National Cancer Institute (NCI) - Recruiting 19 years to 79 years. - A Phase II Trial of Preoperative Soy Isoflavone Supplementation and Molecular Markers in the Prevention of Head and Neck Squamous Carcinoma.
National Cancer Institute (NCI) - Recruiting 18 years or older. - A Phase III Randomized, Double-Blind Trial of Chemoembolization With or Without Sorafenib in Unresectable Hepatocellular Carcinoma (HCC) in Patients With and Without Vascular Invasion.
sorafenib tosylate; placebo; doxorubicin hydrochloride; doxorubicin-eluting beads; cisplatin; mitomycin C
Swiss Group for Clinical Cancer Research - Recruiting 18 years to 75 years. - Dose Intensified Salvage Radiotherapy in Biochemically Relapsed Prostate Cancer Without Macroscopic Disease. A Randomized Phase III Trial..
Centre Hospitalier Universitaire de Nimes - Recruiting 18 years to 80 years. - Evaluation of Oxycodone Hydrochloride Versus Intravenous Morphine Hydrochloride for Postoperative Analgesia After Hip Prosthetic Surgery.
M.D. Anderson Cancer Center - Recruiting 18 years or older. - Randomized, Phase II Trial of Best Systemic Therapy or Best Systemic Therapy (BST) Plus Definitive Treatment (Radiation or Surgery) of the Primary Tumor in Metastatic (M1) Prostate Cancer (PC).
Best Systemic Therapy (BST); Best Systemic Therapy (BST) + Surgery or Radiation Therapy; Questionnaires; Phone Call/Email
Samsung Medical Center - Recruiting N/A to 10 years. - Influence of Tidal Volume During Mechanical Ventilation on Postoperative Clinical Outcome in Pediatric Patients Undergoing Congenital Heart Surgery.
Pfizer - Recruiting 18 years or older. - A Multicenter, Double-Blind, Randomized, Comparison Study Of The Efficacy And Safety Of Tigecycline To Imipenem/Cilastatin To Treat Complicated Intra-Abdominal Infections In Hospitalized Subjects.
Celldex Therapeutics - Recruiting 18 years or older. - An International, Randomized, Double-Blind, Controlled Study of Rindopepimut/GM-CSF With Adjuvant Temozolomide in Patients With Newly Diagnosed, Surgically Resected, EGFRvIII-positive Glioblastoma.
Rindopepimut (CDX-110) with GM-CSF; Temozolomide; KLH
National Surgical Adjuvant Breast and Bowel Project (NSABP) - Recruiting 18 years or older. - A Randomized Phase III Clinical Trial Evaluating Post-Mastectomy Chestwall and Regional Nodal XRT and Post-Lumpectomy Regional Nodal XRT in Patients With Positive Axillary Nodes Before Neoadjuvant Chemotherapy Who Convert to Pathologically Negative Axillary Nodes After Neoadjuvant Chemotherapy.
Boehringer Ingelheim - Recruiting 18 years or older. - Observational Cohort Study to Evaluate Safety and Efficacy of Pradaxa (Dabigatran Etexilate) in Patients With Moderate Renal Impairment (Creatinine Clearance 30-50 ml/Min) Undergoing Elective Total Hip Replacement Surgery or Total Knee Replacement Surgery.
Northwestern University - Recruiting 18 years or older. - An Investigator Initiated Multicenter Prospective Randomized Study of Chemoembolization Versus Radioembolization for the Treatment of Hepatocellular Carcinoma (PREMIERE Trial).
yttrium Y 90 glass microspheres; Cisplatin; Mitomycin; Doxorubicin
National Cancer Institute (NCI) - Recruiting 18 years or older. - A Randomized Phase II Trial of ARQ 197 (Tivantinib) /Cetuximab Versus Cetuximab in Patients With Recurrent/Metastatic Head and Neck Cancer.
National Cancer Institute (NCI) - Recruiting 18 years or older. - A Sequential Safety and Biomarker Study of BRAF-MEK Inhibition on the Immune Response in the Context of CTLA-4 Blockade for BRAF Mutant Melanoma.
Alliance for Clinical Trials in Oncology - Recruiting 18 years or older. - Alternate Approaches for Clinical Stage II or III Estrogen Receptor Positive Breast Cancer Neoadjuvant Treatment (ALTERNATE) in Postmenopausal Women: A Phase III Study.
GEM Hospital & Research Center - Recruiting 30 years to 70 years. - A Prospective Randomized Parallel Group Trial : Laparoscopic Versus Open Pancreatoduodenectomy in Terms of Pathological Radicality & Severity Short Term of Complications According to Expanded Accordion Severity Grading System.
Instituto Mexicano del Seguro Social - Recruiting 18 years to 45 years. - Therapeutic Efficacy of Tricalcium Phosphate and Chitosan as Bone Regenerator Versus Autologous Graft in Surgery for Mandibular Fracture.
Duke University - Recruiting 18 years or older. - Using Mobile Phone Text Messaging and E-mailing to Decrease Anxiety, Pain, Follow-up Visits and Improve Reporting of Surgical Site Infection After Spine Surgery: A Double-Blind Randomized Trial.
Reata Pharmaceuticals, Inc. - Recruiting 18 years or older. - A Multicenter, Randomized, Dose-Ranging, Double-Masked, Placebo-Controlled Phase 2 Study Evaluating the Safety and Efficacy of RTA 408 Ophthalmic Suspension for the Treatment of Ocular Inflammation and Pain Following Ocular Surgery.
Centre Hospitalier Universitaire de NÄ«mes - Recruiting 18 years or older. - Does the Measurement of Pupillary Reactivity to Painful Stimulation by an Automated Pupillometer Determine the Effectiveness of Local Anesthesia When Undergoing General Anesthesia?.
Assistance Publique - HÃ´pitaux de Paris - Recruiting 18 years or older. - Randomized Control Trial Comparing the Impact of a Lengthening of the Interval Between the Radiochemotherapy and Surgery (7 Weeks vs. 11 Weeks) on Complete Pathological Response in Rectal Cancer.
Surgery after 11 weeks of delay after chemoradiotherapy.; Surgery after 7 weeks of delay after chemoradiotherapy
RXi Pharmaceuticals, Corp. - Recruiting 21 years to 55 years. - A Multi-Center, Prospective, Randomized, Single-Blind, Within-Subject Controlled, Phase 2a Study to Evaluate the Effectiveness and Safety of RXI-109 on the Outcome of Keloid Excision Surgery in Healthy Adults.
Hospices Civils de Lyon - Recruiting 18 years or older. - Thoracic Paravertebral Block: a Comparative Study of Ropivacaine With Ropivacaine and Sufentanil for Treating Pain After Video-assisted Thoracic Surgery..
SANUWAVE, Inc. - Recruiting 22 years or older. - A Double-Blind, Multi-center, Randomized, Sham-Controlled, Parallel Group Comparison of the dermaPACEÂ® (Pulsed Acoustic Cellular Expression) Device in Conjunction With Standard of Care Versus Standard of Care Alone in the Treatment of Diabetic Foot Ulcers.
Electrohydraulic-generated shock wave; Sham device plus standard of care
UniversitÃ degli Studi di Sassari - Recruiting 18 years to 65 years. - Neurophysiological, Dynamometric, Functional and Clinical Assessment of the Cross-Training Effect in Patients With Multiple Sclerosis.
Gynecologic Oncology Group - Recruiting 18 years or older. - Randomized Phase III Clinical Trial of Adjuvant Radiation Versus Chemoradiation in Intermediate Risk, Stage I/IIA Cervical Cancer Treated With Initial Radical Hysterectomy and Pelvic Lymphadenectomy.
CytRx - Recruiting 18 years or older. - An Open-Label Pilot Phase 2 Study to Investigate the Preliminary Efficacy and Safety of Aldoxorubicin in Subjects With Unresectable Glioblastoma Whose Tumors Have Progressed Following Prior Treatment With Surgery, Radiation and Temozolomide.
Grifols Biologicals Inc. - Recruiting N/A or older. - A Prospective, Single-blind, Randomized, Phase III Study to Evaluate the Safety and Efficacy of Fibrin Sealant Grifols (FS Grifols) as an Adjunct to Hemostasis During Peripheral Vascular Surgery.
Gynecologic Oncology Group - Recruiting 18 years or older. - A Randomized Phase III Trial of Cisplatin and Tumor Volume Directed Irradiation Followed by Carboplatin and Paclitaxel vs. Carboplatin and Paclitaxel for Optimally Debulked, Advanced Endometrial Carcinoma.
Macrocure Ltd. - Recruiting 18 years or older. - A Phase III Multicenter, Randomized, Double-Blind, Parallel-Group, Sham-Controlled Study to Evaluate the Safety, Tolerability and Efficacy of CureXcellr as an Adjunct to Good Wound Care in Lower Extremity Chronic Ulcers in Adults With Diabetes Mellitus.
Gynecologic Oncology Group - Recruiting N/A or older. - A Randomized Trial of Pelvic Irradiation With or Without Concurrent Weekly Cisplatin in Patients With Pelvic-Only Recurrence of Carcinoma of the Uterine Corpus.
Galapagos NV - Recruiting 18 years or older. - Randomized, Double-blind, Placebo-controlled, Multicenter, Phase IIb Dose Finding Study of GLPG0634 Administered for 24 Weeks in Combination With Methotrexate to Subjects With Moderately to Severely Active Rheumatoid Arthritis Who Have an Inadequate Response to Methotrexate Alone.
Shire Development LLC - Recruiting 18 years or older. - A Phase 2, Single-blind, Randomized, Controlled, Multi-center Study to Evaluate the Efficacy and Safety of SRM003 (Vascugelr) in Improving the Rate of Arteriovenous Fistula Maturation and Use in Subjects Undergoing Surgery for Creation of an Arteriovenous Fistula for Hemodialysis Access.
Odense University Hospital - Recruiting 18 years or older. - Use of Incisional Negative Pressure Wound Therapy for Prevention of Postoperative Infections Following Caesarean Section in Women With BMI >=30.
PICO from Smith&Nephew; Standard postoperative wound dressing
Centre Hospitalier Universitaire de Saint Etienne - Recruiting 18 years or older. - Comparison of Treatment of Atrial Fibrillation (AF) Between Surgical Ultrasonic Technology (EPICOR) or Drug Therapy (Cordarone) for Patients With AF Requiring Mitral Valve Surgery.
Hospital for Special Surgery, New York - Recruiting 35 years or older. - A Prospective Study to Validate Two New Patient Reported Outcome Measures for Dupuytren's Disease in Patients Treated With XIAFLEX.
Ipsen - Recruiting 18 years or older. - A Multi-centre, Prospective, Non-interventional Study to Describe the Efficacy of a Continuous up to 24-week Treatment of Diphereline 3.75mg Following Conservative Surgery in Deep Infiltrating Endometriosis (DIE) Patients Over a Period of 24 Months..
TC Erciyes University - Recruiting 2 years to 11 years. - Intranasal Dexmedetomidine Versus Intranasal Midazolam-ketamine Combination for Premedication of Pediatric Patients Undergoing Strabismus Surgery.
Gynecologic Oncology Group - Recruiting 18 years or older. - Glycoprotein and Glycan Profiling in Patients With Locally Advanced Cervical Cancer (Stage IB2, IIA > 4 CM, IIB to IVA) Undergoing Pelvic and Para-Aortic (Abdominal) Lymphadenectomy.
Shire Development LLC - Recruiting 18 years or older. - A Phase 2, Single-blind, Randomized, Controlled, Multi-center Study to Evaluate the Efficacy and Safety of SRM003 (Vascugelr) in the Treatment of Subjects With Vascular Injury Resulting From Arteriovenous Graft Surgery for Hemodialysis Access.
Ethicon, Inc. - Recruiting 18 years or older. - A Phase III Randomized, Controlled, Superiority Study Evaluating EVARRESTT Fibrin Sealant Patch Versus Standard of Care Treatment in Controlling Parenchymal Bleeding During Hepatic Surgery.
EVARRESTT Fibrin Sealant Patch; Standard of Care (SoC)
Ethicon, Inc. - Recruiting 18 years or older. - A Single-blinded, Randomized, Controlled, Comparative Phase III Study Evaluating the Safety and Effectiveness of EVARRESTT Fibrin Sealant Patch as an Adjunct to Hemostasis During Cardiovascular Surgery.
Xoft, Inc. - Recruiting 40 years or older. - A Safety and Efficacy Study of Intra-Operative Radiation Therapy (IORT) Using the Xoftr Axxentr eBxT System at the Time of Breast Conservation Surgery for Early Stage Breast Cancer.
Pfizer - Recruiting 18 years to 55 years. - A Phase 2, Randomized, Double-blind, Within-Subject, Placebo Controlled Study to Evaluate the Efficacy and Safety of PF-06473871 in Reducing Hypertrophic Skin Scarring.
Roswell Park Cancer Institute - Recruiting 50 years or older. - Phase II Trial of Single Fraction Radiation Therapy (SFRT) at Roswell Park Cancer Institute for Select Patients With Early Stage Breast Cancer.
Rutgers, The State University of New Jersey - Recruiting 18 years to 65 years. - Exparel Use for Popliteal Nerve Block in Postoperative Pain Control; After Ankle Fracture Fixation or Ankle Fusion Surgery: a Case Series.
Ethicon, Inc. - Recruiting 18 years or older. - A Non-Investigational Post-Market Trial Using EVARRESTT Fibrin Sealant Patch as an Adjunct to Hemostasis in Soft Tissue Bleeding During Intra-Abdominal, Retroperitoneal, Pelvic and Non-Cardiac Thoracic Surgery.
Pfizer - Recruiting 6 years to 16 years. - A 12-Week Randomized, Open-Label, Active Comparator Period Followed By A 12-Week Safety Extension Period To Evaluate The Safety And Efficacy Of Fesoterodine In Subjects Aged 6 To 16 Years And >25 Kg With Symptoms Of Detrusor Overactivity Associated With A Neurological Condition (Neurogenic Detrusor Overactivity).
ACOS - Recruiting 12 years or older. - A Multi-Center, Randomized, Controlled Evaluation of the Safety and Efficacy of the KXL System With VibeX (Riboflavin Ophthalmic Solution) for Corneal Collagen Cross-Linking in Eyes With Keratoconus or Corneal Ectasia After Refractive Surgery.
KXL System (15 mW/cm2); KXL System (30 mW/cm2); KXL System (45 mW/cm2); riboflavin ophthalmic solution
Huashan Hospital - Recruiting 18 years to 70 years. - 3.0T High-field Intraoperative MRI Guided Extent of Resection in Cerebral Glioma Surgery: a Single Center Prospective Randomized Triple-blind Controlled Clinical Trial.
Ontario Clinical Oncology Group (OCOG) - Recruiting 60 years or older. - A Prospective Cohort Study Evaluating Risk of Local Recurrence Following Breast Conserving Surgery and Endocrine Therapy in Low Risk Luminal A Breast Cancer.
The University of Texas Health Science Center at San Antonio - Recruiting 18 years or older. - A Phase II Study of Induction Docetaxel, Cisplatin, Cetuximab and Bevacizumab (TPE-A) Followed by Concurrent Radiation, Cisplatin, Cetuximab and Bevacizumab (XPE-A) in Patients With Locally Advanced Head and Neck Cancer (CTRC# 11-36).
Docetaxel, Cisplatin, Cetuximab and Bevacizumab (TPE-A) Followed by Concurrent Radiation, Cisplatin, Cetuximab and Bevacizumab (XPE-A), surgery
Neograft Technologies, Incorporated - Recruiting 18 years to 80 years. - First-In-Human Study to Demonstrate the Preliminary Safety and Efficacy of the Angioshield System to Provide Mechanical Support for Vein Grafts Used in CABG Surgery.
VentiRx Pharmaceuticals Inc. - Recruiting 18 years or older. - A Randomized, Double-Blind, Placebo-Controlled Phase II Study of VTX-2337 in Combination With Pegylated Liposomal Doxorubicin (PLD) in Patients With Recurrent or Persistent Epithelial Ovarian, Fallopian Tube or Primary Peritoneal Cancer.
Medtronic Spinal and Biologics - Recruiting 65 years or older. - A Prospective and Multicenter Evaluation of Outcomes for Quality of Life and Activities of Daily Living for Balloon Kyphoplasty in the Treatment of Vertebral Compression Fractures.
Dr. Reddy's Laboratories Limited - Recruiting 18 years or older. - A Randomized, Blinded, Placebo and Standard of Care Controlled Efficacy, Safety, and Tolerability Study of up to 20 mL of DFA-02 in Patients Undergoing Abdominal Surgery.
National Cancer Institute (NCI) - Recruiting 18 years or older. - Phase I Pharmacokinetic Study of Dasatinib (BMS-354825) (NSC-732517; IND-73969) in Patients With Advanced Malignancies and Varying Levels of Liver Dysfunction.
VU University Medical Center - Recruiting 18 years or older. - A Randomized Multicenter Clinical Trial for Patient With Multi-organ, Colorectal Cancer Metastases Comparing the Combination of Chemotherapy and Maximal Tumor Debulking Versus Chemotherapy Alone..
XELOX regimen according to standard procedures; FOLFOX regimen according to standard procedures; Surgery; radiofrequency ablation (RFA); transarterial chemo-embolization using irinotecan drug-eluted beads ((DEBIRI-)TACE); stereotactic body radiation therapy (SBRT); Bevacizumab; tumor biopsy
Roswell Park Cancer Institute - Recruiting 18 years or older. - A Phase I Study of Surgery Plus Intraoperative Photodynamic Therapy (PDT) With Temoporfin in Patients With Resectable Primary Non-Small Cell Lung Cancer (NSCLC) With Ipsilateral Thoracic Nodal (N1 or N2) or T3/T4 Disease.
Eastern Hepatobiliary Surgery Hospital - Recruiting 18 years to 70 years. - A Randomized Placebo-Controlled Study of Whether Pre-operative Pregabalin 150 mg Will Improve Pain Control in Patients With Hepatocellular Carcinoma Undergoing Partial Hepatectomy.
National Taiwan University Hospital - Recruiting 20 years to 75 years. - Using Non-invasive Near Infra-red Spectroscopy to Measure the Regional Tissue Perfusion in Patients Receiving Off-pump Coronary Artery Bypass Graft Surgery.
Radboud University - Recruiting 18 years or older. - The Efficacy of Cone Beam Computed Tomography (CBCT) Compared to Panoramic Radiography Prior to Third Molar Removal; a Multicentre Randomised Controlled Trial.
USGI Medical - Recruiting 22 years to 60 years. - A RANDOMIZED, SUBJECT AND EVALUATOR-BLINDED, PARALLEL-GROUP, MULTICENTER CLINICAL TRIAL USING AN ENDOSCOPIC SUTURING DEVICE (G-CATH EZT SUTURE ANCHOR DELIVERY CATHETER) FOR PRIMARY WEIGHT LOSS.
placement of g-Cath EZ suture anchors; Sham procedure; Diet and Exercise
Aegea Medical, Inc. - Recruiting 30 years to 50 years. - A Prospective, Multicenter, Clinical Trial to Evaluate the Safety and Effectiveness of the AEGEA Vapor System for the Treatment of Excessive Uterine Bleeding.
Southwest Oncology Group - Recruiting 18 years or older. - A Phase III Randomized Trial Comparing Androgen Deprivation Therapy + TAK-700 With Androgen Deprivation Therapy + Bicalutamide in Patients With Newly Diagnosed Metastatic Sensitive Prostate Cancer.
CSL Behring - Recruiting 18 years or older. - REPLACE (Randomized Evaluation of Fibrinogen Versus Placebo in Complex Cardiovascular Surgery): a Prospective, Multinational, Multicenter, Randomized, Double-blind, Placebo-controlled, Phase III Study for the Use of Fibrinogen Concentrate (Human) (FCH) in Complex Cardiovascular Surgery.
NCIC Clinical Trials Group - Recruiting 18 years or older. - A Phase II/III Study of Intraperitoneal (IP) Plus Intravenous (IV) Chemotherapy Versus IV Carboplatin Plus Paclitaxel in Patients With Epithelial Ovarian Cancer Optimally Debulked at Surgery Following Neoadjuvant Intravenous Chemotherapy.
University of Southern California - Recruiting 18 years or older. - Real Time Contrast Enhanced Ultrasound and Ultrasound-Based Elastography: Novel Techniques in Assessment of Treatment Response to Neoadjuvant Chemotherapy for Breast Cancer.
National Cancer Institute (NCI) - Recruiting 19 years or older. - A Pilot Study of the Immunological Effects of Neo-Adjuvant INCB024360 in Patients With Epithelial Ovarian, Fallopian Tube or Primary Peritoneal Carcinoma.
TriHealth Inc. - Recruiting 18 years to 70 years. - The Effect of Intravenous Acetaminophen on Post-operative Pain and Narcotic Consumption in Vaginal Reconstructive Surgery Patients: A Randomized Controlled Trial.
Grifols Biologicals Inc. - Recruiting 12 years or older. - A Phase II/III Pivotal Trial Evaluating the Safety, Pharmacokinetic Properties and Efficacy of a Plasma-Derived Anti-thrombin III Concentrate With Administration in Surgery, Pregnancy and Thromboembolic or Thrombotic Events..
Mahidol University - Recruiting 18 years to 45 years. - A Prospective Double Blind Randomized Controlled Trial to Study the Effectiveness of a Desogestrel for the Treatment of Pelvic Pain or Dysmenorrhea in the Patients Undergone Conservative Surgery for Pelvic Endometriosis.
University of Ottawa Heart Institute - Recruiting 18 years or older. - A Randomized Controlled Trial to Investigate Whether a Strategy of Continued Versus Interrupted Dabigatran at the Time of Device Surgery, in Patients With Moderate to High Risk of Arterial Thrombo-embolic Events, Leads to a Reduction in the Incidence of Clinically Significant Hematoma.
New York University School of Medicine - Recruiting 21 years or older. - OPTMIZE-OS: Optimization of Pre-surgical Testing With an Intensive Multifactorial Intervention to MinimiZe Cardiovascular Events in Orthopedic Surgery.
Georgetown University - Recruiting 18 years or older. - Pilot Study for Analysis of Tumor Gene Expression by DNA Microarray Analysis in Patients Undergoing Breast Cancer Surgery or Core Biopsy Sampling.
Survey of client health, personal habits, family history; Blood specimen for non-DNA and DNA parts; Biopsy of esophageal/stomach tissue, lymph nodes, tumor; Biopsies from routine clinical surveillance endoscopies
Washington University School of Medicine - Recruiting 18 years or older. - A Pilot Study of Using MRI-Guided Laser Heat Ablation to Induce Disruption of the Peritumoral Blood Brain Barrier to Enhance Delivery and Efficacy of Doxorubicin in the Treatment of Recurrent Glioblastoma Multiforme.
Gynecologic Oncology Group - Recruiting 18 years or older. - A Limited Access Phase II Trial Utilizing Bioimpedance to Measure Lower Extremity Lymphedema Associated With the Surgical Management of a Vulvar Cancer.
Gynecologic Oncology Group - Recruiting 18 years or older. - Evaluation of Physical Function and Quality of Life (QOL) Before and After Non-Radical Surgical Therapy (Extra Fascial Hysterectomy or Cone Biopsy With Pelvic Lymphadenectomy) for Stage IA1 (LVSI+) and IA2-IB1 (=/<2CM) Cervical Cancer.
LEO Pharma - Recruiting 18 years or older. - Efficacy and Safety of Ingenol Mebutate Gel 0.06% When Applied Once Daily for 2, 3 or 4 Consecutive Days to a Treatment Area of Approximately 250 cm2 on Trunk and Extremities in Subjects With Actinic Keratosis.
Holbaek Sygehus - Recruiting 18 years to 85 years. - Transanal Haemorrhoidal Dearterialization (THD) Versus Open Haemorrhoidectomy for the Treatment of Haemorrhoids. An Open Prospective Randomized Study..
Transanal Haemorrhoidal Dearterialization; Open Haemorrhoidectomy
Hoffmann-La Roche - Recruiting 18 years or older. - A Randomized, Double-Blind, Placebo-Controlled, Phase II Study To Assess The Efficacy And Safety Of Oral Vismodegib For The Treatment Of Basal Cell Carcinoma Preceding Excision By Mohs Micrographic Surgery.
University Hospital Inselspital, Berne - Recruiting N/A or older. - The Impact of Preoperative Oral Glutamine Intake on the Immunocompetence and Outcomes of Malnourished Patients Undergoing Major Abdominal Surgery Due to Malignancies - A Randomized, Placebo-controlled Pilot Study.
Paion UK Ltd. - Recruiting 18 years or older. - A Randomized, Single-blind Phase II Study Evaluating the Efficacy, Safety and Pharmacokinetics of Remimazolam in General Anesthesia in Adult Patients Undergoing Cardiac Surgery, Including Follow-up Sedation in the PACU/ICU.
Chinese University of Hong Kong - Recruiting 18 years to 80 years. - Can Electroacupuncture Prevent Prolonged Ileus After Laparoscopic Surgery for Mid and Low Rectal Cancer? A Prospective Study With Matched Historical Controls.
Gustave Roussy, Cancer Campus, Grand Paris - Recruiting 18 years or older. - Phase III Study Comparing Post-Operative Conformal Radiotherapy to No Post-Operative Radiotherapy in Patients With Completely Resected Non-Small Cell Lung Cancer and Mediastinal N2 Involvement [Lung ART].
Chinese University of Hong Kong - Recruiting 18 years to 80 years. - A Randomized Clinical Trial of Electroacupuncture Versus Fast-track Perioperative Program for Reducing Duration of Postoperative Ileus and Hospital Stay After Laparoscopic Colorectal Surgery.
Karolinska Institutet - Recruiting 18 years or older. - Observational Prospective Case-control Study on Prevalence and Impact of Subclinical Hyperthyroidism in Patients Undergoing Atrial Fibrillation Ablation.
University of Ulm - Recruiting 14 years to 25 years. - Effectiveness and Safety of Weight Loss Surgery in Adolescents With Extreme Obesity Within a Structured Pre- and Post-surgery Treatment Program, Subproject 3.
Derma Sciences, Inc. - Recruiting 18 years or older. - A Randomized, Double-Blind, Parallel-group, Vehicle and Standard of Care-controlled Phase 3 Clinical Trial to Evaluate the Efficacy and Safety of DSC127 in Treating Non-healing Foot Ulcers in Subjects With Diabetes Mellitus.
DSC127; placebo vehicle gel; Standard of Care gel, Aquasite
Pfizer - Recruiting 18 years to 70 years. - Phase 3, Randomized, Open-Label Study Of The Efficacy And Safety Of Crizotinib Versus Pemetrexed/Cisplatin Or Pemetrexed/Carboplatin In Previously Untreated East Asian Patients With Non-Squamous Carcinoma Of The Lung Harboring A Translocation Or Inversion Event Involving The Anaplastic Lymphoma Kinase (ALK) Gene Locus.
Eastern Cooperative Oncology Group - Recruiting 18 years or older. - A Randomized Phase III Trial of the Value of Early Local Therapy for the Intact Primary Tumor in Patients With Metastatic Breast Cancer.
National Cancer Institute (NCI) - Recruiting 18 years or older. - A Phase III Randomized Controlled Clinical Trial of Carboplatin and Paclitaxel (or Gemcitabine) Alone or in Combination With Bevacizumab (NSC #704865, IND #113912) Followed by Bevacizumab and Secondary Cytoreductive Surgery in Platinum-Sensitive, Recurrent Ovarian, Peritoneal Primary and Fallopian Tube Cancer. NCI-Supplied Agents: Bevacizumab (NSC #704865, IND #113912).
Eastern Cooperative Oncology Group - Recruiting 18 years or older. - A Phase II Study of L-BLP25 and Bevacizumab in Unresectable Stage IIIA and IIIB Non-Squamous Non-Small Cell Lung Cancer After Definitive Chemoradiation.
University of California, San Francisco - Recruiting 18 years or older. - Intraoperative Use of Infrared Pupillometry During General Anesthesia to Predict Pain and Quality of Regional Anesthesia After Surgery.
Infrared Pupillometry; Anesthesia Premedication, Induction and Maintenance
Memorial Sloan-Kettering Cancer Center - Recruiting 21 years or older. - A Double-Masked Placebo Controlled Clinical Trial of the Postoperative Opioid Sparing Effects of Intraoperative Dexmedetomidine Infusion for Video-Assisted Thoracic Surgery.
Rigshospitalet, Denmark - Recruiting 18 years or older. - CardioPAT Project - Reducing the Need for Allogenic Blood Transfusion After On-pump Cardiac Surgery With Intra- and Postoperative Use of a New Device: a Randomized Trial.
Memorial Sloan-Kettering Cancer Center - Recruiting 18 years or older. - Flexible Fiber-based CO2 Laser Versus Monopolar Cautery for Resection of Benign, Pre-malignant And Malignant Oral Cavity Lesions: A Single Center Randomized Controlled Trial Assessing Pain and Quality of Life Following Surgery.
Flexible Fiber-based CO2 Laser, Quality of Life forms; electrocautery resection and quality of life forms
Institut Cancerologie de l'Ouest - Recruiting 18 years to 65 years. - Multicentric, National, Prospective, Comparative, Non Randomized Study, Assessing Medico-economic Impact of Three Strategies of Sentinel Lymph Node Analysis in Immediately Operable Breast Cancer.
Centre Hospitalier Universitaire Dijon - Recruiting 18 years or older. - THE TAP BLOCK TECHNIQUE VIA THE ANTERIOR APPROACH IN ELECTIVE SURGERY OF THE SPINE: Prospective, Randomised, Double Blind Trial, Comparing TAP BLOCK With Continuous Infiltration of Ropivacaine Versus Placebo.
Thomas Jefferson University - Recruiting 18 years to 79 years. - A Prospective Randomized Study of Two Types of Sternal Closure After Open Heart Surgery: Rigid Sternal Fixation vs. Sternal Wire Closure.
Eastern Cooperative Oncology Group - Recruiting 18 years or older. - A Randomized, Placebo Controlled Phase II Trial of Afatinib (BIBW2992) as Adjuvant Therapy Following Chemoradiation in Patients With Head and Neck Squamous Cell Carcinoma at High Risk of Recurrence.
Vaximm GmbH - Recruiting 18 years or older. - VXM01 Phase I Dose Escalation Study in Patients With Locally Advanced, Inoperable and Stage IV Pancreatic Cancer to Examine Safety, Tolerability, and Immune Response to the Investigational VEGFR-2 DNA Vaccine VXM01.
Penumbra Inc. - Recruiting 18 years to 85 years. - The THERAPY Trial: The Randomized, Concurrent Controlled Trial to Assess the Penumbra System's Safety and Effectiveness in the Treatment of Acute Stroke.
intravenous (IV) recombinant human tissue plasminogen activator (rtPA); Penumbra System
Biocad - Recruiting 18 years to 95 years. - A Multicenter Open-label Randomized Study of BCD-020 (Rituximab, CJSC BIOCAD, Russia) Efficacy and Safety in Comparison With MabThera (F. Hoffmann-La Roche Ltd., Switzerland) in Monotherapy of CD20-positive Indolent Non-Hodgkin's Lymphoma.
University Hospital, Basel, Switzerland - Recruiting 18 years or older. - Novel Biomarkers (TIMP-2 and IGFBP7) of Tubular Renal Cell Damage for the Prediction of the Cardiac Surgery Associated Acute Kidney Injury (CSA-AKI) - A Feasibility Study.
National Cancer Institute (NCI) - Recruiting 18 years or older. - A Phase III Randomized Study of Adjuvant Ipilimumab Anti-CTLA4 Therapy Versus High-Dose Interferon a-2b for Resected High-Risk Melanoma.
Cumberland Pharmaceuticals - Recruiting 18 years or older. - A Multicenter, Prospective, Randomized, Double-blind Study to Determine the Efficacy of Intravenous Ibuprofen Compared to Intravenous Ketorolac for Pain Control Following Arthroscopic Knee Surgery.
Smith & Nephew, Inc. - Recruiting N/A or older. - A Retro-Prospective, Non-randomized, Consecutive Series, SIngle Cohort, Multicenter Adaptive Design Study to Evaluate the Outcomes of Total Knee Arthroplasty (TKA) Using JOURNEYT II BCS TotaL Knee SystEm (The NIMBLE Study).
CEL-SCI Corporation - Recruiting 18 years or older. - Phase III Study of LI [Multikiner] Plus SOC (Surgery + Radiotherapy or Surgery + Concurrent Radiochemotherapy) in Subjects With Advanced Primary Squamous Cell Carcinoma of the Oral Cavity/Soft Palate vs. SOC Only.
Meshalkin Research Institute of Pathology of Circulation - Recruiting 18 years to 65 years. - Left Atrium Reduction Versus no Left Atrium Reduction for Patients With Enlarged Left Atria and Persistent or Long Standing Persistent Atrial Fibrillation Undergoing Mitral Valve Surgery.
maze procedure; mitral valve surgery; left atrial reduction
Galapagos NV - Recruiting 18 years or older. - Randomized, Double-blind, Placebo-controlled, Multicenter, Phase IIb Dose Finding Study of GLPG0634 Administered for 24 Weeks as Monotherapy to Subjects With Moderately to Severely Active Rheumatoid Arthritis Who Have an Inadequate Response to Methotrexate (MTX) Alone.
Aarhus University Hospital Skejby - Recruiting 18 years or older. - The Clinical Impact of an Aggressive Approach Towards Pleural and Pericardial Effusions Following Open Heart Surgery: a Step Towards Standard Guidelines.
University College, London - Recruiting 18 years or older. - A Randomised Double-blind Controlled Phase III Study to Compare the Efficacy and Safety of Intravenous Ferric Carboxymaltose With Placebo in Patients With Anaemia Undergoing Major Open Abdominal Surgery.
Early administration of SAP (Cefuroxime (plus metronidazole in colorectal surgery)) early in anesthetic room (75 to 30 minutes prior to skin incision); Late administration of SAP (Cefuroxime (plus metronidazole in colorectal surgery)) in the operating theatre (within 30 minutes prior to skin incision)
Domp s.p.a. - Recruiting 18 years to 70 years. - A Phase 3, Multicenter, Randomized, Double-blind, Parallel Assignment Study to Assess the Efficacy and Safety of Reparixin in Pancreatic Islet Transplantation.
European Organisation for Research and Treatment of Cancer - EORTC - Recruiting 18 years to 75 years. - Randomized Phase II Trial Evaluating the Efficacy of FOLFOX Alone, FOLFOX Plus Bevacizumab and FOLFOX Plus Panitumumab as Perioperative Treatment in Patients With Resectable Liver Metastases From Wild Type KRAS Colorectal Cancer.
Tianjin Medical University General Hospital - Recruiting 20 years to 60 years. - Effect of Butorphanol Combined With Flurbiprofen Axetil on Preventing Postoperative Hyperalgesia Induced by Remifentanil in Patients Undergoing Lower Abdomimal Surgery.
Charite University, Berlin, Germany - Recruiting 18 years or older. - A Double-blind, Randomized, Placebo Controlled Study to Evaluate the Effectiveness of Etoricoxib as an Additive Analgesic to Epidural Analgesia in Colon or Rectal Fast-track Surgery.
Assistance Publique - Hpitaux de Paris - Recruiting 18 years to 80 years. - Randomized Study Evaluating the Influence of the Strategy Intraoperative Anesthetic (Desflurane Versus Propofol) on Cognitive and Psychomotor Functions in Output Post Interventional Room Monitoring.
Intraoperative anesthetic strategy by Propofol; Intraoperative anesthetic strategy by Desflurane
Case Comprehensive Cancer Center - Recruiting 18 years or older. - A Phase II Trial of Modified FOLFOX-6 Induction Chemotherapy Followed by Esophagectomy and Post-operative Response Based Concurrent Chemoradiotherapy in Patients With Locoregionally Advanced Adenocarcinoma of the Esophagus, Gastro-esophageal Junction, and Gastric Cardia.
National Cancer Institute (NCI) - Recruiting 18 years or older. - A Randomized Phase III Trial Evaluating Pathologic Complete Response Rates in Patients With Hormone Receptor-Positive, HER2-Positive, Large Operable and Locally Advanced Breast Cancer Treated With Neoadjuvant Therapy of Docetaxel, Carboplatin, Trastuzumab, and Pertuzumab (TCHP) With or Without Estrogen Deprivation.
Krankenhaus Barmherzige Schwestern Linz - Recruiting 18 years or older. - A Prospective Randomized Trial on Comparison of Standard- Carbon Dioxide Pressure Pneumoperitoneum Insufflators Versus AirSeal.
Ethicon, Inc. - Recruiting 18 years or older. - A Prospective, Single-Arm, Observational, Non-interventional Study for EVICEL T Fibrin Sealant (Human) When Used as an Adjunct to Haemostasis in Vascular Surgery.
University of Roma La Sapienza - Recruiting 18 years to 75 years. - Influence of Premedication With Oral Morphine Sulphate on Analgesic Consumption in Patient Undergoing Major Urological Surgery. Comparison Between Two Different Doses.
Major Extremity Trauma Research Consortium - Recruiting 18 years to 64 years. - A Prospective Randomized Trial to Assess Fixation Strategies for Severe Open Tibia Fractures:Modern Ring External Fixators versusInternal Fixation.
Surgery with an external ring fixator; Definitive fixation with a locked IM nail or plate
Syntrix Biosystems, Inc. - Recruiting 18 years or older. - A Phase 2 Double-Blind, Placebo-Controlled, Randomized Dose Finding Study For The Efficacy And Safety Of Aminopterin In Methotrexate-Naive Rheumatoid Arthritis.