Sanofi - Recruiting 18 years or older. - A Multicenter, Single Arm, Open Label Clinical Trial to Evaluate the Safety and Health-Related Quality of Life of Aflibercept in Patients With Metastatic Colorectal Cancer (mCRC) Previously Treated With an Oxaliplatin-Containing Regimen.
Boehringer Ingelheim - Recruiting 40 years or older. - Post-Marketing Observational Study of the Impact of Adherence to Treatment With Once-Daily Administered Long-Acting Bronchodilators (LABAs / LAMAs) on Patients Health Related Quality of Life in COPD Patients.
NCIC Clinical Trials Group - Recruiting 18 years or older. - A Phase III Study of the Impact of a Physical Activity Program on Disease-Free Survival in Patients With High Risk Stage II or Stage III Colon Cancer: A Randomized Controlled Trial (CHALLENGE).
exercise intervention; counseling intervention; educational intervention; laboratory biomarker analysis; questionnaire administration; study of socioeconomic and demographic variables; fatigue assessment and management; quality-of-life assessment
City of Hope Medical Center - Recruiting 16 years or older. - Pharmacologic Reversal of Ventricular Remodeling in Childhood Cancer Survivors at Risk for Congestive Heart Failure (PREVENT-CHF): A Phase IIB Randomized Placebo-Controlled Trial.
Northwestern University - Recruiting 60 years or older. - A Phase II Trial of Sequential SGN-35 Therapy With Adriamycin, Vinblastine, and Dacarbazine (S-AVD) for Older Patients With Untreated Hodgkin Lymphoma.
AbbVie - Recruiting 18 years or older. - Long Term Documentation of the Safety and Efficacy as Well as the Effects on Quality of Life and Work Productivity in Patients With Rheumatoid Arthritis Under HUMIRAr (Adalimumab) in Routine Clinical Practice (AGIL).
Roswell Park Cancer Institute - Recruiting 50 years or older. - Phase II Trial of Single Fraction Radiation Therapy (SFRT) at Roswell Park Cancer Institute for Select Patients With Early Stage Breast Cancer.
The Hospital for Sick Children - Recruiting 18 years or older. - Neuropsychological and Quality of Life Outcomes in Untreated Adults With Mild Hyperphenylalaninemia With Phenylalanine Levels Between 360 and 600 æmol/L..
Fred Hutchinson Cancer Research Center - Recruiting 18 years to 75 years. - Phase 2 Study of Early Discharge and Outpatient Management of Adult Patients Following Intensive Chemotherapy for MDS and Non-APL AML.
standard follow-up care; medical chart review; quality-of-life assessment
Medtronic Spinal and Biologics - Recruiting 65 years or older. - A Prospective and Multicenter Evaluation of Outcomes for Quality of Life and Activities of Daily Living for Balloon Kyphoplasty in the Treatment of Vertebral Compression Fractures.
Southwest Oncology Group - Recruiting N/A or older. - S1013: A Prospective Study of Epidermal Growth Factor Receptor (HER-1/EGFR) Inhibitor-Induced Dermatologic Toxicity: Validation of the Functional Assessment of Cancer Therapy-EGFRI 18(FACT-EGFRI 18) Questionnaire for EGFRI-Induced Skin Toxicities.
assessment of therapy complications; psychosocial assessment and care; quality-of-life assessment
Radiation Therapy Oncology Group - Recruiting 18 years or older. - Phase III Randomized Trial Comparing Overall Survival After Photon Versus Proton Chemoradiotherapy for Inoperable Stage II-IIIB NSCLC.
National Institutes of Health Clinical Center (CC) - Recruiting 6 years to 80 years. - Multi-Institutional Prospective Phase II Study of Montelukast for the Treatment of Bronchiolitis Obliterans Following Allogeneic or Autologous Stem Cell Transplantation in Children and Adults.
Galena Biopharma, Inc. - Recruiting 18 years or older. - Rapid Evaluation of Lifestyle, Independence, and Elimination of Breakthrough Cancer Pain With Freedom From Oral Discomfort Through the Use of Abstralr (Fentanyl) Sublingual Tablets.
NCIC Clinical Trials Group - Recruiting 18 years or older. - A Phase II/III Study of Intraperitoneal (IP) Plus Intravenous (IV) Chemotherapy Versus IV Carboplatin Plus Paclitaxel in Patients With Epithelial Ovarian Cancer Optimally Debulked at Surgery Following Neoadjuvant Intravenous Chemotherapy.
Children's Oncology Group - Recruiting 4 years to 21 years. - A Randomized Double Blinded Trial of Topical Caphosol to Prevent Oral Mucositis in Children Undergoing Hematopoietic Stem Cell Transplantation.
Memorial Sloan-Kettering Cancer Center - Recruiting 18 years to 64 years. - Breast Cancer and the Workforce: Ethnic Differences in the Impact of Breast Cancer on Employment Status, Financial Situation, and Quality of Life (BCW).
Gynecologic Oncology Group - Recruiting 18 years or older. - Evaluation of Physical Function and Quality of Life (QOL) Before and After Non-Radical Surgical Therapy (Extra Fascial Hysterectomy or Cone Biopsy With Pelvic Lymphadenectomy) for Stage IA1 (LVSI+) and IA2-IB1 (=/<2CM) Cervical Cancer.
Gynecologic Oncology Group - Recruiting 18 years or older. - A Phase III Randomized Trial of Pulse Actinomycin-D Versus Multi-Day Methotrexate for the Treatment of Low-Risk Gestational Trophoblastic Neoplasia.
City of Hope Medical Center - Recruiting 18 years or older. - Phase I Trial of BKM120 in Combination With Carboplatin and Pemetrexed in Patients With Advanced Non-Squamous Non-Small Cell Lung Cancer (NSCLC).
National Cancer Institute (NCI) - Recruiting 18 years or older. - A Phase III Randomized Controlled Clinical Trial of Carboplatin and Paclitaxel (or Gemcitabine) Alone or in Combination With Bevacizumab (NSC #704865, IND #113912) Followed by Bevacizumab and Secondary Cytoreductive Surgery in Platinum-Sensitive, Recurrent Ovarian, Peritoneal Primary and Fallopian Tube Cancer. NCI-Supplied Agents: Bevacizumab (NSC #704865, IND #113912).
St. Jude Children's Research Hospital - Recruiting N/A to 18 years. - Adcetris Substituting Vincristine in the OEPA/COPDac Regimen [Treatment Group 3 (TG3) of Euro-Net C1] With Low Dose Tailored-Field Radiation Therapy for Unfavorable Risk Pediatric Hodgkin Lymphoma.
brentuximab vedotin; etoposide; prednisone; doxorubicin; cyclophosphamide; Dacarbazine(R); filgrastim; quality of life assessment; radiation therapy
Memorial Sloan-Kettering Cancer Center - Recruiting 18 years or older. - Flexible Fiber-based CO2 Laser Versus Monopolar Cautery for Resection of Benign, Pre-malignant And Malignant Oral Cavity Lesions: A Single Center Randomized Controlled Trial Assessing Pain and Quality of Life Following Surgery.
Flexible Fiber-based CO2 Laser, Quality of Life forms; electrocautery resection and quality of life forms
Norwegian Centre for Ageing and Health - Recruiting N/A to 69 years. - A Nordic Multicentre Observational Study of Persons With Young Onset Dementia and Their Families - Factors Influencing Quality of Life, Theirs Specific Needs and the Use of Healthcare Resources.
Maxx Orthopedics Inc - Recruiting 40 years to 80 years. - A Prospective, Multicenter, Single Arm Adaptive-Design Study to Evaluate the Safety, Functionality, and the Quality of Life of Patients Who Receive the Freedom Total Knee r System.
Freedom Total Knee; Total Knee Replacement; Freedom Total Knee System
McGill University Health Center - Recruiting 2 years to 50 years. - A Comparison of Quality of Sleep and Quality of Life in Patients With Glycogen Storage Disease on Standard and Modified Uncooked Cornstarch.
National Cancer Institute (NCI) - Recruiting 18 years or older. - A Phase III Randomized Study of Adjuvant Ipilimumab Anti-CTLA4 Therapy Versus High-Dose Interferon a-2b for Resected High-Risk Melanoma.
National Cancer Institute (NCI) - Recruiting 65 years or older. - A Randomized Phase III Study of Bendamustine Plus Rituximab Versus Ibrutinib Plus Rituximab Versus Ibrutinib Alone in Untreated Older Patients (ò 65 Years of Age) With Chronic Lymphocytic Leukemia (CLL).
University of California, San Francisco - Recruiting N/A or older. - Pre-Operative Gleason Score and PSA and Clinical Stage in Predicting the Risk of Failure in Patients Undergoing Radiation Therapy for Localized Prostate Cancer.
medical chart review; questionnaire administration; quality-of-life assessment; brachytherapy; radiation therapy
Assistance Publique - Hpitaux de Paris - Recruiting 18 years or older. - Multicenter Randomised, Controlled Trial of a Intensive Care Follow -up Programme in Improving Long-term Outcomes of ICU Survivors.
Hoffmann-La Roche - Recruiting 18 years or older. - A Prospective, Observational, Multicenter Non-interventional Trial Examining Efficacy of Combination Therapy With PEGASYSr Plus COPEGUSr in Patients With Chronic Hepatitis C, Genotype 2, 3, 1 or 4, Undergoing an Opioid Maintenance-Therapy With Special Focus on Patient Compliance and Quality of Life.
Hoffmann-La Roche - Recruiting 18 years or older. - An Open Label, Randomised Phase II Study Assessing Quality of Life Associated With Subcutaneous Trastuzumab Injected Into the Thigh or Upper Arm in Patients With HER2-positive Early Breast Cancer.
National Cancer Institute (NCI) - Recruiting 18 years or older. - Prospective Randomized Phase II Trial of Pazopanib (NSC # 737754, IND 75648) Versus Placebo in Patients With Progressive Carcinoid Tumors.
National Cancer Institute (NCI) - Recruiting 18 years or older. - A Randomized Phase III Trial Evaluating Pathologic Complete Response Rates in Patients With Hormone Receptor-Positive, HER2-Positive, Large Operable and Locally Advanced Breast Cancer Treated With Neoadjuvant Therapy of Docetaxel, Carboplatin, Trastuzumab, and Pertuzumab (TCHP) With or Without Estrogen Deprivation.
Sunnybrook Health Sciences Centre - Recruiting 18 years or older. - The Impact of a Patient Education Intervention on Knowledge, Self-efficacy, Symptom Burden, Health Related Quality of Life and Satisfaction With the Experience of Care for Oncology Ambulatory Patients Post Completion of the Edmonton Screening Assessment System.
Archimedes Development Ltd - Recruiting 18 years or older. - A French, Multicentre, Open-label, Observational Study to Assess Quality of Life and Satisfaction in Subjects Taking PecFentr for the Treatment of Breakthrough Cancer Pain (BTPc).
Radiation Therapy Oncology Group - Recruiting 18 years or older. - Randomized Phase II/III Trial of Surgery and Postoperative Radiation Delivered With Concurrent Cisplatin Versus Docetaxel Versus Docetaxel and Cetuximab for High-Risk Squamous Cell Cancer of the Head and Neck.
Asklepios Kliniken Hamburg GmbH - Recruiting 18 years or older. - Prospektive, Randomisierte Und Kontrollierte Studie Zum Einfluss Des VADOplex-Systems Auf Die Lebensqualitt im Rahmen Der Behandlung Der Chronisch-kritischen Extremittenischmie im Stadium IV Nach Fontaine.
AIO-Studien-gGmbH - Recruiting 18 years or older. - Comparison of Two Preemptive Treatment Strategies of Panitumumab Mediated Skin Toxicity and Assessment of Quality of Life in Patients With Ras-wildtype Colorectal Cancer.
Bayer - Recruiting 18 years or older. - Study to Characterize Patients Treated With Visanne for Their Endometriosis Under Real-life Practice Conditions and Evaluate Their Quality of Life at Baseline and After 6 Months of Treatment With Visanne..
AbbVie - Recruiting 18 years or older. - Analysis of MOtor and NOn Motor Symptoms, Quality of Life and Occurence of Dyskinesias in Advanced Parkinson's Disease Patients With 2 to 4 Hours 'Off-time' and Without Troublesome Dyskinesias Under Duodopa TREATment - a Multi-country Post-marketing Observational Study -MONOTREAT.
Roswell Park Cancer Institute - Recruiting 18 years or older. - A Pilot Study of Stereotactic Body Radiation Therapy (SBRT) After TEMLA for Stage III and IV (Oligometastatic) Non-Small Cell Lung Cancer.
therapeutic lymphadenectomy; stereotactic body radiation therapy; quality-of-life assessment
National Cancer Institute (NCI) - Recruiting N/A to 29 years. - A Phase III Randomized Trial for Patients With de Novo AML Using Bortezomib and Sorafenib (IND#114480; NSC# 681239, NSC# 724772) for Patients With High Allelic Ratio FLT3/ITD.
University of Virginia - Recruiting 18 years or older. - A Single Arm Study of Efficacy and Functional Quality of Life in Patients Treated With Transoral Robotic Surgery for Oropharyngeal and Supraglottic Squamous Cell Carcinoma.
M.D. Anderson Cancer Center - Recruiting N/A or older. - A Pilot Study for Prospective Discovery of Possible Relationship Between Quality of Life, Treatment Modalities, and Patient Treatment/Outcome Expectations in Patients Undergoing Treatment for Locally Recurrent Rectal Adenocarcinoma.
University Hospital, Bonn - Recruiting 20 years to 75 years. - Assessment of Efficacy, Safety and Effects on Quality of Life of Deep Brain Stimulation to the Medial Forebrain Bundle in Patients With Treatment Resistant Major Depression (FORESEE II: FOREbrain Stimulation dEprEssion).
Deep Brain Stimulation with Activa PC Multi-program Neurostimulator
City of Hope Medical Center - Recruiting 18 years or older. - Adjuvant Therapy in Older Versus Younger Women With Breast Cancer: Longitudinal Impact of Adjuvant Chemotherapy on Functional Status, Comorbidity and Quality of Life.
Fred Hutchinson Cancer Research Center - Recruiting 18 years or older. - INSPIRE for Survivorship After Transplant: A Multicenter Randomized Controlled Trial of an Internet and Social-media Program for Long-term Hematopoietic Cell Transplantation Survivors.
National Cancer Institute (NCI) - Recruiting 18 years or older. - Phase I Trial of Escalating High Dose Methotrexate Supported by Glucarpidase to Treat Patients With Primary Central Nervous Lymphoma (PCNSL).
National Cancer Institute (NCI) - Recruiting N/A or older. - An Evaluation of Lesion Control Using Focal Ablation With High Intensity Focused Ultrasound in the Treatment of Non-Metastatic Progressive Prostate Cancer.
USC/Norris Comprehensive Cancer Center - Recruiting 50 years or older. - Exercise and Whey Protein Supplementation as Adjunctive Therapy for Patients With Prostate Cancer Receiving Androgen Deprivation Therapy.
Johns Hopkins University - Recruiting 18 years to 75 years. - The Relationship of a 'Crohn's Disease Diet' in Reducing Symptoms of Crohn's Disease, Improving Quality of Life, and Decreasing Related Health Care Costs..
Elimination Diet; Dietary Guidelines for Americans
Assuta Hospital Systems - Recruiting 14 years to 65 years. - A Prospective Trial for Laparoscopic Adjustable Gastric Banding in Morbidly Obese Patients: Report on Weight Loss, Metabolic Changes and Quality of Life.
Universittsklinikum Hamburg-Eppendorf - Recruiting 18 years to 90 years. - Quality of Life After Bilioenteric Anastomosis in Comparison to Endoscopically Placed Stents in Patients With Unresectable Pancreatic Cancer and Jaundice.
University Hospital, Ghent - Recruiting 18 years or older. - Adaptive, Image-guided, Intensity-modulated Radiotherapy for Head and Neck Cancer in the Reduced Volumes of Elective Neck: a Multicenter, Two-arm, Randomized Phase II Trial..
video fluoroscopy; extra imaging; scoring acute toxicity; scoring of late toxicity; scoring quality of life (QOL)
Hospital Universitari de Bellvitge - Recruiting 18 years to 74 years. - Prospective Multicenter Randomized Controlled Trial Comparing Postoperative Complications and Quality of Life in Low Rectal Cancer Surgery Between Coloanal Anastomosis and Lateral Ileostomy Versus Two-Stage Turnbull-Cutait Coloanal Anastomosis.
Hand-sewn coloanal anastomosis; Two staged Turnbull-Cutait procedure; Ultralow anterior rectal resection with total mesorectal excision
Consorzio Mario Negri Sud - Recruiting 18 years or older. - Effects of the Dose of Erythropoiesis Stimulating Agents on Cardiac-cerebrovascular Outcomes Quality of Life and Costs in Hemodialysis Patients. The Clinical Evaluation of the DOSe of Erythropoietins (C.E. DOSE) Trial.
Erythropoiesis Stimulating Agents (ESAs): epoetin alfa, beta or any other epoetin in equivalent dose.
University of Aarhus - Recruiting 7 years or older. - Short and Long-term Effects of Surgical Repair of Pectus Excavatum and Pectus Carinatum - A Questionnaire Study of Persistent Post-surgical Pain, Health-related Quality of Life, Patient Satisfaction, and Aesthetic Outcome.
Minimally invasive repair of pectus excavatum; Open surgical repair of pectus carinatum
German Cancer Research Center - Recruiting 18 years or older. - Progressive Resistance Training vs. Relaxation for Breast Cancer Patients During Chemotherapy: A Randomized Controlled Intervention Trial to Evaluate the Biological Mechanisms and Effects of Resistance Training on Fatigue and Quality of Life.
University of Heidelberg - Recruiting 18 years to 80 years. - Influence of Respiratory and Exercise Therapy on Oxygen Uptake, Quality of Life in Patients With Severe Associated Pulmonary Arterial Hypertension (APAH) as Part of a Congenital Heart Defect With / Without Eisenmenger's Syndrome.
National Cancer Institute (NCI) - Recruiting 18 years or older. - A Prospective Study of Cognitive Function During Chemotherapy for Front-Line Treatment of Ovarian, Primary Peritoneal or Fallopian Tube Cancer.
Odense University Hospital - Recruiting 18 years or older. - Prospective, Randomized Trial of the Effects on HRQoL, Cost-Utility and Reintervention Rate, of Nurse Home Visits, in Patients With SEMS Treated Malignant Disease in the Esophagus and Cardia..
Washington University School of Medicine - Recruiting 40 years to 70 years. - Connecting the Lab to Everyday Life: The Relevance of Executive Dysfunction to Participation and Quality of Life in PD Without Dementia.
National Cancer Institute (NCI) - Recruiting 18 years or older. - Phase III Trial on Concurrent and Adjuvant Temozolomide Chemotherapy in Non-1p/19q Deleted Anaplastic Glioma. The CATNON Intergroup Trial..
National Cancer Institute (NCI) - Recruiting 18 years or older. - FRAGMATIC - A Randomised Phase III Clinical Trial Investigating the Effect of FRAGMin Added to Standard Therapy In Patients With Lung Cancer.
National Cancer Institute (NCI) - Recruiting 50 years or older. - A Randomised Controlled Trial to Assess the Cost-effectiveness of Intensive Versus no Scheduled Follow-up in Patients Who Have Undergone Resection for Colorectal Cancer With Curative Intent. (FACS - Follow-up After Colorectal Surgery).
laboratory biomarker analysis; computed tomography; magnetic resonance imaging; quality-of-life assessment
Basque Health Service - Recruiting 18 years or older. - Rationale and Design of a Randomised Controlled Trial Evaluating the Effectiveness of an Exercise Program to Improve the Quality of Life of Patients With Heart Failure in Primary Care: The EFICAR Study Protocol.
Supervised progressive exercise program with an aerobic and a strength component + Optimized treatment; Optimized treatment according to the European Society of Cardiology guidelines
Peking University - Recruiting 30 years to 75 years. - The Effects of Gastric Tube on the Quality of Life and Nutritional Status After Ivor-Lewis Esophagectomy: A Randomized Control Trial and Physiological Study.
National Cancer Institute (NCI) - Recruiting 18 years or older. - Surgery and Brachytherapy: A Randomized Evaluation. Randomized Controlled Trial of Brachytherapy Versus Radical Prostatectomy in Good Risk Prostate Cancer: A Feasibility Study.
Helsinki University Central Hospital - Recruiting 18 years or older. - Systematic Provision of Intrauterine Contraception After First Trimester Abortion - Effects on Quality of Life and Risk of Repeat Abortion. A Randomized, Prospective Trial..
National Cancer Institute (NCI) - Recruiting 18 years or older. - A Multicenter Randomized Study of Cochlear Sparing Intensity Modulated Radiotherapy Versus Conventional Radiotherapy in Patients With Parotid Tumors.
Sha'ar Menashe Mental Health Center - Recruiting 18 years to 64 years. - Baclofen as Add-On to Standard Treatment of Alcohol- Dependent Patients and Its Effect on Quality of Life, Clinical and Psychosocial Features: A 12-Week Double-Blind Randomized Controlled Trial.
Baclofen (as add-on to standard treatment of alcohol dependence)
National Cancer Institute (NCI) - Recruiting 18 years or older. - A Phase II Trial to Assess the Efficacy of Efavirenz as Second-line Monotherapy for the Treatment of Advanced Pancreatic Adenocarcinomas..
National Institute of Cancerolog¡a - Recruiting 20 years to 75 years. - A Prospective Randomized Trial: Effect of Docosahexaenoic Acid (DHA) and Eicosapentaenoic Acid (EPA)- Containing Supplement on the Nutritional and Inflammatory Status, Quality of Life, Toxicity and Response Rate to First-line Chemotherapy in Patients With Advanced Lung Cancer.
National Cancer Institute (NCI) - Recruiting 18 years or older. - Study of Doses Escalation on Efficacy on Cyberknife After Docetaxel-Cisplatin Concomitant Radiotherapy for Non Small Cells Lung Cancer Stage III.
National Cancer Institute (NCI) - Recruiting 18 years or older. - A Phase II Open- Labeled, Prospective Study to Determine the Efficacy of Pre- Operative Chemotherapy With Six Cycles of Modified FOLFOX 6 Followed by Total Mesorectal Excision (TME) Followed by an Additional Six Cycles of FOLFOX 6.
University of Dublin, Trinity College - Recruiting 18 years to 80 years. - Randomized Double Blinded Trial to Investigate Effects of an Enteral Nutritional Supplement Enriched With Eicosapentaenoic Acid on Body Composition,Complications,Stress Response,Immune Function & Quality of Life in After Esophagectomy.
Shriners Hospitals for Children - Recruiting 5 years to 21 years. - Safety and Efficacy of Botox Injection in Alleviating Post-Operative Pain and Improving Quality of Life in Lower Extremity Limb Lengthening and Deformity Correction.