University of Texas Southwestern Medical Center - Recruiting 18 years to 90 years. - Phase I Dose Escalation Trial of Nitroglycerin in Addition to 5-flourouracil and Radiation Therapy for Neo-adjuvant Treatment of Operable Rectal Cancer.
Assistance Publique - HÃ´pitaux de Paris - Recruiting 18 years or older. - Randomized Control Trial Comparing the Impact of a Lengthening of the Interval Between the Radiochemotherapy and Surgery (7 Weeks vs. 11 Weeks) on Complete Pathological Response in Rectal Cancer.
Surgery after 11 weeks of delay after chemoradiotherapy.; Surgery after 7 weeks of delay after chemoradiotherapy
Chinese University of Hong Kong - Recruiting 18 years to 80 years. - Can Electroacupuncture Prevent Prolonged Ileus After Laparoscopic Surgery for Mid and Low Rectal Cancer? A Prospective Study With Matched Historical Controls.
Beijing Chao Yang Hospital - Recruiting 18 years to 80 years. - Randomized Clinical Trial of Conventional Versus Individual Extralevator Abdominoperineal Excision for Locally Advanced Lower Rectal Cancer.
University Medical Centre Groningen - Recruiting 18 years or older. - Randomized Multicentre Phase III Study of Short Course Radiation Therapy Followed by Prolonged Pre-operative Chemotherapy and Surgery in Primary High Risk Rectal Cancer Compared to Standard Chemoradiotherapy and Surgery and Optional Adjuvant Chemotherapy..
Swiss Group for Clinical Cancer Research - Recruiting 18 years or older. - Clinical Function After Total Mesorectal Excision and Rectal Replacement. A Prospective Randomized Trial Comparing Side-to-End Anastomosis, Colon-J-Pouch and Straight Coloanal Anastomosis.
5 cm colon-J-pouch; side-to-end anastomosis; straight coloanal anastomosis
AHS Cancer Control Alberta - Recruiting 18 years or older. - A Feasibility Study to Compare the Benefits of Endoscopic Tumor Clip Placement and 3T-MRI Simulation for Accurate Target Volume Definition for Rectal Cancer Patients Undergoing Pre-operative Chemoradiation.
Sun Yat-sen University - Recruiting 18 years to 75 years. - A Phase II/III Randomized Controlled Study of Neoadjuvant FOLFOX6 Treatment With or Without Radiation Compared to 5-Fu Based Chemoradiation in Treating Patients With Resectable Rectal Cancer.
M.D. Anderson Cancer Center - Recruiting N/A or older. - A Pilot Study for Prospective Discovery of Possible Relationship Between Quality of Life, Treatment Modalities, and Patient Treatment/Outcome Expectations in Patients Undergoing Treatment for Locally Recurrent Rectal Adenocarcinoma.
Ohio State University Comprehensive Cancer Center - Recruiting 18 years or older. - A Phase II Study of Panitumumab in Combination With FOLFIRI After Progression on FOLFIRI Plus Bevacizumab in KRAS(Kirsten Rat Sarcoma) Wild-Type Metastatic Colorectal Cancer..
Chinese Academy of Medical Sciences - Recruiting 18 years to 75 years. - Phase II Clinical Trial: The Effect of Bone Marrow-sparing Intensity-Modulated Radiotherapy (BMS-IMRT) on Reduction Acute Hematologic Toxicity in Gastric and Rectal Cancer Patients Treated With Concurrent Chemotherapy and IMRT.
Bone Marrow-sparing Intensity-Modulated Radiotherapy
UNICANCER - Recruiting 18 years to 75 years. - - Randomized Phase III Study Comparing Preoperative Chemoradiotherapy Alone Versus Neoadjuvant Chemotherapy With Folfirinox Regimen Followed by Preoperative Chemoradiotherapy for Patients With Resectable Locally Advanced Rectal Cancer.
mFolfirinox; Radiotherapy 50Gy; Capecitabine; TME surgery; mFolfox6 or capecitabine
PVS Memorial Hospital - Recruiting 25 years to 75 years. - A Randomised Controlled Trial On Mechanical Bowel Preparation Versus No Mechanical Bowel Preparation In Elective Laparoscopic Surgery For Left Sided Colonic Tumours.
Hospital Universitari de Bellvitge - Recruiting 18 years to 74 years. - Prospective Multicenter Randomized Controlled Trial Comparing Postoperative Complications and Quality of Life in Low Rectal Cancer Surgery Between Coloanal Anastomosis and Lateral Ileostomy Versus Two-Stage Turnbull-Cutait Coloanal Anastomosis.
Hand-sewn coloanal anastomosis; Two staged Turnbull-Cutait procedure; Ultralow anterior rectal resection with total mesorectal excision
Catholic University of the Sacred Heart - Recruiting 18 years or older. - INTEnsification Radiotherapy With Accelerated Fractionation or ChemoTherapy And Local Excision After 3D External Radio-chemotherapy.
Asan Medical Center - Recruiting 20 years to 75 years. - Randomized Phase II Trial of Preoperative Chemoradiation With or Without Induction Chemotherapy In Patients With Locally Advanced Or Borderlinely Resectable Rectal Cancer With Resectable Synchronous Liver Metastases.
Catholic University of the Sacred Heart - Recruiting 18 years or older. - A Phase III, Randomized, Double-Blind Placebo Controlled Study of the Probiotic Preparation VSL#3r Versus Placebo in Increasing the Pathological Major Response Rate in Patients Receiving Concurrent Chemotherapy and Pelvic Radiation Therapy.
Radboud University - Recruiting 18 years or older. - CHEMORADIOTHERAPY FOR RECTAL CANCER IN THE DISTAL RECTUM FOLLOWED BY ORGANSPARING TRANSANAL ENDOSCOPIC MICROSURGERY: CARTS Study CApecitabine, Radiotherapy and Tem Surgery. A PHASE II, FEASIBILITY TRIAL.
Capecitabine; radiotherapy; TME resection; TEM surgery
National Cancer Institute (NCI) - Recruiting 18 years to 74 years. - Neoadjuvant Conformal Radiotherapy and Concomitant CPT-11 and EGFR Inhibition With Cetuximab in Patients With Rectal Cancer Phase I Study.
Japan Clinical Oncology Group - Recruiting 21 years to 74 years. - Mesorectal Excision With Lateral Lymph Node Dissection Versus Without Lateral Lymph Node Dissection for Clinical Stage II, III Lower Rectal Cancer (JCOG0212).
Mesorectal excision with lateral lymph node dissection; Mesorectal excision without lateral lymph node excision
Polish Colorectal Cancer Study Group - Recruiting 18 years to 75 years. - Short-course Preoperative Radiotherapy With Consolidating Chemotherapy vs. Preoperative Chemoradiation in Patients With Unresectable Rectal Cancer: Phase III Study.
National Cancer Institute (NCI) - Recruiting 18 years or older. - A Phase II Open- Labeled, Prospective Study to Determine the Efficacy of Pre- Operative Chemotherapy With Six Cycles of Modified FOLFOX 6 Followed by Total Mesorectal Excision (TME) Followed by an Additional Six Cycles of FOLFOX 6.
Hvidovre University Hospital - Recruiting 18 years or older. - Transrectal Vacuum Assisted Drainage: A NEW METHOD OF TREATING ANASTOMOTIC LEAKAGE AFTER RECTAL RESECTION. A Prospective Randomized Multicenter Study in Cooperation With 'The Danish Colorectal Cancer Group'.