30 results found.

Sarcoma Clinical Trial using Specimen protocol

Memorial Sloan-Kettering Cancer Center - Recruiting N/A or older.
- Novel Biochemical and Molecular Determinants for Soft Tissue Sarcoma.
Specimen protocol

Advanced Soft Tissue Sarcoma Clinical Trial using TRC105 and Pazopanib

Tracon Pharmaceuticals Inc. - Recruiting 18 years or older.
- A Phase 1B Dose-escalation Study of TRC105 in Combination With Pazopanib in Patients With Advanced Soft Tissue Sarcoma.
TRC105 and Pazopanib

Ewing's Sarcoma/Soft Tissue Sarcoma, Neuroblastoma, or Brain Tumo Clinical Trial using plerixafor

Sanofi - Recruiting 1 year to 18 years.
- A Phase 1/2 Combined Dose Ranging and Randomized, Open-label, Comparative Study of the Efficacy and Safety of Plerixafor in Addition to Standard Regimens for Mobilization of Haematopoietic Stem Cells Into Peripheral Blood, and Subsequent Collection by Apheresis, Versus Standard Mobilization Regimens Alone in Pediatric Patients, Aged 1 to <18 Years, With Solid Tumours Eligible for Autologous Transplants..
plerixafor

Metastatic and Locally Advanced Soft Tissue Tumor Patients Unfit Clinical Trial using Trabectedin

Italian Sarcoma Group - Recruiting 18 years to 80 years.
- SAFETY AND ACTIVITY OF TRABECTEDIN AS FIRST LINE IN ADVANCED SOFT TISSUE SARCOMA (STS) PATIENTS UNFIT TO RECEIVE STANDARD CHEMOTHERAPY: A PROSPECTIVE PHASE II STUDY WITH CLINICAL AND MOLECULAR CORRELATES.
Trabectedin

Sarcoma Clinical Trial using Regorafenib; Placebo

Centre Oscar Lambret - Recruiting 18 years or older.
- Activity and Safety of Regorafenib in Patients With Metastatic Soft Tissue Sarcoma Previously Treated With Anthracycline-based Chemotherapy : a Multinational, Randomized, Phase II, Placebo-controlled Trial.
Regorafenib; Placebo

Sarcoma Clinical Trial using Trabectedin

Janssen Research & Development, LLC - Recruiting 15 years or older.
- A Multicenter, Open-Label Single-Arm Study of YONDELIS (Trabectedin) for Subjects With Locally Advanced or Metastatic Soft Tissue Sarcoma Excluding Leiomyosarcoma and Liposarcoma Who Have Relapsed or Are Refractory to Standard of Care Treatment.
Trabectedin

Sarcoma Clinical Trial using therapeutic conventional surgery; 3-dimensional conformal radiation therapy

European Organisation for Research and Treatment of Cancer - EORTC - Recruiting 18 years or older.
- A Phase III Randomized Study of Preoperative Radiotherapy Plus Surgery Versus Surgery Alone for Patients With Retroperitoneal Sarcoma (RPS).
therapeutic conventional surgery; 3-dimensional conformal radiation therapy

Adult Rhabdomyosarcoma, Childhood Desmoplastic Small Round Cell T Clinical Trial using biologic sample preservation procedure; laboratory biomarker analysis

Children's Oncology Group - Recruiting N/A to 50 years.
- A COG Soft Tissue Sarcoma Diagnosis, Biology and Banking Protocol.
biologic sample preservation procedure; laboratory biomarker analysis

Hemangiosarcoma, or Soft Tissue Sarcoma Clinical Trial using Paclitaxel in combination with Bevacizumab

Stanford University - Recruiting 13 years or older.
- Paclitaxel in Combination With Bevacizumab (Avastinr) for the Treatment of Metastatic or Unresectable Angiosarcoma.
Paclitaxel in combination with Bevacizumab

Adult Soft Tissue Sarcoma Clinical Trial using NBTXR3

Nanobiotix - Recruiting 18 years or older.
- An Open-Label, Single Arm, Feasibility And Safety Phase I Study With Nbtxr3 Intratumor Implantation (By Injection) And Activated By External Beam Radiation Therapy In Patients With Soft Tissue Sarcoma Of The Extremity And Trunk Wall.
NBTXR3

Sarcoma Clinical Trial using bevacizumab [Avastin]; Standard chemotherapy

Hoffmann-La Roche - Recruiting 6 Months to 18 years.
- An Open-label, Multi-center, Randomized Study of the Safety and Effect on Event-free Survival of Bevacizumab in Combination With Standard Chemotherapy in Childhood and Adolescent Patients With Metastatic Rhabdomyosarcoma and Non-rhabdomyosarcoma Soft Tissue Sarcoma.
bevacizumab [Avastin]; Standard chemotherapy

Refractory Soft Tissue Sarcomas Clinical Trial using Cabozantinib

National Institutes of Health Clinical Center (CC) - Recruiting 18 years or older.
- A Phase 2 Study of Cabozantinib (XL184), a Dual Inhibitor of MET and VEGFR, in Patients With Metastatic Refractory Soft Tissue Sarcoma.
Cabozantinib

Sarcoma, Soft Tissue Sarcoma, Locally Advanced Sarcoma, Unresecta Clinical Trial using Bevacizumab, Gemcitabine, docetaxel and valproic acid

University of Iowa - Recruiting 18 years or older.
- A Pilot Study Targeting Angiogenesis Using Bevacizumab Combined With Chemotherapy and Histone Deacetylase Inhibitor (Valproic Acid) in Advanced Sarcomas.
Bevacizumab, Gemcitabine, docetaxel and valproic acid

Adult Liposarcoma, Adult Synovial Sarcoma, Recurrent Adult Soft T Clinical Trial using cyclophosphamide; NY-ESO-1-specific T cells; laboratory biomarker analysis

Fred Hutchinson Cancer Research Center - Recruiting 18 years or older.
- A Phase I Study To Determine the Feasibility of Using Autologous NY-ESO-1 Specific CD8+ T Cells For the Treatment of Patients With Advanced Myxoid/ Round Cell Liposarcoma and Synovial Sarcoma..
cyclophosphamide; NY-ESO-1-specific T cells; laboratory biomarker analysis

Sarcoma, Soft Tissue Clinical Trial using Pazopanib

Radboud University - Recruiting 18 years or older.
- Individualizing Pazopanib Therapy by exploRing the Role of Early Metabolic responsE and Drug Exposure as a preDICTor for Treatment Outcome in Patients With STS.
Pazopanib

Adult Angiosarcoma, Recurrent Adult Soft Tissue Sarcoma, Stage II Clinical Trial using pazopanib hydrochloride; laboratory biomarker analysis; positron emission tomography; computed tomography; fludeoxyglucose F 18

Fox Chase Cancer Center - Recruiting 18 years or older.
- Phase II Study Evaluating the Role of Pazopanib in Angiosarcoma.
pazopanib hydrochloride; laboratory biomarker analysis; positron emission tomography; computed tomography; fludeoxyglucose F 18

Sarcoma, Leiomyosarcoma, Malignant Peripheral Nerve Sheath Tumor, Clinical Trial using Gemcitabine and Docetaxel in Combination with Pazopanib

Memorial Sloan-Kettering Cancer Center - Recruiting 18 years or older.
- A Phase IB/II Study of Gemcitabine and Docetaxel in Combination With Pazopanib (Gem/Doce/Pzb) for the Neoadjuvant Treatment of Soft Tissue Sarcoma (STS).
Gemcitabine and Docetaxel in Combination with Pazopanib

Sarcoma Clinical Trial using microarray analysis; molecular diagnostic method; biologic sample preservation procedure

National Cancer Institute (NCI) - Recruiting 16 years or older.
- VORTEX-BIOBANK: Prospective Sample Collection for the VORTEX Randomised Radiotherapy Trial in Patients With Extremity Soft Tissue Sarcoma [VORTEX BIOBANK].
microarray analysis; molecular diagnostic method; biologic sample preservation procedure

Soft Tissue Sarcoma Clinical Trial using MRI-DCE

University of Utah - Recruiting 18 years or older.
- Pilot Study: Dynamic Contrast-enhanced Magnetic Resonance Imaging(DCE-MRI)for Assessing Tumor Vascularity and Permeability in Soft Tissue Sarcoma Treated With Preoperative Radiotherapy Followed by Surgical Resection.
MRI-DCE

Sarcoma Clinical Trial using Dacarbazine

Washington University School of Medicine - Recruiting 18 years or older.
- Determination of Tumor Response Rate by RECIST and FDG-PET Criteria to Dacarbazine in Metastatic Soft Tissue and Bone Sarcoma.
Dacarbazine

Soft Tissue Sarcoma Clinical Trial using Pazopanib; Doxorubicin

Hannover Medical School - Recruiting 60 years or older.
- A Randomized Phase II Trial Comparing Pazopanib With Doxorubicin as First Line Treatment in Elderly Patients With Metastatic or Advanced Soft Tissue Sarcoma.
Pazopanib; Doxorubicin

Soft Tissue Sarcoma Clinical Trial using proton radiation; surgery (wide local excision; limb preservation surgery)

Loma Linda University - Recruiting 18 years or older.
- A Phase II Trial of Preoperative Proton Therapy in Soft-tissue Sarcomas of the Extremities and Body Wall.
proton radiation; surgery (wide local excision; limb preservation surgery)

Sarcoma Clinical Trial using DNA analysis; gene expression analysis; protein expression analysis; reverse transcriptase-polymerase chain reaction; western blotting; immunohistochemistry staining method; laboratory biomarker analysis

University of Arizona - Recruiting N/A or older.
- LABORATORY STUDIES OF SOFT TISSUE SARCOMAS.
DNA analysis; gene expression analysis; protein expression analysis; reverse transcriptase-polymerase chain reaction; western blotting; immunohistochemistry staining method; laboratory biomarker analysis

Locally Advanced or Metastatic Soft Tissue Sarcoma Clinical Trial using NGR-hTNF; Doxorubicin

MolMed S.p.A. - Recruiting 18 years or older.
- NGR016: Randomized Phase II Study Evaluating Two Doses of NGR-hTNF Administered Either as Single Agent or in Combination With Doxorubicin in Patients With Advanced Soft Tissue Sarcoma (STS).
NGR-hTNF; Doxorubicin

Bone Metastases, Musculoskeletal Cancer, Soft Tissue Sarcoma, or Clinical Trial using acetylsalicylic acid; enoxaparin; thromboembolism prophylaxis

Ohio State University Comprehensive Cancer Center - Recruiting 18 years or older.
- Aspirin and Compression Devices for VTE Prophylaxis in Orthopaedic Oncology.
acetylsalicylic acid; enoxaparin; thromboembolism prophylaxis

Soft Tissue Sarcoma, or Lung Metastasis Clinical Trial using chest radiography; chest CT

Centre Oscar Lambret - Recruiting 18 years to 70 years.
- Phase II Study Evaluating Strategies of Lung Surveillance of Patients Operated of High Grade Soft Tissue Sarcoma: Chest Radiograph Versus Chest CT.
chest radiography; chest CT

Soft Tissue Sarcoma of Members Clinical Trial using Radiotherapy; absence of radiotherapy

Institut Claudius Regaud - Recruiting 18 years or older.
- Randomised Multicentric Phase III Study Comparing Observation Versus Post-surgery Radiotherapy After Complete Exeresis With Margins Greater Than or Equal to 1 cm in Soft Tissues Members Sarcoma..
Radiotherapy; absence of radiotherapy

Soft Tissue Sarcoma, Fibrous Histiocytoma, Liposarcoma, Leiomyosa Clinical Trial using Bevacizumab; Radiation Therapy

Massachusetts General Hospital - Recruiting 18 years or older.
- A Phase II Study of Neoadjuvant Bevacizumab and Radiation Therapy for Resectable Soft Tissue Sarcomas.
Bevacizumab; Radiation Therapy

Soft Tissue Sarcoma Clinical Trial using Sorafenib

Grupo Espanol de Investigacion en Sarcomas - Recruiting 18 years to 72 years.
- Phase I-II, Not-Randomized, Multicenter Clinical Trial to Evaluate Safety and Efficacy of Sorafenib (BAY-43-9006) in Combination With Ifosfamide in Soft Tissue Sarcoma..
Sorafenib