38 results found.

Chronic Heart Failure Clinical Trial using HeartWarer VAS; Control LVAD

HeartWare, Inc. - Recruiting 18 years or older.
- A Prospective, Randomized, Controlled, Unblinded, Multi-Center Clinical Trial to Evaluate the HeartWarer Ventricular Assist Device System for Destination Therapy of Advanced Heart Failure.
HeartWarer VAS; Control LVAD

Heart Failure Clinical Trial using BAY94-8862; Eplerenone; Placebo

Bayer - Recruiting 18 years or older.
- A Randomized, Double-blind, Double-dummy, Multi-center Study to Assess Safety and Efficacy of BAY94-8862 in Japanese Subjects With Emergency Presentation at the Hospital Because of Worsening Chronic Heart Failure With Left Ventricular Systolic Dysfunction and Either Type 2 Diabetes Mellitus With or Without Chronic Kidney Disease or Moderate Chronic Kidney Disease Alone Versus Eplerenone.
BAY94-8862; Eplerenone; Placebo

Chronic Heart Failure Clinical Trial using Allogeneic Mesenchymal Precursor Cells (MPC); Sham Comparator

Teva Pharmaceutical Industries - Recruiting 18 years to 80 years.
- A Double-blind, Randomized, Sham-procedure-controlled, Parallel-group Efficacy and Safety Study of Allogeneic Mesenchymal Precursor Cells (CEP-41750) in Patients With Chronic Heart Failure Due to Left Ventricular Systolic Dysfunction of Either Ischemic or Nonischemic Etiology.
Allogeneic Mesenchymal Precursor Cells (MPC); Sham Comparator

Chronic Heart Failure Clinical Trial using Enalapril monotherapy; Aliskiren monotherapy; Aliskiren / Enalapril combination therapy

Novartis - Recruiting 18 years or older.
- A Multicenter, Randomized, Double-blind, Parallel Group, Active-controlled Study to Evaluate the Efficacy and Safety of Both Aliskiren Monotherapy and Aliskiren/Enalapril Combination Therapy Compared to Enalapril Monotherapy, on Morbidity and Mortality in Patients With Chronic Heart Failure (NYHA Class II - IV)..
Enalapril monotherapy; Aliskiren monotherapy; Aliskiren / Enalapril combination therapy

Heart Failure Clinical Trial using BAY1021189 (1.25 mg); BAY1021189 (5 mg); Placebo

Bayer - Recruiting 18 years or older.
- A Randomized Parallel-group, Placebo-controlled, Double-blind, Multi-center Dose Finding Phase II Trial Exploring the Pharmacodynamic Effects, Safety and Tolerability, and Pharmacokinetics of Four Dose Regimens of the Oral sGC Stimulator BAY1021189 Over 12 Weeks in Patients With Worsening Heart Failure With Reduced Ejection Fraction (HFrEF).
BAY1021189 (1.25 mg); BAY1021189 (5 mg); Placebo

Heart Failure Clinical Trial using BAY1021189 (1.25 mg); BAY1021189 (5 mg); Placebo

Bayer - Recruiting 18 years or older.
- A Randomized Parallel-group, Placebo-controlled, Double-blind, Multi-center Dose Finding Phase II Trial Exploring the Pharmacodynamic Effects, Safety and Tolerability, and Pharmacokinetics of Four Dose Regimens of the Oral sGC Stimulator BAY1021189 Over 12 Weeks in Patients With Worsening Heart Failure and Preserved Ejection Fraction (HFpEF).
BAY1021189 (1.25 mg); BAY1021189 (5 mg); Placebo

Heart Failure Clinical Trial using Observational study; no intervention.

Erasmus Medical Center - Recruiting 18 years or older.
- Serial Biomarker Measurements and New Echocardiographic Techniques in Chronic Heart Failure Patients Result in Tailored Prediction of Prognosis.
Observational study; no intervention.

Heart Failure Clinical Trial using Eplerenone; Placebo

Pfizer - Recruiting 55 years or older.
- The Effect Of Eplerenone Versus Placebo On Cardiovascular Mortality And Heart Failure Hospitalization In Japanese Subjects With Chronic Heart Failure.
Eplerenone; Placebo

Heart Failure Clinical Trial using Placebo (treatment 1); BAY1067197 (treatment 2)

Bayer - Recruiting 18 years to 75 years.
- A Single Blind, Placebo Controlled Pilot Study to Explore the Safety and Tolerability of a Single Oral Dose of 30 mg BAY1067197 in Patients With Chronic Heart Failure on the Background of Preexisting Beta-blocker Therapy.
Placebo (treatment 1); BAY1067197 (treatment 2)

Atrial Fibrillation, Hypertension, Diabetes, Chronic Heart Failur Clinical Trial using Medtronic Reveal XT implantable loop recorder

Medical University of Graz - Recruiting 18 years or older.
- Randomized Controlled Trial to Evaluate Implanted Event Recorders for the First Diagnosis of Atrial Fibrillation in High-risk Patients.
Medtronic Reveal XT implantable loop recorder

Heart Failure Clinical Trial using BAY1067197 (10 mg); BAY1067197; Placebo (10 mg); Placebo

Bayer - Recruiting 18 years to 75 years.
- A Double Blinded, Placebo Controlled, Study to Investigate the Safety, Tolerability, Pharmacokinetics and Acute Cardiovascular Responses of a 7 Day Oral Treatment With the Partial Adenosine A1 Receptor Agonist BAY1067197 in Patients With Chronic Systolic Heart Failure: the PARSiFAL-pilot Study..
BAY1067197 (10 mg); BAY1067197; Placebo (10 mg); Placebo

Chronic Heart Failure, or Reconditioning to Effort Clinical Trial using initial evaluation; Period of cardiac rehabilitation; final evaluation; Concentric and eccentric exercise sessions

Centre Hospitalier Universitaire Dijon - Recruiting 45 years to 85 years.
- Evaluation of the Effects of Eccentric Muscle Training Versus Conventional Concentric Training in Chronic Heart Failure.
initial evaluation; Period of cardiac rehabilitation; final evaluation; Concentric and eccentric exercise sessions

Heart Failure Clinical Trial using Digoxin; Ivabradine

Kocaeli University - Recruiting 18 years to 75 years.
- Comparing the Effects of Digoxin and Ivabradine on Mortality and Morbidity in Chronic Heart Failure With Reduced Ejection Fraction and Sinus Rhythm.
Digoxin; Ivabradine

Congestive Heart Failure Clinical Trial using Telemonitoring for patients with Congestive Heart Failure

Regione Veneto - Recruiting 65 years or older.
- RENEWING HEALTH - Large Scale Pilot in Veneto Region: Remote Monitoring of Chronic Heart Failure.
Telemonitoring for patients with Congestive Heart Failure

Heart Failure Clinical Trial using BAY94-8862; Placebo; Inspra (eplerenone)

Bayer - Recruiting 18 years or older.
- A Randomized, Double-blind, Double-dummy, Multi-center Study to Assess Safety and Efficacy of Different Oral Doses of BAY94-8862 in Subjects With Emergency Presentation at the Hospital Because of Worsening Chronic Heart Failure With Left Ventricular Systolic Dysfunction and Either Type 2 Diabetes Mellitus With or Without Chronic Kidney Disease or Chronic Kidney Disease Alone Versus Eplerenone.
BAY94-8862; Placebo; Inspra (eplerenone)

Atrial Fibrillation Clinical Trial using 1g of F373280; Placebo

Pierre Fabre Medicament - Recruiting 18 years or older.
- Efficacy and Safety Study of F373280 for Maintenance of Sinus Rhythm After Electrical Cardioversion in Patients With Persistent Atrial Fibrillation and Chronic Heart Failure. International, Multicentric, Randomised, Double-blind, Placebo Controlled Study..
1g of F373280; Placebo

Heart Failure Clinical Trial using Implantation of CRT device; Implantation of conventional VVI(R) pacemaker

Almazov Federal Center of Heart, Blood and Endocrinology - Recruiting 18 years to 75 years.
- Variant of Stimulation in Atrioventricular Node Ablation in Patients With Atrial Fibrillation and Moderate Chronic Heart Failure.
Implantation of CRT device; Implantation of conventional VVI(R) pacemaker

Chronic Heart Failure Clinical Trial using BOOST High Protein

Texas A&M University - Recruiting 45 years or older.
- Metabolic and Functional Changes in Relation to Nutritional Status in Chronic Heart Failure.
BOOST High Protein

Heart Failure, or Coronary Artery Disease Clinical Trial using Rivaroxaban; Placebo; Standard of care for heart failure and coronary artery disease

Janssen Research & Development, LLC - Recruiting 18 years to 95 years.
- A Randomized, Double-blind, Event-driven, Multicenter Study Comparing the Efficacy and Safety of Oral Rivaroxaban With Placebo for Reducing the Risk of Death, Myocardial Infarction or Stroke in Subjects With Chronic Heart Failure and Significant Coronary Artery Disease Following a Hospitalization for Exacerbation of Heart Failure.
Rivaroxaban; Placebo; Standard of care for heart failure and coronary artery disease

Diabetes Mellitus (DM), Congestive Heart Failure (CHF), or Chroni Clinical Trial using Community Paramedicine; Usual Care

St. Michael's Hospital, Toronto - Recruiting 18 years or older.
- The Expanding Paramedicine in the Community (Study).
Community Paramedicine; Usual Care

Heart Failure NYHA Class III, or Heart Failure NYHA Class II Clinical Trial using High-intensity IMT plus walking; Low-intensity IMT plus walking

Texas Woman's University - Recruiting 18 years to 90 years.
- Effects of a Walking Program and Inspiratory Muscle Training on Individuals With Chronic Heart Failure - A Pilot Study.
High-intensity IMT plus walking; Low-intensity IMT plus walking

Heart Failure Clinical Trial using Injection of C3BS-CQR-1; Sham, no injection

Cardio3 BioSciences - Recruiting 18 years to 80 years.
- Efficacy and Safety of Bone Marrow-derived Mesenchymal Cardiopoietic Cells (C3BS-CQR-1) for the Treatment of Chronic Advanced Ischemic Heart Failure..
Injection of C3BS-CQR-1; Sham, no injection

Cancer, Congestive Heart Failure (CHF), Chronic Obstructive Pulmo Clinical Trial using Life Completion; Attention Control

Department of Veterans Affairs - Recruiting 18 years or older.
- Outlook: An Intervention to Improve Quality of Life in Serious Illness Study.
Life Completion; Attention Control

Insulin Resistance, or Chronic Heart Failure Clinical Trial using Metformini hydrochloridum (Siofor 1000 tbl, Berlin); placebo

Institute for Clinical and Experimental Medicine - Recruiting 40 years to 70 years.
- Cardioprotective and Metabolic Effects of Metformin in Patients With Heart Failure and Diabetes.
Metformini hydrochloridum (Siofor 1000 tbl, Berlin); placebo

Chronic Heart Failure Clinical Trial using Remote Patient Management; Usual Care

Charite University, Berlin, Germany - Recruiting 18 years or older.
- Telemedical Interventional Management in Heart Failure II.
Remote Patient Management; Usual Care

Prior Acute Myocardial Infarction, Evidence of Systemic Inflammat Clinical Trial using Cardiopulmonary exercise test; Echocardiogram

Virginia Commonwealth University - Recruiting 18 years or older.
- Substudy of the the CANTOS Trial (Interleukin-1 Blockade With Canakinumab to Improve Exercise Capacity in Patients With Chronic Systolic Heart Failure and Elevated Hs-CRP; CACZ885M2301).
Cardiopulmonary exercise test; Echocardiogram

Heart Failure Clinical Trial using Medium-frequency alternating current; Burst-modulated alternating current; Placebo; Functional electrical stimulation

University of Brasilia - Recruiting 21 years to 80 years.
- Soft-hard Technologies to Assistance and Accessibility in Patients With Chronic Diseases: The Effect of a Five Week Electrical Myostimulation Program..
Medium-frequency alternating current; Burst-modulated alternating current; Placebo; Functional electrical stimulation

Dilated Cardiomyopathy, or Chronic Heart Failure Clinical Trial using Intramyocardial injection; Intracoronary injection

University Medical Centre Ljubljana - Recruiting 18 years to 65 years.
- Intramyocardial Stem Cell Therapy in Patients With Dilated Cardiomyopathy.
Intramyocardial injection; Intracoronary injection

Cardiomyopathy, or Heart Failure Clinical Trial using POMx, pomegranate polyphenol extract; Sugar Pill

University of Michigan - Recruiting 21 years or older.
- The Impact of Pomegranate (Punica Granatum) Polyphenol Extract on Oxidative Stress, Ventricular Remodeling and Endothelial Function in Chronic Cardiomyopathy Complicated by Renal Insufficiency (ImPrOVE): a Pilot Study.
POMx, pomegranate polyphenol extract; Sugar Pill

Heart Failure, or Hyponatremia Clinical Trial using Fluid restriction

Rigshospitalet, Denmark - Recruiting 18 years or older.
- The Significance of the Vasopressin System of the Hemodynamics, Water Balance and Prognosis in Chronic Heart Failure.
Fluid restriction

Chronic Heart Failure Clinical Trial using integrated follow-up; standard care

Jessa Hospital - Recruiting 60 years to 90 years.
- Integration of Follow-up by First and Second Line Practitioners Facilitated by Telemonitoring Versus Stand-alone Telemonitoring in Patients With Severe Heart Failure.
integrated follow-up; standard care

Heart Failure Clinical Trial using autologous CD133pos stem cell application

Asklepios proresearch - Recruiting 18 years to 80 years.
- Pilot Study Comparing the Effect of Intra-coronary Versus Intramyocardial Application of Enriched CD133pos Autologous Bone Marrow Derived Stem Cells for Improving Left Ventricular Function in Chronic Ischemic Cardiomyopathy.
autologous CD133pos stem cell application

Heart Failure, or Vitamin D Deficiency Clinical Trial using CHOLECALCIFEROL; PLACEBO

Azienda Unita' Sanitaria Locale Di Modena - Recruiting 60 years or older.
- Effects of Cholecalciferol Supplementation in Patients With Chronic Heart Failure and LOw vITamind D Levels. A Phase 2 Randomized Double Blind Study.
CHOLECALCIFEROL; PLACEBO

Sleep-disordered Breathing, or Chronic Heart Failure Clinical Trial

LudwLudwig Boltzmann Institute for COPD and Respiratory Epidemiology - Recruiting 18 years to 80 years.
- Prevalence, Incidence and Clinical Characteristics of Sleep Disordered Breathing in Patients With Stable Chronic Heart Failure.

Cardiac and Hemodynamic Response, Blood Flow Distribution and Oxy Clinical Trial using exercise

Chang Gung Memorial Hospital - Recruiting 18 years or older.
- Effects of Aerobic Interval and Continuous Exercise Trainings on Cardiovascular Hemorheological Characteristics and Atherothrombosis/Angiogenesis-related Variables in Patients With Chronic Heart Failure.
exercise

Heart Failure, or Sleep Apnea Clinical Trial

Nanjing Medical University - Recruiting 18 years to 70 years.
- .

Systolic Heart Failure, Myocardial Disease, or Cardiomyopathy Clinical Trial using Verapamil

Medical University of Silesia - Recruiting 18 years to 65 years.
- Prospective, Randomized Comparison of Therapy With Verapamil or Carvedilol on Long-Term Outcomes of Patients With Chronic Heart Failure Secondary to Non-Ischemic Cardiomyopathy.
Verapamil