300 results found.

Recurrent Squamous Cell Carcinoma of the Hypopharynx, Recurrent S Clinical Trial using soy isoflavones; laboratory biomarker analysis; survey administration

National Cancer Institute (NCI) - Recruiting 19 years to 79 years.
- A Phase II Trial of Preoperative Soy Isoflavone Supplementation and Molecular Markers in the Prevention of Head and Neck Squamous Carcinoma.
soy isoflavones; laboratory biomarker analysis; survey administration

Obesity, Bariatric Surgery, Gastric Bypass, Weight Loss, or Hyper Clinical Trial

National Institutes of Health Clinical Center (CC) - Recruiting 18 years or older.
- Effects of Bariatric Surgery on Changes in Insulin Secretion and Insulin Action.

Systemic Lupus Erythematosus, or Antiphospholipid Syndrome Clinical Trial

Hospital for Special Surgery, New York - Recruiting 18 years to 45 years.
- Predictors of Pregnancy Outcome in Systemic Lupus Erythematosus (SLE) and Antiphospholipid Syndrome (APS).

Adult Primary Hepatocellular Carcinoma, Localized Unresectable Ad Clinical Trial using sorafenib tosylate; placebo; doxorubicin hydrochloride; doxorubicin-eluting beads; cisplatin; mitomycin C

National Cancer Institute (NCI) - Recruiting 18 years or older.
- A Phase III Randomized, Double-Blind Trial of Chemoembolization With or Without Sorafenib in Unresectable Hepatocellular Carcinoma (HCC) in Patients With and Without Vascular Invasion.
sorafenib tosylate; placebo; doxorubicin hydrochloride; doxorubicin-eluting beads; cisplatin; mitomycin C

Parkinson's Disease, Essential Tremor, or Dystonia Clinical Trial using Deep Brain Stimulation

National Institutes of Health Clinical Center (CC) - Recruiting 18 years or older.
- Deep Brain Stimulation Surgery for Movement Disorders.
Deep Brain Stimulation

Adenocarcinoma of the Esophagus, Adenocarcinoma of the Gastroesop Clinical Trial using radiation therapy; paclitaxel; carboplatin; trastuzumab; therapeutic conventional surgery; laboratory biomarker analysis; quality-of-life assessment

National Cancer Institute (NCI) - Recruiting 18 years or older.
- A Phase III Trial Evaluating The Addition Of Trastuzumab To Trimodality Treatment Of Her2-Overexpressing Esophageal Adenocarcinoma.
radiation therapy; paclitaxel; carboplatin; trastuzumab; therapeutic conventional surgery; laboratory biomarker analysis; quality-of-life assessment

Prostate Cancer Clinical Trial using radiation therapy

Swiss Group for Clinical Cancer Research - Recruiting 18 years to 75 years.
- Dose Intensified Salvage Radiotherapy in Biochemically Relapsed Prostate Cancer Without Macroscopic Disease. A Randomized Phase III Trial..
radiation therapy

Coronary Artery Bypass Graft Surgery Clinical Trial using Washed RBC; Unwashed RBC

University of Miami - Recruiting 18 years or older.
- Microparticles in Stored Red Blood Cells (RBC) as Potential Mediators of Transfusion Complications (II): Clinical Study.
Washed RBC; Unwashed RBC

Arthroplasty, Replacement, Hip Clinical Trial using Standard Care morphine hydrochloride; Oxycodone

Centre Hospitalier Universitaire de Nimes - Recruiting 18 years to 80 years.
- Evaluation of Oxycodone Hydrochloride Versus Intravenous Morphine Hydrochloride for Postoperative Analgesia After Hip Prosthetic Surgery.
Standard Care morphine hydrochloride; Oxycodone

Prostate Cancer Clinical Trial using Best Systemic Therapy (BST); Best Systemic Therapy (BST) + Surgery or Radiation Therapy; Questionnaires; Phone Call/Email

M.D. Anderson Cancer Center - Recruiting 18 years or older.
- Randomized, Phase II Trial of Best Systemic Therapy or Best Systemic Therapy (BST) Plus Definitive Treatment (Radiation or Surgery) of the Primary Tumor in Metastatic (M1) Prostate Cancer (PC).
Best Systemic Therapy (BST); Best Systemic Therapy (BST) + Surgery or Radiation Therapy; Questionnaires; Phone Call/Email

Recurrent Melanoma, Stage IA Melanoma, Stage IB Melanoma, Stage I Clinical Trial using fluorescein sodium injection; diagnostic microscopy; therapeutic conventional surgery; laboratory biomarker analysis

Roswell Park Cancer Institute - Recruiting 18 years or older.
- A Pilot Study of Feasibility of Performing Intravital Microscopy in Melanoma Patients.
fluorescein sodium injection; diagnostic microscopy; therapeutic conventional surgery; laboratory biomarker analysis

Stage IA Endometrial Carcinoma, Stage IB Endometrial Carcinoma, S Clinical Trial using lymph node mapping; sentinel lymph node biopsy; isosulfan blue; indocyanine green solution; therapeutic conventional surgery; lymphadenectomy

Case Comprehensive Cancer Center - Recruiting N/A or older.
- Sentinel Lymph Node Mapping for Endometrial Cancer.
lymph node mapping; sentinel lymph node biopsy; isosulfan blue; indocyanine green solution; therapeutic conventional surgery; lymphadenectomy

Patients Undergoing Surgery for Congenital Heart Disease Clinical Trial using surgery for congenital heart disease

Samsung Medical Center - Recruiting N/A to 10 years.
- Incidence, Risk Factors, and Risk Model of Acute Kidney Injury in Pediatric Patients Who Undergoing Surgery for Congenital Heart Disease.
surgery for congenital heart disease

Coronary Artery Bypass Surgery, Acute Kidney Injury, Creatinine, Clinical Trial using Coronary artery bypass surgery

Samsung Medical Center - Recruiting 20 years or older.
- Predicting Acute Kidney Injury After Coronary Artery Bypass Graft : a Simplified Clinical Risk Scoring Model.
Coronary artery bypass surgery

Patients Who Underwent Surgery for Congenital Heart Disease Clinical Trial using Surgery for congenital heart disease

Samsung Medical Center - Recruiting N/A to 10 years.
- Influence of Tidal Volume During Mechanical Ventilation on Postoperative Clinical Outcome in Pediatric Patients Undergoing Congenital Heart Surgery.
Surgery for congenital heart disease

Surgery for Congenital Heart Disease, or Pediatric Patients Clinical Trial using surgery for congenital heart disease with cardiopulmonary bypass

Samsung Medical Center - Recruiting N/A to 10 years.
- The Predictability of Intraoperative Rotational Thromboelastometry on Postoperative Bleeding and Transfusion Requirements.
surgery for congenital heart disease with cardiopulmonary bypass

Intra-abdominal Infection Clinical Trial using Tigecycline; Imipenem/cilastatin

Pfizer - Recruiting 18 years or older.
- A Multicenter, Double-Blind, Randomized, Comparison Study Of The Efficacy And Safety Of Tigecycline To Imipenem/Cilastatin To Treat Complicated Intra-Abdominal Infections In Hospitalized Subjects.
Tigecycline; Imipenem/cilastatin

Sinus Node Dysfunction Clinical Trial using Evidence based guidelines and tools

Medtronic Cardiac Rhythm Disease Management - Recruiting 18 years or older.
- Registry to Improve the Adoption of Consensus Treatment Guidelines (IMPROVE Brady).
Evidence based guidelines and tools

Glioblastoma, Small Cell Glioblastoma, Giant Cell Glioblastoma, G Clinical Trial using Rindopepimut (CDX-110) with GM-CSF; Temozolomide; KLH

Celldex Therapeutics - Recruiting 18 years or older.
- An International, Randomized, Double-Blind, Controlled Study of Rindopepimut/GM-CSF With Adjuvant Temozolomide in Patients With Newly Diagnosed, Surgically Resected, EGFRvIII-positive Glioblastoma.
Rindopepimut (CDX-110) with GM-CSF; Temozolomide; KLH

Stage IB Breast Cancer, or Stage II Breast Cancer Clinical Trial using regional nodal XRT; chestwall XRT; WBI

National Surgical Adjuvant Breast and Bowel Project (NSABP) - Recruiting 18 years or older.
- A Randomized Phase III Clinical Trial Evaluating Post-Mastectomy Chestwall and Regional Nodal XRT and Post-Lumpectomy Regional Nodal XRT in Patients With Positive Axillary Nodes Before Neoadjuvant Chemotherapy Who Convert to Pathologically Negative Axillary Nodes After Neoadjuvant Chemotherapy.
regional nodal XRT; chestwall XRT; WBI

Arthroplasty, Replacement, or Thromboembolism Clinical Trial

Boehringer Ingelheim - Recruiting 18 years or older.
- Observational Cohort Study to Evaluate Safety and Efficacy of Pradaxa (Dabigatran Etexilate) in Patients With Moderate Renal Impairment (Creatinine Clearance 30-50 ml/Min) Undergoing Elective Total Hip Replacement Surgery or Total Knee Replacement Surgery.

Liver Cancer Clinical Trial using yttrium Y 90 glass microspheres; Cisplatin; Mitomycin; Doxorubicin

Northwestern University - Recruiting 18 years or older.
- An Investigator Initiated Multicenter Prospective Randomized Study of Chemoembolization Versus Radioembolization for the Treatment of Hepatocellular Carcinoma (PREMIERE Trial).
yttrium Y 90 glass microspheres; Cisplatin; Mitomycin; Doxorubicin

Glioblastoma, or Recurrent Metastatic Cancer to the Brain Clinical Trial using ExAblate 4000

InSightec - Recruiting 18 years to 70 years.
- A Feasibility Study to Evaluate the Safety and Feasibility of Transcranial MRI-Guided Focused Ultrasound Surgery in the Treatment of Brain Lesions.
ExAblate 4000

Cystoid Macular Edema, Cataract, or Diabetes Mellitus Clinical Trial using Bromfenac; Dexamethasone; Bevacizumab; Triamcinolone Acetonide

Maastricht University Medical Center - Recruiting 21 years or older.
- PRevention of Macular EDema After Cataract Surgery.
Bromfenac; Dexamethasone; Bevacizumab; Triamcinolone Acetonide

Glioma, or Metastatic Brain Cancer Clinical Trial using ExAblate Transcranial System

InSightec - Recruiting 18 years to 75 years.
- A Study to Evaluate the Safety and Feasibility of Transcranial MRI-Guided Focused Ultrasound Surgery in the Treatment of Brain Tumors.
ExAblate Transcranial System

Rotator Cuff Tear Clinical Trial using Regular Wait Time; Early Surgery

Panam Clinic - Recruiting 45 years to 70 years.
- Effect of Surgical Wait Times on Outcomes of Rotator Cuff Surgery.
Regular Wait Time; Early Surgery

Metastatic Squamous Neck Cancer With Occult Primary Squamous Cell Clinical Trial using tivantinib; cetuximab; laboratory biomarker analysis

National Cancer Institute (NCI) - Recruiting 18 years or older.
- A Randomized Phase II Trial of ARQ 197 (Tivantinib) /Cetuximab Versus Cetuximab in Patients With Recurrent/Metastatic Head and Neck Cancer.
tivantinib; cetuximab; laboratory biomarker analysis

Recurrent Thyroid Cancer Clinical Trial using lapatinib ditosylate; dabrafenib; pharmacological study; laboratory biomarker analysis

National Cancer Institute (NCI) - Recruiting 18 years or older.
- A Phase 1 Study of Dabrafenib in Combination With Lapatinib in BRAF Mutant Thyroid Cancer.
lapatinib ditosylate; dabrafenib; pharmacological study; laboratory biomarker analysis

Recurrent Melanoma, Stage IIIA Melanoma, Stage IIIB Melanoma, Sta Clinical Trial using dabrafenib; ipilimumab; trametinib; laboratory biomarker analysis

National Cancer Institute (NCI) - Recruiting 18 years or older.
- A Sequential Safety and Biomarker Study of BRAF-MEK Inhibition on the Immune Response in the Context of CTLA-4 Blockade for BRAF Mutant Melanoma.
dabrafenib; ipilimumab; trametinib; laboratory biomarker analysis

Estrogen Receptor-positive Breast Cancer, HER2-negative Breast Ca Clinical Trial using fulvestrant; anastrozole

Alliance for Clinical Trials in Oncology - Recruiting 18 years or older.
- Alternate Approaches for Clinical Stage II or III Estrogen Receptor Positive Breast Cancer Neoadjuvant Treatment (ALTERNATE) in Postmenopausal Women: A Phase III Study.
fulvestrant; anastrozole

Rectal Cancer Clinical Trial

Uppsala University - Recruiting 18 years or older.
- IPC Status as a Surgical Quality Marker in Rectal Cancer Surgery.

Adenocarcinoma of Head of Pancreas, Cholangio Carcinoma, Duodenal Clinical Trial using Open surgery; Laparoscopic surgery

GEM Hospital & Research Center - Recruiting 30 years to 70 years.
- A Prospective Randomized Parallel Group Trial : Laparoscopic Versus Open Pancreatoduodenectomy in Terms of Pathological Radicality & Severity Short Term of Complications According to Expanded Accordion Severity Grading System.
Open surgery; Laparoscopic surgery

Mandibular Fractures Clinical Trial using Tricalcium Phosphate / Chitosan; Autologous Graft

Instituto Mexicano del Seguro Social - Recruiting 18 years to 45 years.
- Therapeutic Efficacy of Tricalcium Phosphate and Chitosan as Bone Regenerator Versus Autologous Graft in Surgery for Mandibular Fracture.
Tricalcium Phosphate / Chitosan; Autologous Graft

Kidney Transplant Clinical Trial using Ropivacaine 500mg/100ml Naropeine; 0.9% sodium chloride BAXTER

Centre Hospitalier Universitaire Dijon - Recruiting 18 years or older.
- Transversus Abdominis Plane Block During Kidney Transplant Surgery: Prospective Controlled Randomized Double-blind Trial Comparing Ropivacaine 0.2% With Placebo..
Ropivacaine 500mg/100ml Naropeine; 0.9% sodium chloride BAXTER

Sacroiliac Joint Dysfunction Clinical Trial using SImmetry

Zyga Technology, Inc. - Recruiting 18 years or older.
- Evolusion Study Using the Zyga SImmetry Sacroiliac Joint Fusion System.
SImmetry

Glioblastoma, Small Cell Glioblastoma, Giant Cell Glioblastoma, G Clinical Trial using Bevacizumab; Rindopepimut (CDX-110) with GM-CSF; KLH

Celldex Therapeutics - Recruiting 18 years or older.
- A Phase II Study of Rindopepimut/GM-CSF in Patients With Relapsed EGFRvIII-Positive Glioblastoma.
Bevacizumab; Rindopepimut (CDX-110) with GM-CSF; KLH

Anxiety, Pain, or Surgical Site Infection Clinical Trial using cellular device/computers

Duke University - Recruiting 18 years or older.
- Using Mobile Phone Text Messaging and E-mailing to Decrease Anxiety, Pain, Follow-up Visits and Improve Reporting of Surgical Site Infection After Spine Surgery: A Double-Blind Randomized Trial.
cellular device/computers

Third Molar Extraction Clinical Trial using Placebo injection; Ropivacaine injection

Centre Hospitalier Universitaire de NÄ«mes - Recruiting 16 years to 65 years.
- Postoperative Analgesia in Third Molar Surgery Under General Anesthesia: Ropivacaine Versus Placebo.
Placebo injection; Ropivacaine injection

Inflammation and Pain Following Ocular Surgery Clinical Trial using RTA 408 0.5% Ophthalmic Suspension; RTA 408 1.0% Ophthalmic Suspension

Reata Pharmaceuticals, Inc. - Recruiting 18 years or older.
- A Multicenter, Randomized, Dose-Ranging, Double-Masked, Placebo-Controlled Phase 2 Study Evaluating the Safety and Efficacy of RTA 408 Ophthalmic Suspension for the Treatment of Ocular Inflammation and Pain Following Ocular Surgery.
RTA 408 0.5% Ophthalmic Suspension; RTA 408 1.0% Ophthalmic Suspension

Breast Cancer, or Lymphedema Clinical Trial using Supportive care (lymphedema education); Lymphedema Survey; bilateral upper extremities (BUE) measurements

Case Comprehensive Cancer Center - Recruiting 18 years or older.
- Effect of Intensive Education on Breast Cancer Patient's Understanding of Lymphedema.
Supportive care (lymphedema education); Lymphedema Survey; bilateral upper extremities (BUE) measurements

Respiratory Insufficiency Clinical Trial using TOSCA 500 monitor

Baylor Research Institute - Recruiting 18 years to 85 years.
- Pilot Study: Transcutaneous Carbon Dioxide Monitoring Post Cardiac Surgery: Incidence and Severity of Respiratory Insufficiency.
TOSCA 500 monitor

Knee Surgery, Arthroplasty, or Ligament Reconstruction Clinical Trial using AlgiScan

Centre Hospitalier Universitaire de NÄ«mes - Recruiting 18 years or older.
- Does the Measurement of Pupillary Reactivity to Painful Stimulation by an Automated Pupillometer Determine the Effectiveness of Local Anesthesia When Undergoing General Anesthesia?.
AlgiScan

Branched-chain Amino Acid Metabolism, or Insulin Sensitivity Clinical Trial using Pre-Diabetes Group - 6-mo Aerobic and Resistance combined exercise training; GBP Group - Non-diabetics intending to undergo Gastric Bypass surgery

Duke University - Recruiting 30 years to 65 years.
- Regulation of Branched-chain Amino Acid Metabolism in Pre-Diabetes: Responses to Exercise Training and Gastric Bypass Surgery.
Pre-Diabetes Group - 6-mo Aerobic and Resistance combined exercise training; GBP Group - Non-diabetics intending to undergo Gastric Bypass surgery

Ankle Osteoarthritis Clinical Trial using Total Ankle Replacement Surgery

Duke University - Recruiting 18 years to 95 years.
- Prospective Randomized Evaluation Of A Two And Three Piece Total Ankle Replacement.
Total Ankle Replacement Surgery

Shoulder Pain Clinical Trial using interscalene nerve catheter

Thomas Jefferson University - Recruiting 18 years or older.
- Comparison of In-Plane vs. Out-of-Plane Ultrasound-Guided Approach for Interscalene Nerve Catheters: a Prospective, Randomized Trial.
interscalene nerve catheter

Eye Manifestations Clinical Trial

Duke University - Recruiting 18 years or older.
- Intraoperative OCT Guidance of Intraocular Surgery.

Rectal Cancer Clinical Trial using Surgery after 11 weeks of delay after chemoradiotherapy.; Surgery after 7 weeks of delay after chemoradiotherapy

Assistance Publique - Hôpitaux de Paris - Recruiting 18 years or older.
- Randomized Control Trial Comparing the Impact of a Lengthening of the Interval Between the Radiochemotherapy and Surgery (7 Weeks vs. 11 Weeks) on Complete Pathological Response in Rectal Cancer.
Surgery after 11 weeks of delay after chemoradiotherapy.; Surgery after 7 weeks of delay after chemoradiotherapy

Chronic Pain Clinical Trial

Istituto Ortopedico Gaetano Pini - Recruiting 18 years or older.
- LA PREDISPOSIZIONE AL DOLORE PERSISTENTE POST OPERATORIO IN AMBITO ORTOPEDICO: ASPETTI GENETICI.

Surgical Conditions, Rating Scales, Laparoscopy, Neuromuscular Bl Clinical Trial using Rocuronium; sugammadex; placebo

Herlev Hospital - Recruiting 18 years or older.
- Validation of Subjective Rating Scales Used to Assess Surgical Conditions in Abdominal Surgery.
Rocuronium; sugammadex; placebo

Elective Knee Surgery Clinical Trial using InfinitiPlus (TM) needle system

The Cleveland Clinic - Recruiting 18 years to 85 years.
- Effect of InfinitiPlusTM Needle Guidance in Ultrasound Guided Regional Anesthesia.
InfinitiPlus (TM) needle system

Keloid Clinical Trial using RXI-109 Cohort 1; RXI-109 Cohort 2

RXi Pharmaceuticals, Corp. - Recruiting 21 years to 55 years.
- A Multi-Center, Prospective, Randomized, Single-Blind, Within-Subject Controlled, Phase 2a Study to Evaluate the Effectiveness and Safety of RXI-109 on the Outcome of Keloid Excision Surgery in Healthy Adults.
RXI-109 Cohort 1; RXI-109 Cohort 2

Pain, Postoperative Clinical Trial using Ropivacaine + Sufentanil; Ropivacaine

Hospices Civils de Lyon - Recruiting 18 years or older.
- Thoracic Paravertebral Block: a Comparative Study of Ropivacaine With Ropivacaine and Sufentanil for Treating Pain After Video-assisted Thoracic Surgery..
Ropivacaine + Sufentanil; Ropivacaine

Diabetic Foot Ulcers Clinical Trial using Electrohydraulic-generated shock wave; Sham device plus standard of care

SANUWAVE, Inc. - Recruiting 22 years or older.
- A Double-Blind, Multi-center, Randomized, Sham-Controlled, Parallel Group Comparison of the dermaPACE® (Pulsed Acoustic Cellular Expression) Device in Conjunction With Standard of Care Versus Standard of Care Alone in the Treatment of Diabetic Foot Ulcers.
Electrohydraulic-generated shock wave; Sham device plus standard of care

Amyotrophic Lateral Sclerosis (ALS) Clinical Trial using NeuRx® Diaphragm Pacing System™ (DPS)

State University of New York - Upstate Medical University - Recruiting 21 years or older.
- Multi-Center, Randomized Controlled Study of the NeuRx® Diaphragm Pacing System™ (DPS)In Participants With Amyotrophic Lateral Sclerosis (ALS).
NeuRx® Diaphragm Pacing System™ (DPS)

Body Fat Disorder Clinical Trial using The Zeltiq System

Zeltiq Aesthetics - Recruiting 18 years to 65 years.
- Non-Invasive Fat Layer Reduction in the Lateral Thighs With a Cryolipolysis System Using Varied Treatment Parameters.
The Zeltiq System

Body Fat Disorder Clinical Trial using The Zeltiq System

Zeltiq Aesthetics - Recruiting 18 years to 65 years.
- Non-Invasive Reduction of Subcutaneous Fat Layer With an Alternative Treatment Parameter.
The Zeltiq System

Multiple Sclerosis, Weakness, or Fatigue Clinical Trial using Cross-Training healthy subjects; Cross-Training multiple sclerosis; Standard-training multiple sclerosis

Università degli Studi di Sassari - Recruiting 18 years to 65 years.
- Neurophysiological, Dynamometric, Functional and Clinical Assessment of the Cross-Training Effect in Patients With Multiple Sclerosis.
Cross-Training healthy subjects; Cross-Training multiple sclerosis; Standard-training multiple sclerosis

Lymphedema, Stage IA Cervical Cancer, Stage IA Endometrial Carcin Clinical Trial using therapeutic lymphadenectomy; therapeutic conventional surgery; therapeutic laparoscopic surgery; study of high risk factors; questionnaire administration; psychosocial assessment and care; quality-of-life assessment

Gynecologic Oncology Group - Recruiting 18 years or older.
- The Lymphedema and Gynecologic Cancer (LEG) Study: Incidence, Risk Factors, and Impact in Newly Diagnosed Patients.
therapeutic lymphadenectomy; therapeutic conventional surgery; therapeutic laparoscopic surgery; study of high risk factors; questionnaire administration; psychosocial assessment and care; quality-of-life assessment

Cervical Cancer Clinical Trial using cisplatin; external beam radiation therapy; intensity-modulated radiation therapy

Gynecologic Oncology Group - Recruiting 18 years or older.
- Randomized Phase III Clinical Trial of Adjuvant Radiation Versus Chemoradiation in Intermediate Risk, Stage I/IIA Cervical Cancer Treated With Initial Radical Hysterectomy and Pelvic Lymphadenectomy.
cisplatin; external beam radiation therapy; intensity-modulated radiation therapy

Glioblastoma Clinical Trial using aldoxorubicin

CytRx - Recruiting 18 years or older.
- An Open-Label Pilot Phase 2 Study to Investigate the Preliminary Efficacy and Safety of Aldoxorubicin in Subjects With Unresectable Glioblastoma Whose Tumors Have Progressed Following Prior Treatment With Surgery, Radiation and Temozolomide.
aldoxorubicin

Long-term Effects Secondary to Cancer Therapy in Adults, or Vulva Clinical Trial using clinical observation; adjuvant therapy; sentinel lymph node biopsy; therapeutic conventional surgery; therapeutic lymphadenectomy; selective external radiation therapy

Gynecologic Oncology Group - Recruiting 18 years or older.
- Groningen International Study on Sentinel Nodes in Vulvar Cancer (GROINSS-V) II: An Observational Study.
clinical observation; adjuvant therapy; sentinel lymph node biopsy; therapeutic conventional surgery; therapeutic lymphadenectomy; selective external radiation therapy

Peripheral Vascular Surgical Bleeding Clinical Trial using Fibrin Sealant Grifols; Manual Compression

Grifols Biologicals Inc. - Recruiting N/A or older.
- A Prospective, Single-blind, Randomized, Phase III Study to Evaluate the Safety and Efficacy of Fibrin Sealant Grifols (FS Grifols) as an Adjunct to Hemostasis During Peripheral Vascular Surgery.
Fibrin Sealant Grifols; Manual Compression

Atherosclerosis of Autologous Vein Coronary Artery Bypass Graft(s Clinical Trial using eSVS Mesh treated saphenous vein graft; Control saphenous vein graft

Kips Bay Medical, Inc. - Recruiting 21 years to 80 years.
- A Multi-center, International Study of External Saphenous Vein Support Using eSVSr Mesh in CABG Surgery: The eMESH I Study.
eSVS Mesh treated saphenous vein graft; Control saphenous vein graft

Osteoarthritis, Osteoarthritis, Knee, or Osteonecrosis Clinical Trial using Signature Custom Guides; Conventional Instrumentation

Biomet, Inc. - Recruiting 21 years or older.
- A Global Comparison of Signature Guides and Conventional Instrumentation in the Oxford Partial Knee.
Signature Custom Guides; Conventional Instrumentation

Full Aniridia, or Partial Aniridia Clinical Trial using Artificial Iris (CustomFlex)

Clinical Research Consultants, Inc. - Recruiting 22 years or older.
- Safety and Effectiveness of the CustomFlex Artificial Iris Prosthesis for the Treatment of Iris Defects.
Artificial Iris (CustomFlex)

Endometrial Clear Cell Carcinoma, Endometrial Papillary Serous Ca Clinical Trial using cisplatin; paclitaxel; carboplatin; brachytherapy

Gynecologic Oncology Group - Recruiting 18 years or older.
- A Randomized Phase III Trial of Cisplatin and Tumor Volume Directed Irradiation Followed by Carboplatin and Paclitaxel vs. Carboplatin and Paclitaxel for Optimally Debulked, Advanced Endometrial Carcinoma.
cisplatin; paclitaxel; carboplatin; brachytherapy

Lower Extremity Chronic Ulcers in Diabetics Clinical Trial using CureXcellr; Sham injection

Macrocure Ltd. - Recruiting 18 years or older.
- A Phase III Multicenter, Randomized, Double-Blind, Parallel-Group, Sham-Controlled Study to Evaluate the Safety, Tolerability and Efficacy of CureXcellr as an Adjunct to Good Wound Care in Lower Extremity Chronic Ulcers in Adults With Diabetes Mellitus.
CureXcellr; Sham injection

Endometrial Cancer Clinical Trial using cisplatin; brachytherapy; external beam radiation therapy

Gynecologic Oncology Group - Recruiting N/A or older.
- A Randomized Trial of Pelvic Irradiation With or Without Concurrent Weekly Cisplatin in Patients With Pelvic-Only Recurrence of Carcinoma of the Uterine Corpus.
cisplatin; brachytherapy; external beam radiation therapy

Rheumatoid Arthritis Clinical Trial using GLPG0634; Placebo

Galapagos NV - Recruiting 18 years or older.
- Randomized, Double-blind, Placebo-controlled, Multicenter, Phase IIb Dose Finding Study of GLPG0634 Administered for 24 Weeks in Combination With Methotrexate to Subjects With Moderately to Severely Active Rheumatoid Arthritis Who Have an Inadequate Response to Methotrexate Alone.
GLPG0634; Placebo

Arteriovenous Fistula Clinical Trial using SRM003; Participating Site's standard practice

Shire Development LLC - Recruiting 18 years or older.
- A Phase 2, Single-blind, Randomized, Controlled, Multi-center Study to Evaluate the Efficacy and Safety of SRM003 (Vascugelr) in Improving the Rate of Arteriovenous Fistula Maturation and Use in Subjects Undergoing Surgery for Creation of an Arteriovenous Fistula for Hemodialysis Access.
SRM003; Participating Site's standard practice

Childhood Central Nervous System Choriocarcinoma, Childhood Centr Clinical Trial using therapeutic conventional surgery; 3-dimensional conformal radiation therapy; intensity-modulated radiation therapy; carboplatin; etoposide; ifosfamide

Children's Oncology Group - Recruiting 3 years to 21 years.
- Phase 2 Trial of Response-Based Radiation Therapy for Patients With Localized Central Nervous System Germ Cell Tumors (CNS GCT).
therapeutic conventional surgery; 3-dimensional conformal radiation therapy; intensity-modulated radiation therapy; carboplatin; etoposide; ifosfamide

Surgical Wound Infection, Infection; Cesarean Section, Cesarean S Clinical Trial using PICO from Smith&Nephew; Standard postoperative wound dressing

Odense University Hospital - Recruiting 18 years or older.
- Use of Incisional Negative Pressure Wound Therapy for Prevention of Postoperative Infections Following Caesarean Section in Women With BMI >=30.
PICO from Smith&Nephew; Standard postoperative wound dressing

Mitral Valvulopathy, or Atrial Fibrillation Clinical Trial using EPICOR; Amiodarone

Centre Hospitalier Universitaire de Saint Etienne - Recruiting 18 years or older.
- Comparison of Treatment of Atrial Fibrillation (AF) Between Surgical Ultrasonic Technology (EPICOR) or Drug Therapy (Cordarone) for Patients With AF Requiring Mitral Valve Surgery.
EPICOR; Amiodarone

Dupuytren's Disease Clinical Trial

Hospital for Special Surgery, New York - Recruiting 35 years or older.
- A Prospective Study to Validate Two New Patient Reported Outcome Measures for Dupuytren's Disease in Patients Treated With XIAFLEX.

Bladder Cancer Clinical Trial using Collect Blood and Survey Instruments

UNC Lineberger Comprehensive Cancer Center - Recruiting 18 years or older.
- PORCH: A Registry of Prospective Outcomes of Radical Cystectomy With or Without Chemotherapy.
Collect Blood and Survey Instruments

Deep Infiltrating Endometriosis (DIE) Clinical Trial using Triptorelin Acetate 3.75mg intramuscular injection

Ipsen - Recruiting 18 years or older.
- A Multi-centre, Prospective, Non-interventional Study to Describe the Efficacy of a Continuous up to 24-week Treatment of Diphereline 3.75mg Following Conservative Surgery in Deep Infiltrating Endometriosis (DIE) Patients Over a Period of 24 Months..
Triptorelin Acetate 3.75mg intramuscular injection

Pelvic Organ Prolapse, or PONV Clinical Trial using Dexamethasone; Placebo

TriHealth Inc. - Recruiting 18 years to 81 years.
- Effects of Preoperative Dexamethasone on Postoperative Quality of Recovery Following Vaginal Reconstructive Surgery: A Randomized Controlled Trial.
Dexamethasone; Placebo

Premedication, or Oculocardiac Reflex Clinical Trial using Dexmedetomidine; Ketamine

TC Erciyes University - Recruiting 2 years to 11 years.
- Intranasal Dexmedetomidine Versus Intranasal Midazolam-ketamine Combination for Premedication of Pediatric Patients Undergoing Strabismus Surgery.
Dexmedetomidine; Ketamine

Cervical Adenocarcinoma, Cervical Adenosquamous Cell Carcinoma, C Clinical Trial using laboratory biomarker analysis; lymphadenectomy

Gynecologic Oncology Group - Recruiting 18 years or older.
- Glycoprotein and Glycan Profiling in Patients With Locally Advanced Cervical Cancer (Stage IB2, IIA > 4 CM, IIB to IVA) Undergoing Pelvic and Para-Aortic (Abdominal) Lymphadenectomy.
laboratory biomarker analysis; lymphadenectomy

Arteriovenous Graft Clinical Trial using SRM003; Participating Site's standard practice

Shire Development LLC - Recruiting 18 years or older.
- A Phase 2, Single-blind, Randomized, Controlled, Multi-center Study to Evaluate the Efficacy and Safety of SRM003 (Vascugelr) in the Treatment of Subjects With Vascular Injury Resulting From Arteriovenous Graft Surgery for Hemodialysis Access.
SRM003; Participating Site's standard practice

Arthritis Clinical Trial using Birmingham Hip Resurfacing

Smith & Nephew, Inc. - Recruiting 20 years to 75 years.
- Birmingham Hip Resurfacing System (BHR) Post Approval Study: A Prospective, Multi-Centered Study of the Birmingham Hip Resurfacing System.
Birmingham Hip Resurfacing

Unspecified Adult Solid Tumor, Protocol Specific Clinical Trial using PI3K inhibitor BKM120; docetaxel; pharmacological study; questionnaire administration; laboratory biomarker analysis

Roswell Park Cancer Institute - Recruiting 18 years or older.
- A Phase I Study of the PI3-Kinase Inhibitor BKM120 in Combination With Docetaxel in Patients With Advanced Solid Tumors..
PI3K inhibitor BKM120; docetaxel; pharmacological study; questionnaire administration; laboratory biomarker analysis

Hemorrhage Clinical Trial using EVARRESTT Fibrin Sealant Patch; Standard of Care (SoC)

Ethicon, Inc. - Recruiting 18 years or older.
- A Phase III Randomized, Controlled, Superiority Study Evaluating EVARRESTT Fibrin Sealant Patch Versus Standard of Care Treatment in Controlling Parenchymal Bleeding During Hepatic Surgery.
EVARRESTT Fibrin Sealant Patch; Standard of Care (SoC)

Cardiovascular Disease Clinical Trial using EVARRESTT Fibrin Sealant Patch; Topical hemostat

Ethicon, Inc. - Recruiting 18 years or older.
- A Single-blinded, Randomized, Controlled, Comparative Phase III Study Evaluating the Safety and Effectiveness of EVARRESTT Fibrin Sealant Patch as an Adjunct to Hemostasis During Cardiovascular Surgery.
EVARRESTT Fibrin Sealant Patch; Topical hemostat

Invasive Ductal Carcinoma, or Ductal Carcinoma in Situ Clinical Trial using Intra-operative Radiation Therapy - IORT

Xoft, Inc. - Recruiting 40 years or older.
- A Safety and Efficacy Study of Intra-Operative Radiation Therapy (IORT) Using the Xoftr Axxentr eBxT System at the Time of Breast Conservation Surgery for Early Stage Breast Cancer.
Intra-operative Radiation Therapy - IORT

Reduction of Hypertrophic Skin Scarring Clinical Trial using PF-06473871

Pfizer - Recruiting 18 years to 55 years.
- A Phase 2, Randomized, Double-blind, Within-Subject, Placebo Controlled Study to Evaluate the Efficacy and Safety of PF-06473871 in Reducing Hypertrophic Skin Scarring.
PF-06473871

Ductal Breast Carcinoma in Situ, Estrogen Receptor-negative Breas Clinical Trial using therapeutic conventional surgery; radiation therapy; quality-of-life assessment

Roswell Park Cancer Institute - Recruiting 50 years or older.
- Phase II Trial of Single Fraction Radiation Therapy (SFRT) at Roswell Park Cancer Institute for Select Patients With Early Stage Breast Cancer.
therapeutic conventional surgery; radiation therapy; quality-of-life assessment

Surgery for Primary Lung Cancer Clinical Trial using Manufacturer (VPAP ST)

University Hospital, Brest - Recruiting 18 years or older.
- Evaluation of Non-Invasive Ventilation Preoperative Lung Resection Surgery.
Manufacturer (VPAP ST)

Ankle Fracture Clinical Trial using Exparel

Rutgers, The State University of New Jersey - Recruiting 18 years to 65 years.
- Exparel Use for Popliteal Nerve Block in Postoperative Pain Control; After Ankle Fracture Fixation or Ankle Fusion Surgery: a Case Series.
Exparel

Persistent Atrial Fibrillation, or Longstanding Persistent Atrial Clinical Trial using Synergy Ablation System

AtriCure, Inc. - Recruiting 18 years or older.
- AtriCure Synergy Ablation Lesions for Non-Paroxysmal Forms of Atrial Fibrillation Treatment During Concomitant On-Pump Endo/Epicardial Cardiac Surgery.
Synergy Ablation System

Hemorrhage, or Soft Tissue Bleeding Clinical Trial using EVARRESTT Fibrin Sealant Patch; Standard of Care

Ethicon, Inc. - Recruiting 18 years or older.
- A Non-Investigational Post-Market Trial Using EVARRESTT Fibrin Sealant Patch as an Adjunct to Hemostasis in Soft Tissue Bleeding During Intra-Abdominal, Retroperitoneal, Pelvic and Non-Cardiac Thoracic Surgery.
EVARRESTT Fibrin Sealant Patch; Standard of Care

Adult Primary Hepatocellular Carcinoma, Advanced Adult Primary Li Clinical Trial using yttrium Y 90 glass microspheres; laboratory biomarker analysis

Ohio State University Comprehensive Cancer Center - Recruiting 18 years or older.
- A Humanitarian Device Exemption Treatment Protocol of TheraSpherer For Treatment of Unresectable Hepatocellular Carcinoma.
yttrium Y 90 glass microspheres; laboratory biomarker analysis

Patients With Subjective Tinnitus Clinical Trial using real repetitive Transcranial Magnetic Stimulation; sham repetitive Transcranial Magnetic Stimulation

Dongtan Sacred Heart Hospital - Recruiting 18 years or older.
- Repetitive Transcranial Magnetic Stimulation (rTMS) Effect on Tinnitus.
real repetitive Transcranial Magnetic Stimulation; sham repetitive Transcranial Magnetic Stimulation

Diabetic Foot Ulcer Clinical Trial using ReCellr; skin graft

First Affiliated Hospital, Sun Yat-Sen University - Recruiting 18 years to 85 years.
- ReCellr Versus Classic Skin Grafts in Treatment of Diabetic Foot Ulcers: a Comparative Randomized Controlled Trial.
ReCellr; skin graft

Urinary Bladder, Neurogenic Clinical Trial using Fesoterodine 4 mg; Fesoterodine 8 mg; Oxybutynin; Fesoterodine

Pfizer - Recruiting 6 years to 16 years.
- A 12-Week Randomized, Open-Label, Active Comparator Period Followed By A 12-Week Safety Extension Period To Evaluate The Safety And Efficacy Of Fesoterodine In Subjects Aged 6 To 16 Years And >25 Kg With Symptoms Of Detrusor Overactivity Associated With A Neurological Condition (Neurogenic Detrusor Overactivity).
Fesoterodine 4 mg; Fesoterodine 8 mg; Oxybutynin; Fesoterodine

Adult Spinal Deformity Clinical Trial

AOSpine International - Recruiting 60 years or older.
- Prospective Evaluation of Elderly Deformity Surgery: A Prospective Observational, Multicenter Study.

Keratoconus, or Corneal Ectasia Clinical Trial using KXL System (15 mW/cm2); KXL System (30 mW/cm2); KXL System (45 mW/cm2); riboflavin ophthalmic solution

ACOS - Recruiting 12 years or older.
- A Multi-Center, Randomized, Controlled Evaluation of the Safety and Efficacy of the KXL System With VibeX (Riboflavin Ophthalmic Solution) for Corneal Collagen Cross-Linking in Eyes With Keratoconus or Corneal Ectasia After Refractive Surgery.
KXL System (15 mW/cm2); KXL System (30 mW/cm2); KXL System (45 mW/cm2); riboflavin ophthalmic solution

Glioma Clinical Trial using iMRI; conventional neuronavigation

Huashan Hospital - Recruiting 18 years to 70 years.
- 3.0T High-field Intraoperative MRI Guided Extent of Resection in Cerebral Glioma Surgery: a Single Center Prospective Randomized Triple-blind Controlled Clinical Trial.
iMRI; conventional neuronavigation

Post Operative Surgical Site Infection Clinical Trial using Supplemental Perioperative Oxygen

Major Extremity Trauma Research Consortium - Recruiting 18 years to 80 years.
- Supplemental Perioperative Oxygen to Reduce Surgical Site Infection After High Energy Fracture Surgery (OXYGEN Study).
Supplemental Perioperative Oxygen

Breast Cancer Clinical Trial

Ontario Clinical Oncology Group (OCOG) - Recruiting 60 years or older.
- A Prospective Cohort Study Evaluating Risk of Local Recurrence Following Breast Conserving Surgery and Endocrine Therapy in Low Risk Luminal A Breast Cancer.

Unspecified Adult Solid Tumor, Protocol Specific Clinical Trial using calcitriol; cisplatin; gemcitabine hydrochloride; pharmacological study

Roswell Park Cancer Institute - Recruiting 18 years or older.
- A Phase I Clinical Trial of Oral Calcitriol With Fixed Dose of Cisplatin and Gemcitabine in Patients With Advanced Solid Tumors.
calcitriol; cisplatin; gemcitabine hydrochloride; pharmacological study

Obesity Clinical Trial

Geisinger Clinic - Recruiting 18 years to 70 years.
- Physical Fitness and Macro- and Micro- Nutrient Intake in a Morbidly Obese Bariatric Surgery Population.

Acute Kidney Injury Clinical Trial using sodium bicarbonate; Saline

Yonsei University - Recruiting 20 years to 90 years.
- .
sodium bicarbonate; Saline

Carcinoma, Squamous Cell of Head and Neck Clinical Trial using Docetaxel, Cisplatin, Cetuximab and Bevacizumab (TPE-A) Followed by Concurrent Radiation, Cisplatin, Cetuximab and Bevacizumab (XPE-A), surgery

The University of Texas Health Science Center at San Antonio - Recruiting 18 years or older.
- A Phase II Study of Induction Docetaxel, Cisplatin, Cetuximab and Bevacizumab (TPE-A) Followed by Concurrent Radiation, Cisplatin, Cetuximab and Bevacizumab (XPE-A) in Patients With Locally Advanced Head and Neck Cancer (CTRC# 11-36).
Docetaxel, Cisplatin, Cetuximab and Bevacizumab (TPE-A) Followed by Concurrent Radiation, Cisplatin, Cetuximab and Bevacizumab (XPE-A), surgery

Coronary Artery Disease Clinical Trial using Angioshield

Neograft Technologies, Incorporated - Recruiting 18 years to 80 years.
- First-In-Human Study to Demonstrate the Preliminary Safety and Efficacy of the Angioshield System to Provide Mechanical Support for Vein Grafts Used in CABG Surgery.
Angioshield

Adult Primary Hepatocellular Carcinoma, Adult Primary Undifferent Clinical Trial using sorafenib tosylate; laboratory biomarker analysis

Roswell Park Cancer Institute - Recruiting N/A or older.
- Granzyme B Production as a Biomarker for the Immunomodulatory Activity of Sorafenib in HCC.
sorafenib tosylate; laboratory biomarker analysis

Epithelial Ovarian Cancer, Fallopian Tube Cancer, or Primary Peri Clinical Trial using pegylated liposomal doxorubicin (PLD); VTX-2337; Placebo

VentiRx Pharmaceuticals Inc. - Recruiting 18 years or older.
- A Randomized, Double-Blind, Placebo-Controlled Phase II Study of VTX-2337 in Combination With Pegylated Liposomal Doxorubicin (PLD) in Patients With Recurrent or Persistent Epithelial Ovarian, Fallopian Tube or Primary Peritoneal Cancer.
pegylated liposomal doxorubicin (PLD); VTX-2337; Placebo

Compression Fracture of Vertebral Body, Osteoporosis, or Cancer Clinical Trial using Balloon kyphoplasty

Medtronic Spinal and Biologics - Recruiting 65 years or older.
- A Prospective and Multicenter Evaluation of Outcomes for Quality of Life and Activities of Daily Living for Balloon Kyphoplasty in the Treatment of Vertebral Compression Fractures.
Balloon kyphoplasty

Postoperative Complications Clinical Trial using Incentive spirometry (IS); Breath Stacking (BS)

Federal University of Sao Paulo - Recruiting 18 years to 80 years.
- Comparison Between Incentive Spirometry and Breath Stacking After Cardiac Surgery.
Incentive spirometry (IS); Breath Stacking (BS)

Surgery, or Individuality Clinical Trial

Huazhong University of Science and Technology - Recruiting 18 years to 65 years.
- Association of CYP3A4 rs2242480 With Sufentanil Plasma Concentration and PCA Consumption.

Surgical Site Infections Clinical Trial using DFA-02 Antibiotic Gel; DFA-02 Placebo Gel

Dr. Reddy's Laboratories Limited - Recruiting 18 years or older.
- A Randomized, Blinded, Placebo and Standard of Care Controlled Efficacy, Safety, and Tolerability Study of up to 20 mL of DFA-02 in Patients Undergoing Abdominal Surgery.
DFA-02 Antibiotic Gel; DFA-02 Placebo Gel

Adult Acute Lymphoblastic Leukemia in Remission, Adult Nasal Type Clinical Trial using dasatinib; pharmacological study

National Cancer Institute (NCI) - Recruiting 18 years or older.
- Phase I Pharmacokinetic Study of Dasatinib (BMS-354825) (NSC-732517; IND-73969) in Patients With Advanced Malignancies and Varying Levels of Liver Dysfunction.
dasatinib; pharmacological study

Prostate Cancer Clinical Trial using Software for acquiring ultrasound and endoscopic images

University Hospital, Grenoble - Recruiting 18 years to 90 years.
- Merging of Endoscopic and Ultrasound Images for Laparoscopic Surgery.
Software for acquiring ultrasound and endoscopic images

Kidney Cancer Clinical Trial using everolimus; placebo

Southwest Oncology Group - Recruiting 18 years or older.
- EVEREST: EVErolimus for Renal Cancer Ensuing Surgical Therapy, A Phase III Study.
everolimus; placebo

Multi-organ Metastatic Colorectal Cancer Clinical Trial using XELOX regimen according to standard procedures; FOLFOX regimen according to standard procedures; Surgery; radiofrequency ablation (RFA); transarterial chemo-embolization using irinotecan drug-eluted beads ((DEBIRI-)TACE); stereotactic body radiation therapy (SBRT); Bevacizumab; tumor biopsy

VU University Medical Center - Recruiting 18 years or older.
- A Randomized Multicenter Clinical Trial for Patient With Multi-organ, Colorectal Cancer Metastases Comparing the Combination of Chemotherapy and Maximal Tumor Debulking Versus Chemotherapy Alone..
XELOX regimen according to standard procedures; FOLFOX regimen according to standard procedures; Surgery; radiofrequency ablation (RFA); transarterial chemo-embolization using irinotecan drug-eluted beads ((DEBIRI-)TACE); stereotactic body radiation therapy (SBRT); Bevacizumab; tumor biopsy

Recurrent Non-small Cell Lung Cancer, Stage IIA Non-small Cell Lu Clinical Trial using HPPH; therapeutic conventional surgery; photodynamic therapy

Roswell Park Cancer Institute - Recruiting 18 years or older.
- A Phase I Study of Surgery Plus Intraoperative Photodynamic Therapy (PDT) With Temoporfin in Patients With Resectable Primary Non-Small Cell Lung Cancer (NSCLC) With Ipsilateral Thoracic Nodal (N1 or N2) or T3/T4 Disease.
HPPH; therapeutic conventional surgery; photodynamic therapy

Pain, Postoperative, or Hepatocellular Carcinoma Clinical Trial using Pregabalin; Placebo (for Pregabalin)

Eastern Hepatobiliary Surgery Hospital - Recruiting 18 years to 70 years.
- A Randomized Placebo-Controlled Study of Whether Pre-operative Pregabalin 150 mg Will Improve Pain Control in Patients With Hepatocellular Carcinoma Undergoing Partial Hepatectomy.
Pregabalin; Placebo (for Pregabalin)

Coronary Artery Disease Clinical Trial

National Taiwan University Hospital - Recruiting 20 years to 75 years.
- Using Non-invasive Near Infra-red Spectroscopy to Measure the Regional Tissue Perfusion in Patients Receiving Off-pump Coronary Artery Bypass Graft Surgery.

Distal Urethral Cancer, Metastatic Transitional Cell Cancer of th Clinical Trial using eribulin mesylate; laboratory biomarker analysis; pharmacological study

National Cancer Institute (NCI) - Recruiting 18 years or older.
- A Phase I/II Study of E7389 Halichondrin B Analog (NSC # 707389) in Metastatic Urothelial Tract Cancer and Renal Insufficiency.
eribulin mesylate; laboratory biomarker analysis; pharmacological study

Inferior Alveolar Nerve Injury Clinical Trial using Third molar removal

Radboud University - Recruiting 18 years or older.
- The Efficacy of Cone Beam Computed Tomography (CBCT) Compared to Panoramic Radiography Prior to Third Molar Removal; a Multicentre Randomised Controlled Trial.
Third molar removal

Obesity Clinical Trial using placement of g-Cath EZ suture anchors; Sham procedure; Diet and Exercise

USGI Medical - Recruiting 22 years to 60 years.
- A RANDOMIZED, SUBJECT AND EVALUATOR-BLINDED, PARALLEL-GROUP, MULTICENTER CLINICAL TRIAL USING AN ENDOSCOPIC SUTURING DEVICE (G-CATH EZT SUTURE ANCHOR DELIVERY CATHETER) FOR PRIMARY WEIGHT LOSS.
placement of g-Cath EZ suture anchors; Sham procedure; Diet and Exercise

Emphysema Clinical Trial using EBV; Optimal Medical Management

Pulmonx, Inc. - Recruiting 40 years to 75 years.
- Lung Function Improvement After Bronchoscopic Lung Volume Reduction With Pulmonx Endobronchial Valves Used in Treatment of Emphysema.
EBV; Optimal Medical Management

Menorrhagia Clinical Trial using AEGEA Vapor System(TM)

Aegea Medical, Inc. - Recruiting 30 years to 50 years.
- A Prospective, Multicenter, Clinical Trial to Evaluate the Safety and Effectiveness of the AEGEA Vapor System for the Treatment of Excessive Uterine Bleeding.
AEGEA Vapor System(TM)

Anal Cancer, Nonneoplastic Condition, Penile Cancer, or Precancer Clinical Trial using quadrivalent human papillomavirus (types 6, 11, 16, 18) recombinant vaccine; laboratory biomarker analysis

AIDS Malignancy Clinical Trials Consortium - Recruiting 13 years to 26 years.
- AMC-072: Protective Effect of Quadrivalent Vaccine in Young HIV-Positive Males Who Have Sex With Males.
quadrivalent human papillomavirus (types 6, 11, 16, 18) recombinant vaccine; laboratory biomarker analysis

Prostate Cancer Clinical Trial using TAK-700; Bicalutamide

Southwest Oncology Group - Recruiting 18 years or older.
- A Phase III Randomized Trial Comparing Androgen Deprivation Therapy + TAK-700 With Androgen Deprivation Therapy + Bicalutamide in Patients With Newly Diagnosed Metastatic Sensitive Prostate Cancer.
TAK-700; Bicalutamide

Image-Guided Surgery Clinical Trial using 3D Roadmap software

National Institutes of Health Clinical Center (CC) - Recruiting 18 years or older.
- Prospective Randomized Multicenter Trial Comparing Navigation With 3D Roadmap vs. Conventional Angiography During Transarterial Embolization.
3D Roadmap software

Colorectal Cancer, Liver Metastasis, or Colorectal Adenocarcinoma Clinical Trial using Sulindac; Placebo

National Institutes of Health Clinical Center (CC) - Recruiting 18 years or older.
- Phase 2 Prospective Randomized Double Blind Trial Comparing Metastasectomy Plus Sulindac Versus Metastasectomy Alone in Patients With Stage IV Colorectal Cancer.
Sulindac; Placebo

Acute Kidney Injury Clinical Trial using AC607; Vehicle Only

AlloCure Inc. - Recruiting 21 years or older.
- A Randomized, Multicenter, Double-Blind, Placebo-Controlled Study of AC607 for the Treatment of Acute Kidney Injury in Cardiac Surgery Subjects.
AC607; Vehicle Only

Epilepsy, Epilepsy, Temporal Lobe, or Partial Epilepsy Clinical Trial using Surgery

National Institutes of Health Clinical Center (CC) - Recruiting 8 years or older.
- Surgery as a Treatment for Medically Intractable Epilepsy.
Surgery

Acinar Cell Adenocarcinoma of the Pancreas, Duct Cell Adenocarcin Clinical Trial using vismodegib; sirolimus; positron emission tomography; computed tomography; pharmacological study; laboratory biomarker analysis; fludeoxyglucose F 18

Mayo Clinic - Recruiting 18 years or older.
- Phase I Trial of The Combination of Vismodegib and Sirolimus.
vismodegib; sirolimus; positron emission tomography; computed tomography; pharmacological study; laboratory biomarker analysis; fludeoxyglucose F 18

Tuberculosis Clinical Trial using RIF; INH; PZA; KM; MXF

National Institutes of Health Clinical Center (CC) - Recruiting 20 years or older.
- Pharmacokinetics of Standard First and Second Line Anti-TB Drugs in the Lung and Lesions of Subjects Elected for Resection Surgery.
RIF; INH; PZA; KM; MXF

Colorectal Neoplasms, Gastric Neoplasms, Cholangiocarcinoma, Bile Clinical Trial

National Institutes of Health Clinical Center (CC) - Recruiting 18 years to 90 years.
- Tumor, Normal Tissue and Specimens From Patients Undergoing Evaluation or Surgical Resection of Solid Tumors.

Adrenocortical Carcinoma, or Peritoneal Carcinomatosis Clinical Trial using Surgical resection and debulking; Heated intraperitoneal chemotherapy; Cisplatin

National Institutes of Health Clinical Center (CC) - Recruiting 18 years or older.
- Phase II Trial of Surgical Resection and Heated Intraperitoneal Peritoneal Chemotherapy (HIPEC) for Adrenocortical Carcinoma.
Surgical resection and debulking; Heated intraperitoneal chemotherapy; Cisplatin

Pain Clinical Trial using ropivacaine, ketorelac and epinephrine; Placebo

G”teborg University - Recruiting 18 years to 75 years.
- Local Infiltration Analgesia After Abdominal Hysterectomy.
ropivacaine, ketorelac and epinephrine; Placebo

Ductal Breast Carcinoma in Situ, Invasive Ductal Breast Carcinoma Clinical Trial using Behavioral dietary intervention; Therapeutic conventional surgery; Radiation therapy; Counseling intervention; Quality-of-life assessment

Thomas Jefferson University - Recruiting 18 years or older.
- A Feasibility Pilot Trial Evaluating Caloric Restriction for Oncology Research in Early Stage Breast Cancer Patients.
Behavioral dietary intervention; Therapeutic conventional surgery; Radiation therapy; Counseling intervention; Quality-of-life assessment

Surgical Blood Loss, or Postoperative Blood Loss Clinical Trial using Fibrinogen Concentrate (Human) (FCH); Placebo

CSL Behring - Recruiting 18 years or older.
- REPLACE (Randomized Evaluation of Fibrinogen Versus Placebo in Complex Cardiovascular Surgery): a Prospective, Multinational, Multicenter, Randomized, Double-blind, Placebo-controlled, Phase III Study for the Use of Fibrinogen Concentrate (Human) (FCH) in Complex Cardiovascular Surgery.
Fibrinogen Concentrate (Human) (FCH); Placebo

Fallopian Tube Cancer, Metastatic Cancer, Ovarian Cancer, or Peri Clinical Trial using carboplatin; cisplatin; paclitaxel; quality-of-life assessment

NCIC Clinical Trials Group - Recruiting 18 years or older.
- A Phase II/III Study of Intraperitoneal (IP) Plus Intravenous (IV) Chemotherapy Versus IV Carboplatin Plus Paclitaxel in Patients With Epithelial Ovarian Cancer Optimally Debulked at Surgery Following Neoadjuvant Intravenous Chemotherapy.
carboplatin; cisplatin; paclitaxel; quality-of-life assessment

Urinary Incontinence Clinical Trial using Surgery; Medical Treatment

University of British Columbia - Recruiting 5 years to 18 years.
- Treatment of Persistent Urinary Incontinence in Children.
Surgery; Medical Treatment

Endometriosis Clinical Trial using Surgery for endometriosis

The Cleveland Clinic - Recruiting 18 years or older.
- Laparoscopy vs. Robotic Surgery for Endometriosis (LAROSE): a Prospective Randomized Controlled Trial.
Surgery for endometriosis

Vulvar Neoplasm Clinical Trial using Surgery, radiotherapy and chemotherapy; Surgery

Instituto do Cancer do Estado de Sao Paulo - Recruiting 18 years or older.
- New Strategy for the Treatment of Vulvar Cancer Employing Sentinel Scintigraphy, Surgery, Chemotherapy, and Radiotherapy.
Surgery, radiotherapy and chemotherapy; Surgery

Breast Cancer Clinical Trial using dynamic contrast-enhanced ultrasound imaging; shear wave elastography

University of Southern California - Recruiting 18 years or older.
- Real Time Contrast Enhanced Ultrasound and Ultrasound-Based Elastography: Novel Techniques in Assessment of Treatment Response to Neoadjuvant Chemotherapy for Breast Cancer.
dynamic contrast-enhanced ultrasound imaging; shear wave elastography

Total Knee Arthroplasty(TKA) Clinical Trial using soft tissue repair in flexion position; soft tissue repair in extension position

Isfahan University of Medical Sciences - Recruiting N/A or older.
- .
soft tissue repair in flexion position; soft tissue repair in extension position

Stage IIIA Fallopian Tube Cancer, Stage IIIA Ovarian Epithelial C Clinical Trial using IDO1 inhibitor INCB024360; therapeutic conventional surgery; laboratory biomarker analysis

National Cancer Institute (NCI) - Recruiting 19 years or older.
- A Pilot Study of the Immunological Effects of Neo-Adjuvant INCB024360 in Patients With Epithelial Ovarian, Fallopian Tube or Primary Peritoneal Carcinoma.
IDO1 inhibitor INCB024360; therapeutic conventional surgery; laboratory biomarker analysis

Post Operative Pain Clinical Trial using IV Acetaminophen

TriHealth Inc. - Recruiting 18 years to 70 years.
- The Effect of Intravenous Acetaminophen on Post-operative Pain and Narcotic Consumption in Vaginal Reconstructive Surgery Patients: A Randomized Controlled Trial.
IV Acetaminophen

Antithrombin III Deficiency Clinical Trial using Plasma-derived AT-III concentrate

Grifols Biologicals Inc. - Recruiting 12 years or older.
- A Phase II/III Pivotal Trial Evaluating the Safety, Pharmacokinetic Properties and Efficacy of a Plasma-Derived Anti-thrombin III Concentrate With Administration in Surgery, Pregnancy and Thromboembolic or Thrombotic Events..
Plasma-derived AT-III concentrate

Obesity, Morbid, or Diabetes Mellitus Type 2 Clinical Trial

Merck Sharp & Dohme Corp. - Recruiting 20 years to 60 years.
- Gut Hormone Profiling in Peripheral Blood After Bariatric Surgery in Obese Patients With Type 2 Diabetes.

Endometriosis Clinical Trial using Desogestrel; Placebo capsule

Mahidol University - Recruiting 18 years to 45 years.
- A Prospective Double Blind Randomized Controlled Trial to Study the Effectiveness of a Desogestrel for the Treatment of Pelvic Pain or Dysmenorrhea in the Patients Undergone Conservative Surgery for Pelvic Endometriosis.
Desogestrel; Placebo capsule

Brain Tumor Clinical Trial using SVV; CVP

Yonsei University - Recruiting 20 years to 65 years.
- .
SVV; CVP

Surgery, Anesthesia, or Pain Clinical Trial using Endotracheal intubation; Deep Sedation; Fentanyl (Sublimaze TM); fluoromethyl hexafluoroisopropyl ether (Sevoflurane TM); Succinylcholine (Suxamethonium chloride); Rocuronium (Zemuron TM); Propofol (Diprivan TM); Ketamine

Northwestern University - Recruiting 18 years or older.
- A Comparison of the Effect of Intravenous Sedation Versus General Anesthesia in Patients Undergoing Minor Gynecologic Surgery.
Endotracheal intubation; Deep Sedation; Fentanyl (Sublimaze TM); fluoromethyl hexafluoroisopropyl ether (Sevoflurane TM); Succinylcholine (Suxamethonium chloride); Rocuronium (Zemuron TM); Propofol (Diprivan TM); Ketamine

Pain Clinical Trial using Saline; Ketamine continuous infusion

Northwestern University - Recruiting 18 years to 65 years.
- Analgesic Effect of Ketamine in Patients Undergoing Hysteroscopic Endometrial Thermal Ablation Surgery.
Saline; Ketamine continuous infusion

Lower Extremity Surgery, Surgical Site Infection, Bacterial Colon Clinical Trial using Chloraprep

Sanford Health - Recruiting 18 years or older.
- Role of Post-operative Re-application of Chloraprepr Following Lower Extremity Surgeries on Surgical Site Bacterial Colonization..
Chloraprep

Gastric Cancer With Metabolic Syndrome or Metabolic Disease Clinical Trial using subtotal gastrectomy with gastroduodenostomy; subtotal gastrectomy with Roux-en-Y gastrojejunostomy,; total gastrectomy with Rou-en-Y esophagojejunostomy

Yonsei University - Recruiting 20 years to 80 years.
- .
subtotal gastrectomy with gastroduodenostomy; subtotal gastrectomy with Roux-en-Y gastrojejunostomy,; total gastrectomy with Rou-en-Y esophagojejunostomy

Orthognathic Surgery Clinical Trial using b-blocker(Atenolol); ACE inhibitor(Enapril); control

Yonsei University - Recruiting 18 years to 29 years.
- .
b-blocker(Atenolol); ACE inhibitor(Enapril); control

Postoperative Analgesia, or Opioid Consumption Clinical Trial using Bupivacaine; Dexmedetomidine; serum physiologic

TC Erciyes University - Recruiting 18 years to 65 years.
- Postoperative Analgesic Effects of Dexmedetomidine Added to Bupivacaine for Transversus Abdominis Plane Block for Lower Abdominal Surgery.
Bupivacaine; Dexmedetomidine; serum physiologic

Sarcoma Clinical Trial using therapeutic conventional surgery; 3-dimensional conformal radiation therapy

European Organisation for Research and Treatment of Cancer - EORTC - Recruiting 18 years or older.
- A Phase III Randomized Study of Preoperative Radiotherapy Plus Surgery Versus Surgery Alone for Patients With Retroperitoneal Sarcoma (RPS).
therapeutic conventional surgery; 3-dimensional conformal radiation therapy

Hematoma Clinical Trial using Dabigatran

University of Ottawa Heart Institute - Recruiting 18 years or older.
- A Randomized Controlled Trial to Investigate Whether a Strategy of Continued Versus Interrupted Dabigatran at the Time of Device Surgery, in Patients With Moderate to High Risk of Arterial Thrombo-embolic Events, Leads to a Reduction in the Incidence of Clinically Significant Hematoma.
Dabigatran

Osteoarthritis, or Cardiovascular Disease Clinical Trial using Metoprolol; Lisinopril; Atorvastatin; Lifestyle counseling

New York University School of Medicine - Recruiting 21 years or older.
- OPTMIZE-OS: Optimization of Pre-surgical Testing With an Intensive Multifactorial Intervention to MinimiZe Cardiovascular Events in Orthopedic Surgery.
Metoprolol; Lisinopril; Atorvastatin; Lifestyle counseling

Cardiovascular Diseases, Coronary Disease, Coronary Artery Diseas Clinical Trial using cardiac catheterization; coronary artery bypass graft surgery; percutaneous coronary intervention; Lifestyle; Medication

New York University School of Medicine - Recruiting 21 years or older.
- International Study of Comparative Health Effectiveness With Medical and Invasive Approaches (ISCHEMIA).
cardiac catheterization; coronary artery bypass graft surgery; percutaneous coronary intervention; Lifestyle; Medication

Breast Cancer Clinical Trial using microarray analysis; breast biopsy

Georgetown University - Recruiting 18 years or older.
- Pilot Study for Analysis of Tumor Gene Expression by DNA Microarray Analysis in Patients Undergoing Breast Cancer Surgery or Core Biopsy Sampling.
microarray analysis; breast biopsy

Macular Holes Clinical Trial

Wenzhou Medical University - Recruiting 18 years to 80 years.
- Macular Hole Surgery With and Without Internal Limiting Membrane Peeling:A Systematic Review and Meta-analysis.

Colorectal Cancer Clinical Trial using Early urinary catheter removal

Stanford University - Recruiting 18 years or older.
- Early Removal of Urinary Catheters in Patients After Rectal Surgery: a Prospective Study.
Early urinary catheter removal

Burns Clinical Trial using Flamazine; BCT Antimicrobial Dressing

Bio-medical Carbon Technology Co., Ltd. - Recruiting 20 years to 80 years.
- To Study the Healing Effect of Nano Silver Impregnated Activated Carbon Wound Dressing on Superficial Dermal Burn.
Flamazine; BCT Antimicrobial Dressing

Arthroplasty, Replacement, Hip Clinical Trial using Restoration ADM X3 Device

Stryker Orthopaedics - Recruiting 18 years to 75 years.
- A Prospective, Post-market, Multi-center Study of the Restorationr ADM X3r Acetabular System.
Restoration ADM X3 Device

Pelvic Organ Prolapse Clinical Trial using Axis

Coloplast A/S - Recruiting 18 years or older.
- .
Axis

Burns Clinical Trial using BCT Antimicrobial Dressing; Flamazine

Bio-medical Carbon Technology Co., Ltd. - Recruiting 20 years to 80 years.
- To Study the Healing Effect of Nano Silver Impregnated Activated Carbon Wound Dressing on Deep Dermal Burn.
BCT Antimicrobial Dressing; Flamazine

Esophageal Cancer, Gastroesophageal Reflux Disease, Esophageal Di Clinical Trial using Survey of client health, personal habits, family history; Blood specimen for non-DNA and DNA parts; Biopsy of esophageal/stomach tissue, lymph nodes, tumor; Biopsies from routine clinical surveillance endoscopies

University of Pittsburgh - Recruiting 18 years or older.
- Esophageal Cancer Risk Registry.
Survey of client health, personal habits, family history; Blood specimen for non-DNA and DNA parts; Biopsy of esophageal/stomach tissue, lymph nodes, tumor; Biopsies from routine clinical surveillance endoscopies

Lung Cancer Clinical Trial using Cervical mediastinoscopy

Centre hospitalier de l'Universit‚ de Montr‚al (CHUM) - Recruiting 18 years or older.
- Cervical Video Assisted Thoracoscopic Surgery (C-VATS)Using a Flexible Endoscope for Thoracoscopy.
Cervical mediastinoscopy

Advanced Melanoma Clinical Trial using paclitaxel albumin-stabilized nanoparticle formulation

Mayo Clinic - Recruiting 18 years or older.
- .
paclitaxel albumin-stabilized nanoparticle formulation

Glioblastoma Clinical Trial using Blood draw - biomarkers; MRI-guided Laser Heat Ablation (MLA); Doxorubicin

Washington University School of Medicine - Recruiting 18 years or older.
- A Pilot Study of Using MRI-Guided Laser Heat Ablation to Induce Disruption of the Peritumoral Blood Brain Barrier to Enhance Delivery and Efficacy of Doxorubicin in the Treatment of Recurrent Glioblastoma Multiforme.
Blood draw - biomarkers; MRI-guided Laser Heat Ablation (MLA); Doxorubicin

Cardiac Surgery Clinical Trial using NeuroSave device

NeuroSave Inc. - Recruiting 18 years or older.
- Targeted Cerebral Hypothermia During Cardiac Surgery: A Feasibility Trial.
NeuroSave device

Lymphedema, Perioperative/Postoperative Complications, Stage IA V Clinical Trial using bioimpedance spectroscopy; therapeutic conventional surgery; lymphadenectomy

Gynecologic Oncology Group - Recruiting 18 years or older.
- A Limited Access Phase II Trial Utilizing Bioimpedance to Measure Lower Extremity Lymphedema Associated With the Surgical Management of a Vulvar Cancer.
bioimpedance spectroscopy; therapeutic conventional surgery; lymphadenectomy

Cervical Adenocarcinoma, Cervical Adenosquamous Cell Carcinoma, C Clinical Trial using quality-of-life assessment; questionnaire administration; cone biopsy; loop electrosurgical excision procedure

Gynecologic Oncology Group - Recruiting 18 years or older.
- Evaluation of Physical Function and Quality of Life (QOL) Before and After Non-Radical Surgical Therapy (Extra Fascial Hysterectomy or Cone Biopsy With Pelvic Lymphadenectomy) for Stage IA1 (LVSI+) and IA2-IB1 (=/<2CM) Cervical Cancer.
quality-of-life assessment; questionnaire administration; cone biopsy; loop electrosurgical excision procedure

Actinic Keratosis Clinical Trial using ingenol mebutate

LEO Pharma - Recruiting 18 years or older.
- Efficacy and Safety of Ingenol Mebutate Gel 0.06% When Applied Once Daily for 2, 3 or 4 Consecutive Days to a Treatment Area of Approximately 250 cm2 on Trunk and Extremities in Subjects With Actinic Keratosis.
ingenol mebutate

Breast Neoplasms Clinical Trial using Aromasin (exemestane)

Pfizer - Recruiting 18 years or older.
- A Prospective Non-Interventional Study Of China Early Invasive Breast Cancer Patients Receiving Adjuvant Therapy With Aromasinr.
Aromasin (exemestane)

Hemorrhoids Clinical Trial using Transanal Haemorrhoidal Dearterialization; Open Haemorrhoidectomy

Holbaek Sygehus - Recruiting 18 years to 85 years.
- Transanal Haemorrhoidal Dearterialization (THD) Versus Open Haemorrhoidectomy for the Treatment of Haemorrhoids. An Open Prospective Randomized Study..
Transanal Haemorrhoidal Dearterialization; Open Haemorrhoidectomy

Basal Cell Carcinoma Clinical Trial using vismodegib; Placebo

Hoffmann-La Roche - Recruiting 18 years or older.
- A Randomized, Double-Blind, Placebo-Controlled, Phase II Study To Assess The Efficacy And Safety Of Oral Vismodegib For The Treatment Of Basal Cell Carcinoma Preceding Excision By Mohs Micrographic Surgery.
vismodegib; Placebo

Estrogen Receptor-negative Breast Cancer, Estrogen Receptor-posit Clinical Trial using zoledronic acid; laboratory biomarker analysis; therapeutic conventional surgery

City of Hope Medical Center - Recruiting N/A or older.
- A Pilot Study of the Impact of a Single Dose of Zoledronic Acid on Biomarkers in Breast Cancer.
zoledronic acid; laboratory biomarker analysis; therapeutic conventional surgery

Duct Cell Adenocarcinoma of the Pancreas, Recurrent Pancreatic Ca Clinical Trial using ipilimumab; gemcitabine hydrochloride; laboratory biomarker analysis

Northwestern University - Recruiting 18 years or older.
- Ipilimumab and Gemcitabine for Advanced Pancreas Cancer: A Phase Ib Study.
ipilimumab; gemcitabine hydrochloride; laboratory biomarker analysis

Malnourishment, or Gastrointestinal Tumors Clinical Trial using Glutamine; Placebo

University Hospital Inselspital, Berne - Recruiting N/A or older.
- The Impact of Preoperative Oral Glutamine Intake on the Immunocompetence and Outcomes of Malnourished Patients Undergoing Major Abdominal Surgery Due to Malignancies - A Randomized, Placebo-controlled Pilot Study.
Glutamine; Placebo

Acinar Cell Adenocarcinoma of the Pancreas, Duct Cell Adenocarcin Clinical Trial using gemcitabine hydrochloride; dasatinib; erlotinib hydrochloride

National Cancer Institute (NCI) - Recruiting 18 years or older.
- A Phase 1 Study of Gemcitabine, Dasatinib and Erlotinib in Patients With Advanced Pancreatic Carcinoma.
gemcitabine hydrochloride; dasatinib; erlotinib hydrochloride

Non-Small Cell Lung Cancer Clinical Trial using Tarceva (erlotinib)

Albert Einstein College of Medicine of Yeshiva University - Recruiting 18 years or older.
- EValuation of Erlotinib as a Neoadjuvant Therapy in Stage III Non-small Cell Lung Cancer Patients With EGFR Mutations (EVENT Trial)..
Tarceva (erlotinib)

General Anesthesia Clinical Trial using Remimazolam; Propofol; Sevoflurane; Remifentanil; Fentanyl; Rocuronium

Paion UK Ltd. - Recruiting 18 years or older.
- A Randomized, Single-blind Phase II Study Evaluating the Efficacy, Safety and Pharmacokinetics of Remimazolam in General Anesthesia in Adult Patients Undergoing Cardiac Surgery, Including Follow-up Sedation in the PACU/ICU.
Remimazolam; Propofol; Sevoflurane; Remifentanil; Fentanyl; Rocuronium

Recurrent Non-small Cell Lung Cancer, Stage IIB Non-small Cell Lu Clinical Trial using trametinib; carboplatin; paclitaxel; intensity-modulated radiation therapy; 3-dimensional conformal radiation therapy; image-guided radiation therapy; pharmacological study; laboratory biomarker analysis

National Cancer Institute (NCI) - Recruiting 18 years or older.
- A Phase 1 Study of Trametinib in Combination With Chemoradiation for KRAS Mutant Non-Small Cell Lung Cancer.
trametinib; carboplatin; paclitaxel; intensity-modulated radiation therapy; 3-dimensional conformal radiation therapy; image-guided radiation therapy; pharmacological study; laboratory biomarker analysis

Recurrent Melanoma, Stage IIIA Melanoma, Stage IIIB Melanoma, Sta Clinical Trial using dabrafenib; trametinib; navitoclax; pharmacological study; laboratory biomarker analysis

National Cancer Institute (NCI) - Recruiting 18 years or older.
- Phase I/II Study of Dabrafenib, Trametinib, and Navitoclax in BRAF Mutant Melanoma and Other Solid Tumors.
dabrafenib; trametinib; navitoclax; pharmacological study; laboratory biomarker analysis

Postoperative Ileus Clinical Trial using Electroacupuncture

Chinese University of Hong Kong - Recruiting 18 years to 80 years.
- Can Electroacupuncture Prevent Prolonged Ileus After Laparoscopic Surgery for Mid and Low Rectal Cancer? A Prospective Study With Matched Historical Controls.
Electroacupuncture

Non-small Cell Lung Cancer Clinical Trial using clinical observation; adjuvant therapy; 3-dimensional conformal radiation therapy

Gustave Roussy, Cancer Campus, Grand Paris - Recruiting 18 years or older.
- Phase III Study Comparing Post-Operative Conformal Radiotherapy to No Post-Operative Radiotherapy in Patients With Completely Resected Non-Small Cell Lung Cancer and Mediastinal N2 Involvement [Lung ART].
clinical observation; adjuvant therapy; 3-dimensional conformal radiation therapy

Adult Primary Hepatocellular Carcinoma, Advanced Adult Primary Li Clinical Trial using tivozanib; pharmacological study; laboratory biomarker analysis

Roswell Park Cancer Institute - Recruiting 18 years or older.
- Multicenter Phase 1b/2 Study of Tivozanib in Patients With Advanced Inoperable Hepatocellular Carcinoma.
tivozanib; pharmacological study; laboratory biomarker analysis

Postoperative Ileus Clinical Trial using Electroacupuncture; Fast-track program

Chinese University of Hong Kong - Recruiting 18 years to 80 years.
- A Randomized Clinical Trial of Electroacupuncture Versus Fast-track Perioperative Program for Reducing Duration of Postoperative Ileus and Hospital Stay After Laparoscopic Colorectal Surgery.
Electroacupuncture; Fast-track program

Atrial Fibrillation, or Subclinical Hyperthyroidism Clinical Trial

Karolinska Institutet - Recruiting 18 years or older.
- Observational Prospective Case-control Study on Prevalence and Impact of Subclinical Hyperthyroidism in Patients Undergoing Atrial Fibrillation Ablation.

Obesity, or Extreme Obesity Clinical Trial using bariatric surgery; conservative care

University of Ulm - Recruiting 14 years to 25 years.
- Effectiveness and Safety of Weight Loss Surgery in Adolescents With Extreme Obesity Within a Structured Pre- and Post-surgery Treatment Program, Subproject 3.
bariatric surgery; conservative care

Hearing Loss, Deafness, Hearing Disorders, Ear Diseases, or Otorh Clinical Trial using HiResT 90K Advantage implant with HiFocusT Mid-Scala electrode

Advanced Bionics - Recruiting 18 years or older.
- Evaluation of Hearing Preservation in Adults With Partial Low-Frequency Hearing Implanted With the HiFocusT Mid-Scala Electrode.
HiResT 90K Advantage implant with HiFocusT Mid-Scala electrode

Breast Cancer Clinical Trial using One-stage dermal matrix/implant procedure; Two-stage tissue expander/implant procedure

University Health Network, Toronto - Recruiting 18 years to 75 years.
- Acellular Dermal Matrix in One-Stage Breast Reconstruction: A RCT.
One-stage dermal matrix/implant procedure; Two-stage tissue expander/implant procedure

Ulcerative Colitis Clinical Trial using tofacitinib; Placebo

Pfizer - Recruiting 18 years or older.
- Double-Blind, Placebo-Controlled, Parallel-Group Study Of Oral CP-690,550 As An Induction Therapy In Subjects With Moderate To Severe Ulcerative Colitis.
tofacitinib; Placebo

Diabetic Foot Ulcers Clinical Trial using DSC127; placebo vehicle gel; Standard of Care gel, Aquasite

Derma Sciences, Inc. - Recruiting 18 years or older.
- A Randomized, Double-Blind, Parallel-group, Vehicle and Standard of Care-controlled Phase 3 Clinical Trial to Evaluate the Efficacy and Safety of DSC127 in Treating Non-healing Foot Ulcers in Subjects With Diabetes Mellitus.
DSC127; placebo vehicle gel; Standard of Care gel, Aquasite

NSCLC (Non-small Cell Lung Cancer) Clinical Trial using Crizotinib; Pemetrexed/Cisplatin; Pemetrexed/Carboplatin

Pfizer - Recruiting 18 years to 70 years.
- Phase 3, Randomized, Open-Label Study Of The Efficacy And Safety Of Crizotinib Versus Pemetrexed/Cisplatin Or Pemetrexed/Carboplatin In Previously Untreated East Asian Patients With Non-Squamous Carcinoma Of The Lung Harboring A Translocation Or Inversion Event Involving The Anaplastic Lymphoma Kinase (ALK) Gene Locus.
Crizotinib; Pemetrexed/Cisplatin; Pemetrexed/Carboplatin

Breast Cancer Clinical Trial using palliative surgery; therapeutic conventional surgery; palliative radiation therapy; radiation therapy

Eastern Cooperative Oncology Group - Recruiting 18 years or older.
- A Randomized Phase III Trial of the Value of Early Local Therapy for the Intact Primary Tumor in Patients With Metastatic Breast Cancer.
palliative surgery; therapeutic conventional surgery; palliative radiation therapy; radiation therapy

Brenner Tumor, Fallopian Tube Cancer, Ovarian Clear Cell Cystaden Clinical Trial using paclitaxel; docetaxel; carboplatin; bevacizumab; gemcitabine hydrochloride; laboratory biomarker analysis; quality-of-life assessment

National Cancer Institute (NCI) - Recruiting 18 years or older.
- A Phase III Randomized Controlled Clinical Trial of Carboplatin and Paclitaxel (or Gemcitabine) Alone or in Combination With Bevacizumab (NSC #704865, IND #113912) Followed by Bevacizumab and Secondary Cytoreductive Surgery in Platinum-Sensitive, Recurrent Ovarian, Peritoneal Primary and Fallopian Tube Cancer. NCI-Supplied Agents: Bevacizumab (NSC #704865, IND #113912).
paclitaxel; docetaxel; carboplatin; bevacizumab; gemcitabine hydrochloride; laboratory biomarker analysis; quality-of-life assessment

Lung Cancer Clinical Trial using bevacizumab; emepepimut-S; carboplatin; cyclophosphamide; paclitaxel; radiation therapy

Eastern Cooperative Oncology Group - Recruiting 18 years or older.
- A Phase II Study of L-BLP25 and Bevacizumab in Unresectable Stage IIIA and IIIB Non-Squamous Non-Small Cell Lung Cancer After Definitive Chemoradiation.
bevacizumab; emepepimut-S; carboplatin; cyclophosphamide; paclitaxel; radiation therapy

Acute or Programmed Hip Replacement (Gamma Nail, Total Prosthesis Clinical Trial

Assistance Publique - H“pitaux de Paris - Recruiting 18 years or older.
- Assessment of Blood Loss With a Point Of Care Device During Hip/Knee Surgery Performed On Dual/Single Antiplatelet Therapy.

Postoperative Pain, or Sedation Clinical Trial using Infrared Pupillometry; Anesthesia Premedication, Induction and Maintenance

University of California, San Francisco - Recruiting 18 years or older.
- Intraoperative Use of Infrared Pupillometry During General Anesthesia to Predict Pain and Quality of Regional Anesthesia After Surgery.
Infrared Pupillometry; Anesthesia Premedication, Induction and Maintenance

Surgical Wound Infection Clinical Trial using Cefazolin; Placebo

Rabin Medical Center - Recruiting 18 years or older.
- Antibiotic Prophylaxis for Revision, Clean Head and Neck Surgery.
Cefazolin; Placebo

Pain Clinical Trial using Dexmedetomidine; Placebo

Memorial Sloan-Kettering Cancer Center - Recruiting 21 years or older.
- A Double-Masked Placebo Controlled Clinical Trial of the Postoperative Opioid Sparing Effects of Intraoperative Dexmedetomidine Infusion for Video-Assisted Thoracic Surgery.
Dexmedetomidine; Placebo

Coronary Artery Disease, Aortic Stenosis, Aortic Insufficiency, M Clinical Trial using cardioPAT cell saver

Rigshospitalet, Denmark - Recruiting 18 years or older.
- CardioPAT Project - Reducing the Need for Allogenic Blood Transfusion After On-pump Cardiac Surgery With Intra- and Postoperative Use of a New Device: a Randomized Trial.
cardioPAT cell saver

Hip Fracture Clinical Trial using tranexamic acid

Mayo Clinic - Recruiting 18 years or older.
- Is Tranexamic Acid Effective in Limiting Transfusion After Hip Replacement for Femoral Neck Fracture: A Randomized Controlled Trial.
tranexamic acid

Ischemic Heart Disease Clinical Trial using Human embryonic stem cell-derived CD15+ Isl-1+ progenitors

Assistance Publique - H“pitaux de Paris - Recruiting 18 years to 80 years.
- Transplantation of Human Embryonic Stem Cell-derived CD15+ Isl-1+ Progenitors in Severe Heart Failure.
Human embryonic stem cell-derived CD15+ Isl-1+ progenitors

Advanced Stage Head and Neck Cancer Clinical Trial using Quality of Life Questionaires & Interview: EORTC QLQ C-30, EORTC QLQ H&N-35, Health Behaviors, Subjective Significance Questionnaire, Qualitative Assessment

Memorial Sloan-Kettering Cancer Center - Recruiting 21 years or older.
- RECONSTRUCTIVE SURGERY For Head And Neck Cancer Patients: A Prospective Analysis Of Quality Of Life And Symptom Relief.
Quality of Life Questionaires & Interview: EORTC QLQ C-30, EORTC QLQ H&N-35, Health Behaviors, Subjective Significance Questionnaire, Qualitative Assessment

Head and Neck Cancer Clinical Trial using Flexible Fiber-based CO2 Laser, Quality of Life forms; electrocautery resection and quality of life forms

Memorial Sloan-Kettering Cancer Center - Recruiting 18 years or older.
- Flexible Fiber-based CO2 Laser Versus Monopolar Cautery for Resection of Benign, Pre-malignant And Malignant Oral Cavity Lesions: A Single Center Randomized Controlled Trial Assessing Pain and Quality of Life Following Surgery.
Flexible Fiber-based CO2 Laser, Quality of Life forms; electrocautery resection and quality of life forms

Breast Cancer, or Surgery Clinical Trial using SLN detection +/- complementary axillary lymphadenectomy

Institut Cancerologie de l'Ouest - Recruiting 18 years to 65 years.
- Multicentric, National, Prospective, Comparative, Non Randomized Study, Assessing Medico-economic Impact of Three Strategies of Sentinel Lymph Node Analysis in Immediately Operable Breast Cancer.
SLN detection +/- complementary axillary lymphadenectomy

Diffuse Hyperplastic Perilobar Nephroblastomatosis, Rhabdoid Tumo Clinical Trial using doxorubicin hydrochloride; therapeutic conventional surgery; dactinomycin; cyclophosphamide; carboplatin; etoposide phosphate; vincristine sulfate; adjuvant therapy; neoadjuvant therapy

Children's Oncology Group - Recruiting N/A to 29 years.
- Treatment for Patients With Bilateral, Multicentric, or Bilaterally-Predisposed Unilateral Wilms Tumor.
doxorubicin hydrochloride; therapeutic conventional surgery; dactinomycin; cyclophosphamide; carboplatin; etoposide phosphate; vincristine sulfate; adjuvant therapy; neoadjuvant therapy

Fuchs' Endothelial Corneal Dystrophy Clinical Trial using DSAEK surgery

Aarhus University Hospital - Recruiting 40 years or older.
- Fuchs' Endothelial Dystrophy: Clinical Characteristics, Treatment Outcome, and Pathology.
DSAEK surgery

Stage I Breast Carcinoma, or Stage II Breast Carcinoma Clinical Trial using intra-operative MRI

Dana-Farber Cancer Institute - Recruiting 18 years to 75 years.
- A Pilot Study to Evaluate Image-guided Breast Conserving Surgery in the Advanced Multimodality Image Guided Operating Suite (AMIGO).
intra-operative MRI

Normal Pressure Hydrocephalus Patients Clinical Trial using Shunt surgery

Mayo Clinic - Recruiting 60 years or older.
- Prognostic Value of Aá Imaging in NPH Prior to Shunt Placement.
Shunt surgery

Elective Surgery of the Spine by Laparotomy Clinical Trial using Ropivacaine 0.2%; Chlorure de sodium 0.9%

Centre Hospitalier Universitaire Dijon - Recruiting 18 years or older.
- THE TAP BLOCK TECHNIQUE VIA THE ANTERIOR APPROACH IN ELECTIVE SURGERY OF THE SPINE: Prospective, Randomised, Double Blind Trial, Comparing TAP BLOCK With Continuous Infiltration of Ropivacaine Versus Placebo.
Ropivacaine 0.2%; Chlorure de sodium 0.9%

Pain Clinical Trial using Sternalock Rigid Fixation

Thomas Jefferson University - Recruiting 18 years to 79 years.
- A Prospective Randomized Study of Two Types of Sternal Closure After Open Heart Surgery: Rigid Sternal Fixation vs. Sternal Wire Closure.
Sternalock Rigid Fixation

Stage 0/1 Breast Cancer, Post Biopsy, or Pre-surgery Clinical Trial using IV/oral n-acetylcysteine

Thomas Jefferson University - Recruiting 18 years or older.
- Pilot Study of Anti-oxidant Supplementation With N-Acetyl Cysteine in Stage 0/I Breast Cancer.
IV/oral n-acetylcysteine

Cataract Clinical Trial using CENTURION Vision System (CVS); INFINITI Vision System (IVS)

Alcon Research - Recruiting 55 years or older.
- Intra-Operative Metrics and Clinical Outcomes After Cataract Surgery With the CENTURION Vision System and the INFINITI Vision System.
CENTURION Vision System (CVS); INFINITI Vision System (IVS)

Acute Kidney Injury Clinical Trial using atrovastatin; Placebo

Yonsei University - Recruiting 20 years or older.
- .
atrovastatin; Placebo

Metastatic Squamous Neck Cancer With Occult Primary Squamous Cell Clinical Trial using afatinib; placebo; laboratory biomarker analysis

Eastern Cooperative Oncology Group - Recruiting 18 years or older.
- A Randomized, Placebo Controlled Phase II Trial of Afatinib (BIBW2992) as Adjuvant Therapy Following Chemoradiation in Patients With Head and Neck Squamous Cell Carcinoma at High Risk of Recurrence.
afatinib; placebo; laboratory biomarker analysis

Aseptic Loosening, Osteolysis, Traumatic Fracture, or Failed Tota Clinical Trial using Modular Revision Hip System

Encore Medical, L.P. - Recruiting 18 years or older.
- Prospective Multicenter Open Label Study Examining the Short-term Safety and Efficacy of the Modular Revision Hip System (MRHS).
Modular Revision Hip System

Graft -Versus-host-disease Clinical Trial using Mesenchymal stromal cells

Karolinska Institutet - Recruiting 18 years to 80 years.
- Treatment of Oral Mucosa in Patients With Graft-versus-host Disease Following Injection of Mesenchymal Stem Cells - Human Pilot Study.
Mesenchymal stromal cells

Stage IV Pancreatic Cancer Clinical Trial using VXM01; Placebo

Vaximm GmbH - Recruiting 18 years or older.
- VXM01 Phase I Dose Escalation Study in Patients With Locally Advanced, Inoperable and Stage IV Pancreatic Cancer to Examine Safety, Tolerability, and Immune Response to the Investigational VEGFR-2 DNA Vaccine VXM01.
VXM01; Placebo

Ischemic Stroke Clinical Trial using intravenous (IV) recombinant human tissue plasminogen activator (rtPA); Penumbra System

Penumbra Inc. - Recruiting 18 years to 85 years.
- The THERAPY Trial: The Randomized, Concurrent Controlled Trial to Assess the Penumbra System's Safety and Effectiveness in the Treatment of Acute Stroke.
intravenous (IV) recombinant human tissue plasminogen activator (rtPA); Penumbra System

Follicular Non-Hodgkin's Lymphoma, Nodal Marginal Zone Lymphoma, Clinical Trial using rituximab

Biocad - Recruiting 18 years to 95 years.
- A Multicenter Open-label Randomized Study of BCD-020 (Rituximab, CJSC BIOCAD, Russia) Efficacy and Safety in Comparison With MabThera (F. Hoffmann-La Roche Ltd., Switzerland) in Monotherapy of CD20-positive Indolent Non-Hodgkin's Lymphoma.
rituximab

Acute Kidney Injury Clinical Trial

University Hospital, Basel, Switzerland - Recruiting 18 years or older.
- Novel Biomarkers (TIMP-2 and IGFBP7) of Tubular Renal Cell Damage for the Prediction of the Cardiac Surgery Associated Acute Kidney Injury (CSA-AKI) - A Feasibility Study.

Pediatric Perioperative Blood Pressure Management Clinical Trial using clevidipine

The Medicines Company - Recruiting N/A to 17 years.
- Open Label Study to Assess the Efficacy, Safety and Dosing of Clevidipine in Pediatric Patients Undergoing Surgery.
clevidipine

Recurrent Melanoma, Stage IIIB Melanoma, Stage IIIC Melanoma, or Clinical Trial using ipilimumab; recombinant interferon alfa-2b; quality-of-life assessment

National Cancer Institute (NCI) - Recruiting 18 years or older.
- A Phase III Randomized Study of Adjuvant Ipilimumab Anti-CTLA4 Therapy Versus High-Dose Interferon a-2b for Resected High-Risk Melanoma.
ipilimumab; recombinant interferon alfa-2b; quality-of-life assessment

Patients Undergoing Major Abdominal Surgery Clinical Trial using Analysis of PSP and PAP from venous blood samples

University of Zurich - Recruiting 18 years or older.
- Peri-operative Expression Analysis of Pancreatic Stone Protein and Pancreatitis-associated Protein in a Surgical Study Population.
Analysis of PSP and PAP from venous blood samples

Pain Clinical Trial using IV ibuprofen; Ketorolac

Cumberland Pharmaceuticals - Recruiting 18 years or older.
- A Multicenter, Prospective, Randomized, Double-blind Study to Determine the Efficacy of Intravenous Ibuprofen Compared to Intravenous Ketorolac for Pain Control Following Arthroscopic Knee Surgery.
IV ibuprofen; Ketorolac

Osteoarthritis, Knee Clinical Trial using TKA with Journey II BCS Total Knee System

Smith & Nephew, Inc. - Recruiting N/A or older.
- A Retro-Prospective, Non-randomized, Consecutive Series, SIngle Cohort, Multicenter Adaptive Design Study to Evaluate the Outcomes of Total Knee Arthroplasty (TKA) Using JOURNEYT II BCS TotaL Knee SystEm (The NIMBLE Study).
TKA with Journey II BCS Total Knee System

Lung Cancer Clinical Trial using Afatinib; Radiation; Cisplatin; Pemetrexed; Surgery

Massachusetts General Hospital - Recruiting 18 years or older.
- Afatinib Sequenced With Concurrent Chemotherapy and Radiation in EGFR-Mutant Non-Small Cell Lung Tumors: The ASCENT Trial.
Afatinib; Radiation; Cisplatin; Pemetrexed; Surgery

Squamous Cell Carcinoma of the Oral Cavity, or Squamous Cell Carc Clinical Trial using LI plus CIZ; Standard of Care (SOC); LI + SOC

CEL-SCI Corporation - Recruiting 18 years or older.
- Phase III Study of LI [Multikiner] Plus SOC (Surgery + Radiotherapy or Surgery + Concurrent Radiochemotherapy) in Subjects With Advanced Primary Squamous Cell Carcinoma of the Oral Cavity/Soft Palate vs. SOC Only.
LI plus CIZ; Standard of Care (SOC); LI + SOC

Male Breast Cancer, Recurrent Melanoma, Stage IV Breast Cancer, S Clinical Trial using propranolol hydrochloride; Correlative Studies

Ohio State University Comprehensive Cancer Center - Recruiting 18 years or older.
- A Pilot Study of Beta-Blockers in Patients With Advanced Cancer.
propranolol hydrochloride; Correlative Studies

Atrial Fibrillation Clinical Trial using atrial tissue

University of Pittsburgh - Recruiting 18 years or older.
- Assessment of Atrial Tissue Obtained From Patients Undergoing Heart Surgery and Tissue Banking.
atrial tissue

Acinar Cell Adenocarcinoma of the Pancreas, Duct Cell Adenocarcin Clinical Trial using oxaliplatin; leucovorin calcium; irinotecan hydrochloride; fluorouracil; therapeutic conventional surgery; laboratory biomarker analysis

Yale University - Recruiting 18 years or older.
- Phase II Study of Peri-Operative Modified Folfirinox in Localized Pancreatic Cancer.
oxaliplatin; leucovorin calcium; irinotecan hydrochloride; fluorouracil; therapeutic conventional surgery; laboratory biomarker analysis

Recurrent Prostate Cancer, Stage I Prostate Cancer, Stage IIA Pro Clinical Trial using stereotactic body radiation therapy; quality-of-life assessment; laboratory biomarker analysis

City of Hope Medical Center - Recruiting 19 years or older.
- Stereotactic Body Radiation Therapy to the Prostate Fossa: Phase I Dose Escalation Study.
stereotactic body radiation therapy; quality-of-life assessment; laboratory biomarker analysis

Gynecologic Cancer Clinical Trial using Questionnaire

M.D. Anderson Cancer Center - Recruiting N/A or older.
- Prospective Evaluation of Robot-Assisted Surgery in Gynecologic Oncology.
Questionnaire

Atrial Fibrillation Clinical Trial using maze procedure; mitral valve surgery; left atrial reduction

Meshalkin Research Institute of Pathology of Circulation - Recruiting 18 years to 65 years.
- Left Atrium Reduction Versus no Left Atrium Reduction for Patients With Enlarged Left Atria and Persistent or Long Standing Persistent Atrial Fibrillation Undergoing Mitral Valve Surgery.
maze procedure; mitral valve surgery; left atrial reduction

Gastrointestinal Fistula Clinical Trial

Jinling Hospital, China - Recruiting 18 years to 80 years.
- a Prospective Study to Investigate the Role of Enteral Nutrition in Nonthyroidal Illness Syndrome Among Fistula Patients.

Rheumatoid Arthritis Clinical Trial using GLPG0634; Placebo

Galapagos NV - Recruiting 18 years or older.
- Randomized, Double-blind, Placebo-controlled, Multicenter, Phase IIb Dose Finding Study of GLPG0634 Administered for 24 Weeks as Monotherapy to Subjects With Moderately to Severely Active Rheumatoid Arthritis Who Have an Inadequate Response to Methotrexate (MTX) Alone.
GLPG0634; Placebo

Heart Disease, Pleural Effusion, or Pericardial Effusion Clinical Trial using pleuracentesis

Aarhus University Hospital Skejby - Recruiting 18 years or older.
- The Clinical Impact of an Aggressive Approach Towards Pleural and Pericardial Effusions Following Open Heart Surgery: a Step Towards Standard Guidelines.
pleuracentesis

Peripheral Vascular Disease, Peripheral Artery Disease, Carotid S Clinical Trial

New York University School of Medicine - Recruiting 21 years or older.
- Platelet Activity in Vascular Surgery.

Acute Kidney Injury, or Cardiac Surgery Clinical Trial using Sodium Bicarbonate; Sodium Chloride

North Shore Long Island Jewish Health System - Recruiting N/A to 21 years.
- Sodium Bicarbonate to Prevent Acute Kidney Injury in Children Undergoing Cardiac Surgery: A Randomized Clinical Trial.
Sodium Bicarbonate; Sodium Chloride

Anaemia Clinical Trial using Ferric carboxymaltose; Normal saline

University College, London - Recruiting 18 years or older.
- A Randomised Double-blind Controlled Phase III Study to Compare the Efficacy and Safety of Intravenous Ferric Carboxymaltose With Placebo in Patients With Anaemia Undergoing Major Open Abdominal Surgery.
Ferric carboxymaltose; Normal saline

Strabismus, Delirium on Emergence, or Pediatric Disorders Clinical Trial using Dexmedetomidine; Placebo

New York University School of Medicine - Recruiting 1 year to 7 years.
- Efficacy of Single-Shot Dexmedetomidine Versus Placebo in Preventing Pediatric Emergence Delirium in Strabismus Surgery.
Dexmedetomidine; Placebo

Surgical Site Infection Clinical Trial using Early administration of SAP (Cefuroxime (plus metronidazole in colorectal surgery)) early in anesthetic room (75 to 30 minutes prior to skin incision); Late administration of SAP (Cefuroxime (plus metronidazole in colorectal surgery)) in the operating theatre (within 30 minutes prior to skin incision)

University Hospital, Basel, Switzerland - Recruiting 18 years or older.
- Randomized Controlled Trial to Evaluate the Optimal Timing of Surgical Antimicrobial Prophylaxis.
Early administration of SAP (Cefuroxime (plus metronidazole in colorectal surgery)) early in anesthetic room (75 to 30 minutes prior to skin incision); Late administration of SAP (Cefuroxime (plus metronidazole in colorectal surgery)) in the operating theatre (within 30 minutes prior to skin incision)

Lupus Erythematosus, Systemic Clinical Trial using Mycophenolate Mofetil; Hydroxychloroquine or Chloroquine; Prednisone

National Institute of Allergy and Infectious Diseases (NIAID) - Recruiting 18 years to 65 years.
- An Investigator-Initiated, Phase II, Randomized, Withdrawal Study of Mycophenolate Mofetil (MMF) in Patients With Stable, Quiescent Systemic Lupus Erythematosus (SLE).
Mycophenolate Mofetil; Hydroxychloroquine or Chloroquine; Prednisone

Psoriasis Clinical Trial using DFD01 Spray; Comp01 Lotion; Vehicle Lotion; Vehicle Spray

Promius Pharma, LLC - Recruiting 18 years or older.
- .
DFD01 Spray; Comp01 Lotion; Vehicle Lotion; Vehicle Spray

Islet Transplantation in Diabetes Mellitus Type 1, Clinical Trial using Reparixin; Placebo

Domp‚ s.p.a. - Recruiting 18 years to 70 years.
- A Phase 3, Multicenter, Randomized, Double-blind, Parallel Assignment Study to Assess the Efficacy and Safety of Reparixin in Pancreatic Islet Transplantation.
Reparixin; Placebo

Heart Disease Clinical Trial using Fibrinogen; Saline solution; Prothrombin complex

IRCCS Policlinico S. Donato - Recruiting 18 years or older.
- The ZEroPLASmaTrial (ZEPLAST): a Randomized, Controlled Trial on Transfusion Avoidance in High Transfusion-risk Cardiac Surgery Patients.
Fibrinogen; Saline solution; Prothrombin complex

Colorectal Cancer Metastatic, Liver Metastases, or KRAS Wild Type Clinical Trial using FOLFOX6; Bevacizumab; Panitumumab; Surgery

European Organisation for Research and Treatment of Cancer - EORTC - Recruiting 18 years to 75 years.
- Randomized Phase II Trial Evaluating the Efficacy of FOLFOX Alone, FOLFOX Plus Bevacizumab and FOLFOX Plus Panitumumab as Perioperative Treatment in Patients With Resectable Liver Metastases From Wild Type KRAS Colorectal Cancer.
FOLFOX6; Bevacizumab; Panitumumab; Surgery

Acoustic Schwannoma, Adult Anaplastic Astrocytoma, Adult Anaplast Clinical Trial using fluorine F 18 fluorodopa; positron emission tomography; computed tomography; diffusion-weighted magnetic resonance imaging; perfusion-weighted magnetic resonance imaging; therapeutic conventional surgery; biopsy; laboratory biomarker analysis

Mayo Clinic - Recruiting 7 years or older.
- Evaluating the Impact of 18F-DOPA-PET on Neurosurgical Planning for Gliomas.
fluorine F 18 fluorodopa; positron emission tomography; computed tomography; diffusion-weighted magnetic resonance imaging; perfusion-weighted magnetic resonance imaging; therapeutic conventional surgery; biopsy; laboratory biomarker analysis

Any Condition Requiring Surgical Treatment Via Colectomy Clinical Trial

Ethicon Endo-Surgery - Recruiting 18 years to 80 years.
- Initial Clinical Experience With the ENSEALr G2 Articulating Tissue Sealer in Laparoscopic Colectomy.

Inflammation, or Cataracts Clinical Trial using IBI-10090; Placebo

ICON Bioscience Inc - Recruiting 40 years or older.
- .
IBI-10090; Placebo

Colles Fracture Clinical Trial using Tablets Ibumetin and placebo

Northern Orthopaedic Division, Denmark - Recruiting 50 years to 80 years.
- The Influence of Non-steroid Antiinflammatory Drugs (NSAID) to Heal Colles Fracture..
Tablets Ibumetin and placebo

Inflammatory Bowel Diseases, Crohn's Disease, Gastrointestinal Di Clinical Trial using Mesalazine, Tripterygium glycosides

Jinling Hospital, China - Recruiting 18 years to 75 years.
- Prospective Experimental of Tripterygium Glycoside in the Treatment of Crohn's Disease for Induction Remission.
Mesalazine, Tripterygium glycosides

Lower Extremity Lymphedema, or Endometrial Cancer Clinical Trial

Duke University - Recruiting 18 years or older.
- A Pilot Study of Postoperative Lower-extremity Lymphedema and Quality of Life Among Women Undergoing Endometrial Cancer Staging Surgery.

Pain, or Anesthesia Clinical Trial using Normal Saline; Butorphanol; Flurbiprofen axetil

Tianjin Medical University General Hospital - Recruiting 20 years to 60 years.
- Effect of Butorphanol Combined With Flurbiprofen Axetil on Preventing Postoperative Hyperalgesia Induced by Remifentanil in Patients Undergoing Lower Abdomimal Surgery.
Normal Saline; Butorphanol; Flurbiprofen axetil

Breast Cancer Clinical Trial using axillary lymph node dissection; isosulfan blue based lymphatic mapping; quality-of-life assessment; Questionnaire administration

City of Hope Medical Center - Recruiting N/A or older.
- Reducing Extremity Lymphedema Through Axillary Lymphatic Preservation Surgery.
axillary lymph node dissection; isosulfan blue based lymphatic mapping; quality-of-life assessment; Questionnaire administration

Scar Clinical Trial using Natural Vitamin E Tocotrienol (TCT); Natural Vitamin E Tocotrienol (TCT); Placebo; Placebo Cream

Ohio State University - Recruiting 18 years or older.
- Efficacy of Natural Vitamin E Tocotrienol on the Treatment of Surgical Scars.
Natural Vitamin E Tocotrienol (TCT); Natural Vitamin E Tocotrienol (TCT); Placebo; Placebo Cream

Cerebral Palsy Clinical Trial using Autologous Stem Cells

The University of Texas Health Science Center, Houston - Recruiting 2 years to 10 years.
- Autologous Cell Therapies for Cerebral Palsy-Chronic (ACT for CP).
Autologous Stem Cells

Malignant Tumor Clinical Trial using Novilase Interstitial Laser Therapy

Novian Health Inc. - Recruiting 18 years to 80 years.
- A Multicenter 'Ablate and Resect' Study of Novilaser Interstitial Laser Therapy for the Ablation of Small Breast Cancers.
Novilase Interstitial Laser Therapy

Post-operative Pain Clinical Trial using Arcoxiar120 mg; P Tablet White Lichtenstein

Charite University, Berlin, Germany - Recruiting 18 years or older.
- A Double-blind, Randomized, Placebo Controlled Study to Evaluate the Effectiveness of Etoricoxib as an Additive Analgesic to Epidural Analgesia in Colon or Rectal Fast-track Surgery.
Arcoxiar120 mg; P Tablet White Lichtenstein

Lung Cancer, or Metastatic Cancer Clinical Trial using computed tomography; 3-dimensional conformal radiation therapy; fludeoxyglucose F 18; radiation therapy treatment planning/simulation

ICORG- All Ireland Cooperative Oncology Research Group - Recruiting 18 years or older.
- Prospective Evaluation of PET-CT Scan in Patients With Non-operable or Non-resectable NSCLC Treated by Radical 3-Dimensional Conformal Radiation Therapy.
computed tomography; 3-dimensional conformal radiation therapy; fludeoxyglucose F 18; radiation therapy treatment planning/simulation

Hepatectomy, Elective Hepatectomy, or Malignant Tumors Clinical Trial using Oral immunonutrition; Placebo

Assistance Publique - H“pitaux de Paris - Recruiting 18 years or older.
- Interest of Preoperative Immunonutrition in Liver Resection for Cancer.
Oral immunonutrition; Placebo

Non-small Cell Lung Cancer (NSCLC) Clinical Trial using Endocutter

Ethicon Endo-Surgery - Recruiting 18 years or older.
- A Prospective, Multi-Center Evaluation of a Powered Surgical Stapler in Video-Assisted Thoracoscopic Lung Resection Procedures.
Endocutter

Orthopedic Surgery, Total Hip Prosthesis, or Total Knee Replaceme Clinical Trial using Intraoperative anesthetic strategy by Propofol; Intraoperative anesthetic strategy by Desflurane

Assistance Publique - H“pitaux de Paris - Recruiting 18 years to 80 years.
- Randomized Study Evaluating the Influence of the Strategy Intraoperative Anesthetic (Desflurane Versus Propofol) on Cognitive and Psychomotor Functions in Output Post Interventional Room Monitoring.
Intraoperative anesthetic strategy by Propofol; Intraoperative anesthetic strategy by Desflurane

Lesion of Ligament of Wrist and/or Hand Clinical Trial using SportWelding Fiji Anchor

SportWelding GmbH - Recruiting 18 years or older.
- Prospective Clinical Evaluation of the Bioabsorbable SportWelding FijiAnchorr for Ligament Repair of the Hand and Hand Wrist.
SportWelding Fiji Anchor

Adenocarcinoma of the Esophagus, Adenocarcinoma of the Gastroesop Clinical Trial using oxaliplatin; leucovorin calcium; fluorouracil; therapeutic conventional surgery; radiation therapy; carboplatin; paclitaxel

Case Comprehensive Cancer Center - Recruiting 18 years or older.
- A Phase II Trial of Modified FOLFOX-6 Induction Chemotherapy Followed by Esophagectomy and Post-operative Response Based Concurrent Chemoradiotherapy in Patients With Locoregionally Advanced Adenocarcinoma of the Esophagus, Gastro-esophageal Junction, and Gastric Cardia.
oxaliplatin; leucovorin calcium; fluorouracil; therapeutic conventional surgery; radiation therapy; carboplatin; paclitaxel

Disorder; Heart, Functional, Postoperative, Cardiac Surgery Clinical Trial using Restrictive Transfusion Strategy; Liberal transfusion strategy

St. Michael's Hospital, Toronto - Recruiting 18 years or older.
- An International, Multi-centre, Randomized Controlled Trial to Assess Transfusion Thresholds in Patients Undergoing Cardiac Surgery.
Restrictive Transfusion Strategy; Liberal transfusion strategy

Estrogen Receptor-positive Breast Cancer, HER2-positive Breast Ca Clinical Trial using docetaxel; carboplatin; trastuzumab; pertuzumab; goserelin acetate; therapeutic conventional surgery; whole breast irradiation; quality-of-life assessment; laboratory biomarker analysis; aromatase inhibition therapy

National Cancer Institute (NCI) - Recruiting 18 years or older.
- A Randomized Phase III Trial Evaluating Pathologic Complete Response Rates in Patients With Hormone Receptor-Positive, HER2-Positive, Large Operable and Locally Advanced Breast Cancer Treated With Neoadjuvant Therapy of Docetaxel, Carboplatin, Trastuzumab, and Pertuzumab (TCHP) With or Without Estrogen Deprivation.
docetaxel; carboplatin; trastuzumab; pertuzumab; goserelin acetate; therapeutic conventional surgery; whole breast irradiation; quality-of-life assessment; laboratory biomarker analysis; aromatase inhibition therapy

Colorectal Disorders, Hernia, or Incidence for Cholecystectomy Clinical Trial using Laparoscopic surgery

Krankenhaus Barmherzige Schwestern Linz - Recruiting 18 years or older.
- A Prospective Randomized Trial on Comparison of Standard- Carbon Dioxide Pressure Pneumoperitoneum Insufflators Versus AirSeal.
Laparoscopic surgery

Peripheral Vascular Disease, or Hemorrhage Clinical Trial using EVICEL T Fibrin Sealant (Human)

Ethicon, Inc. - Recruiting 18 years or older.
- A Prospective, Single-Arm, Observational, Non-interventional Study for EVICEL T Fibrin Sealant (Human) When Used as an Adjunct to Haemostasis in Vascular Surgery.
EVICEL T Fibrin Sealant (Human)

Anesthesia Intubation Complication, or Tracheal Disease Clinical Trial using Ketorolac; Dexamethasone; Placebo

Yeungnam University College of Medicine - Recruiting 20 years to 60 years.
- The Effect of Prophylactic Ketorolac on Sore Throat After Thyroid Surgery.
Ketorolac; Dexamethasone; Placebo

Pain Clinical Trial

University of Roma La Sapienza - Recruiting 18 years to 75 years.
- Influence of Premedication With Oral Morphine Sulphate on Analgesic Consumption in Patient Undergoing Major Urological Surgery. Comparison Between Two Different Doses.

Severe Open Fractures of the Tibia (Shin) Bone Clinical Trial using Surgery with an external ring fixator; Definitive fixation with a locked IM nail or plate

Major Extremity Trauma Research Consortium - Recruiting 18 years to 64 years.
- A Prospective Randomized Trial to Assess Fixation Strategies for Severe Open Tibia Fractures:Modern Ring External Fixators versusInternal Fixation.
Surgery with an external ring fixator; Definitive fixation with a locked IM nail or plate

Effectiveness of Microscope During Apical Surgery in Endodontic T Clinical Trial using Surgical treatment with microscope

Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) - Recruiting N/A or older.
- The Effectiveness of a Microscope During Apical Surgery; a Prospective Randomized Controlled Clinical Trial..
Surgical treatment with microscope

Rheumatoid Arthritis Clinical Trial using LD-aminopterin; placebo

Syntrix Biosystems, Inc. - Recruiting 18 years or older.
- A Phase 2 Double-Blind, Placebo-Controlled, Randomized Dose Finding Study For The Efficacy And Safety Of Aminopterin In Methotrexate-Naive Rheumatoid Arthritis.
LD-aminopterin; placebo