hagen Ambrock eV - Recruiting 20 years to 80 years.
- Respiratory Physiology Measurements Under Transnasal High Flow Therapy in Patients With Tracheostoma After Long Term Ventilation.
High flow therapy

Anemia Clinical Trial

Hoffmann-La Roche - Recruiting 18 years or older.
- An Observational, Prospective Study to Evaluate the Hemoglobin Levels in Non-dialysis Chronic Kidney Disease Subjects With Renal Anaemia, Treated With MIRCERAr (Methoxy-polyethylene-glycol-epoetin Beta) (OPTIMA)..

Kidney Disease, Chronic Clinical Trial

Hoffmann-La Roche - Recruiting 18 years or older.
- A Non Interventional Study to Assess the Hemoglobin Level Depending on the Comorbidity Index in Chronic Kidney Disease (CDK) Patients Not in Dialysis Treated With Mircera.

Anemia, or Renal Insufficiency, Chronic Clinical Trial using BAY85-3934; Darbepoetin alfa

Bayer - Recruiting 18 years or older.
- A Randomized, Parallel Group, Open-label, Multicenter Study to Investigate the Efficacy and Safety of Oral BAY85-3934 and Active Comparator (Darbepoetin Alfa) in the Maintenance Treatment of Anemia in Pre-dialysis Subjects With Chronic Kidney Disease on Darbepoetin Treatment in Europe and Asia Pacific.
BAY85-3934; Darbepoetin alfa

Chronic Obstructive Pulmonary Disease, or COPD Exacerbation Clinical Trial

Cantonal Hosptal, Baselland - Recruiting 40 years or older.
- Swiss Chronic Obstructive Pulmonary Disease (COPD) Management Cohort COPD-Management: Eine Klinisch-epidemiologische Verlaufsbeobachtung in Hausarztpraxen.

GVHD, or Ocular Rosacea Clinical Trial using IPL

Mayo Clinic - Recruiting 18 years or older.
- Intense Pulsed Light (IPL) and Meibomian Gland Expression to Treat Ocular Rosacea Secondary to Inactive Chronic Ocular Graft Versus Host Disease (GVHD).
IPL

Graft vs Host Disease Clinical Trial

University of British Columbia - Recruiting N/A to 18 years.
- Applying Biomarkers to Long-term Effects in Child and Adolescent Cancer Treatment (ABLE Team) - Predictive Biomarkers For Pediatric Chronic Graft-Versus-Host Disease.

Low Back Pain, or Chronic Disease Clinical Trial using Myofascial Soft Tissue Release; Mobilization with impulse technique.

Universidad de Almeria - Recruiting 18 years to 60 years.
- Effects of Myofascial Soft Tissue Release and Mobilization With Impulse Technique Torsion in Subjects With Chronic Non-specific Low Back Pain: A Randomized Clinical Trial.
Myofascial Soft Tissue Release; Mobilization with impulse technique.

Pulmonary Disease, Chronic Obstructive Clinical Trial using fluticasone propionate/salmeterol 50/250mcg; fluticasone propionate/salmeterol placebo; tiotropium bromide 18mcg; tiotropium bromide placebo; fluticasone propionate/salmeterol 50/250mcg and tiotropium 18mcg

GlaxoSmithKline - Recruiting 40 years to 80 years.
- Evaluating the Control of COPD Symptoms in Patients Treated With Tiotropium Bromide 18mcg Once Daily Alone, ADOAIR 50/250mcg Twice Daily Alone or ADOAIR 50/250mcg Plus Tiotropium Bromide 18mcg.
fluticasone propionate/salmeterol 50/250mcg; fluticasone propionate/salmeterol placebo; tiotropium bromide 18mcg; tiotropium bromide placebo; fluticasone propionate/salmeterol 50/250mcg and tiotropium 18mcg

Chronic Obstructive Pulmonary Disease Clinical Trial using JNJ 49095397; Placebo

Janssen Research & Development, LLC - Recruiting 40 years to 80 years.
- A Phase 2, Randomized, Double-blind, Placebo-controlled, Efficacy and Safety Study of Inhaled JNJ 49095397 (RV568) in Subjects With Moderate to Severe Chronic Obstructive Pulmonary Disease.
JNJ 49095397; Placebo

Anaemia Clinical Trial using GSK1278863; Placebo; rhEPO

GlaxoSmithKline - Recruiting 18 years or older.
- A Phase IIB, Randomized, Blinded, Dose-ranging, Active-controlled, Parallel-group, Multi-center Study to Evaluate the Dose Response Relationship of GSK1278863 Over the First 4 Weeks of Treatment and Evaluate the Safety and Efficacy of GSK1278863 Over 24 Weeks in Hemodialysis-Dependent Subjects With Anemia Associated With Chronic Kidney Disease Who Switch From Recombinant Human Erythropoietin.
GSK1278863; Placebo; rhEPO

Chronic Kidney Disease, Chronic Kidney Insufficiency, Chronic Ren Clinical Trial using Facilitated Clinical Decision Support; Clinical Decision Support Only

American Academy of Family Physicians - Recruiting 18 years or older.
- Improving Evidence-Based Primary Care for Chronic Kidney Disease.
Facilitated Clinical Decision Support; Clinical Decision Support Only

Pulmonary Disease, Chronic Obstructive Clinical Trial using Spirometry

GlaxoSmithKline - Recruiting 40 years or older.
- Assessment of Comorbidities in Chronic Obstructive Pulmonary Disease (COPD) in European Symptomatic Subjects From Primary Care.
Spirometry

Pulmonary Disease, Chronic Obstructive Clinical Trial using FF/VI; Existing Maintenance Therapy

GlaxoSmithKline - Recruiting 40 years or older.
- A 12-month, Open Label, Randomised, Effectiveness Study to Evaluate Fluticasone Furoate (FF, GW685698)/Vilanterol (VI, GW642444) Inhalation Powder Delivered Once Daily Via a Novel Dry Powder Inhaler (NDPI) Compared With the Existing COPD Maintenance Therapy Alone in Subjects With Chronic Obstructive Pulmonary Disease (COPD).
FF/VI; Existing Maintenance Therapy

Anaemia Clinical Trial using GSK1278863; Placebo

GlaxoSmithKline - Recruiting 20 years or older.
- A 4-Week, Phase II, Randomized, Double-Blind, Dose-Ranging, Placebo-Controlled, Parallel-Group, Multi-Center Study to Evaluate the Safety, Efficacy and Pharmacokinetics of GSK1278863 in Japanese Hemodialysis-Dependent Subjects With Anemia Associated With Chronic Kidney Disease.
GSK1278863; Placebo

Pulmonary Disease, Chronic Obstructive Clinical Trial using fluticasone furoate/vilanterol; fluticasone furoate; vilanterol; Placebo

GlaxoSmithKline - Recruiting 40 years to 80 years.
- A Clinical Outcomes Study to Compare the Effect of Fluticasone Furoate/Vilanterol Inhalation Powder 100/25mcg With Placebo on Survival in Subjects With Moderate Chronic Obstructive Pulmonary Disease (COPD) and a History of or at Increased Risk for Cardiovascular Disease.
fluticasone furoate/vilanterol; fluticasone furoate; vilanterol; Placebo

Pulmonary Disease, Chronic Obstructive Clinical Trial using GSK2256294

GlaxoSmithKline - Recruiting 18 years or older.
- A Study to Evaluate the Effect of Age, Food and Gender on Tolerability and Pharmacokinetics of GSK2256294 Following a Single Oral Administration in Healthy Fed and Fasted Elderly Subjects. This Study Will Also Evaluate the Biliary Metabolites in Healthy Young Males Following a Single Dose of GSK2256294.
GSK2256294

Type 2 Diabetes Mellitus Clinical Trial using Ertugliflozin; Placebo

Merck Sharp & Dohme Corp. - Recruiting 25 years or older.
- A Phase III, Multicenter, Randomized, Double-Blind, Placebo-Controlled Clinical Trial to Evaluate the Efficacy and Safety of Ertugliflozin (MK-8835/PF-04971729) in Subjects With Type 2 Diabetes Mellitus With Stage 3 Chronic Kidney Disease Who Have Inadequate Glycemic Control on Background Antihyperglycemic Therapy.
Ertugliflozin; Placebo

Hepatitis C, Liver Disease Clinical Trial using DEB025 200mg; DEB025 300mg; DEB025 400mg

Novartis - Recruiting 18 years or older.
- A Multicenter, Open-label, Randomized, 3-arm, Phase II Profiling Trial of Pharmacokinetics, Pharmacodynamics and Safety of DEB025/Alisporivir in Combination With Ribavirin Therapy in Chronic Hepatitis C Genotype 2 and 3 Treatment na‹ve Patients.
DEB025 200mg; DEB025 300mg; DEB025 400mg

Chronic Obstructive Pulmonary Disease Clinical Trial using Quercetin

University of Michigan - Recruiting 40 years to 80 years.
- Phase I/II Study to Determine the Safety and Efficacy of Quercetin in COPD Patients.
Quercetin

Chronic Liver Disease Clinical Trial

Association HGE CHU Bordeaux Sud - Recruiting 18 years or older.
- Prognosis Value of Non-invasive Methods for the Diagnosis of Chronic Liver Disease. a Retrospective and Prospective 20-year Follow-up..

Chronic Disease Clinical Trial using PREPARE Intervention

University of California, San Francisco - Recruiting 55 years or older.
- Improving Advance Care Planning by Preparing Diverse Seniors for Decision Making.
PREPARE Intervention

Chronic HCV Infection Clinical Trial using LDV/SOF; RBV

Gilead Sciences - Recruiting 18 years or older.
- A Phase 2, Multicenter, Open-Label Study to Investigate the Safety and Efficacy of Sofosbuvir/Ledipasvir Fixed-Dose Combination + Ribavirin Administered in Subjects Infected With Chronic HCV Who Have Advanced Liver Disease or Are Post-Liver Transplant.
LDV/SOF; RBV

Chronic Myeloid Leukemia (CML), Acute Myelogenous Leukemia (AML); Clinical Trial using CliniMACS CD34+ Reagent System; Thiotepa; Cyclophosphamide; Alemtuzumab; Tacrolimus; Melphalan; Busulfan; Fludarabine

Columbia University - Recruiting N/A to 22 years.
- CD34+ Stem Cell Selection for Patients Receiving a Matched or Partially Matched Family or Unrelated Adult Donor Allogeneic Stem Cell Transplant for Malignant Disease.
CliniMACS CD34+ Reagent System; Thiotepa; Cyclophosphamide; Alemtuzumab; Tacrolimus; Melphalan; Busulfan; Fludarabine

Chronic Kidney Disease, Acute Myeloid Leukemia (AML), Acute Lymph Clinical Trial using Haploidentical Bone Marrow/Kidney

Massachusetts General Hospital - Recruiting 18 years to 70 years.
- Combined Haploidentical Reduced Intensity Bone Marrow and Kidney Transplantation for Patients With Chronic Kidney Disease and Advanced Hematological Disorders.
Haploidentical Bone Marrow/Kidney

Pulmonary Hypertension, or Chronic Obstructive Pulmonary Disease Clinical Trial using Inhaled NO; Placebo

INO Therapeutics - Recruiting 40 years to 80 years.
- A Placebo-Controlled, Double-Blind, Parallel, Randomized, Two-Part, Clinical Dose-Confirming Study Of Pulsed, Inhaled Nitric Oxide (iNO) In Subjects With World Health Organization (WHO) Group 3 Pulmonary Hypertension (PH) Associated With Chronic Obstructive Pulmonary Disease (COPD) On Long Term Oxygen Therapy (LTOT) INHALE 1.
Inhaled NO; Placebo

Chronic Obstructive Pulmonary Disease (COPD) Clinical Trial using AZD4721; Placebo; AZD5069

AstraZeneca - Recruiting 18 years to 50 years.
- A Phase I Study in Healthy Volunteers to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of AZD4721 After Once Daily Administration of Multiple Ascending Doses for 10 Days, and an Open-label Comparison With the Pharmacodynamics of AZD5069 Given Twice Daily for 3 Days.
AZD4721; Placebo; AZD5069

Hyperphosphataemia in Chronic Kidney Disease Clinical Trial using Lanthanum carbonate; Calcium carbonate

Shire Development LLC - Recruiting 6 Months to 17 years.
- A 3-part Open-label Study to Assess the Pharmacokinetics of Lanthanum Carbonate, Compare the Efficacy, Safety and Tolerability of 8 Weeks of Treatment With Lanthanum Carbonate and Calcium Carbonate Using a Crossover Design and Investigate the Efficacy and Safety of 12 Months of Treatment With Lanthanum Carbonate in Hyperphosphataemic Children and Adolescents Aged 6 Months to <18 Years With Chronic Kidney Disease on Dialysis.
Lanthanum carbonate; Calcium carbonate

Coronary Artery Disease Clinical Trial

University of Texas Southwestern Medical Center - Recruiting N/A or older.
- Multicenter Registry of Chronic Total Occlusion Interventions.

Atrial Fibrillation, Hypertension, Diabetes, Chronic Heart Failur Clinical Trial using Medtronic Reveal XT implantable loop recorder

Medical University of Graz - Recruiting 18 years or older.
- Randomized Controlled Trial to Evaluate Implanted Event Recorders for the First Diagnosis of Atrial Fibrillation in High-risk Patients.
Medtronic Reveal XT implantable loop recorder

Asthma,, or Pulmonary Disease, Chronic Obstructive Clinical Trial using Medical tests

Janssen Research & Development, LLC - Recruiting 18 years to 70 years.
- A Multicenter Longitudinal Study for Disease Profiling of Asthma and Chronic Obstructive Pulmonary Disease.
Medical tests

Hemodialysis, or Hyperphosphatemia Clinical Trial using Lanthanum Carbonate; Calcium Carbonate

Translational Research Informatics Center, Kobe, Hyogo, Japan - Recruiting N/A or older.
- Outcome Study of Lanthanum Carbonate Compared With Calcium Carbonate on Cardiovascular Mortality and Morbidity in Patients With Chronic Kidney Disease on Hemodialysis (CKD5D).
Lanthanum Carbonate; Calcium Carbonate

Pulmonary Disease, Chronic Obstructive Clinical Trial using Fatiguing exercise

Laval University - Recruiting 50 years to 75 years.
- Muscle Oxygenation and Metabolism in Response to a Localized Fatigue-inducing Exercise in Patients With Chronic Obstructive Pulmonary Disease.
Fatiguing exercise

Chronic Obstructive Pulmonary Disease, or Metabolic Syndrome Clinical Trial using Roflumilast; Placebo

Laval University - Recruiting 40 years to 80 years.
- Impact of Roflumilast on Visceral Adiposity and MetaBolic Profile in Chronic Obstructive Lung Disease: a Randomized and Controlled Trial: the RAMBO Trial..
Roflumilast; Placebo

Chronic Obstructive Pulmonary Disease Clinical Trial

University of British Columbia - Recruiting 19 years to 95 years.
- Clinical Implementation and Outcomes Evaluation of Blood-Based Biomarkers for Chronic Obstructive Pulmonary Disease Management.

Pulmonary Disease, Chronic Obstructive Clinical Trial using Self-Management and Motivational Interviewing

Mayo Clinic - Recruiting 40 years or older.
- Multicomponent Intervention to Decrease COPD-related Hospitalizations.
Self-Management and Motivational Interviewing

HIV, COPD, Chronic Obstructive Pulmonary Disease, or Smoking Clinical Trial using Examination of the interaction of HIV directly on the small airway epithelium

Weill Medical College of Cornell University - Recruiting 18 years or older.
- HIV-related Accelerated Aging of the Airway Epithelium.
Examination of the interaction of HIV directly on the small airway epithelium

Chronic Kidney Disease Clinical Trial using Storage of kidney in refrigerated solution; Kidney perfused by pulsatile machine

Mario Negri Institute for Pharmacological Research - Recruiting 50 years or older.
- A PROSPECTIVE STUDY TO COMPARE EARLY GRAFT FUNCTION OF RECIPIENTS OF SINGLE OR DUAL KIDNEY ORGANS STORED IN ICE COLD SOLUTION OR PULSED PERFUSION.
Storage of kidney in refrigerated solution; Kidney perfused by pulsatile machine

COPD, Exercise, or Resistance Training Clinical Trial using Resistance training; Endurance training

Rigshospitalet, Denmark - Recruiting 40 years to 80 years.
- The Effects of Physical Exercise Training on in Patients With Chronic Obstructive Pulmonary Disease.
Resistance training; Endurance training

CORONARY ARTERY DISEASE Clinical Trial using caffeine; not caffeine

University of Roma La Sapienza - Recruiting 18 years to 80 years.
- 'Potential Effect of Acute and Chronic Caffeine Administration on Platelet Reactivity in Patient With Coronary Artery Disease on Dual Antiplatelet Therapy'.
caffeine; not caffeine

Chronic Beryllium Disease Clinical Trial using Mesalamine; Placebo

National Jewish Health - Recruiting 18 years to 80 years.
- Targeting Oxidative Stress in Chronic Beryllium Disease.
Mesalamine; Placebo

Anemia Clinical Trial using methoxy polyethylene glycol-epoetin beta [Mircera]

Hoffmann-La Roche - Recruiting 5 years to 17 years.
- An Open Label Multi-center, Multiple Dose Study to Determine the Optimum Starting Dose of Intravenous MIRCERA for Maintenance Treatment of Anemia in Pediatric Patients With Chronic Kidney Disease on Dialysis..
methoxy polyethylene glycol-epoetin beta [Mircera]

Acute Myelogenous Leukemia (AML) in 1st or Subsequent Remission, Clinical Trial using POL6326; Leukapheresis; PBSC Transplant

Polyphor Ltd. - Recruiting 18 years to 75 years.
- A Phase I/II Study Evaluating the Safety and Efficacy of Intravenous POL6326 for the Mobilization and Transplantation of HLA-Matched Sibling Donor Hematopoietic Stem Cells in Patients With Advanced Hematological Malignancies.
POL6326; Leukapheresis; PBSC Transplant

Radiofrequency Ablation, Liver Abscesses -Staphylococcus Infectio Clinical Trial using RFA - Radiofrequency Ablation; Scans - Liver; Liver; Drawn

National Institutes of Health Clinical Center (CC) - Recruiting 18 years to 75 years.
- Radiofrequency Ablation (RFA) for the Treatment of Liver Abscesses in Patients With Chronic Granulomatous Disease.
RFA - Radiofrequency Ablation; Scans - Liver; Liver; Drawn

Pulmonary Disease, Chronic Obstructive Clinical Trial using Telemedicine

Aalborg University - Recruiting N/A or older.
- Effectiveness and Cost-effectiveness of Telemedicine for Chronic Obstructive Pulmonary Disease: The Danish 'TeleCare North' Pragmatic Cluster-randomized Trial..
Telemedicine

Chronic Kidney Disease, or Type 2 Diabetes Mellitus Clinical Trial using AZD1722; Placebo

Ardelyx - Recruiting 18 years to 80 years.
- An Exploratory Phase 2, Randomized, Double-blind, Placebo-controlled, Parallel Design Study to Evaluate the Safety, Tolerability, and Pharmacodynamics of AZD1722 in CKD Patients With Type 2 Diabetes Mellitus and Albuminuria.
AZD1722; Placebo

Anemia, or Chronic Kidney Disease Clinical Trial using Darbepoetin alfa

Amgen - Recruiting N/A to 1 year.
- An Open-label, Single-dose Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Darbepoetin Alfa in Paediatric Subjects From Birth to Less Than 1 Year of Age With Anemia Due to Chronic Kidney Disease.
Darbepoetin alfa

Pulmonary Disease, Chronic Obstructive Clinical Trial using Fluticasone Furoate/Vilanterol; Vilanterol; Placebo

GlaxoSmithKline - Recruiting 40 years or older.
- A 24-week Study to Evaluate the Effect of Fluticasone Furoate/Vilanterol 100/25 Mcg Inhalation Powder Delivered Once-daily Via a Novel Dry Powder Inhaler on Arterial Stiffness Compared With Placebo and Vilanterol in Subjects With Chronic Obstructive Pulmonary Disease (COPD)..
Fluticasone Furoate/Vilanterol; Vilanterol; Placebo

Anemia, or Renal Insufficiency, Chronic Clinical Trial using BAY85-3934; Epoetin alfa/beta

Bayer - Recruiting 18 years or older.
- A Randomized, Parallel Group, Open-label, Multicenter Study to Investigate the Efficacy and Safety of Oral BAY85-3934 and Active Comparator (Epoetin Alfa / Beta) in the Maintenance Treatment of Subjects With Anemia Associated With Chronic Kidney Disease Who Are on Dialysis and on Treatment With an Erythropoiesis-stimulating Agent in the United States and Japan.
BAY85-3934; Epoetin alfa/beta

Chronic HCV Infection Clinical Trial using SOF/LDV FDC; RBV

Gilead Sciences - Recruiting 18 years or older.
- A Phase 2, Multicenter, Open-Label Study to Investigate the Safety and Efficacy of Sofosbuvir/Ledipasvir Fixed-Dose Combination + Ribavirin Administered in Subjects Infected With Chronic HCV Who Have Advanced Liver Disease or Are Post-Liver Transplant.
SOF/LDV FDC; RBV

Invasive Pulmonary Aspergillosis, or Chronic Obstructive Pulmonar Clinical Trial using caspofungin

The First Affiliated Hospital of Guangzhou Medical University - Recruiting 18 years or older.
- Prospective, Open-label Study of the Efficacy and Safety of Caspofungin for the Treatment of Invasive Pulmonary Aspergillosis Underlying Chronic Obstructive Pulmonary Disease.
caspofungin

Chronic Graft Versus Host Disease Clinical Trial using Ofatumumab

H. Lee Moffitt Cancer Center and Research Institute - Recruiting 18 years or older.
- Ofatumumab in Combination With Glucocorticoids for Primary Therapy of Chronic Graft Versus Host Disease.
Ofatumumab

GVHD (Acute or Chronic), Acute Myeloid or Lymphoblastic Leukemia Clinical Trial using milatuzumab

Immunomedics, Inc. - Recruiting 18 years or older.
- A Phase I Study of Milatuzumab (hLL1) for Prevention of Acute Graft Versus Host Disease Following Reduced-Intensity Conditioning Allogeneic Stem Cell Transplant in Patients With Hematologic Malignancies.
milatuzumab

Pulmonary Disease, Chronic Obstructive Clinical Trial using tiotropium bromide; Placebo

Boehringer Ingelheim Pharmaceuticals - Recruiting 40 years or older.
- A Randomized, Placebo-controlled, Double-blind, Parallel Group, Multi Center Study to Assess the Safety and Efficacy of Tiotropium Bromide (18 æg) Delivered Via the HandiHalerr in Chronic Obstructive Pulmonary Disease (COPD) Subjects Recovering From Hospitalization for an Acute Exacerbation (Hospital Discharge Study 1).
tiotropium bromide; Placebo

Chronic Disease Clinical Trial using Grp 1 Low Cognition, Low Activation; Grp 2 Low Cognition, High Activation; Grp 3 Normal Cognition, Low Activation; Grp 4 Normal Cognition, High Activation

University of Nebraska - Recruiting 19 years or older.
- Home Based Care Transitions Tailored by Cognition and Patient Activation: A Prudent Use of Transitional Care Resources.
Grp 1 Low Cognition, Low Activation; Grp 2 Low Cognition, High Activation; Grp 3 Normal Cognition, Low Activation; Grp 4 Normal Cognition, High Activation

Pulmonary Disease, Chronic Obstructive Clinical Trial using self-monitoring for patients with severe COPD; nurse-monitoring for patients with severe COPD

Regione Veneto - Recruiting 18 years or older.
- RENEWING HEALTH - Large Scale Pilot in Veneto Region: Life-long Monitoring in COPD.
self-monitoring for patients with severe COPD; nurse-monitoring for patients with severe COPD

Anemia, Kidney Disease, Chronic Clinical Trial using methoxy polyethylene glycol-epoetin beta [Mircera]

Hoffmann-La Roche - Recruiting 18 years or older.
- Comparative Study to Assess the Effect of the Altitude on Dose Requirements of Methoxy Polyethylene Glycol-epoetin Beta to Correct Haemoglobin Levels in Chronic Renal Anemia in Pre-dialysis and Dialysis Patients.
methoxy polyethylene glycol-epoetin beta [Mircera]

Anemia Clinical Trial

Hoffmann-La Roche - Recruiting 18 years or older.
- Non-interventional Study on the Use of Mircera in the Treatment of Chronic Renal Anemia in Patients With Chronic Kidney Disease Stages III-IV Not on Dialysis and in Patients on Stage V on Hemodialysis.

Heart Failure Clinical Trial using BAY94-8862; Placebo; Inspra (eplerenone)

Bayer - Recruiting 18 years or older.
- A Randomized, Double-blind, Double-dummy, Multi-center Study to Assess Safety and Efficacy of Different Oral Doses of BAY94-8862 in Subjects With Emergency Presentation at the Hospital Because of Worsening Chronic Heart Failure With Left Ventricular Systolic Dysfunction and Either Type 2 Diabetes Mellitus With or Without Chronic Kidney Disease or Chronic Kidney Disease Alone Versus Eplerenone.
BAY94-8862; Placebo; Inspra (eplerenone)

Chronic Obstructive Pulmonary Disease Clinical Trial

AstraZeneca - Recruiting N/A or older.
- Oxis 9mcg Turbuhaler Clinical Experience Investigation.

Anemia Clinical Trial using methoxy polyethylene glycol-epoetin beta [Mircera]; ESAs (darbepoetin alfa, epoetin alfa or epoetin beta)

Hoffmann-La Roche - Recruiting 18 years or older.
- A Randomized, Open Label Study to Assess All-cause Mortality and Cardiovascular Morbidity in Patients With Chronic Kidney Disease on Dialysis and Those Not on Renal Replacement Therapy Under Treatment With Mircera or Reference ESAs..
methoxy polyethylene glycol-epoetin beta [Mircera]; ESAs (darbepoetin alfa, epoetin alfa or epoetin beta)

Chronic Obstructive Pulmonary Disease Clinical Trial

AstraZeneca - Recruiting N/A or older.
- Symbicort Turbuhaler 30/60 Special Clinical Experience Investigation for Long-term Use for COPD Patients.

Thrombocytopenia Associated With Liver Disease Clinical Trial using avatrombopag (lower baseline platelet count); placebo (lower baseline platlet count); avatrombopag (higher baseline platelet count); placebo (higher baseline platelet count)

Eisai Inc. - Recruiting 18 years or older.
- A Randomized, Global, Double-blind, Placebo-controlled, Parallel-group Study to Evaluate the Efficacy and Safety of Once-daily Oral Avatrombopag for the Treatment of Adults With Thrombocytopenia Associated With Liver Disease Prior to an Elective Procedure.
avatrombopag (lower baseline platelet count); placebo (lower baseline platlet count); avatrombopag (higher baseline platelet count); placebo (higher baseline platelet count)

Hyperphosphatemia, or Kidney Disease Clinical Trial using Fosrenol (Lanthanum Carbonate, BAY77-1931)

Bayer - Recruiting N/A or older.
- Drug Use Investigation of Fosrenol for Hyperphosphatemia With Chronic Kidney Disease Not on Dialysis.
Fosrenol (Lanthanum Carbonate, BAY77-1931)

Chronic Kidney Disease Clinical Trial using aerobic and resistance training; aerobic combined with balance training

Region Skane - Recruiting 18 years or older.
- Long-term Effects of Basic Aerobic Training Combined With Either Resistance - or Balance Training in CKD Patients - a Comparative Study.
aerobic and resistance training; aerobic combined with balance training

Chronic Renal Insufficiency, or Diabetes Mellitus Clinical Trial using Sodium bicarbonate; Placebo

Department of Veterans Affairs - Recruiting 18 years or older.
- Investigations of the Optimum Serum Bicarbonate Level in Renal Disease.
Sodium bicarbonate; Placebo

Chronic Graft Versus Host Disease, Chronic GVHD, or Complications Clinical Trial using Treg-enriched infusion; Interleukin-2

Dana-Farber Cancer Institute - Recruiting 18 years or older.
- A Phase I Trial of Regulatory T-cells Plus Low-Dose Interleukin-2 for Steroid-Refractory Chronic Graft-versus-Host-Disease.
Treg-enriched infusion; Interleukin-2

Chronic Kidney Disease Clinical Trial

University of California, San Francisco - Recruiting 18 years to 90 years.
- Endothelial Function and Arterio-Venous Fistula Maturation.

CHB Patients Without Significant Alcohol Consumption or Other Kno Clinical Trial

Seoul National University Boramae Hospital - Recruiting 20 years to 80 years.
- Association Between Insulin Resistance and Hepatic Fibrosis in Combined Chronic Hepatitis B and Non-alcoholic Fatty Liver Disease.

Chronic Obstructive Pulmonary Disease (COPD) Clinical Trial using QVA149; Tiotropium; placebo

Novartis - Recruiting 40 years or older.
- A Placebo and Active Controlled Study to Assess the Long-term Safety of Once Daily QVA149 for 52 Weeks in Chronic Obstructive Pulmonary Disease (COPD) Patients With Moderate to Severe Airflow Limitation.
QVA149; Tiotropium; placebo

Chronic Liver Disease, Hazardous Alcohol Use, Type 2 Diabetes, or Clinical Trial using Fibrosis Biomarkers

University of Nottingham - Recruiting 18 years or older.
- The Stratification of Liver Disease in the Community Using Fibrosis Biomarkers.
Fibrosis Biomarkers

Chronic Kidney Disease (CKD) Clinical Trial using CKD Registry; ATSM + Health Coach; Usual care

University of California, San Francisco - Recruiting 18 years or older.
- The Kidney Awareness Registry and Education Study.
CKD Registry; ATSM + Health Coach; Usual care

Immune Disorders, Chronic Granulomatous Disease, Genetic Immunolo Clinical Trial

National Institutes of Health Clinical Center (CC) - Recruiting N/A or older.
- Screening Protocol for Detection and Characterization of Infections and Infection Susceptibility.

Accelerated Phase Chronic Myelogenous Leukemia, Acute Myeloid Leu Clinical Trial using fludarabine phosphate; cyclosporine; sirolimus; mycophenolate mofetil; allogeneic hematopoietic stem cell transplantation; peripheral blood stem cell transplantation; total-body irradiation

Fred Hutchinson Cancer Research Center - Recruiting N/A or older.
- A Randomized Phase III Study to Determine the Most Promising Postgrafting Immunosuppression for Prevention of Acute GVHD After Unrelated Donor Hematopoietic Cell Transplantation Using Nonmyeloablative Conditioning for Patients With Hematologic Malignancies: A Multi-Center Trial.
fludarabine phosphate; cyclosporine; sirolimus; mycophenolate mofetil; allogeneic hematopoietic stem cell transplantation; peripheral blood stem cell transplantation; total-body irradiation

Graft vs Host Disease Clinical Trial

National Institutes of Health Clinical Center (CC) - Recruiting 1 year to 75 years.
- Natural History Study of Clinical and Biological Factors Determining Outcomes in Chronic Graft-Versus-Host Disease.

Graft vs Host Disease, or Graft-Versus-Host Disease Clinical Trial using Pomalidomide

National Institutes of Health Clinical Center (CC) - Recruiting 18 years to 75 years.
- A Randomized Phase 2 Single-Center Study of Pomalidomide for Chronic GvHD.
Pomalidomide

Vesicoureteral Reflux, Renal Hypodysplasia, Nonsyndromic, 1, or C Clinical Trial using nitrofurantoin; No prophylaxis; Amoxicillin-Potassium Clavulanate Combination; Trimethoprim/sulfamethoxazole; Cefixime

Azienda Ospedaliera Universitaria di Bologna Policlinico S. Orsola Malpighi - Recruiting 1 Month to 4 Months.
- Antibiotic Prophylaxis and Renal Damage In Congenital Abnormalities of the Kidney and Urinary Tract.
nitrofurantoin; No prophylaxis; Amoxicillin-Potassium Clavulanate Combination; Trimethoprim/sulfamethoxazole; Cefixime

Oral Chronic Graft vs Host Disease Clinical Trial using Clobetasol Oral Rinse; Chronic GVHD organ staging; Assessment of Oral GVHD; Numeric rating scales for oral pain; Oral Global Scale; Painometer (POM) Assessment; Oral Health Impact Profile-OHIP-14; Biopsy of buccal mucosa; Short ACTH stimulation test

National Institutes of Health Clinical Center (CC) - Recruiting 12 years or older.
- A Randomized Double-Blind Pilot Study of Topical Clobetasol 0.05% Oral Rinse for Oral Chronic Graft-Versus-Host-Disease.
Clobetasol Oral Rinse; Chronic GVHD organ staging; Assessment of Oral GVHD; Numeric rating scales for oral pain; Oral Global Scale; Painometer (POM) Assessment; Oral Health Impact Profile-OHIP-14; Biopsy of buccal mucosa; Short ACTH stimulation test

Chronic Hepatitis C Virus, or Non Alcoholic Fatty Liver Disease Clinical Trial using normocaloric low cholesterol diet

University of Roma La Sapienza - Recruiting 40 years to 70 years.
- Prospective Clinical Study on the Role of the Immune Response, in Relation to Diet, in Patients With Either Chronic Hepatitis C Virus (HCV) Infection or Non Alcoholic Fatty Liver Disease (NAFLD). Director Prof. V. Barnaba, Head of Internal Medicine; Principal Investigator, Prof. C. Balsano.
normocaloric low cholesterol diet

Chronic Myelogenous Leukemia, Acute Myelogenous Leukemia, Acute L Clinical Trial

National Institutes of Health Clinical Center (CC) - Recruiting N/A or older.
- Relapsed Hematologic Malignancy After Allogeneic Hematopoietic Stem Cell Transplantation: Screening, Disease Characterization and Natural History.

Recurrent or Tophaceous Gout Clinical Trial using Control; Gout Disease Management Program

Kaiser Permanente - Recruiting 21 years to 80 years.
- Evaluating the Effectiveness of a Chronic Disease Management Program for Gout.
Control; Gout Disease Management Program

Graft vs Host Disease Clinical Trial using Dexamethasone 0.01% Solution

National Institutes of Health Clinical Center (CC) - Recruiting 12 years or older.
- Pilot Study of Topical Dexamethasone 0.01% Solution for Prevention of Oral Chronic Graft Versus Host Disease.
Dexamethasone 0.01% Solution

Chronic Obstructive Pulmonary Disease Clinical Trial using Adipose-Derived Stem Cell (ADSC) Therapy

Ageless Regenerative Institute - Recruiting 18 years to 80 years.
- An Open-label, Non-Randomized, Multi-Center Study to Assess the Safety and Effects of Intra-venous Implantation of Autologous Adipose-Derived Stem Cells in Patients With Chronic Obstructive Pulmonary Disease.
Adipose-Derived Stem Cell (ADSC) Therapy

Chronic Kidney Disease Clinical Trial using The FLEX System will be used to percutaneously create a fistula in CKD patients who require hemodialysis vascular access

TVA Medical Inc. - Recruiting 18 years or older.
- Novel Endovascular Access Trial (NEAT): A Study of the FLEX System for Percutaneous AV Fistula Creation in Hemodialysis Patients.
The FLEX System will be used to percutaneously create a fistula in CKD patients who require hemodialysis vascular access

Chronic Obstructive Pulmonary Disease, or Patients Hospitalized f Clinical Trial using PEP

University Hospital, Brest - Recruiting 18 years or older.
- Frequency of Diagnostic Symptomatic Pulmonary Embolism's in Patients Hospitalized for Clinical Exacerbation of Chronic Obstructive Pulmonary Disease (COPD).
PEP

Chronic Obstructive Pulmonary Disease (COPD) Clinical Trial using NVA237; Long-acting beta 2-agonist (LABA); Placebo

Novartis - Recruiting 40 years or older.
- A Multi-center, Randomized, Double-blind, 52-week Study to Assess the Safety of NVA237 Compared to QAB149 in Patients With Chronic Obstructive Pulmonary Disease (COPD) Who Have Moderate to Severe Airflow Limitation.
NVA237; Long-acting beta 2-agonist (LABA); Placebo

Graft Versus Host Disease, or Systemic Scleroderma Clinical Trial using imatinib mesylate; rituximab; questionnaire administration

Fred Hutchinson Cancer Research Center - Recruiting 2 years or older.
- A Randomized Phase II Study of Imatinib and Rituximab for Cutaneous Sclerosis After Allogeneic Hematopoietic Cell Transplantation.
imatinib mesylate; rituximab; questionnaire administration

End-stage Renal Disease, or Kidney Failure, Chronic Clinical Trial using HAVG graft implantation

Humacyte, Inc. - Recruiting 18 years to 75 years.
- A Pilot Study for Evaluation of the Safety and Efficacy of Humacyte's Human Acellular Vascular Graft for Use as a Vascular Prosthesis for Hemodialysis Access in Patients With End-Stage Renal Disease.
HAVG graft implantation

Chronic Hypoparathyroidism Clinical Trial using None [Natural history registry]

NPS Pharmaceuticals - Recruiting N/A or older.
- PARADIGHM (Physicians Advancing Disease Knowledge in Hypoparathyroidism): A Natural History Registry for Patients With Chronic Hypoparathyroidism.
None [Natural history registry]

Chronic Kidney Failure Clinical Trial using Boost High Protein

Texas A&M University - Recruiting 55 years or older.
- Chronic Kidney Disease in Relation to Alterations in Protein and Amino Acid Metabolism and Function.
Boost High Protein

Chronic Kidney Diseases, or Chronic Kidney Insufficiency Clinical Trial using general management; self-management; peer-assisted management

China Medical University Hospital - Recruiting 20 years to 85 years.
- The Cost Effectiveness and Evaluation of Disease Management of Chronic Kidney Disease and High Risk Population.
general management; self-management; peer-assisted management

Leukemia, or Lymphoma Clinical Trial using valproic acid; western blotting; laboratory biomarker analysis; pharmacological study

National Cancer Institute (NCI) - Recruiting 18 years or older.
- Epigenetic Therapy With Valproic Acid, an HDAC Inhibitor, in Refractory/Relapsed Non-Hodgkin Lymphoma, Hodgkin's Disease and CLL.
valproic acid; western blotting; laboratory biomarker analysis; pharmacological study

Heart Failure, or Coronary Artery Disease Clinical Trial using Rivaroxaban; Placebo; Standard of care for heart failure and coronary artery disease

Janssen Research & Development, LLC - Recruiting 18 years to 95 years.
- A Randomized, Double-blind, Event-driven, Multicenter Study Comparing the Efficacy and Safety of Oral Rivaroxaban With Placebo for Reducing the Risk of Death, Myocardial Infarction or Stroke in Subjects With Chronic Heart Failure and Significant Coronary Artery Disease Following a Hospitalization for Exacerbation of Heart Failure.
Rivaroxaban; Placebo; Standard of care for heart failure and coronary artery disease

Diabetes Mellitus (DM), Congestive Heart Failure (CHF), or Chroni Clinical Trial using Community Paramedicine; Usual Care

St. Michael's Hospital, Toronto - Recruiting 18 years or older.
- The Expanding Paramedicine in the Community (Study).
Community Paramedicine; Usual Care

Chronic Myeloproliferative Disorders, Graft Versus Host Disease, Clinical Trial using filgrastim; allogeneic bone marrow transplantation; peripheral blood stem cell transplantation

National Cancer Institute (NCI) - Recruiting 16 years to 65 years.
- A Randomized Multicentre Study Comparing G-CSF Mobilized Peripheral Blood and G-CSF Stimulated Bone Marrow in Patients Undergoing Matched Sibling Transplantation for Hematologic Malignancies.
filgrastim; allogeneic bone marrow transplantation; peripheral blood stem cell transplantation

Pulmonary Disease, Chronic Obstructive Clinical Trial using CNTO 6785; Placebo

Janssen Research & Development, LLC - Recruiting 40 years to 75 years.
- A Randomized, Placebo Controlled Double-Blind, Multi-Center, Phase II Study to Assess the Efficacy and Safety of CNTO6785 in Patients With Moderate to Severe Chronic Obstructive Pulmonary Disease.
CNTO 6785; Placebo

Metabolic Acidosis, or Chronic Kidney Disease Clinical Trial using Sodium bicarbonate; Control

University of Colorado, Denver - Recruiting 40 years to 70 years.
- Effect of Treatment of Metabolic Acidosis on Vascular Function in Patients With Chronic Kidney Disease: A Pilot Study.
Sodium bicarbonate; Control

Chronic Liver Disease, Non-Alcoholic Fatty Liver Disease, HCV Coi Clinical Trial using Shear Wave sonoelastography

Massachusetts General Hospital - Recruiting 18 years or older.
- Evaluate the Utility of Shear Wave Sonoelastography as a Tool to Measure Liver Fibrosis Grade..
Shear Wave sonoelastography

Chronic Kidney Disease Clinical Trial using Conventional low protein diet; Very low protein diet supplemented with Ketosteril

Anemia Working Group Romania - Recruiting 18 years to 85 years.
- Effect of Very Low Protein Diet Supplemented With Ketoanalogues of the Essential Amino Acids on the Progression of Chronic Kidney Disease.
Conventional low protein diet; Very low protein diet supplemented with Ketosteril

Pulmonary Disease, Chronic Obstructive Clinical Trial using tiotropium bromide; Placebo

Boehringer Ingelheim Pharmaceuticals - Recruiting 40 years or older.
- A Randomized, Placebo-controlled, Double-blind, Parallel Group, Multi Center Study to Assess the Safety and Efficacy of Tiotropium Bromide (18 æg) Delivered Via the HandiHalerr in Chronic Obstructive Pulmonary Disease (COPD) Subjects Recovering From Hospitalization for an Acute Exacerbation (Hospital Discharge Study 2).
tiotropium bromide; Placebo

Remote Patient Monitoring in COPD Patients Clinical Trial using Remote Patient Monitoring; Usual care

Novartis - Recruiting 40 years or older.
- A 52-week Multi-center Randomized Trial to Evaluate Remote Patient Monitoring Using the EXACT Patient-reported Outcome Tool on Reduction of Hospitalizations From Exacerbations in Patients With Chronic Obstructive Pulmonary Disease as Compared to Those Managed by Usual Care.
Remote Patient Monitoring; Usual care

Leukemia Clinical Trial using Ruxolitinib; TKI

M.D. Anderson Cancer Center - Recruiting 18 years or older.
- Phase I-II Study of Ruxolitinib (INCB18424) for Patients With Chronic Myeloid Leukemia (CML) With Minimal Residual Disease While on Therapy With Tyrosine Kinase Inhibitors.
Ruxolitinib; TKI

Pulmonary Disease, Chronic Obstructive Clinical Trial using Aclidinium Bromide / Formoterol Fumarate; Salmeterol / Fluticasone

Almirall, S.A. - Recruiting 40 years or older.
- A Randomised, Double-blind, Double-dummy, Active-controlled Study Evaluating the Efficacy, Safety and Tolerability of Twice-daily Aclidinium Bromide/Formoterol Fumarate Compared With Twice-daily Salmeterol/Fluticasone Propionate for 24 Weeks Treatment in Symptomatic Patients With Chronic Obstructive Pulmonary Disease (COPD).
Aclidinium Bromide / Formoterol Fumarate; Salmeterol / Fluticasone

Chronic Gastrointestinal Graft vs Host Disease Clinical Trial using orBec; Placebo

Soligenix - Recruiting 18 years or older.
- A Phase 2, Randomized, Double-Blind, Placebo-Controlled, Multicenter Study of the Safety and Efficacy of orBecr (Oral Beclomethasone 17,21-Dipropionate) Administered as Monotherapy in the Treatment of Upper Gastrointestinal (GI) Symptoms Caused by GVHD in Patients With Chronic GI GVHD.
orBec; Placebo

COPD Clinical Trial using Peforomist-Placebo; Perforomist, nebulization, COPD

Dey - Recruiting 40 years or older.
- A Randomized, Double-blind, Placebo-controlled Study to Evaluate the Safety of Long-Term Use of Perforomistr (Formoterol Fumarate) Inhalation Solution in Subjects With Chronic Obstructive Pulmonary Disease (COPD).
Peforomist-Placebo; Perforomist, nebulization, COPD

Anemia in Chronic Kidney Disease in Non-dialysis Patients Clinical Trial using FG-4592; Placebo

Astellas Pharma Inc - Recruiting 18 years or older.
- A Phase 3, Randomized, Double-Blind, Placebo Controlled Study of the Efficacy and Safety of FG-4592 for the Treatment of Anemia in Chronic Kidney Disease Patients Not on Dialysis.
FG-4592; Placebo

Angioplasty, Cardiovascular Disease, Chronic Coronary Occlusion, Clinical Trial using XIENCE PRIME Everolimus Eluting Coronary Stent System (EECSS)

Abbott Vascular - Recruiting 18 years or older.
- Evaluate the Continued Safety and Effectiveness of the XIENCE PRIME EECSS in a Cohort of Real-world Patients Receiving the XIENCE PRIME EECSS During Commercial Use..
XIENCE PRIME Everolimus Eluting Coronary Stent System (EECSS)

Chronic Kidney Disease Clinical Trial using Cholecalciferol

Federal University of Sao Paulo - Recruiting 18 years to 80 years.
- Impact of Treatment With Cholecalciferol on Immunological Markers in Patients With Hypovitaminosis D on Dialysis.
Cholecalciferol

Parkinson's Disease Clinical Trial using RM-131; Placebo

Rhythm Pharmaceuticals, Inc. - Recruiting 18 years to 80 years.
- A Phase 2, Randomized, Double-blind, Placebo-controlled, Multiple Dose, Parallel Group Study to Evaluate the Pharmacodynamics, Efficacy and Safety of RM-131 Administered to Patients With Parkinson's Disease and Chronic Constipation Dissatisfied With Current Therapy.
RM-131; Placebo

Hurler Syndrome, Fanconi Anemia, Glanzmann Thrombasthenia, Wiskot Clinical Trial using 4 doses of abatacept; 6 doses of abatacept

Emory University - Recruiting N/A to 21 years.
- Abatacept for Post-Transplant Immune Suppression in Children and Adolescents Receiving Allogeneic Hematopoietic Stem Cell Transplants for Non-Malignant Disease: a Dose Assessment Pilot.
4 doses of abatacept; 6 doses of abatacept

Quality of Life, Chronic Disease, or Chronic Illness Clinical Trial using Med Complex Children Intervention

Seton Family of Hospitals - Recruiting N/A to 17 years.
- Comprehensive Care of Children With Medical Complexity: Piloting an Innovative Model.
Med Complex Children Intervention

Pulmonary Disease, Chronic Obstructive Clinical Trial using Fluticasone Furoate; Vilanterol

GlaxoSmithKline - Recruiting 40 years or older.
- A Randomised, Double-Blind, Placebo-Controlled, Cross-Over, Single-Centre Study to Investigate the Acute Lung Deflation Effects of Fluticasone Furoate/Vilanterol Inhalation Powder 100/25mcg Once Daily on Cardiac Biventricular Function and Arterial Stiffness in Adults With Chronic Obstructive Pulmonary Disease (COPD).
Fluticasone Furoate; Vilanterol

Chronic Obstructive Pulmonary Disease (COPD) Clinical Trial using Implementation educational programme

Medical Universtity of Lodz - Recruiting 18 years or older.
- Tailored Implementation for Chronic Diseases..
Implementation educational programme

Coronary Artery Disease, or Chronic Kidney Disease Clinical Trial

Chang Gung Memorial Hospital - Recruiting 18 years to 85 years.
- Clinical Feature and Outcome of Angiographic Coronary Artery Disease in Chronic Kidney Disease Patients.

Renal Insufficiency, Chronic Clinical Trial

Universitaire Ziekenhuizen Leuven - Recruiting 18 years to 95 years.
- Study on Colonic Fermentation in Chronic Kidney Disease Patients.

Chronic Obstructive Pulmonary Disease Clinical Trial using niv plus oxygen therapy; oxygen therapy

Guangzhou Institute of Respiratory Disease - Recruiting 30 years to 80 years.
- The Efficacy of Non-invasive Mechanical Ventilation as a Rescue Therapy for Relieving Dyspnea in Patients With Stable Severe COPD.
niv plus oxygen therapy; oxygen therapy

Cancer, Congestive Heart Failure (CHF), Chronic Obstructive Pulmo Clinical Trial using Life Completion; Attention Control

Department of Veterans Affairs - Recruiting 18 years or older.
- Outlook: An Intervention to Improve Quality of Life in Serious Illness Study.
Life Completion; Attention Control

Autoimmune Diseases, Sickle Cell Disease, or Chronic Graft Versus Clinical Trial using Acoustic Radiation Force Impulse (ARFI); Laser Doppler Flowmetry (LDF); Laser Doppler Perfusion Imaging (LDI); Optical Coherence Tomography (OCT); Orthogonal Polarization Spectral Imaging (OPSI); Nail fold video capillaroscopy (NVC)

Duke University - Recruiting 18 years or older.
- Mechanistic Study: Non-Invasive Cutaneous Microvascular and Fibrosis Imaging of Patients With Systemic Sclerosis, Sickle Cell Disease and Chronic Graft-Versus-Host Disease (GVHD) Compared to Healthy Subjects.
Acoustic Radiation Force Impulse (ARFI); Laser Doppler Flowmetry (LDF); Laser Doppler Perfusion Imaging (LDI); Optical Coherence Tomography (OCT); Orthogonal Polarization Spectral Imaging (OPSI); Nail fold video capillaroscopy (NVC)

Accelerated Phase Chronic Myelogenous Leukemia, Blastic Phase Chr Clinical Trial using total-body irradiation; thiotepa; fludarabine phosphate; allogeneic hematopoietic stem cell transplantation; T cell-depleted hematopoietic stem cell transplantation; peripheral blood stem cell transplantation; tacrolimus; methotrexate; laboratory biomarker analysis

Fred Hutchinson Cancer Research Center - Recruiting N/A to 21 years.
- A Phase II Study of Selective Depletion of CD45RA+ T Cells From Allogeneic Peripheral Blood Stem Cell Grafts for the Prevention of GVHD in Children.
total-body irradiation; thiotepa; fludarabine phosphate; allogeneic hematopoietic stem cell transplantation; T cell-depleted hematopoietic stem cell transplantation; peripheral blood stem cell transplantation; tacrolimus; methotrexate; laboratory biomarker analysis

GVHD, Adult Acute Myeloid Leukemia, Adult Acute Lymphoid Leukemia Clinical Trial using US-ATG-F; Placebo

Neovii Biotech - Recruiting 18 years to 65 years.
- Phase 3 Study of US-ATG-F to Prevent Moderate to Severe Chronic GVHD in Adult Acute Myeloid Leukemia, Acute Lymphoid Leukemia, and Myelodysplastic Syndrome Patients After Allogeneic Stem Cell Transplantation From Unrelated Donors.
US-ATG-F; Placebo

Cancer, Cardiovascular Disease, Diabetes, or Non Communicable Chr Clinical Trial

Yale University - Recruiting 40 years or older.
- Eastern Caribbean Health Outcomes Research Network (ECHORN).

Non Small Cell Lung Cancer, or Chronic Obstructive Pulmonary Dise Clinical Trial

University of Virginia - Recruiting 18 years or older.
- The Use of Circulating Tumor Cells in Non-Small Cell Lung Cancer: Novel Isolation Methods and Clinical Applications.

Chronic Obstructive Pulmonary Disease Clinical Trial using NVA237; Tiotropium; Placebo to NVA237; Placebo to tiotropium; Salbutamol

Novartis - Recruiting 40 years or older.
- A Randomized, Double-blind, Multicenter, 2-period Single-dose Cross-over Study to Assess the Early Bronchodilation of Glycopyrronium Bromide (44 æg o.d.) Compared to Tiotropium (18 æg. o.d.) in Patients With Moderate to Severe COPD (FAST Study).
NVA237; Tiotropium; Placebo to NVA237; Placebo to tiotropium; Salbutamol

Chronic Obstructive Pulmonary Disease, COPD, or Chronic Bronchiti Clinical Trial using Inhaled HS home treatment

University of North Carolina, Chapel Hill - Recruiting 40 years to 80 years.
- Novel Therapies for Muco-Obstructive Lung Diseases: Sustained Effects of Hypertonic Saline on Mucociliary Clearance and Clinical Tolerability in Subjects With Chronic Bronchitis.
Inhaled HS home treatment

Obesity, Diabetes, Hypertension, or Asthma/COPD With Tobacco Depe Clinical Trial using CHW Goal Support

University of Pennsylvania - Recruiting N/A or older.
- Community Health Worker Support to Help Patients Control Chronic Disease.
CHW Goal Support

COPD Clinical Trial using bambuterol; Placebo

The First Affiliated Hospital of Guangzhou Medical University - Recruiting 40 years to 80 years.
- A 12-week, Double-blind, Multicenter, 3-crossover, Placebo Controlled and Randomized Trial to Investigate the Efficacy and Safety of 10mg and 5mg Bambuterol Tablets Once Daily in Patients With Chronic Obstructive Pulmonary Disease (COPD).
bambuterol; Placebo

Chronic Obstructive Pulmonary Disease Clinical Trial using Fiberoptic bronchoscopy; blood draw; intravenous catheter

Department of Veterans Affairs - Recruiting 18 years to 80 years.
- Apoptotic Cell Ingestion by Normal Human Alveolar Macrophages.
Fiberoptic bronchoscopy; blood draw; intravenous catheter

Lung Cancer, Chronic Obstructive Pulmonary Disease, Emphysema, or Clinical Trial using Lung surgery

Hopital Foch - Recruiting 18 years to 75 years.
- Relationship Between Blood, Hair and Lung Metals/Metalloids Concentration (Cadmium, Iron, Copper, Nickel, Chrome, Arsenic, Vanadium, Beryllium, and Zinc) and Lung Cancer or Chronic Obstructive Pulmonary Disease..
Lung surgery

Low Birth Weight Infant Clinical Trial

University of Utah - Recruiting N/A to 5 Days.
- Platelet-activating Factor Acetylhydrolase (Paf-ah) Gene Expression And The Incidence Of Chronic Lung Disease (Cld) In Very Low Birth Weight Infants.

High Blood Pressure Clinical Trial using Placebo; Nebivolol

University of Chicago - Recruiting 40 years to 75 years.
- Nebivolol in Chronic Obstructive Pulmonary Disease.
Placebo; Nebivolol

Chronic Obstructive Pulmonary Disease, or Lung Cancer Clinical Trial

Katholieke Universiteit Leuven - Recruiting 25 years or older.
- Serum, Plasma, DNA and Tissue Bank of Patients With Chronic Obstructive Pulmonary Disease, Lung Cancer and Smoking Controls..

Stage 5 Chronic Kidney Disease Clinical Trial using Multidisciplinary, intensive and collaborative care

National University, Singapore - Recruiting 21 years or older.
- Impact of a Multidisciplinary Intensive Management Clinic on Clinical, Patient-Reported and Economic Outcomes in Multi-Ethnic Asian Incident Hemodialysis Patients.
Multidisciplinary, intensive and collaborative care

Severe Combined Immunodeficiency (SCID), Immunodeficiency With Pr Clinical Trial using CD3/CD19 negative allogeneic hematopoietic stem cells

University of Pittsburgh - Recruiting 5 years to 40 years.
- Bilateral Orthotopic Lung Transplant in Tandem With CD3+ and CD19+ Cell Depleted Bone Marrow Transplant From Partially HLA-Matched Cadaveric Donors.
CD3/CD19 negative allogeneic hematopoietic stem cells

Lung Transplantation, or Chronic Obstructive Pulmonary Disease Clinical Trial

Katholieke Universiteit Leuven - Recruiting 18 years to 80 years.
- Confocal Laser Micro-endoscopy: New Insights in COPD and Lung Transplant Recipients.

Chronic Kidney Disease, or End-Stage Renal Disease Clinical Trial using Medication Information Transfer Intervention; Usual care for hospital discharge

Providence Medical Research Center - Recruiting 21 years or older.
- Medication Intervention in Transitional Care to Optimize Outcomes & Costs in CKD & ESRD.
Medication Information Transfer Intervention; Usual care for hospital discharge

Chronic Obstructive Pulmonary Disease Clinical Trial

Katholieke Universiteit Leuven - Recruiting 40 years or older.
- Adherence to Medication and Its Impact on COPD Exacerbations: The AMICE Prospective Study.

Chronic Kidney Disease Clinical Trial using GCS-100; Placebo, Saline

La Jolla Pharmaceutical Company - Recruiting 18 years to 80 years.
- A Phase 2a, Placebo-Controlled, Randomized, Single-Blind Study of Weekly Doses of GCS-100 in Patients With Chronic Kidney Disease.
GCS-100; Placebo, Saline

Transfusion-related Acute Lung Injury, Chronic Liver Disease, or Clinical Trial

University of Colorado, Denver - Recruiting 18 years to 85 years.
- Endogenous Heparinoid Interference With Coagulation on Thromboelastogram as a Predictive Biomarker for Transfusion Related Acute Lung Injury (TRALI).

Pulmonary Disease, Chronic Obstructive, or Lung Diseases, Obstruc Clinical Trial using Blood drawing; Bronchoalveolar lavage during indicated bronchoscopy

University of Michigan - Recruiting 40 years or older.
- Innate and Adaptive Immunity in COPD Exacerbations: Clinically-Indicated Bronchoscopies.
Blood drawing; Bronchoalveolar lavage during indicated bronchoscopy

Autoimmune Pancytopenia, Autoimmune Lymphoproliferative Syndrome Clinical Trial using sirolimus

Children's Hospital of Philadelphia - Recruiting 1 year to 30 years.
- Sirolimus for Patients With Chronic and/or Refractory Autoimmune Cytopenias: A Pilot Series.
sirolimus

Chronic Obstructive Pulmonary Disease Clinical Trial using Altitude exposure

University of Zurich - Recruiting 18 years to 75 years.
- Nocturnal Breathing and Sleep in Patients With Chronic Obstructive Pulmonary Disease Staying at Altitude.
Altitude exposure

Chronic Obstructive Pulmonary Disease, or Type 2 Diabetes Clinical Trial using Tool; Self-management Support Program

Maastricht University Medical Center - Recruiting 40 years to 70 years.
- RCT It's LiFe! to Evaluate the Effectiveness of the Monitoring and Feedback Tool and the Corresponding Counseling Protocol (Self-management Support Program) to be Executed by Practice Nurses in Primary Care.
Tool; Self-management Support Program

Chronic Kidney Disease Clinical Trial using Vitamin D2 (ergocalciferol); Vitamin D3 (cholecalciferol)

University of Kansas - Recruiting 18 years or older.
- Differential Effects of Ergocalciferol and Cholecalciferol Therapies in Chronic Kidney Disease.
Vitamin D2 (ergocalciferol); Vitamin D3 (cholecalciferol)

Early Gastric Cancer Clinical Trial using gastrectomy; Endoscopic submucosal dissection

National Cancer Center, Korea - Recruiting 20 years to 80 years.
- Effect of Gastrectomy and Anastomosis on Chronic Metabolic Disease Such as Diabetes and Hypertension in Early Gastric Cancer Patients.
gastrectomy; Endoscopic submucosal dissection

Kidney Failure, Chronic, or End Stage Renal Disease, Requiring Di Clinical Trial using NxStage System One

NxStage Medical - Recruiting 18 years or older.
- Comparison of Nocturnal Hemodialysis (NHD) and Short Daily Hemodialysis (DHD) With the NxStager System OneT.
NxStage System One

Chronic Kidney Disease (CKD), or End-Stage Renal Disease (ESRD) Clinical Trial

Los Angeles Biomedical Research Institute - Recruiting 18 years to 85 years.
- Malnutrition, Diet and Racial Disparities in Chronic Kidney Disease (CKD) - A Prospective Data Collection Study.

Kidney Diseases Clinical Trial using High/ Low Phosphate diet

University of British Columbia - Recruiting 19 years or older.
- Study of Dietary Phosphate and Mineral Homeostasis in Early Chronic Kidney Disease.
High/ Low Phosphate diet

Chronic Obstructive Pulmonary Disease, or Multiple Comorbidity Clinical Trial using 40 minute standardized education session; Individualized action plan; Individualized care plan; Standardized reinforcement/motivational interviewing and action plan teach-back sessions; Tele-home monitoring; Coordinated and improved communication; Priority access; Dictated patient summary; in-hospital rehabilitation/self-management program; Smoking cessation; Action plan Respirologist; Web based self management materials

Toronto East General Hospital - Recruiting 50 years or older.
- Program of Integrated Care for Patients With Chronic Obstructive Pulmonary Disease and Multiple Comorbidities: A Randomized Controlled Trial.
40 minute standardized education session; Individualized action plan; Individualized care plan; Standardized reinforcement/motivational interviewing and action plan teach-back sessions; Tele-home monitoring; Coordinated and improved communication; Priority access; Dictated patient summary; in-hospital rehabilitation/self-management program; Smoking cessation; Action plan Respirologist; Web based self management materials

Anemia Clinical Trial using FG-4592; Placebo

FibroGen - Recruiting 18 years or older.
- A Phase 3, Randomized, Double-Blind, Placebo Controlled Study of the Efficacy and Safety of FG-4592 for the Treatment of Anemia in Chronic Kidney Disease Patients Not on Dialysis.
FG-4592; Placebo

Acute Myelogenous Leukemia, Acute Lymphoid Leukemia, Myeloprolife Clinical Trial using ARM A Cyclophosphamide; ARM B Calcineurin inhibitor and methotrexate

Hospital Israelita Albert Einstein - Recruiting 18 years to 60 years.
- Randomized Study to Compare Post Bone Marrow Transplant Cyclophosphamide With the Combination of Methotrexate Plus Calcineurin Inhibitor for Graft Versus Host Disease Prophylaxis.
ARM A Cyclophosphamide; ARM B Calcineurin inhibitor and methotrexate

Chronic Kidney Disease, or Hemodialysis Clinical Trial

Renal Research Institute - Recruiting 18 years to 88 years.
- Red Blood Cell Lifespan and Inflammation in Dialysis Patients.

COPD Clinical Trial using Lysozyme hydrochloride; Placebo

Eisai Inc. - Recruiting 20 years to 84 years.
- Effects of Lysozyme On Acute Exacerbation of Chronic Obstructive Pulmonary Disease : A Randomised Placebo-Controlled Study.
Lysozyme hydrochloride; Placebo

Chronic Kidney Disease Clinical Trial using Kidney and/or Pancreas biopsy

University of Michigan - Recruiting N/A or older.
- Michigan Nephrology Research BioBank for Molecular Analysis of Renal Disease 'Nephrology Research BioBank'.
Kidney and/or Pancreas biopsy

Chronic Obstructive Pulmonary Disease Clinical Trial

Columbia University - Recruiting 50 years to 75 years.
- Pulmonary Vascular Changes in Early Chronic Obstructive Pulmonary (MESA-COPD).

CHRONIC OBSTRUCTIVE PULMONARY DISEASE, ASTHMA, or HEALTHY SUBJECT Clinical Trial using SALBUTAMOL

Imperial College London - Recruiting 18 years or older.
- Improving Inhaler Treatment and Small Airways Assessment in Chronic Obstructive Pulmonary Disease (COPD).
SALBUTAMOL

Hypertension, Pulmonary, or Pulmonary Disease, Chronic Obstructiv Clinical Trial

Wissenschaftliches Institut Bethanien e.V - Recruiting 18 years or older.
- Chronisch Obstruktive Lungenerkrankung Und Pulmonale Hypertonie: Pr„valenz Und Lebensqualit„t.

Chronic Kidney Disease, Secondary Hyperparathyroidism (SHPT), or Clinical Trial using CTAP101 30 æg capsules; CTAP101 60 æg capsules; CTAP101 30 æg sugar pill capsule; CTAP101 60 æg sugar pill capsules

Cytochroma Inc. - Recruiting 18 years to 85 years.
- A Multi-Center, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate Efficacy and Safety of CTAP101 Capsules to Treat Secondary Hyperparathyroidism in Subjects With Stage 3 or 4 Chronic Kidney Disease and Vitamin D Insufficiency.
CTAP101 30 æg capsules; CTAP101 60 æg capsules; CTAP101 30 æg sugar pill capsule; CTAP101 60 æg sugar pill capsules

Non-diabetic Chronic Kidney Disease, or Atherosclerosis Clinical Trial

Kocaeli Derince Education and Research Hospital - Recruiting 18 years to 75 years.
- The Relationship Between Serum Omentin-1 and IL-6 and Carotid Atherosclerosis In Non-Diabetic Chronic Kidney Disease.

COPD Clinical Trial using Exercise training

Universidade Norte do Paraná - Recruiting 50 years or older.
- Effects of Two Training Protocols in Physical Activity in Daily Life and Balance in Patients With COPD: Land Versus Water.
Exercise training

Heart Disease Clinical Trial using Intramyocardial Cell therapy

Asklepios proresearch - Recruiting 18 years to 80 years.
- Protocol on an Evaluative Study on Bone Marrow Derived Mononuclear Cells for Optimization of Biventricular Pacing in Patients With Chronic Ischemic Left Ventricular Dysfunction.
Intramyocardial Cell therapy

Chronic Obstructive Pulmonary Disease (COPD) Clinical Trial

Cardiff University - Recruiting 35 years to 80 years.
- Assessment of Risk in Chronic Airways Disease Evaluation (ARCADE).

Chronic Obstructive Pulmonary Disease and Allied Conditions Clinical Trial using Roflumilast; Placebo

LudwLudwig Boltzmann Institute for COPD and Respiratory Epidemiology - Recruiting 40 years to 80 years.
- Effects of ROFLUMILAST on Markers of Subclinical Atherosclerosis In Stable COPD; the ELASTIC-trial.
Roflumilast; Placebo

Chronic Obstructive Pulmonary Disease Clinical Trial using AVAPS-AE; AVAPS-AE mode of ventilator therapy

Philips Respironics - Recruiting 18 years or older.
- Engineering Validation of the AVAPS-AE Algorithm in Chronic Obstructive Pulmonary Disease (COPD)Patients.
AVAPS-AE; AVAPS-AE mode of ventilator therapy

Chronic Obstructive Pulmonary Disease Clinical Trial using theophylline; placebo

Hospital Son Espases - Recruiting 45 years to 90 years.
- Multicenter 52 Weeks Double Blind Placebo-controlled Trial for the Assessment of Theophylline on Top of Combination Therapy in Severe COPD.
theophylline; placebo

Chronic Stable Angina, Coronary Artery Disease, Atrial Fibrillati Clinical Trial using ranolazine; placebo

Cardiovascular Consultants of Nevada - Recruiting 35 years or older.
- Safety of Amiodarone and Ranolazine Together in Patients With Stable Angina.
ranolazine; placebo

Osteoporosis, or Obstructive Lung Disease Clinical Trial

University of British Columbia - Recruiting 65 years or older.
- A Prospective Baseline Assessment of the Risk of Osteoporosis in Patients With Chronic Obstructive Lung Disease and Outcomes After 2 Years; a Pilot Study.

Asthma, Cystic Fibrosis, Chronic Lung Disease, or Pneumonia Clinical Trial

Maastricht University Medical Center - Recruiting 6 years to 18 years.
- Optimising and Standardising Measurements of Inflammatory Markers in Exhaled Breath (EB) and Exhaled Breath Condensate (EBC).

Obesity, or Chronic Obstructive Pulmonary Disease Clinical Trial using Ventilator setting changes

Bridgeport Hospital - Recruiting 18 years or older.
- What Ventilator Settings Are Most Comfortable for Patients With COPD or Obesity..
Ventilator setting changes

Chronic Kidney Disease Clinical Trial using AST-120

Seoul National University Hospital - Recruiting 18 years or older.
- K-STAR (Kremezin STudy Against Renal Disease Progression in Korea) Randomized, Open-label, Controlled Study.
AST-120

Old Myocardial Infarction, Chronic Myocardial Ischemia, or Left V Clinical Trial using bone marrow mononuclear cells injection; placebo intramyocardial injection

Chinese PLA General Hospital - Recruiting 18 years to 75 years.
- A Prospective,Randomized, Placebo-Controlled Study of Intramyocardial Injection of Autologous Bone-Marrow Mononuclear Cells in Patients With Severe, Chronic Ischemic Heart Disease Undergoing Coronary Bypass Surgery.
bone marrow mononuclear cells injection; placebo intramyocardial injection

Cardiovascular Disease, Chronic Kidney Disease Patients, Hemodial Clinical Trial

China Medical University Hospital - Recruiting 20 years or older.
- L5 as a Risk Factor of Cardiovascular Disease in Chronic Kidney Disease and Dialysis Patients.

Chronic Disease, Kidney Diseases, or Cardiovascular Diseases Clinical Trial using rosiglitazone

Hospital Authority, Hong Kong - Recruiting 20 years to 75 years.
- Targeting Peroxisome Proliferator-activated Receptor-gamma in Peritoneal Dialysis Patients - Will it Reduce Inflammation, Atherosclerosis, Calcification and Improve Survival of Peritoneal Dialysis Patients?.
rosiglitazone

Chronic Kidney Disease, or Obesity Clinical Trial using laparoscopic sleeve gastrectomy; weight management program

King's College Hospital NHS Trust - Recruiting 18 years or older.
- The Effect of Weight Loss Surgery on Preservation of Kidney Function and Cardiovascular Disease Risk Factors in Obese Patients With Stages 3-4 Chronic Kidney Disease: a Randomised Controlled Trial.
laparoscopic sleeve gastrectomy; weight management program

Chronic Obstructive Pulmonary Disease Clinical Trial

UPECLIN HC FM Botucatu Unesp - Recruiting 40 years to 95 years.
- Three-Years Follow-up of Diagnostic and Prognostic Markers in Chronic Obstructive Pulmonary Disease.

Acute Myeloid Leukemia, or Acute Lymphoblastic Leukemia Clinical Trial using ATG FRESENIUS (Anti-Lymphocyte-Globulin)

Universit„tsklinikum Hamburg-Eppendorf - Recruiting 18 years to 65 years.
- Prophylaxis of Chronic Graft-Versus-Host Disease (cGvHD) With or Without Anti-T-Lymphocyte-Globulin (ATG Fresenius) Prior Allogeneic Peripheral Stem Cell Transplantation From HLA-Identical Siblings After Myeloablative Conditioning in Patients With Acute Leukemia: A Randomized Phase III-Study.
ATG FRESENIUS (Anti-Lymphocyte-Globulin)

Chronic Obstructive Pulmonary Disease, or Asthma Clinical Trial

Bispebjerg Hospital - Recruiting 18 years or older.
- Trefoil Peptides in Lung Diseases.

Emphysema, or Chronic Obstructive Pulmonary Disease Clinical Trial using Bronchoscopic Lung Volume Reduction (BLVR)

LudwLudwig Boltzmann Institute for COPD and Respiratory Epidemiology - Recruiting 40 years to 75 years.
- A Multi-Center, Prospective, Clinical Trial Designed to Study the Efficacy of One-Way Valve Implantation Based on a New Treatment Algorithm in Patients With Heterogeneous Emphysema.
Bronchoscopic Lung Volume Reduction (BLVR)

Chronic Kidney Disease Clinical Trial using Pharmacy care arm

San Francisco Veterans Administration Medical Center - Recruiting 18 years or older.
- Impact of a Pharmacist's Collaborative Management, Adherence,and Medication Education Program (CAMP) in an Ambulatory Renal Clinic.
Pharmacy care arm

Chronic Obstructive Pulmonary Disease, or Acute Respiratory Failu Clinical Trial

University Hospital, Grenoble - Recruiting 18 years or older.
- Predictive Factors of Endothelial Function in Chronic Obstructive Disease Patients at the End of a Acute Exacerbation..

Leukemia Clinical Trial using Immunotoxin therapy; CAT-8015 immunotoxin; Biological therapy

Cambridge Antibody Technology - Recruiting 18 years or older.
- A Phase 1, Multicenter, Dose Escalation Study of CAT-8015 in Patients With Relapse or Refractory Chronic Lymphocytic Leukemia (CLL), Prolymphocytic Leukemia (PLL), or Small Lymphocytic Lymphoma (SLL).
Immunotoxin therapy; CAT-8015 immunotoxin; Biological therapy

Chronic Obstructive Pulmonary Disease Clinical Trial

Imperial College London - Recruiting 38 years to 80 years.
- The Effect of Inhaled Mannitol on Ciliary Beat Frequency in COPD Patients.

Chronic Kidney Disease, or Hypertension Clinical Trial using Procedure: Regional phenylephrine arterial infusion

University of Michigan - Recruiting 18 years to 55 years.
- Alpha-Adrenoceptor Vascular Function In Chronic Kidney Disease Focus On The Role Of Endothelial Nitric Oxide.
Procedure: Regional phenylephrine arterial infusion

Systolic Heart Failure, Myocardial Disease, or Cardiomyopathy Clinical Trial using Verapamil

Medical University of Silesia - Recruiting 18 years to 65 years.
- Prospective, Randomized Comparison of Therapy With Verapamil or Carvedilol on Long-Term Outcomes of Patients With Chronic Heart Failure Secondary to Non-Ischemic Cardiomyopathy.
Verapamil

Hepatitis C, Hepatitis B, Autoimmune Hepatitis, Liver Cirrhosis, Clinical Trial

University Health Network, Toronto - Recruiting 18 years to 85 years.
- Differential Gene Expression in Liver Tissue and Blood From Individuals With Chronic Viral Hepatitis With or Without a Complicating Hepatoma or Autoimmune Liver Disease.

End-Stage Renal Disease Clinical Trial using Cool Dialysate

National Institute of Nursing Research (NINR) - Recruiting 21 years to 75 years.
- The Effects of Hemodialysis on the Sleep/Wake Cycle.
Cool Dialysate

Chronic Obstructive Airway Disease, or Healthy Volunteers Clinical Trial using Up to 100ml blood will be taken by venupuncture.

Imperial College London - Recruiting 21 years to 75 years.
- Regulation of the Release of Inflammatory Mediators From Blood Leukocytes: A Comparison of Healthy Subjects, Healthy Smokers and Patients With COPD..
Up to 100ml blood will be taken by venupuncture.