Heinrich-Heine University, Duesseldorf - Recruiting 18 years or older. - CVP-guided Aquapheresis for the Treatment of Acute Congestion in Heart Failure - A Pilot Study to Optimize Individualized Volume Depletion.
HeartWare, Inc. - Recruiting 18 years or older. - A Prospective, Randomized, Controlled, Unblinded, Multi-Center Clinical Trial to Evaluate the HeartWarer Ventricular Assist Device System for Destination Therapy of Advanced Heart Failure.
City of Hope Medical Center - Recruiting 16 years or older. - Pharmacologic Reversal of Ventricular Remodeling in Childhood Cancer Survivors at Risk for Congestive Heart Failure (PREVENT-CHF): A Phase IIB Randomized Placebo-Controlled Trial.
Aastrom Biosciences - Recruiting 30 years to 86 years. - MULTICENTER, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED, PARALLEL GROUP STUDY TO EVALUATE THE EFFICACY, SAFETY AND TOLERABILITY OF TRANSENDOCARDIAL INJECTION OF IXMYELOCEL-T IN SUBJECTS WITH HEART FAILURE DUE TO ISCHEMIC DILATED CARDIOMYOPATHY (IDCM)..
Central Hospital, Nancy, France - Recruiting 43 years to 72 years. - Role of the Renin Angiotensin Aldosterone System and Remodeling of the Matrix Cardiac Extra Cellular in the Mechanisms of Transition to Heart Failure in Abdominal Obesity: Prospective Longitudinal Study R2C2 II.
Urine sample; Blood sample; Assessment of sleep apnea syndrome; Electrocardiogram; Glucose tolerance test; Echocardiography; cardiac and abdominal magnetic resonance imaging; Ambulatory blood pressure monitoring; Echotracking; Pulse wave velocity; Composition of body mass by Dual x-ray absorptiometry
Bayer - Recruiting 18 years or older. - A Randomized, Double-blind, Double-dummy, Multi-center Study to Assess Safety and Efficacy of BAY94-8862 in Japanese Subjects With Emergency Presentation at the Hospital Because of Worsening Chronic Heart Failure With Left Ventricular Systolic Dysfunction and Either Type 2 Diabetes Mellitus With or Without Chronic Kidney Disease or Moderate Chronic Kidney Disease Alone Versus Eplerenone.
Sulfagenix Australia Pty Ltd. - Recruiting 35 years to 85 years. - A Dose Escalation Study to Assess the Safety and Ability of SG1002 to Overcome Circulating Deficits in Hydrogen Sulfide Found in Heart Failure Patients.
Teva Pharmaceutical Industries - Recruiting 18 years to 80 years. - A Double-blind, Randomized, Sham-procedure-controlled, Parallel-group Efficacy and Safety Study of Allogeneic Mesenchymal Precursor Cells (CEP-41750) in Patients With Chronic Heart Failure Due to Left Ventricular Systolic Dysfunction of Either Ischemic or Nonischemic Etiology.
Novartis - Recruiting 18 years or older. - A Multicenter, Randomized, Double-blind, Parallel Group, Active-controlled Study to Evaluate the Efficacy and Safety of Both Aliskiren Monotherapy and Aliskiren/Enalapril Combination Therapy Compared to Enalapril Monotherapy, on Morbidity and Mortality in Patients With Chronic Heart Failure (NYHA Class II - IV)..
AstraZeneca - Recruiting N/A or older. - A Pharmacoepidemiological Study to Examine Patient Characteristics, Drug Utilization Pattern and Crude Incidence Rates of Selected Outcomes in New Users of Ticagrelor, Clopidogrel and Prasugrel in National Swedish Registries.
Bayer - Recruiting 18 years or older. - A Randomized Parallel-group, Placebo-controlled, Double-blind, Multi-center Dose Finding Phase II Trial Exploring the Pharmacodynamic Effects, Safety and Tolerability, and Pharmacokinetics of Four Dose Regimens of the Oral sGC Stimulator BAY1021189 Over 12 Weeks in Patients With Worsening Heart Failure With Reduced Ejection Fraction (HFrEF).
Bayer - Recruiting 18 years or older. - A Randomized Parallel-group, Placebo-controlled, Double-blind, Multi-center Dose Finding Phase II Trial Exploring the Pharmacodynamic Effects, Safety and Tolerability, and Pharmacokinetics of Four Dose Regimens of the Oral sGC Stimulator BAY1021189 Over 12 Weeks in Patients With Worsening Heart Failure and Preserved Ejection Fraction (HFpEF).
Erasmus Medical Center - Recruiting 18 years or older. - Serial Biomarker Measurements and New Echocardiographic Techniques in Chronic Heart Failure Patients Result in Tailored Prediction of Prognosis.
Bayer - Recruiting 18 years to 75 years. - A Single Blind, Placebo Controlled Pilot Study to Explore the Safety and Tolerability of a Single Oral Dose of 30 mg BAY1067197 in Patients With Chronic Heart Failure on the Background of Preexisting Beta-blocker Therapy.
BioControl Medical - Recruiting 18 years or older. - INcrease Of VAgal TonE in CHF (INOVATE-HF) - A Randomized Study to Establish the Safety and Efficacy of CardioFitr for the Treatment of Subjects With Heart Failure and Left Ventricular Dysfunction.
Bayer - Recruiting 18 years to 75 years. - A Double Blinded, Placebo Controlled, Study to Investigate the Safety, Tolerability, Pharmacokinetics and Acute Cardiovascular Responses of a 7 Day Oral Treatment With the Partial Adenosine A1 Receptor Agonist BAY1067197 in Patients With Chronic Systolic Heart Failure: the PARSiFAL-pilot Study..
Juventas Therapeutics, Inc. - Recruiting 18 years or older. - A Phase I/II Study to Evaluate the Safety and Efficacy of JVS-100 Administered by Retrograde Delivery to Cohorts of Adults With Ischemic Heart Failure.
Placebo; 30 mg dose of JVS-100; 45 mg dose of JVS-100
University of Saskatchewan - Recruiting N/A to 18 years. - Viral Illness in the Pediatric Critical Care Setting: the Incidence, Timing and Severity of Associated Myocardial Dysfunction and Acute Kidney Injury..
Cardiorentis - Recruiting 18 years to 85 years. - Phase III, Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial to Evaluate the Efficacy and Safety of Ularitide (Urodilatin) Intravenous Infusion in Patients Suffering From Acute Decompensated Heart Failure [TRUE-AHF].
Kocaeli University - Recruiting 18 years to 75 years. - Comparing the Effects of Digoxin and Ivabradine on Mortality and Morbidity in Chronic Heart Failure With Reduced Ejection Fraction and Sinus Rhythm.
Trevena Inc. - Recruiting 21 years to 85 years. - A Randomized, Double-Blind, Placebo-Controlled, Dose Ranging Study to Explore the Efficacy of TRV027 in Patients Hospitalized for Acute Decompensated Heart Failure.
Bayer - Recruiting 18 years or older. - A Randomized, Double-blind, Double-dummy, Multi-center Study to Assess Safety and Efficacy of Different Oral Doses of BAY94-8862 in Subjects With Emergency Presentation at the Hospital Because of Worsening Chronic Heart Failure With Left Ventricular Systolic Dysfunction and Either Type 2 Diabetes Mellitus With or Without Chronic Kidney Disease or Chronic Kidney Disease Alone Versus Eplerenone.
Pierre Fabre Medicament - Recruiting 18 years or older. - Efficacy and Safety Study of F373280 for Maintenance of Sinus Rhythm After Electrical Cardioversion in Patients With Persistent Atrial Fibrillation and Chronic Heart Failure. International, Multicentric, Randomised, Double-blind, Placebo Controlled Study..
National University Hospital, Singapore - Recruiting 18 years or older. - Renal Sympathectomy in Heart Failure (the RESPECT-HF Study) - a Study of Renal Denervation for Heart Failure With Preserved Ejection Fraction.
Ikaria Holdings Inc. - Recruiting 18 years or older. - A Placebo Controlled , Multicenter, Randomized, Double Blind Trial to Evaluate the Safety and Effectiveness of IK-5001 for the Prevention of Remodeling of the Ventricle and Congestive Heart Failure After Acute Myocardial Infarction - Preservation I Trial.
Sodium Alginate and Calcium Gluconate; Saline Solution
University of Florida - Recruiting 7 years to 74 years. - Developing a Non-invasive Cardiac Functional Health Status Measurement Device to be Used in a Critical Population of Adults and Children With Heart Failure..
Janssen Research & Development, LLC - Recruiting 18 years to 95 years. - A Randomized, Double-blind, Event-driven, Multicenter Study Comparing the Efficacy and Safety of Oral Rivaroxaban With Placebo for Reducing the Risk of Death, Myocardial Infarction or Stroke in Subjects With Chronic Heart Failure and Significant Coronary Artery Disease Following a Hospitalization for Exacerbation of Heart Failure.
Rivaroxaban; Placebo; Standard of care for heart failure and coronary artery disease
LoneStar Heart, Inc. - Recruiting 18 years to 79 years. - A Randomized, Controlled Study to Evaluate the Safety and Cardiovascular Effects of Algisyl-LVRT as a Method of Left Ventricular Augmentation in Patients With Dilated Cardiomyopathy (AUGMENT-HF).
Cardio3 BioSciences - Recruiting 18 years to 80 years. - Efficacy and Safety of Bone Marrow-derived Mesenchymal Cardiopoietic Cells (C3BS-CQR-1) for the Treatment of Chronic Advanced Ischemic Heart Failure..
Cardiovascular Clinical Science Foundation - Recruiting 18 years or older. - A Phase 3 Randomized, Double-Blind, Placebo Controlled Study of the Short Term Clinical Effects of Tolvaptan in Patients Hospitalized for Worsening Heart Failure With Challenging Volume Management.
University Hospital, Bordeaux - Recruiting 18 years or older. - Randomized Comparison of Endocardial Versus Epicardial - From the Coronary Sinus - Left Ventricular Pacing for Resynchronization in Heart Failure..
Resynchronization using a transeptal approach; Resynchronization using a coronary sinus approach
University of Cincinnati - Recruiting 18 years to 75 years. - Initial Study on the Use of Probenecid as a Positive Inotrope for the Treatment of Systolic Heart Failure in Stable NYHA Class II to IV Patients.
Celladon Corporation - Recruiting 18 years to 80 years. - A Phase 2b, Double-Blind, Placebo-Controlled, Multinational, Multicenter, Randomized Study Evaluating the Safety and Efficacy of Intracoronary Administration of MYDICARr (AAV1/SERCA2a) in Subjects With Heart Failure.
Ageless Regenerative Institute - Recruiting 18 years to 80 years. - An Open-label, Non-Randomized, Multi-Center Study to Assess the Safety and Cardiovascular Effects of Intramyocardial and Intravenous Implantation of Autologous Adipose-Derived Stem Cells in Non-Ischemic Congestive Heart Failure Patients.
Harvesting and Implantation of Adipose-Derived Stem Cells (ASCs)
Virginia Commonwealth University - Recruiting 18 years or older. - Substudy of the the CANTOS Trial (Interleukin-1 Blockade With Canakinumab to Improve Exercise Capacity in Patients With Chronic Systolic Heart Failure and Elevated Hs-CRP; CACZ885M2301).
Region Skane - Recruiting 18 years or older. - Individually Tailored Cardiac Resynchronization Therapy - Combing Myocardial Strain and Cardiac CT to Optimize Left Ventricular Lead Placement in Cardiac Resynchronization Therapy.
Vanderbilt University - Recruiting 18 years or older. - A Comparison of Dilute Unfractionated Heparin and Standard Concentrated Unfractionated Heparin Protocols for Anticoagulation of the Extra-corporeal Circuit During Continuous Renal Replacement Therapy in the ICU.
Dilute unfractionated heparin; Standard concentration unfractionated heparin
University of Sao Paulo General Hospital - Recruiting 18 years to 70 years. - Effects of Low-frequency Electrical Stimulation in Sympathetic Nerve Activity and Peripheral Vasoconstriction in Patients With Advanced HF.
University of Brasilia - Recruiting 21 years to 80 years. - Soft-hard Technologies to Assistance and Accessibility in Patients With Chronic Diseases: The Effect of a Five Week Electrical Myostimulation Program..
Sunshine Heart Inc. - Recruiting 18 years to 75 years. - A Prospective Study to Assess the Safety and Indications of Performance of the C-PulseT System in Relieving Heart Failure Symptoms in Patients With ACC/AHA Stage C, NYHA Class III-ambulatory Class IV Heart Failure..
University Hospital Olomouc - Recruiting 18 years to 80 years. - Long Term Study on the Possible Beneficial Effects of Catheterised Renal Denervation in Patients With Heart Failure and Left Ventricular Systolic Dysfunction Who Are Already on Standard Medical Therapy..
German Heart Institute - Recruiting 18 years to 70 years. - A Controlled, Single-Center Clinical Pilot Study to Evaluate the Performance of CoSeal as a Barrier for Adhesion Prevention in Patients Submitted to Ventricular Assist Device VAD).
University of Michigan - Recruiting 21 years or older. - The Impact of Pomegranate (Punica Granatum) Polyphenol Extract on Oxidative Stress, Ventricular Remodeling and Endothelial Function in Chronic Cardiomyopathy Complicated by Renal Insufficiency (ImPrOVE): a Pilot Study.
Jessa Hospital - Recruiting 60 years to 90 years. - Integration of Follow-up by First and Second Line Practitioners Facilitated by Telemonitoring Versus Stand-alone Telemonitoring in Patients With Severe Heart Failure.
Asklepios proresearch - Recruiting 18 years to 80 years. - Pilot Study Comparing the Effect of Intra-coronary Versus Intramyocardial Application of Enriched CD133pos Autologous Bone Marrow Derived Stem Cells for Improving Left Ventricular Function in Chronic Ischemic Cardiomyopathy.
Azienda Unita' Sanitaria Locale Di Modena - Recruiting 60 years or older. - Effects of Cholecalciferol Supplementation in Patients With Chronic Heart Failure and LOw vITamind D Levels. A Phase 2 Randomized Double Blind Study.
Basque Health Service - Recruiting 18 years or older. - Rationale and Design of a Randomised Controlled Trial Evaluating the Effectiveness of an Exercise Program to Improve the Quality of Life of Patients With Heart Failure in Primary Care: The EFICAR Study Protocol.
Supervised progressive exercise program with an aerobic and a strength component + Optimized treatment; Optimized treatment according to the European Society of Cardiology guidelines
Johns Hopkins University - Recruiting 18 years to 70 years. - Personalized Risk Identification and Management for Arrhythmias and Heart Failure by 12 Lead Electrocardiogram and Cardiac Magnetic Resonance Imaging..
Chang Gung Memorial Hospital - Recruiting 18 years or older. - Effects of Aerobic Interval and Continuous Exercise Trainings on Cardiovascular Hemorheological Characteristics and Atherothrombosis/Angiogenesis-related Variables in Patients With Chronic Heart Failure.
University of Michigan - Recruiting 50 years or older. - Effects of the Dietary Approaches to Stop Hypertension(DASH) Sodium-restricted Diet on Ventriculovascular Function in Heart Failure With Preserved Systolic Function.
Medical University of Silesia - Recruiting 18 years to 65 years. - Prospective, Randomized Comparison of Therapy With Verapamil or Carvedilol on Long-Term Outcomes of Patients With Chronic Heart Failure Secondary to Non-Ischemic Cardiomyopathy.