300 results found.

Adult Primary Hepatocellular Carcinoma, Localized Unresectable Ad Clinical Trial using sorafenib tosylate; placebo; doxorubicin hydrochloride; doxorubicin-eluting beads; cisplatin; mitomycin C

National Cancer Institute (NCI) - Recruiting 18 years or older.
- A Phase III Randomized, Double-Blind Trial of Chemoembolization With or Without Sorafenib in Unresectable Hepatocellular Carcinoma (HCC) in Patients With and Without Vascular Invasion.
sorafenib tosylate; placebo; doxorubicin hydrochloride; doxorubicin-eluting beads; cisplatin; mitomycin C

Adenocarcinoma, Pancreas, or Neuroendocrine Tumor, Pancreas Clinical Trial using iopromide; CT

Seoul National University Hospital - Recruiting 18 years or older.
- Evaluation of Diagnostic Efficacy of Perfusion CT Using Wide Detector for Staging and Response Prediction After Chemotherapy in Pancreatic Cancer.
iopromide; CT

Metastatic Colorectal Cancer, Metastatic Gastric Cancer, Metastat Clinical Trial using CD8+ young TIL; Aldesleukin; Cyclophosphamide; Fludarabine

National Institutes of Health Clinical Center (CC) - Recruiting 18 years to 66 years.
- A Phase II Study Using Short-Term Cultured, Autologous Tumor-Infiltrating Lymphocytes Following a Lymphocyte Depleting Regimen in Metastatic Digestive Tract Cancers.
CD8+ young TIL; Aldesleukin; Cyclophosphamide; Fludarabine

Brain and Central Nervous System Tumors, Cognitive/Functional Eff Clinical Trial using modafinil; placebo

University of South Florida - Recruiting 6 years to 17 years.
- A Phase II Placebo-Controlled Trial of Modafinil to Improve Neurocognitive Deficits in Children Treated for a Primary Brain Tumor.
modafinil; placebo

Melanoma (Skin) Clinical Trial using gene expression analysis; polymerase chain reaction; polymorphism analysis; matrix-assisted laser desorption/ionization time of flight mass spectrometry; medical chart review

Case Comprehensive Cancer Center - Recruiting N/A or older.
- Identification of Genomic Lesions Promoting Nodal Metastasis in Malignant Melanoma.
gene expression analysis; polymerase chain reaction; polymorphism analysis; matrix-assisted laser desorption/ionization time of flight mass spectrometry; medical chart review

Metastatic Melanoma, or Skin Cancer Clinical Trial using Cyclophosphamide; Fludarabine; Young TIL

National Institutes of Health Clinical Center (CC) - Recruiting 18 years to 70 years.
- A Pilot Study of the Administration of Young Tumor Infiltrating Lymphocytes Following a Non-Myeloablative Lymphocyte Depleting Chemotherapy Regimen in Metastatic Melanoma.
Cyclophosphamide; Fludarabine; Young TIL

Prostate Cancer Clinical Trial using Best Systemic Therapy (BST); Best Systemic Therapy (BST) + Surgery or Radiation Therapy; Questionnaires; Phone Call/Email

M.D. Anderson Cancer Center - Recruiting 18 years or older.
- Randomized, Phase II Trial of Best Systemic Therapy or Best Systemic Therapy (BST) Plus Definitive Treatment (Radiation or Surgery) of the Primary Tumor in Metastatic (M1) Prostate Cancer (PC).
Best Systemic Therapy (BST); Best Systemic Therapy (BST) + Surgery or Radiation Therapy; Questionnaires; Phone Call/Email

Metastatic Lesions in Vertebral Bodies Clinical Trial using START Tumor Ablation System and StabiliTr Vertebral Augmentation System

DFINE Inc. - Recruiting 18 years or older.
- A Prospective, Multicenter Clinical Study to Evaluate the Clinical Outcomes of the START Tumor Ablation System and StabiliTr Vertebral Augmentation System to Treat Painful Metastatic Vertebral Body Tumor(s) in the Spine.
START Tumor Ablation System and StabiliTr Vertebral Augmentation System

Recurrent Melanoma, Stage IA Melanoma, Stage IB Melanoma, Stage I Clinical Trial using fluorescein sodium injection; diagnostic microscopy; therapeutic conventional surgery; laboratory biomarker analysis

Roswell Park Cancer Institute - Recruiting 18 years or older.
- A Pilot Study of Feasibility of Performing Intravital Microscopy in Melanoma Patients.
fluorescein sodium injection; diagnostic microscopy; therapeutic conventional surgery; laboratory biomarker analysis

Glioblastoma, Small Cell Glioblastoma, Giant Cell Glioblastoma, G Clinical Trial using Rindopepimut (CDX-110) with GM-CSF; Temozolomide; KLH

Celldex Therapeutics - Recruiting 18 years or older.
- An International, Randomized, Double-Blind, Controlled Study of Rindopepimut/GM-CSF With Adjuvant Temozolomide in Patients With Newly Diagnosed, Surgically Resected, EGFRvIII-positive Glioblastoma.
Rindopepimut (CDX-110) with GM-CSF; Temozolomide; KLH

Lymphoma, Follicular Clinical Trial using BI 695500; MabThera

Boehringer Ingelheim - Recruiting 18 years or older.
- A Randomized, Double-blind, Parallel-arm, Phase I Study to Evaluate the Pharmacokinetics and Pharmacodynamics of BI 695500 vs. Rituximab (MabThera) Induction Immunotherapy as a First-line Treatment in Patients With Low Tumor Burden Follicular Lymphoma.
BI 695500; MabThera

Indolent Non-Hodgkin's Lymphoma, Follicular Lymphoma, Small Lymph Clinical Trial using Idelalisib

Gilead Sciences - Recruiting 18 years or older.
- Single-agent CAL-101 for Previously Teated Low-grade Lymphoma: A Phase 1/2 Study of Safety, Efficacy, and Flow-cytometric Assessment of Tumor-cell Signaling Events.
Idelalisib

Cancer, Solid Tumor Clinical Trial using MK-3475 1 mg/kg; MK-3475 3 mg/kg; MK-3475 10 mg/kg; MK-3475 MEL; MK-3475 NSCLC; MK-3475 MEL Low Dose; MK-3475 MEL High Dose; MK-3475 NSCLC Low Dose; MK-3475 NSCLC High Dose; MK-3475 NSCLC Medium Dose

Merck Sharp & Dohme Corp. - Recruiting 18 years or older.
- Phase I Study of Single Agent MK-3475 in Patients With Progressive Locally Advanced or Metastatic Carcinoma, Melanoma, and Non-Small Cell Lung Carcinoma.
MK-3475 1 mg/kg; MK-3475 3 mg/kg; MK-3475 10 mg/kg; MK-3475 MEL; MK-3475 NSCLC; MK-3475 MEL Low Dose; MK-3475 MEL High Dose; MK-3475 NSCLC Low Dose; MK-3475 NSCLC High Dose; MK-3475 NSCLC Medium Dose

Leukemia, or Lymphoma Clinical Trial using Rasburicase; Allopurinol

M.D. Anderson Cancer Center - Recruiting N/A or older.
- A Randomized Phase 2 Study to Evaluate the Efficacy of Rasburicase in Patients at Risk for TLS During Two Cycles of Chemotherapy.
Rasburicase; Allopurinol

Metastatic Ocular Melanoma, or Metastatic Uveal Melanoma Clinical Trial using Aldesleukin; Cyclophosphamide; Fludarabine; Tumor Infiltrating Lymphocytes

National Institutes of Health Clinical Center (CC) - Recruiting 16 years to 75 years.
- Phase II Study in Patients With Metastatic Ocular Melanoma Using a Non-Myeloablative Lymphocyte Depleting Regimen of Chemotherapy Followed by Infusion of Autologous Tumor-Infiltrating Lymphocytes With or Without High Dose Aldesleukin.
Aldesleukin; Cyclophosphamide; Fludarabine; Tumor Infiltrating Lymphocytes

Cancer, or Solid Tumor Clinical Trial using MK-3475

Merck Sharp & Dohme Corp. - Recruiting 18 years or older.
- A Phase Ib Multi-Cohort Study of MK-3475 in Subjects With Advanced Solid Tumors.
MK-3475

Hepatic Complications, Liver Metastases, or Unspecified Adult Sol Clinical Trial using trametinib; pharmacological study; laboratory biomarker analysis

National Cancer Institute (NCI) - Recruiting 18 years or older.
- A Phase I Trial of Single Agent Trametinib (GSK1120212) in Advanced Cancer Patients With Hepatic Dysfunction.
trametinib; pharmacological study; laboratory biomarker analysis

Recurrent Childhood Medulloblastoma, Recurrent Childhood Pineobla Clinical Trial using temozolomide; irinotecan hydrochloride; bevacizumab

National Cancer Institute (NCI) - Recruiting N/A to 21 years.
- Temozolomide With Irinotecan Versus Temozolomide, Irinotecan Plus Bevacizumab (NSC# 704865) for Recurrent/Refractory Medulloblastoma/CNS PNET of Childhood, a COG Randomized Phase II Screening Trial.
temozolomide; irinotecan hydrochloride; bevacizumab

HIV Infection, or Unspecified Adult Solid Tumor, Protocol Specifi Clinical Trial using cabozantinib-s-malate; pharmacological study; laboratory biomarker analysis

National Cancer Institute (NCI) - Recruiting 18 years or older.
- Phase I Trial of Cabozantinib (XL184) for Advanced Solid Tumors in Persons With HIV Infection.
cabozantinib-s-malate; pharmacological study; laboratory biomarker analysis

Hepatitis B, Chronic, or Tumor Clinical Trial using TDF

Chang Gung Memorial Hospital - Recruiting 18 years to 70 years.
- Phase IV; Different Extend Treatment Duration (6 Months vs 12 Months After Chemotherapy) to Prevent HBV Relapse With Tenofovir for Prophylaxis in Patients With Malignant Tumor Combined With HBV Carrier Receiving Chemotherapy.
TDF

Glioblastoma, Small Cell Glioblastoma, Giant Cell Glioblastoma, G Clinical Trial using Bevacizumab; Rindopepimut (CDX-110) with GM-CSF; KLH

Celldex Therapeutics - Recruiting 18 years or older.
- A Phase II Study of Rindopepimut/GM-CSF in Patients With Relapsed EGFRvIII-Positive Glioblastoma.
Bevacizumab; Rindopepimut (CDX-110) with GM-CSF; KLH

Estrogen Receptor-positive Breast Cancer, HER2-negative Breast Ca Clinical Trial using fulvestrant; anastrozole

Alliance for Clinical Trials in Oncology - Recruiting 18 years or older.
- Alternate Approaches for Clinical Stage II or III Estrogen Receptor Positive Breast Cancer Neoadjuvant Treatment (ALTERNATE) in Postmenopausal Women: A Phase III Study.
fulvestrant; anastrozole

Lymphoma, B-Cell, Non-Hodgkin's Lymphoma Clinical Trial using DCDS4501A; rituximab [MabThera/Rituxan]; cyclophosphamide; prednisone; doxorubicin

Genentech - Recruiting 60 years to 80 years.
- A PHASE Ib STUDY EVALUATING THE SAFETY, TOLERABILITY AND ANTI-TUMOR ACTIVITY OF DCDS4501A IN COMBINATION WITH RITUXIMAB, CYCLOPHOSPHAMIDE, DOXORUBICIN, AND PREDNISONE IN PATIENTS WITH B-CELL NON-HODGKIN'S LYMPHOMA.
DCDS4501A; rituximab [MabThera/Rituxan]; cyclophosphamide; prednisone; doxorubicin

Li-Fraumeni Syndrome, or Cardiovascular Capacity Clinical Trial

National Institutes of Health Clinical Center (CC) - Recruiting 18 years or older.
- Metabolic Regulation by Tumor Suppressor p53 in Li-Fraumeni Syndrome.

Metastatic Melanoma Clinical Trial

Centre Hospitalier Universitaire de NÄ«mes - Recruiting 18 years or older.
- Circulating Tumor Cells and Melanoma: Comparing the EPISPOT (EPithelial ImmunoSPOT) and CellSearch Techniques.

Childhood Germ Cell Tumor, Ovarian Cancer, or Teratoma Clinical Trial using carboplatin; etoposide; ifosfamide; paclitaxel; thiotepa; autologous hematopoietic stem cell transplantation; Mesna; filgrastim

Masonic Cancer Center, University of Minnesota - Recruiting 10 years to 69 years.
- Autologous Peripheral Blood Stem Cell Transplant for Germ Cell Tumors.
carboplatin; etoposide; ifosfamide; paclitaxel; thiotepa; autologous hematopoietic stem cell transplantation; Mesna; filgrastim

Epithelial Cancer Clinical Trial using Lapatinib; Radiation therapy

Virginia Commonwealth University - Recruiting 18 years or older.
- A Randomized Study of Lapatinib With Radiation Versus Radiation Alone in Advanced Solid Tumor Cancer Patients Receiving Radiation Therapy for Metastatic Disease.
Lapatinib; Radiation therapy

Solid Tumor, Ovarian Cancer, Non-small Cell Lung Cancer, Chronic Clinical Trial

Cancer Centre of Monoclonal Therapy, LLC - Recruiting 18 years or older.
- Prognostic Potential of Cell Surface Markers and Pim Kinases in Patients With Selected Refractory or Relapsed Hematologic Malignancies or Solid Tumors.

Diffuse Large B-cell Lymphoma, or Follicle Center Lymphoma Clinical Trial using Zevalin (ibritumomab tiuxetan)

Spectrum Pharmaceuticals, Inc - Recruiting 60 years or older.
- A Phase 3, Open-label, Multicenter, Randomized Study of Sequential Zevalin (Ibritumomab Tiuxetan) Versus Observation in Patients at Least 60 Years of Age With Newly Diagnosed Diffuse Large B-cell Lymphoma in PET-negative Complete Remission After R-CHOP or R-CHOP-like Therapy.
Zevalin (ibritumomab tiuxetan)

Breast Tumor, Breast Cancer, Cancer of the Breast, Estrogen Recep Clinical Trial using nab-Paclitaxel 125 mg/m2 plus carboplatin AUC 2 in triple negative metastatic breast cancer (TNMBC) subjects; Carboplatin AUC 2; gemcitabine 1000 mg

Celgene Corporation - Recruiting 18 years or older.
- A Phase 2/3, Multi-center, Open-label, Randomized Study of Weekly Nab-paclitaxel in Combination With Gemcitabine or Carboplatin, Compared to the Combination of Gemcitabine and Carboplatin, as First-line Treatment in Female Subjects With ER, PgR, and HER2 Negative (Triple Negative) Metastatic Breast Cancer.
nab-Paclitaxel 125 mg/m2 plus carboplatin AUC 2 in triple negative metastatic breast cancer (TNMBC) subjects; Carboplatin AUC 2; gemcitabine 1000 mg

Brenner Tumor, Fallopian Tube Cancer, Ovarian Clear Cell Cystaden Clinical Trial using laboratory biomarker analysis

Gynecologic Oncology Group - Recruiting 18 years or older.
- A Prospective, Longitudinal Study of YKL-40 in Patients With FIGO Stage III or IV Invasive Epithelial Ovarian, Primary Peritoneal, or Fallopian Tube Cancer Undergoing Primary Chemotherapy.
laboratory biomarker analysis

Endometrial Clear Cell Carcinoma, Endometrial Papillary Serous Ca Clinical Trial using cisplatin; paclitaxel; carboplatin; brachytherapy

Gynecologic Oncology Group - Recruiting 18 years or older.
- A Randomized Phase III Trial of Cisplatin and Tumor Volume Directed Irradiation Followed by Carboplatin and Paclitaxel vs. Carboplatin and Paclitaxel for Optimally Debulked, Advanced Endometrial Carcinoma.
cisplatin; paclitaxel; carboplatin; brachytherapy

Rectal Cancer Clinical Trial using Advanced MR Imaging

Memorial Sloan-Kettering Cancer Center - Recruiting 21 years or older.
- Pilot Study of Advanced MR Imaging for Early Biologic Tumor Changes to Neoadjuvant Chemoradiation Treatment for Rectal Cancer.
Advanced MR Imaging

Breast Cancer Clinical Trial using Capecitabine; Exemestane; Everolimus

Novartis - Recruiting 18 years or older.
- Phase II Study of Everolimus in Combination With Exemestane Versus Everolimus Alone Versus Capecitabine in the Treatment of Postmenopausal Women With ER+Locally Advanced, Recurrent, or Metastatic Breast Cancer After Recurrence or Progression on Prior Letrozole or Anastrozole..
Capecitabine; Exemestane; Everolimus

Childhood Central Nervous System Choriocarcinoma, Childhood Centr Clinical Trial using therapeutic conventional surgery; 3-dimensional conformal radiation therapy; intensity-modulated radiation therapy; carboplatin; etoposide; ifosfamide

Children's Oncology Group - Recruiting 3 years to 21 years.
- Phase 2 Trial of Response-Based Radiation Therapy for Patients With Localized Central Nervous System Germ Cell Tumors (CNS GCT).
therapeutic conventional surgery; 3-dimensional conformal radiation therapy; intensity-modulated radiation therapy; carboplatin; etoposide; ifosfamide

Brenner Tumor, Ovarian Clear Cell Cystadenocarcinoma, Ovarian End Clinical Trial using behavioral dietary intervention; exercise intervention; counseling intervention; educational intervention; compliance monitoring; questionnaire administration; quality-of-life assessment; laboratory biomarker analysis

Gynecologic Oncology Group - Recruiting 18 years or older.
- Can Diet and Physical Activity Modulate Ovarian, Fallopian Tube and Primary Peritoneal Cancer Progression-Free Survival?.
behavioral dietary intervention; exercise intervention; counseling intervention; educational intervention; compliance monitoring; questionnaire administration; quality-of-life assessment; laboratory biomarker analysis

Brenner Tumor, Ovarian Clear Cell Cystadenocarcinoma, Ovarian End Clinical Trial using elesclomol sodium; paclitaxel

Gynecologic Oncology Group - Recruiting 18 years or older.
- A PHASE II EVALUATION OF ELESCLOMOL SODIUM AND WEEKLY PACLITAXEL IN THE TREATMENT OF RECURRENT OR PERSISTENT PLATINUM-RESISTANT OVARIAN, FALLOPIAN TUBE OR PRIMARY PERITONEAL CANCER.
elesclomol sodium; paclitaxel

Leukemia, Lymphoma, Unspecified Adult Solid Tumor, Protocol Speci Clinical Trial using allogeneic Epstein-Barr virus-specific cytotoxic T lymphocytes

Memorial Sloan-Kettering Cancer Center - Recruiting N/A or older.
- An Evaluation of the Toxicity and Therapeutic Effects of Epstein-Barr Virus-Immune (EBV)-Immune T-Lymphocytes Derived From Normal HLA-Compatible or Haplotype-Matched Donor in the Treatment of EBV-Associated Lymphoproliferative Diseases or Malignancies and Patients With Detectable Circulating Levels of EBV DNA Who Are at High Risk for EBV-Associated Lymphoproliferative Diseases.
allogeneic Epstein-Barr virus-specific cytotoxic T lymphocytes

Medulloblastoma Clinical Trial using Craniospinal Irradiation with boost to the primary tumor site; Cyclophosphamide; Cisplatin; Vincristine; Vismodegib; Pemetrexed; Gemcitabine; Aerobic Training; Neurocognitive Remediation

St. Jude Children's Research Hospital - Recruiting 3 years to 21 years.
- A Clinical and Molecular Risk-Directed Therapy for Newly Diagnosed Medulloblastoma.
Craniospinal Irradiation with boost to the primary tumor site; Cyclophosphamide; Cisplatin; Vincristine; Vismodegib; Pemetrexed; Gemcitabine; Aerobic Training; Neurocognitive Remediation

Malignant Glioma Clinical Trial using 18F-FMISO; PET without SCS; SCS; PET without/with SCS; Radiotherapy; Temozolomide

Dr. Negrin University Hospital - Recruiting 18 years to 75 years.
- Positron Emission Tomography With Fluoro-misonidazole (PET-FMISO) in High Grade Gliomas: Assessment of Tumor Hypoxia and Effect of Spinal Cord Stimulation.
18F-FMISO; PET without SCS; SCS; PET without/with SCS; Radiotherapy; Temozolomide

Tumor or Lymphoma Clinical Trial using JNJ-42756493

Janssen Research & Development, LLC - Recruiting 18 years or older.
- A Phase 1 Study to Evaluate the Safety, Pharmacokinetics, and Pharmacodynamics of JNJ-42756493, a Pan-Fibroblast Growth Factor Receptor (FGFR) Tyrosine Kinase Inhibitor, in Subjects With Advanced or Refractory Solid Tumors or Lymphoma.
JNJ-42756493

Unspecified Adult Solid Tumor, Protocol Specific Clinical Trial using PI3K inhibitor BKM120; docetaxel; pharmacological study; questionnaire administration; laboratory biomarker analysis

Roswell Park Cancer Institute - Recruiting 18 years or older.
- A Phase I Study of the PI3-Kinase Inhibitor BKM120 in Combination With Docetaxel in Patients With Advanced Solid Tumors..
PI3K inhibitor BKM120; docetaxel; pharmacological study; questionnaire administration; laboratory biomarker analysis

Recurrent Fallopian Tube Cancer, Recurrent Ovarian Epithelial Can Clinical Trial using ALVAC(2)-NY-ESO-1 (M)/TRICOM vaccine; sirolimus; laboratory biomarker analysis; sargramostim

Roswell Park Cancer Institute - Recruiting 18 years or older.
- A Phase I Clinical Trial of mTOR Inhibition With Sirolimus for Enhancing ALVAC(2)-NY-ESO-1(M)/TRICOM Vaccine Induced Anti-Tumor Immunity in Ovarian, Fallopian Tube, and Primary Peritoneal Cancer.
ALVAC(2)-NY-ESO-1 (M)/TRICOM vaccine; sirolimus; laboratory biomarker analysis; sargramostim

Chemotherapeutic Agent Toxicity, Cognitive/Functional Effects, Ne Clinical Trial using questionnaire administration; cognitive assessment; psychosocial assessment and care; quality-of-life assessment

Children's Oncology Group - Recruiting 1 Month to 21 years.
- Neuropsychological, Social, Emotional, and Behavioral Outcomes in Children With Cancer.
questionnaire administration; cognitive assessment; psychosocial assessment and care; quality-of-life assessment

Breast Cancer Clinical Trial using trastuzumab emtansine; trastuzumab

Hoffmann-La Roche - Recruiting 18 years or older.
- A Randomized, Multicenter, Open-Label Phase III Study to Evaluate the Efficacy and Safety of Trastuzumab Emtansine Versus Trastuzumab as Adjuvant Therapy for Patients With HER2-Positive Primary Breast Cancer Who Have Residual Tumor Present Pathologically in the Breast or Axillary Lymph Nodes Following Preoperative Therapy.
trastuzumab emtansine; trastuzumab

Malignant Solid Neoplasms Clinical Trial using Nilotinib (400 mg BID); Everolimus (10 mg QD); Sorafenib (400 mg BID); Lapatinib (1500 mg QD); Pazopanib (800 mg QD)

Centre Leon Berard - Recruiting 18 years or older.
- A Two-period, Multicenter, Randomized, Open-label, Phase II Study Evaluating the Clinical Benefit of a Maintenance Treatment Targeting Tumor Molecular Alterations in Patients With Progressive Locally-advanced or Metastatic Solid Tumors.
Nilotinib (400 mg BID); Everolimus (10 mg QD); Sorafenib (400 mg BID); Lapatinib (1500 mg QD); Pazopanib (800 mg QD)

Non Small Cell Lung Cancer Clinical Trial using DCE-MRI scan; Stereotactic Body Radiation Therapy; 4D-CT scan

Dana-Farber Cancer Institute - Recruiting 18 years or older.
- Feasibility Study of the Utility of Pulmonary Dynamic Contrast Enhanced MRI for Assessment of Tumor Response and Lung Injury and for Treatment Planning for Stereotactic Body Radiation Therapy for Early Stage Non-Small Cell Lung Cancer.
DCE-MRI scan; Stereotactic Body Radiation Therapy; 4D-CT scan

Phyllodes Tumor Clinical Trial using Partial breast radiation after lumpectomy

Dartmouth-Hitchcock Medical Center - Recruiting 18 years or older.
- A Prospective Study of Partial Breast Adjuvant Radiation Therapy After Resection of Borderline and Malignant Phyllodes Tumors.
Partial breast radiation after lumpectomy

Unspecified Adult Solid Tumor, Protocol Specific Clinical Trial using calcitriol; cisplatin; gemcitabine hydrochloride; pharmacological study

Roswell Park Cancer Institute - Recruiting 18 years or older.
- A Phase I Clinical Trial of Oral Calcitriol With Fixed Dose of Cisplatin and Gemcitabine in Patients With Advanced Solid Tumors.
calcitriol; cisplatin; gemcitabine hydrochloride; pharmacological study

Pancreatic Cancer Patients Diagnosed With Locally Advanced or Met Clinical Trial using L19IL2 monoclonal antibody-cytokine fusion protein in combination with gemcitabine

Philogen S.p.A. - Recruiting 18 years to 70 years.
- Phase I Study of the Tumor-targeting Human L19IL2 Monoclonal Antibody-cytokine Fusion Protein in Combination With Gemcitabine in Patients With Advanced Pancreatic Cancer.
L19IL2 monoclonal antibody-cytokine fusion protein in combination with gemcitabine

Cancer Cachexia Clinical Trial using Ruxolitinib

Kantonsspital Aarau - Recruiting 18 years or older.
- The RUXexia Trial: An Open-label Phase II Trial of Ruxolitinib in the Treatment of Cachexia in Patients With Tumor-Associated Chronic Wasting Diseases..
Ruxolitinib

Nausea, Vomiting, or Glioma Clinical Trial using Aprepitant; Ondansetron

Duke University - Recruiting 18 years or older.
- A Randomized Open Label Phase II Trial of Aprepitant (Emend) in Combination With Ondansetron Compared to Standard 5HT3 Serotonin Antagonist (Ondansetron) in the Prevention of Acute and Delayed Chemotherapy Induced Nausea and Vomiting (CINV) in Glioma Patients Receiving a Temozolomide Based Regimen.
Aprepitant; Ondansetron

Recurrent Glioblastoma Clinical Trial using Nivolumab; Ipilimumab; Bevacizumab

Bristol-Myers Squibb - Recruiting 18 years or older.
- A Randomized Phase IIb, Open Label Study of Nivolumab or Nivolumab in Combination With Ipilimumab Versus Bevacizumab in Adult Subjects With Recurrent Glioblastoma (GBM).
Nivolumab; Ipilimumab; Bevacizumab

Renal Cell Carcinoma(RCC) Clinical Trial using Anlotinib hydrochloric capsule

Jiangsu Chia-tai Tianqing Pharmaceutical Co.,Ltd - Recruiting 18 years to 75 years.
- A Phase II Study of Anlotinib(AL3818) Hydrochloric Capsule in Patients With Advanced Renal Cell Carcinoma(RCC) That Have Failed Or Are Intolerant To TKIs Therapy.
Anlotinib hydrochloric capsule

Anlotinib, or RCC Clinical Trial using Anlotinib hydrochloric capsule; Sunitinib maleate

Jiangsu Chia-tai Tianqing Pharmaceutical Co.,Ltd - Recruiting 18 years to 75 years.
- A Randomized, Positive-controlled, Multicenter, Phase II Study of Anlotinib(AL3818) Hydrochloric Capsule in Patients With Advanced Renal Cell Carcinoma(RCC).
Anlotinib hydrochloric capsule; Sunitinib maleate

Solid Tumors, or Metastatic Disease Clinical Trial using Histological biopsy procedure

UMC Utrecht - Recruiting 18 years or older.
- Protocol to Obtain Tumor Biopsies From Patients With Locally Advanced (Incurable) or Metastatic Cancer to Improve Selection for Clinical Trials. (CPCT - 05 Biopsy Protocol Patient Selection).
Histological biopsy procedure

Adult Acute Lymphoblastic Leukemia in Remission, Adult Nasal Type Clinical Trial using dasatinib; pharmacological study

National Cancer Institute (NCI) - Recruiting 18 years or older.
- Phase I Pharmacokinetic Study of Dasatinib (BMS-354825) (NSC-732517; IND-73969) in Patients With Advanced Malignancies and Varying Levels of Liver Dysfunction.
dasatinib; pharmacological study

Colorectal Cancer Clinical Trial using pharmacodynamic purposes of 89Zr-labelled cetuximab and kinase activity profiles

VU University Medical Center - Recruiting 18 years or older.
- Treatment Optimization of Cetuximab in Patients With Metastatic Colorectal Cancer Based on Tumor Uptake of 89Zr-labeled Cetuximab Assessed by PET.
pharmacodynamic purposes of 89Zr-labelled cetuximab and kinase activity profiles

Cancer, or Advanced Solid Tumors Clinical Trial using Sunitinib; Sorafenib; Erlotinib; Everolimus; Lapatinib; Dasatinib; Pazopanib; Vemurafenib; tumor biopsy; skin biopsy (optional)

VU University Medical Center - Recruiting 18 years or older.
- Pilot Study on the Determination of Intratumoral Concentrations of Kinase Inhibitors in Patients With Advanced Solid Malignancies..
Sunitinib; Sorafenib; Erlotinib; Everolimus; Lapatinib; Dasatinib; Pazopanib; Vemurafenib; tumor biopsy; skin biopsy (optional)

Multi-organ Metastatic Colorectal Cancer Clinical Trial using XELOX regimen according to standard procedures; FOLFOX regimen according to standard procedures; Surgery; radiofrequency ablation (RFA); transarterial chemo-embolization using irinotecan drug-eluted beads ((DEBIRI-)TACE); stereotactic body radiation therapy (SBRT); Bevacizumab; tumor biopsy

VU University Medical Center - Recruiting 18 years or older.
- A Randomized Multicenter Clinical Trial for Patient With Multi-organ, Colorectal Cancer Metastases Comparing the Combination of Chemotherapy and Maximal Tumor Debulking Versus Chemotherapy Alone..
XELOX regimen according to standard procedures; FOLFOX regimen according to standard procedures; Surgery; radiofrequency ablation (RFA); transarterial chemo-embolization using irinotecan drug-eluted beads ((DEBIRI-)TACE); stereotactic body radiation therapy (SBRT); Bevacizumab; tumor biopsy

Metastatic Pancreatic Adenocarcinoma Clinical Trial using Ipilimumab; Vaccine; FOLFIRINOX

Sidney Kimmel Comprehensive Cancer Center - Recruiting 18 years or older.
- A Phase 2, Multicenter Study of FOLFIRINOX Followed by Ipilimumab in Combination With Allogeneic GM-CSF Transfected Pancreatic Tumor Vaccine (GVAX) in the Treatment of Metastatic Pancreatic Cancer.
Ipilimumab; Vaccine; FOLFIRINOX

Recurrent Melanoma, Stage IIIA Melanoma, Stage IIIB Melanoma, Sta Clinical Trial using cyclophosphamide; fludarabine phosphate; therapeutic tumor infiltrating lymphocytes; aldesleukin; laboratory biomarker analysis

Fred Hutchinson Cancer Research Center - Recruiting 18 years or older.
- Cellular Adoptive Immunotherapy Using Autologous Tumor-Infiltrating Lymphocytes Following Lymphodepletion With Cyclophosphamide and Fludarabine for Patients With Metastatic Melanoma.
cyclophosphamide; fludarabine phosphate; therapeutic tumor infiltrating lymphocytes; aldesleukin; laboratory biomarker analysis

Renal Cell Cancer Clinical Trial

VU University Medical Center - Recruiting 18 years or older.
- Prediction of Response to Kinase Inhibitors Based on Protein Phosphorylation Profiles in Tumor Tissue From Advanced Renal Cell Cancer Patients.

Kidney Cancer Clinical Trial using everolimus; placebo

Southwest Oncology Group - Recruiting 18 years or older.
- EVEREST: EVErolimus for Renal Cancer Ensuing Surgical Therapy, A Phase III Study.
everolimus; placebo

Solid Tumor, or Non-small Cell Lung Cancer Clinical Trial using MK-3475; Cisplatin; Pemetrexed; Carboplatin; Paclitaxel

Merck Sharp & Dohme Corp. - Recruiting 20 years or older.
- A Phase I Study of MK-3475 Alone in Subjects With Advanced Solid Tumors and in Combination With Cisplatin/Pemetrexed or Carboplatin/Paclitaxel in Subjects With Advanced Non-Small Cell Lung Cancer.
MK-3475; Cisplatin; Pemetrexed; Carboplatin; Paclitaxel

Image-Guided Surgery Clinical Trial using 3D Roadmap software

National Institutes of Health Clinical Center (CC) - Recruiting 18 years or older.
- Prospective Randomized Multicenter Trial Comparing Navigation With 3D Roadmap vs. Conventional Angiography During Transarterial Embolization.
3D Roadmap software

Leukemia, Lymphoma, Neuroblastoma, Sarcoma, or Desmoplastic Small Clinical Trial using Melphalan; Fludarabine; Cyclophosphamide; Cytarabine; Prednisone; Vincristine; Doxorubicin; Etoposide; Filgrastim; NK-DLI Infusions

National Institutes of Health Clinical Center (CC) - Recruiting 4 years to 35 years.
- A Phase I Study of NK Cell Infusion Following Allogeneic Peripheral Blood Stem Cell Transplantation From Related or Matched Unrelated Donors in Pediatric Patients With Solid Tumors and Leukemias.
Melphalan; Fludarabine; Cyclophosphamide; Cytarabine; Prednisone; Vincristine; Doxorubicin; Etoposide; Filgrastim; NK-DLI Infusions

Solid Tumor, Leukemia, or Neurofibromatosis Clinical Trial

National Institutes of Health Clinical Center (CC) - Recruiting 6 years or older.
- Validation of the English Version of the Pain Interference Index and the Pain Rating Scale in Children, Adolescents, and Young Adults With Chronic Illness and Their Parents.

Solid Tumors, Brain Tumors, Sarcoma, Wilm's Tumor, or Rhabdomyosa Clinical Trial using NK cellular therapy; rhIL-15

National Institutes of Health Clinical Center (CC) - Recruiting 2 years to 29 years.
- A Phase I Study of Autologous Activated Natural Killer (NK) Cells +/- rhIL15 in Children and Young Adults With Refractory Solid Tumors.
NK cellular therapy; rhIL-15

Astrocytoma, Central Nervous System Tumor, Glioblastoma, Glioma, Clinical Trial

National Institutes of Health Clinical Center (CC) - Recruiting 1 year or older.
- Evaluation of the Natural History of Patients With Tumors of the Central Nervous System.

Lung or Prostatic Neoplasms, Colorectal or Kidney Neoplasms, Panc Clinical Trial using NK cells +CliniMACs CD3 and CD56 systems

National Institutes of Health Clinical Center (CC) - Recruiting 18 years to 70 years.
- Safety and the Anti-Tumor Effects of Escalating Doses of Adoptively Infused Ex Vivo Expanded Autologous Natural Killer (NK) Cells Against Metastatic Cancers or Hematological Malignancies Sensitized to NK TRAIL Cytotoxicity With Bortezomib.
NK cells +CliniMACs CD3 and CD56 systems

Epithelial Neoplasms, Malignant, Epithelial Tumors, Malignant, or Clinical Trial using NHS-IL-12

National Institutes of Health Clinical Center (CC) - Recruiting 18 years or older.
- First In-Human Phase I Trial of NHS-IL12 in Subjects With Metastatic Solid Tumors.
NHS-IL-12

Cervical Cancer, Oropharyngeal Cancer, Vaginal Cancer, Anal Cance Clinical Trial using Fluderabine; Cycolphosphamide; Young TIL; Aldesleukin

National Institutes of Health Clinical Center (CC) - Recruiting 18 years to 66 years.
- A Phase II Study of Lymphodepletion Followed by Autologous Tumor-Infiltrating Lymphocytes and High-Dose Aldesleukin for Human Papillomavirus-Associated Cancers.
Fluderabine; Cycolphosphamide; Young TIL; Aldesleukin

Metastatic Melanoma, or Skin Cancer Clinical Trial using Cyclophosphamide; Fludarabine; Tumor Infiltrating Lymphocytes; IL-15

National Institutes of Health Clinical Center (CC) - Recruiting 18 years to 66 years.
- A Phase I/II Study of IL-15 Administration Following a Non-Myeloablative Lymphocyte Depleting Chemotherapy Regimen and Autologous Lymphocyte Transfer in Metastatic Melanoma.
Cyclophosphamide; Fludarabine; Tumor Infiltrating Lymphocytes; IL-15

HIV Infection, or Kaposi's Sarcoma Clinical Trial

National Institutes of Health Clinical Center (CC) - Recruiting 18 years or older.
- Collection of Blood, Bone Marrow, Tumor, or Tissue Samples From Patients With HIV Infection, KSHV Infection, Viral-Related Pre-Malignant Lesions, and/or Cancer.

Recurrent Wilms Tumor and Other Childhood Kidney Tumors, Stage I Clinical Trial using laboratory biomarker analysis

Children's Oncology Group - Recruiting N/A or older.
- Categorization of Wilms Tumors by Genetic Expression.
laboratory biomarker analysis

Acinar Cell Adenocarcinoma of the Pancreas, Duct Cell Adenocarcin Clinical Trial using vismodegib; sirolimus; positron emission tomography; computed tomography; pharmacological study; laboratory biomarker analysis; fludeoxyglucose F 18

Mayo Clinic - Recruiting 18 years or older.
- Phase I Trial of The Combination of Vismodegib and Sirolimus.
vismodegib; sirolimus; positron emission tomography; computed tomography; pharmacological study; laboratory biomarker analysis; fludeoxyglucose F 18

Neoplasms, Nervous System Disease, or Vestibular Disease Clinical Trial

National Institutes of Health Clinical Center (CC) - Recruiting 18 years to 50 years.
- Using Positron Emission Tomography (PET) to Predict Intracranial Tumor Growth in Neurofibromatosis Type II (NF2) Patients.

Breast Cancer, Breast Neoplasm, Breast Tumor, or Cancer of the Br Clinical Trial using Proton Radiotherapy

Proton Collaborative Group - Recruiting 50 years or older.
- Phase II Protocol of Proton Therapy for Partial Breast Irradiation in Early Stage Breast Cancer.
Proton Radiotherapy

Metastatic Melanoma Clinical Trial using Aldesleukin; Fludarabine; Cyclophosphamide; Young Tumor Infiltrating Lymphocytes (young TIL)

National Institutes of Health Clinical Center (CC) - Recruiting 18 years to 66 years.
- A Phase II Prospective Randomized Study of Cell Transfer Therapy for Metastatic Melanoma Using Tumor Infiltrating Lymphocytes Plus IL-2 Comparing Two Different Chemotherapy Preparative Regimens.
Aldesleukin; Fludarabine; Cyclophosphamide; Young Tumor Infiltrating Lymphocytes (young TIL)

Neurofibromatosis Type 1, Malignant Peripheral Nerve Sheath Tumor Clinical Trial

National Institutes of Health Clinical Center (CC) - Recruiting N/A or older.
- Natural History Study and Longitudinal Assessment of Children, Adolescents, and Adults With Neurofibromatosis Type 1.

Metastatic Melanoma, or Skin Cancer Clinical Trial using Aldesleukin; Cyclophosphamide; Fludarabine; Young Tumor Infiltrating Lymphocytes; 1200 Gy Irradiation

National Institutes of Health Clinical Center (CC) - Recruiting 18 years to 66 years.
- Prospective Randomized Study of Cell Transfer Therapy for Metastatic Melanoma Using Tumor Infiltrating Lymphocytes Plus IL-2 Following Non-Myeloablative Lymphocyte Depleting Chemo Regimen Alone or in Conjunction With 12Gy Total Body Irradiation (TBI).
Aldesleukin; Cyclophosphamide; Fludarabine; Young Tumor Infiltrating Lymphocytes; 1200 Gy Irradiation

Breast Cancer, Breast Neoplasm, Breast Tumor, or Cancer of the Br Clinical Trial using Proton Radiotherapy

Proton Collaborative Group - Recruiting 18 years or older.
- Phase II Study of Postoperative, Cardiac-Sparing Proton Radiotherapy for Women With Stage III,Loco-Regional, Non-Metastatic Breast Cancer.
Proton Radiotherapy

Colorectal Neoplasms, Gastric Neoplasms, Cholangiocarcinoma, Bile Clinical Trial

National Institutes of Health Clinical Center (CC) - Recruiting 18 years to 90 years.
- Tumor, Normal Tissue and Specimens From Patients Undergoing Evaluation or Surgical Resection of Solid Tumors.

Gastrointestinal Neoplasms, Cancer of Gastrointestinal Tract, Can Clinical Trial

National Institutes of Health Clinical Center (CC) - Recruiting 18 years or older.
- Acquisition of Blood and Tumor Tissue Samples From Patients With Gastrointestinal Cancer.

Neuroblastoma;, Rhabdomyosarcoma;, Ewing's Sarcoma;, Ewing's Tumo Clinical Trial using nab-paclitaxel

Celgene Corporation - Recruiting 6 Months to 21 years.
- A Phase 1 / 2, Multicenter, Open-label, Dose-finding Study to Assess the Safety, Tolerability, and Preliminary Efficacy of Weekly Nab-paclitaxel in Pediatric Patients With Recurrent or Refractory Solid Tumors.
nab-paclitaxel

Adult Anaplastic Astrocytoma, Adult Anaplastic Oligodendroglioma, Clinical Trial using DEC-205-NY-ESO-1 fusion protein vaccine; sirolimus; laboratory biomarker analysis

Roswell Park Cancer Institute - Recruiting 18 years or older.
- A Phase I Clinical Trial of mTOR Inhibition With Rapamycin for Enhancing Intranodal Dendritic Cell Vaccine Induced Anti-tumor Immunity in Patients With NY-ESO-1 Expressing Solid Tumors.
DEC-205-NY-ESO-1 fusion protein vaccine; sirolimus; laboratory biomarker analysis

Askin Tumor, Localized Ewing Sarcoma/Peripheral Primitive Neuroec Clinical Trial using laboratory biomarker analysis

Children's Oncology Group - Recruiting N/A to 21 years.
- A COG Study for Collecting and Banking Ewing Sarcoma Specimens.
laboratory biomarker analysis

Neoplasm Malignant Clinical Trial using SAR566658

Sanofi - Recruiting 18 years or older.
- Dose Escalation, Safety and Pharmacokinetic, First in Man Study, of SAR566658 Administered as a Single Agent by Intravenous Infusion Every 3 Weeks in Adult Patients With CA6-Positive and Refractory Solid Tumors.
SAR566658

Stage III Ovarian Cancer, or Stage IV Ovarian Cancer Clinical Trial using Vaccine: FANGT Vaccine; Carboplatinum; Carboplatinum and Taxol; FANG

Gradalis, Inc. - Recruiting 18 years or older.
- Phase II Trial of Adjuvant Bi-shRNAfurin and GMCSF Augmented Autologous Tumor Cell Vaccine (FANGT) Integrated With Chemotherapy for Patients With Recurrent Cisplatinum Sensitive Ovarian Cancer Participating in Study CL-PTL 105.
Vaccine: FANGT Vaccine; Carboplatinum; Carboplatinum and Taxol; FANG

Ewing Sarcoma, Gastrointestinal Tumor, Germ Cell Tumor, Hepatic T Clinical Trial using alemtuzumab; fludarabine; sirolimus; Busulfan; melphalan; stem cells

St. Jude Children's Research Hospital - Recruiting 2 years to 21 years.
- A Phase I Study of CD45RA+ Depleted Haploidentical Stem Cell Transplantation in Children With Relapsed or Refractory Solid Tumors and Lymphomas.
alemtuzumab; fludarabine; sirolimus; Busulfan; melphalan; stem cells

Solid Tumor Clinical Trial using Oraxol

Kinex Pharmaceuticals Inc - Recruiting 18 years or older.
- A Dose-regimen Finding Study to Evaluate Safety, Tolerability, Pharmacokinetics and Activity of Oraxol in Subjects With Advanced Malignancies.
Oraxol

B-cell Chronic Lymphocytic Leukemia Clinical Trial using Lenalidomide; Placebo

Celgene Corporation - Recruiting 18 years or older.
- A Phase 3, Multicenter, Randomized, Double-blind, Placebo-controlled, Parallel-group Study of Efficacy and Safety of Lenalidomide (Revlimidr) as Maintenance Therapy for Patients With B-Cell Chronic Lymphocytic Leukemia Following Second Line Therapy (THE CONTINUUM TRIAL).
Lenalidomide; Placebo

Solid Tumors, or Advanced Cancer Clinical Trial using Anastrozole; Bevacizumab; Everolimus; Sorafenib; Erlotinib

M.D. Anderson Cancer Center - Recruiting 18 years or older.
- Hormone Receptor Positive Disease Across Solid Tumor Types: A Phase I Study of Single-Agent Hormone Blockade and Combination Approaches With Targeted Agents to Provide Synergy and Overcome Resistance.
Anastrozole; Bevacizumab; Everolimus; Sorafenib; Erlotinib

Glioma, Glioblastoma, or Brain Tumor, Recurrent Clinical Trial using ANG1005; Bevacizumab

Angiochem Inc - Recruiting 18 years or older.
- A Phase II, Open-Label, Multi-Center Study of ANG1005 in Patients With Recurrent High-Grade Glioma.
ANG1005; Bevacizumab

Unspecified Adult Solid Tumor, Protocol Specific Clinical Trial using veliparib; mitomycin C; laboratory biomarker analysis

National Cancer Institute (NCI) - Recruiting 18 years or older.
- ABT-888 as Monotherapy and in Combination With Mitomycin C in Patients With Solid Tumors With Deficiency in Homologous Recombination Repair.
veliparib; mitomycin C; laboratory biomarker analysis

Brain Tumor Clinical Trial using SVV; CVP

Yonsei University - Recruiting 20 years to 65 years.
- .
SVV; CVP

Neuroendocrine Tumor (NET) Liver Metastases Clinical Trial using Holmium-166 microspheres hepatic radioembolization.

UMC Utrecht - Recruiting N/A or older.
- Adjuvant Hepatic Holmium-166-radioembolization in Patients With Unresectable Liver Metastases of Neuroendocrine Origin, Who Have Been Treated With Lutetium-177-dotatate; a Single Center, Interventional, Non-randomized, Non-comparative, Open Label, Phase II Study.
Holmium-166 microspheres hepatic radioembolization.

Hodgkin Lymphoma, Non-Hodgkin Lymphoma, or Hodgkin Disease Clinical Trial using Antigen Escalation Stage; Dose escalation study of T cells

Baylor College of Medicine - Recruiting N/A or older.
- Administration of Tumor-Associated Antigen (TAA)-Specific Cytotoxic T-Lymphocytes to Patients With Active or Relapsed Hodgkin or Non-Hodgkin Lymphoma.
Antigen Escalation Stage; Dose escalation study of T cells

Metastatic and Locally Advanced Soft Tissue Tumor Patients Unfit Clinical Trial using Trabectedin

Italian Sarcoma Group - Recruiting 18 years to 80 years.
- SAFETY AND ACTIVITY OF TRABECTEDIN AS FIRST LINE IN ADVANCED SOFT TISSUE SARCOMA (STS) PATIENTS UNFIT TO RECEIVE STANDARD CHEMOTHERAPY: A PROSPECTIVE PHASE II STUDY WITH CLINICAL AND MOLECULAR CORRELATES.
Trabectedin

Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor (PNET) Clinical Trial using laboratory biomarker analysis; questionnaire administration

Children's Oncology Group - Recruiting N/A or older.
- Genetic Epidemiology of Ewing's Sarcoma.
laboratory biomarker analysis; questionnaire administration

B-cell Childhood Acute Lymphoblastic Leukemia, Philadelphia Chrom Clinical Trial using doxorubicin hydrochloride; cytarabine; vincristine sulfate; dexamethasone; pegaspargase; methotrexate; mercaptopurine tablet; leucovorin calcium; cyclophosphamide; thioguanine; quality-of-life assessment; questionnaire administration; laboratory biomarker analysis

Children's Oncology Group - Recruiting 1 year to 30 years.
- Treatment of Patients With Newly Diagnosed Standard Risk B-Precursor Acute Lymphoblastic Leukemia (ALL).
doxorubicin hydrochloride; cytarabine; vincristine sulfate; dexamethasone; pegaspargase; methotrexate; mercaptopurine tablet; leucovorin calcium; cyclophosphamide; thioguanine; quality-of-life assessment; questionnaire administration; laboratory biomarker analysis

Lung Cancer, Non-Small Cell Clinical Trial using Recombinant PRAME protein combined with the AS15 Adjuvant System GSK2302032A; Placebo

GlaxoSmithKline - Recruiting 18 years or older.
- GSK2302032A Antigen-Specific Cancer Immunotherapeutic as Adjuvant Therapy in Patients With Non-Small Cell Lung Cancer.
Recombinant PRAME protein combined with the AS15 Adjuvant System GSK2302032A; Placebo

Thrombocytopaenia Clinical Trial using Eltrombopag olamine; Placebo

GlaxoSmithKline - Recruiting 18 years or older.
- A Randomized, Blinded, Placebo-controlled, Two-Phase, Sequential Cohort, Dose Finding Study to Assess the Safety and Efficacy of an Oral Thrombopoietin Receptor Agonist, Eltrombopag (SB-497115-GR), Administered to Patients With Solid Tumors Receiving Gemcitabine Monotherapy or the Combination of Gemcitabine Plus Carboplatin or Cisplatin.
Eltrombopag olamine; Placebo

Neoplasm Malignant Clinical Trial using Cabazitaxel (XRP6258)

Sanofi - Recruiting 18 years or older.
- Phase I Safety and Pharmacokinetic Study of XRP6258 (Cabazitaxel) In Advanced Solid Tumor Patients With Varying Degrees of Hepatic Impairment.
Cabazitaxel (XRP6258)

Desmoid Tumor Clinical Trial using Sirolimus

Maine Medical Center - Recruiting N/A to 29 years.
- A Pilot Study Evaluating the Use of mTor Inhibitor Sirolimus in Children and Young Adults With Desmoid-Type Fibromatosis.
Sirolimus

Ovarian Cancer, Fallopian Tube Cancer, or Peritoneal Cancer Clinical Trial using Rucaparib

Clovis Oncology, Inc. - Recruiting 18 years or older.
- A Phase I/II, Open-Label, Safety, Pharmacokinetic, and Preliminary Efficacy Study of Oral Rucaparib in Patients With gBRCA Mutation Ovarian Cancer or Other Solid Tumor.
Rucaparib

Acute Undifferentiated Leukemia, Atypical Chronic Myeloid Leukemi Clinical Trial using cytology specimen collection procedure

Children's Oncology Group - Recruiting N/A to 30 years.
- A Children's Oncology Group Protocol for Collecting and Banking Pediatric Research Specimens Including Rare Pediatric Tumors.
cytology specimen collection procedure

Adult Rhabdomyosarcoma, Childhood Desmoplastic Small Round Cell T Clinical Trial using biologic sample preservation procedure; laboratory biomarker analysis

Children's Oncology Group - Recruiting N/A to 50 years.
- A COG Soft Tissue Sarcoma Diagnosis, Biology and Banking Protocol.
biologic sample preservation procedure; laboratory biomarker analysis

Herpes Zoster Clinical Trial using V212; Placebo

Merck Sharp & Dohme Corp. - Recruiting 18 years or older.
- A Phase III Randomized, Placebo-Controlled, Clinical Trial to Study the Safety and Efficacy of V212 in Adult Patients With Solid Tumor or Hematologic Malignancy.
V212; Placebo

Rheumatoid Arthritis Clinical Trial

UCB, Inc. - Recruiting 18 years or older.
- A Multi-center, Noninterventional Study With Certolizumab Pegol in Comparison With Any Other Subcutaneous TNF Inhibitor in Two Parallel Groups in Biologic Naive Patients With Rheumatoid Arthritis.

Head and Neck Cancer, Lung Cancer, Lip Cancer, Lip Neoplasms, or Clinical Trial using Tumor biopsy; Phlebotomy

Stanford University - Recruiting 18 years or older.
- Identification of Secreted Markers for Tumor Hypoxia in Patients With Head and Neck or Lung Cancers.
Tumor biopsy; Phlebotomy

Disseminated Neuroblastoma, Localized Resectable Neuroblastoma, L Clinical Trial using laboratory biomarker analysis; cytology specimen collection procedure

Children's Oncology Group - Recruiting N/A to 30 years.
- Neuroblastoma Biology Studies.
laboratory biomarker analysis; cytology specimen collection procedure

Esophageal Cancer, Gastroesophageal Reflux Disease, Esophageal Di Clinical Trial using Survey of client health, personal habits, family history; Blood specimen for non-DNA and DNA parts; Biopsy of esophageal/stomach tissue, lymph nodes, tumor; Biopsies from routine clinical surveillance endoscopies

University of Pittsburgh - Recruiting 18 years or older.
- Esophageal Cancer Risk Registry.
Survey of client health, personal habits, family history; Blood specimen for non-DNA and DNA parts; Biopsy of esophageal/stomach tissue, lymph nodes, tumor; Biopsies from routine clinical surveillance endoscopies

Bladder Cancer Clinical Trial using Dovitinib

Hoosier Oncology Group - Recruiting 18 years or older.
- A Phase II Trial of Dovitinib in Bacillus Calmette-Guerin(BCG) Refractory Urothelial Carcinoma Patients With Tumor Fibroblast Growth Factor Receptor 3(FGFR3) Mutations or Over-expression: Hoosier Oncology Group GU12-157.
Dovitinib

Breast Cancer Clinical Trial using microarray analysis; breast biopsy

Georgetown University - Recruiting 18 years or older.
- Pilot Study for Analysis of Tumor Gene Expression by DNA Microarray Analysis in Patients Undergoing Breast Cancer Surgery or Core Biopsy Sampling.
microarray analysis; breast biopsy

Non-small Cell Lung Cancer Clinical Trial using Biopsy of the major carinal area; Biopsy of abnormal & suspicious areas of the bronchial tree; Evaluation of the tumor for DNA mutations; Bronchoalveolar Lavage (BAL) for cytokine analysis; Correlation of flow cytometric & RT PCR for TNM stage; Analysis of lymph nodes

University of Pittsburgh - Recruiting 18 years to 85 years.
- Detection of Genetic Markers of Lung Cancer Initiation and Progression.
Biopsy of the major carinal area; Biopsy of abnormal & suspicious areas of the bronchial tree; Evaluation of the tumor for DNA mutations; Bronchoalveolar Lavage (BAL) for cytokine analysis; Correlation of flow cytometric & RT PCR for TNM stage; Analysis of lymph nodes

Melanoma, Metastatic Melanoma, or Solid Tumor Clinical Trial using MLN2480

Millennium Pharmaceuticals, Inc. - Recruiting 18 years or older.
- An Open-Label, Phase 1, Dose Escalation Study of MLN2480 in Patients With Relapsed or Refractory Solid Tumors Followed by a Dose Expansion Phase in Patients With Metastatic Melanoma.
MLN2480

Lung Cancer Clinical Trial using PET Scan; CT Scan; SABR

Stanford University - Recruiting 18 years or older.
- Phase II Trial of Individualized Lung Tumor Stereotactic Ablative Radiotherapy (iSABR).
PET Scan; CT Scan; SABR

Cancer, GCT, Giant Cell Tumor of Bone, or Benign GCT Clinical Trial using Denosumab

Amgen - Recruiting 12 years or older.
- An Open-label, Multi-center, Phase 2 Study of Denosumab in Subjects With Giant Cell Tumor of Bone.
Denosumab

Untreated Adult Acute Lymphoblastic Leukemia, or Untreated Childh Clinical Trial using laboratory biomarker analysis

Children's Oncology Group - Recruiting N/A to 30 years.
- Classification of Newly Diagnosed Acute Lymphoblastic Leukemia (ALL).
laboratory biomarker analysis

Metastatic Colorectal Cancer Clinical Trial using Blood analysis by EPISPOT and Cellsearch

University Hospital, Montpellier - Recruiting 18 years or older.
- Assessment by EPISPOT of Circulating Tumor Cells as an Early Predictive Marker of Response to Chemotherapy and Targeted Therapy in Patients With Metastatic Colorectal Cancer in First Line of Treatment.
Blood analysis by EPISPOT and Cellsearch

Adult Supratentorial Primitive Neuroectodermal Tumor (PNET), Ewin Clinical Trial using etoposide; ifosfamide; intensity-modulated radiation therapy; topotecan hydrochloride; busulfan; melphalan; autologous hematopoietic stem cell transplantation; peripheral blood stem cell transplantation; autologous bone marrow transplantation

City of Hope Medical Center - Recruiting 6 Months to 40 years.
- A Pilot Study of Whole-body MRI-guided Intensity Modulated Radiation Therapy Combined With Systemic Chemotherapy Followed by High-Dose Chemotherapy With Busulfan, Melphalan and Topotecan and Stem Cell Rescue in Patients With Poor Risk Ewing's Sarcoma.
etoposide; ifosfamide; intensity-modulated radiation therapy; topotecan hydrochloride; busulfan; melphalan; autologous hematopoietic stem cell transplantation; peripheral blood stem cell transplantation; autologous bone marrow transplantation

Brain Tumor, or Central Nervous System Tumor Clinical Trial using cisplatin; cyclophosphamide; lomustine; vincristine sulfate; radiation therapy

Children's Oncology Group - Recruiting 3 years to 21 years.
- A Study Evaluating Limited Target Volume Boost Irradiation and Reduced Dose Craniospinal Radiotherapy (18.00 Gy) and Chemotherapy in Children With Newly Diagnosed Standard Risk Medulloblastoma: A Phase III Double Randomized Trial.
cisplatin; cyclophosphamide; lomustine; vincristine sulfate; radiation therapy

Radiation Injury, or Brain Tumor Clinical Trial

University of Michigan - Recruiting 18 years or older.
- .

Gestational Trophoblastic Tumor, Hydatidiform Mole, Low Risk Meta Clinical Trial using leucovorin calcium; dactinomycin; methotrexate; quality-of-life assessment

Gynecologic Oncology Group - Recruiting 18 years or older.
- A Phase III Randomized Trial of Pulse Actinomycin-D Versus Multi-Day Methotrexate for the Treatment of Low-Risk Gestational Trophoblastic Neoplasia.
leucovorin calcium; dactinomycin; methotrexate; quality-of-life assessment

Breast Neoplasms Clinical Trial using Sorafenib (Nexavar, BAY43-9006); Eribulin

Bayer - Recruiting 18 years or older.
- A Phase 1, Multi-center, Non-randomized, Open Label, Dose Escalation Design Study of Sorafenib (BAY43-9006) in Combination With Eribulin in Subjects With Advanced, Metastatic or Refractory Solid Tumors.
Sorafenib (Nexavar, BAY43-9006); Eribulin

Adult Alveolar Soft-part Sarcoma, Adult Angiosarcoma, Adult Desmo Clinical Trial using vismodegib; gamma-secretase/Notch signalling pathway inhibitor RO4929097; laboratory biomarker analysis; pharmacological study

National Cancer Institute (NCI) - Recruiting 18 years or older.
- A Phase 1B/II Study of GDC-0449 (NSC 747691) in Combination With RO4929097, a Gamma-Secretase Inhibitor (GSI) in Advanced/Metastatic Sarcomas.
vismodegib; gamma-secretase/Notch signalling pathway inhibitor RO4929097; laboratory biomarker analysis; pharmacological study

BRCA1 Mutation Carrier, BRCA2 Mutation Carrier, or Unspecified Ad Clinical Trial using veliparib; dinaciclib; carboplatin; laboratory biomarker analysis; pharmacological study

National Cancer Institute (NCI) - Recruiting 18 years or older.
- Phase 1 Trial of ABT-888 and SCH727965 Without or With Carboplatin in Patients With Advanced Solid Tumors.
veliparib; dinaciclib; carboplatin; laboratory biomarker analysis; pharmacological study

Recurrent Melanoma, Stage IIIA Melanoma, Stage IIIB Melanoma, Sta Clinical Trial using dabrafenib; trametinib; navitoclax; pharmacological study; laboratory biomarker analysis

National Cancer Institute (NCI) - Recruiting 18 years or older.
- Phase I/II Study of Dabrafenib, Trametinib, and Navitoclax in BRAF Mutant Melanoma and Other Solid Tumors.
dabrafenib; trametinib; navitoclax; pharmacological study; laboratory biomarker analysis

Crohn's Disease Clinical Trial

AbbVie - Recruiting 18 years to 65 years.
- Improvement of Work Productivity and Quality of Life With Anti-TNF Therapies Used in Crohn's Disease in Routine Clinical Practice in Turkey.

Unspecified Adult Solid Tumor, Protocol Specific Clinical Trial using dabrafenib; pazopanib hydrochloride; Correlative studies

Ohio State University Comprehensive Cancer Center - Recruiting 18 years or older.
- A Phase I Trial of Dabrafenib (BRAFi) and Pazopanib in Patients With BRAF-mutated Advanced Malignant Tumors.
dabrafenib; pazopanib hydrochloride; Correlative studies

Adult Acute Megakaryoblastic Leukemia (M7), Adult Acute Minimally Clinical Trial using cytarabine; daunorubicin hydrochloride; idarubicin; vorinostat; allogeneic hematopoietic stem cell transplantation; laboratory biomarker analysis

National Cancer Institute (NCI) - Recruiting 18 years to 60 years.
- A Randomized Phase III Study of Standard Cytarabine Plus Daunorubicin (7+3) Therapy or Idarubicin With High Dose Cytarabine (IA) Versus IA With Vorinostat (NSC-701852) (IA+V) in Younger Patients With Previously Untreated Acute Myeloid Leukemia (AML).
cytarabine; daunorubicin hydrochloride; idarubicin; vorinostat; allogeneic hematopoietic stem cell transplantation; laboratory biomarker analysis

Well-differentiated Pancreatic Neuroendocrine Tumor Clinical Trial using sunitinib

Pfizer - Recruiting 18 years or older.
- A Single Arm Open-Label International Multi Center Study Of The Efficacy And Safety Of Sunitinib Malate (SU011248, Sutentr) In Patients With Progressive Advanced Metastatic Well Differentiated Unresectable Pancreatic Neuroendocrine Tumors.
sunitinib

Carcinoma, Renal Cell, Advanced, Lymphoma, Mantle-Cell, or Gastro Clinical Trial using Temsirolimus; Sunitinib; Axitinib

Pfizer - Recruiting 18 years or older.
- STAR-TOR - Registry for the Evaluation of the Safety, Tolerability and Efficacy of Temsirolimus (Toriselr), Sunitinib (Sutentr), and Axitnib (Inlytar) for the Treatment of Subjects With Advanced Renal Cell Carcinoma (mRCC), Mantle Cell Lymphoma (MCL), and Gastro-Intestinal Stroma Tumor (GIST).
Temsirolimus; Sunitinib; Axitinib

Gastrointestinal Stromal Tumors Clinical Trial using sunitinib malate dose escalation; sunitinib malate

Pfizer - Recruiting 6 years to 21 years.
- A Phase 1/2 Study Of Sunitinib In Young Patients With Advanced Gastrointestinal Stromal Tumor.
sunitinib malate dose escalation; sunitinib malate

NSCLC (Non-small Cell Lung Cancer) Clinical Trial using Crizotinib; Pemetrexed/Cisplatin; Pemetrexed/Carboplatin

Pfizer - Recruiting 18 years to 70 years.
- Phase 3, Randomized, Open-Label Study Of The Efficacy And Safety Of Crizotinib Versus Pemetrexed/Cisplatin Or Pemetrexed/Carboplatin In Previously Untreated East Asian Patients With Non-Squamous Carcinoma Of The Lung Harboring A Translocation Or Inversion Event Involving The Anaplastic Lymphoma Kinase (ALK) Gene Locus.
Crizotinib; Pemetrexed/Cisplatin; Pemetrexed/Carboplatin

Breast Cancer Clinical Trial using palliative surgery; therapeutic conventional surgery; palliative radiation therapy; radiation therapy

Eastern Cooperative Oncology Group - Recruiting 18 years or older.
- A Randomized Phase III Trial of the Value of Early Local Therapy for the Intact Primary Tumor in Patients With Metastatic Breast Cancer.
palliative surgery; therapeutic conventional surgery; palliative radiation therapy; radiation therapy

Brenner Tumor, Fallopian Tube Cancer, Ovarian Clear Cell Cystaden Clinical Trial using paclitaxel; docetaxel; carboplatin; bevacizumab; gemcitabine hydrochloride; laboratory biomarker analysis; quality-of-life assessment

National Cancer Institute (NCI) - Recruiting 18 years or older.
- A Phase III Randomized Controlled Clinical Trial of Carboplatin and Paclitaxel (or Gemcitabine) Alone or in Combination With Bevacizumab (NSC #704865, IND #113912) Followed by Bevacizumab and Secondary Cytoreductive Surgery in Platinum-Sensitive, Recurrent Ovarian, Peritoneal Primary and Fallopian Tube Cancer. NCI-Supplied Agents: Bevacizumab (NSC #704865, IND #113912).
paclitaxel; docetaxel; carboplatin; bevacizumab; gemcitabine hydrochloride; laboratory biomarker analysis; quality-of-life assessment

Advanced Solid Tumor, or Lymphomas Clinical Trial using LEE011

Novartis - Recruiting 18 years or older.
- A phase1 Multi-center, Open Label, Dose-escalation Study of Oral LEE011 in Patients With Advanced Solid Tumors or Lymphoma.
LEE011

Recurrent Ovarian Epithelial Cancer, Recurrent Primary Peritoneal Clinical Trial using veliparib; topotecan hydrochloride; pharmacogenomic studies; pharmacological study; laboratory biomarker analysis

National Cancer Institute (NCI) - Recruiting 18 years or older.
- A Phase I/II Trial of ABT-888, an Inhibitor of Poly (ADP-ribose) Polymerase (PARP), and Topotecan (TPT) in Patients With Solid Tumors (Phase I) and Relapsed or Refractory Ovarian Cancer or Primary Peritoneal Cancer (Phase II) After Prior Platinum Containing First-Line Chemotherapy.
veliparib; topotecan hydrochloride; pharmacogenomic studies; pharmacological study; laboratory biomarker analysis

Lymphoma, or Hodgkin Disease Clinical Trial using tumor tissue aspiration; phlebotomy

Stanford University - Recruiting N/A to 21 years.
- Consent for Obtaining Additional Tissue at the Time of a Diagnostic Biopsy.
tumor tissue aspiration; phlebotomy

Adult Supratentorial Primitive Neuroectodermal Tumor (PNET), Chil Clinical Trial using vincristine sulfate; doxorubicin hydrochloride; cyclophosphamide; ifosfamide; etoposide; topotecan hydrochloride; laboratory biomarker analysis

Children's Oncology Group - Recruiting N/A to 50 years.
- A Phase III Randomized Trial of Adding Vincristine-Topotecan-Cyclophosphamide to Standard Chemotherapy in Initial Treatment of Non-Metastatic Ewing Sarcoma.
vincristine sulfate; doxorubicin hydrochloride; cyclophosphamide; ifosfamide; etoposide; topotecan hydrochloride; laboratory biomarker analysis

Diffuse Hyperplastic Perilobar Nephroblastomatosis, Rhabdoid Tumo Clinical Trial using doxorubicin hydrochloride; therapeutic conventional surgery; dactinomycin; cyclophosphamide; carboplatin; etoposide phosphate; vincristine sulfate; adjuvant therapy; neoadjuvant therapy

Children's Oncology Group - Recruiting N/A to 29 years.
- Treatment for Patients With Bilateral, Multicentric, or Bilaterally-Predisposed Unilateral Wilms Tumor.
doxorubicin hydrochloride; therapeutic conventional surgery; dactinomycin; cyclophosphamide; carboplatin; etoposide phosphate; vincristine sulfate; adjuvant therapy; neoadjuvant therapy

Leukemia, or Acute Lymphoblastic Leukemia Clinical Trial using gene-modified T cells targeted to B-ALL tumor cells

Memorial Sloan-Kettering Cancer Center - Recruiting 18 years or older.
- A Phase I Trial of Precursor B Cell Acute Lymphoblastic Leukemia (B-ALL) Treated With Autologous T Cells Genetically Targeted to the B Cell Specific Antigen CD19.
gene-modified T cells targeted to B-ALL tumor cells

Tumor Clinical Trial using 18 fluoro-deoxy-glucose positrons emission tomography combined with computed tomography

Nantes University Hospital - Recruiting 18 years or older.
- Evaluation of 18 Fluoro-deoxy-glucose Positrons Emission Tomography Combined With Computed Tomography (18-FDG TEP-CT ) in the Diagnosis of the Degeneration of Intraductal Papillary Mucinous Tumor of the Pancreas.
18 fluoro-deoxy-glucose positrons emission tomography combined with computed tomography

Congenital Combined Immunodeficiency, Fungal Infection, Hematopoi Clinical Trial using caspofungin acetate; fluconazole; voriconazole; laboratory biomarker analysis

Children's Oncology Group - Recruiting N/A to 20 years.
- A Phase III Open-Label Trial of Caspofungin vs. Azole Prophylaxis for Patients at High-Risk for Invasive Fungal Infections (IFI) Following Allogeneic Hematopoietic Cell Transplantation (HCT).
caspofungin acetate; fluconazole; voriconazole; laboratory biomarker analysis

Accelerated Phase Chronic Myelogenous Leukemia, Acute Myeloid Leu Clinical Trial using survey administration; assessment of therapy complications; long-term screening; study of high risk factors

Children's Oncology Group - Recruiting N/A or older.
- Umbrella Long-Term Follow-Up Protocol.
survey administration; assessment of therapy complications; long-term screening; study of high risk factors

Childhood Infratentorial Ependymoma, Childhood Supratentorial Epe Clinical Trial using liposomal vincristine sulfate; clinical observation; 3-dimensional conformal radiation therapy; carboplatin; cyclophosphamide; etoposide; cisplatin; laboratory biomarker analysis

Children's Oncology Group - Recruiting 1 year to 21 years.
- Phase III Randomized Trial of Post-Radiation Chemotherapy in Patients With Newly Diagnosed Ependymoma Ages 1 to 21 Years.
liposomal vincristine sulfate; clinical observation; 3-dimensional conformal radiation therapy; carboplatin; cyclophosphamide; etoposide; cisplatin; laboratory biomarker analysis

Adult Acute Megakaryoblastic Leukemia (M7), Adult Acute Minimally Clinical Trial using caspofungin acetate; fluconazole; laboratory biomarker analysis

Children's Oncology Group - Recruiting 3 Months to 30 years.
- A Randomized Open-Label Trial of Caspofungin Versus Fluconazole to Prevent Invasive Fungal Infections in Children Undergoing Chemotherapy for Acute Myeloid Leukemia (AML).
caspofungin acetate; fluconazole; laboratory biomarker analysis

Gastrinoma, Glucagonoma, Insulinoma, Islet Cell Carcinoma, Pancre Clinical Trial using temozolomide; capecitabine; laboratory biomarker analysis

Eastern Cooperative Oncology Group - Recruiting 18 years or older.
- A Randomized Phase II Study of Temozolomide or Temozolomide and Capecitabine in Patients With Advanced Pancreatic Neuroendocrine Tumors.
temozolomide; capecitabine; laboratory biomarker analysis

Androgen-independent Prostate Cancer Clinical Trial using Realisation of blood sample, urinary sample and tumor biopsy

Institut Paoli-Calmettes - Recruiting 18 years or older.
- Analysis of the Mechanisms of Actions of Hsp27 Responsible of the Androgen-independent Evolution in Prostate Cancer.
Realisation of blood sample, urinary sample and tumor biopsy

Indolent Non-Hodgkin's Lymphoma Clinical Trial using Arm A: Rituximab; Arm B: GA101

PrECOG, LLC. - Recruiting 18 years or older.
- Phase II Randomized Trial Comparing GA101 (Obinutuzumab) and Rituximab in Patients With Previously Untreated Low Tumor Burden Indolent Non-Hodgkin's Lymphoma.
Arm A: Rituximab; Arm B: GA101

Advanced Breast Cancer Clinical Trial

Dartmouth-Hitchcock Medical Center - Recruiting 18 years or older.
- Developing Plasma DNA as a Surrogate for Tumor Biopsy to Identify Tumor Genetic Alterations in Patients With Advanced Breast Cancer.

Breast Cancer Clinical Trial

Thomas Jefferson University - Recruiting 18 years or older.
- Tumor Suppressor Status as a Predictor of Chemotherapy Response in Triple Negative Breast Cancer..

Merkel Cell Carcinoma Clinical Trial using Arm A: F16IL2 in combination with paclitaxel; Arm B: Paclitaxel

Philogen S.p.A. - Recruiting 18 years to 75 years.
- Phase II Study of the Tumor-targeting Human F16IL2 Monoclonal Antibody-cytokine Fusion Protein in Combination With Paclitaxel in Patients With Metastatic Merkel Cell Carcinoma.
Arm A: F16IL2 in combination with paclitaxel; Arm B: Paclitaxel

Non-Small Cell Lung Cancer Clinical Trial using erlotinib [Tarceva]; gemcitabine; cisplatin

Hoffmann-La Roche - Recruiting 18 years or older.
- A Multiple Center, Open-label, Randomized Phase III Study to Evaluate the Efficacy and Safety of Erlotinib (Tarceva) Versus Gemcitabine/Cisplatin as the First-line Treatment for Stage IIIB/IV NSCLC Patients With Mutations in the Tyrosine Kinase Domain of Epidermal Growth Factor Receptor (EGFR) in Their Tumor.
erlotinib [Tarceva]; gemcitabine; cisplatin

Prostate Cancer Clinical Trial using CABAZITAXEL (XRP6258); Prednisone; Ciprofloxacin; G-CSF (Granulocyte colony-stimulating factor)

Sanofi - Recruiting 18 years or older.
- A Phase IV, Multicenter, National, Non-comparative, Open-label Study of Cabazitaxel, Combined With Prednisone and Prophylaxis of Neutropenia Complications in the Second-line Treatment of Patients With Metastatic Castration-resistant Prostate Cancer and After Failure of Docetaxel-based Chemotherapy. Descriptive Assessment of the Circulating Tumor Cells in This Context..
CABAZITAXEL (XRP6258); Prednisone; Ciprofloxacin; G-CSF (Granulocyte colony-stimulating factor)

Brain and Central Nervous System Tumors Clinical Trial

St. Jude Children's Research Hospital - Recruiting N/A to 21 years.
- Molecular and Histopathologic Characterization of Atypical Teratoid Rhabdoid Tumors, Choroid Plexus Carcinomas, Ependymomas and Medulloblastoma/PNET of the Pediatric CNS.

Glioblastoma Multiforme, or Gliosarcoma Clinical Trial using AMG 102 with Avastin

Duke University - Recruiting 18 years or older.
- Phase II Study to Evaluate the Efficacy and Safety of AMG 102 and Avastin in Subjects With Recurrent Malignant Glioma.
AMG 102 with Avastin

Recurrent Melanoma, Stage IIIB Melanoma, Stage IIIC Melanoma, or Clinical Trial using ipilimumab; recombinant interferon alfa-2b; quality-of-life assessment

National Cancer Institute (NCI) - Recruiting 18 years or older.
- A Phase III Randomized Study of Adjuvant Ipilimumab Anti-CTLA4 Therapy Versus High-Dose Interferon a-2b for Resected High-Risk Melanoma.
ipilimumab; recombinant interferon alfa-2b; quality-of-life assessment

Lung Cancer, Esophageal Cancer, Malignant Pleural Mesothelioma, S Clinical Trial using H1299 Lysate Vaccine; Cyclophosphamide; Celecoxib

National Institutes of Health Clinical Center (CC) - Recruiting 18 years or older.
- Adjuvant Tumor Lysate Vaccine and Iscomatrix With or Without Metronomic Oral Cyclophosphamide and Celecoxib in Patients With Malignancies Involving Lungs, Esophagus, Pleura, or Mediastinum.
H1299 Lysate Vaccine; Cyclophosphamide; Celecoxib

Melanoma Clinical Trial using Blood Draw

Comprehensive Cancer Centers of Nevada - Recruiting 18 years or older.
- Culture and Characterization of Circulating Tumor Cells (CTC) From Patients With Malignant Melanoma and Other Cancers.
Blood Draw

Head and Neck Squamous Cell Carcinoma Clinical Trial using IMRT; PET/CT; Docetaxel; Fluorouracil; Cisplatin

Lithuanian University of Health Sciences - Recruiting 18 years to 75 years.
- Assessing Tumor Response and IMRT Treatment Planning After Induction Chemotherapy Based on FDG-PET/CT for Locally Advanced Head and Neck Squamous Cell Carcinoma..
IMRT; PET/CT; Docetaxel; Fluorouracil; Cisplatin

Advanced Solid Tumor, or Lymphoma Clinical Trial using DS-3032

Daiichi Sankyo Inc. - Recruiting 18 years or older.
- A Phase 1 Multiple Ascending Dose Study of DS-3032b, an Oral MDM2 Inhibitor, in Subjects With Advanced Solid Tumors or Lymphomas.
DS-3032

Male Breast Cancer, Recurrent Melanoma, Stage IV Breast Cancer, S Clinical Trial using propranolol hydrochloride; Correlative Studies

Ohio State University Comprehensive Cancer Center - Recruiting 18 years or older.
- A Pilot Study of Beta-Blockers in Patients With Advanced Cancer.
propranolol hydrochloride; Correlative Studies

Unspecified Adult Solid Tumor, Protocol Specific Clinical Trial using nanosomal docetaxel lipid suspension; pharmacological study

USC/Norris Comprehensive Cancer Center - Recruiting 18 years to 64 years.
- An Open Label, Randomized Study to Evaluate Safety and Pharmacokinetics of Intravenous Infusion of Nanosomal Docetaxel Lipid Suspension for Injection in Patients With Advanced Solid Tumors.
nanosomal docetaxel lipid suspension; pharmacological study

Locally Advanced Tumor, Metastatic Solid Tissue Tumors, Liver Can Clinical Trial using DCVax-Direct

Northwest Biotherapeutics - Recruiting 18 years to 75 years.
- A PHASE I/II CLINICAL TRIAL EVALUATING DCVax-Direct, AUTOLOGOUS ACTIVATED DENDRITIC CELLS FOR INTRATUMORAL INJECTION, IN PATIENTS WITH SOLID TUMORS.
DCVax-Direct

Islet Cell Tumor, Pancreatic Cancer, or Pancreatic Disease Clinical Trial using medical chart review; survey administration; biospecimen collection

Mayo Clinic - Recruiting 18 years or older.
- Biospecimen Resource for Pancreas Research, a Data & Tissue Bank (Also Known as a Bio-repository, Bio-bank, Data & Tissue Database, Data & Tissue Registry, Etc.) to Help Advance Research in Pancreas Disease.
medical chart review; survey administration; biospecimen collection

Colorectal Cancer Clinical Trial

National Surgical Adjuvant Breast and Bowel Project (NSABP) - Recruiting 18 years or older.
- NSABP Patient Registry and Biospecimen Profiling Repository.

CANCER, NOS Clinical Trial using Lirilumab; Ipilimumab

Bristol-Myers Squibb - Recruiting 18 years or older.
- A Phase 1 Study of BMS-986015, an Anti-KIR Monoclonal Antibody, Administered With Ipilimumab, an Anti-CTLA4 Monoclonal Antibody, in Subjects With Select Advanced Solid Tumors.
Lirilumab; Ipilimumab

Pigmented Villonodular Synovitis, Diffuse-type Giant Cell Tumor, Clinical Trial using nilotinib

Dana-Farber Cancer Institute - Recruiting 18 years or older.
- A Multi-Center Single Agent Phase II Study of the Efficacy of Nilotinib in Patients With Relapsed or Metastatic Pigmented Villonodular Synovitis/Tenosynovial Giant Cell Tumor/Diffuse-Type Giant Cell Tumor.
nilotinib

Spinal Cord Compression, or Unspecified Adult Solid Tumor, Protoc Clinical Trial using radiation therapy

ICORG- All Ireland Cooperative Oncology Research Group - Recruiting 18 years or older.
- A Randomised Phase III Trial of Two Fractionation Schemes in the Treatment of Malignant Spinal Cord Compression.
radiation therapy

Adult Primary Liver Cancer, or Kidney Tumor Clinical Trial using ultrasound elasticity imaging

Stanford University - Recruiting 19 years or older.
- US Elastography for Characterizing Focal Lesions in the Liver and Kidney.
ultrasound elasticity imaging

Brain Cancer Clinical Trial

University of Utah - Recruiting 18 years or older.
- Assessment of Primary and Metastatic Brain Tumor Hypoxia With 18F-Fluoromisonidazole, [18F]Fluoro-2-deoxy-D-glucose (FDG) and [15O]Water (H215O).

Solid Tumor and Hematologic Malignancies Clinical Trial using MEK162

Novartis - Recruiting 18 years or older.
- Modular Phase II Study to Link Targeted Therapy to Patients With Pathway Activated Tumors: Module 3 - MEK162 for Patients With RAS/RAF/MEK Activated Tumors.
MEK162

Tumor Pathway Activations Inhibited by Dovitinib Clinical Trial using Dovitinib (TKI258)

Novartis - Recruiting 18 years or older.
- Modular Phase II Study to Link Targeted Therapy to Patients With Pathway Activated Tumors: Module 2 - Dovitinib for Patients With Tumor Pathway Activations Inhibited by Dovitinib Including Tumors With Mutations or Translocations of FGFR, PDGFR, VEGF, cKIT, FLT3, CSFR1, Trk and RET.
Dovitinib (TKI258)

Leukemia, Pediatric Clinical Trial using Dasatinib

Bristol-Myers Squibb - Recruiting 1 year to 17 years.
- A Phase 2 Multi-Center, Historically Controlled Study of Dasatinib Added to Standard Chemotherapy in Pediatric Patients With Newly Diagnosed Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia.
Dasatinib

Malignant Tumor Clinical Trial using Novilase Interstitial Laser Therapy

Novian Health Inc. - Recruiting 18 years to 80 years.
- A Multicenter 'Ablate and Resect' Study of Novilaser Interstitial Laser Therapy for the Ablation of Small Breast Cancers.
Novilase Interstitial Laser Therapy

Adult Anaplastic Oligodendroglioma, Adult Giant Cell Glioblastoma Clinical Trial using trebananib; placebo; bevacizumab; pharmacological study; laboratory biomarker analysis

National Cancer Institute (NCI) - Recruiting 18 years or older.
- Phase II Double-Blinded Placebo-Controlled Study of Bevacizumab With or Without AMG 386 in Patients With Recurrent Glioblastoma or Gliosarcoma.
trebananib; placebo; bevacizumab; pharmacological study; laboratory biomarker analysis

B-cell Chronic Lymphocytic Leukemia Clinical Trial using B-CLL Vaccine; Lenalidomide

Baylor College of Medicine - Recruiting 18 years to 75 years.
- Treatment of B-CLL With Autologous IL2 and CD40 Ligand-Expressing Tumor Cells + Lenalidomide.
B-CLL Vaccine; Lenalidomide

Hepatic Complications, Renal Failure, or Unspecified Adult Solid Clinical Trial using dabrafenib; pharmacological study; laboratory biomarker analysis

National Cancer Institute (NCI) - Recruiting 18 years or older.
- A Phase 1 and Pharmacokinetic Study of Dabrafenib (GSK2118436B) in Patients With BRAFV600X Mutations and Renal or Hepatic Dysfunction.
dabrafenib; pharmacological study; laboratory biomarker analysis

Brain Cancer Clinical Trial using preoperative fMRI. DTI and DSI with tractography

Memorial Sloan-Kettering Cancer Center - Recruiting 18 years or older.
- Using Functional MRI and Diffusion Tensor Imaging of the Motor and Language Pathways to Optimize Brain Tumor Resection.
preoperative fMRI. DTI and DSI with tractography

Malignant Pleural Mesothelioma (MPM), Choroidal Nevus, Primary Uv Clinical Trial using tumor specimens

Memorial Sloan-Kettering Cancer Center - Recruiting 18 years or older.
- Clinical and Histopathologic Characteristics of BAP1 Mutations.
tumor specimens

Crohn's Disease Clinical Trial using MEDI2070; placebo

AstraZeneca - Recruiting 18 years to 65 years.
- A Phase 2a Study to Evaluate the Efficacy and Safety of MEDI2070 in Subjects With Moderate to Severe Crohn's Disease Who Have Failed or Are Intolerant to Anti-tumor Necrosis Factor-alpha Therapy.
MEDI2070; placebo

Metastatic Gastrointestinal Carcinoid Tumor, Pulmonary Carcinoid Clinical Trial using pazopanib hydrochloride; placebo; quality-of-life assessment; laboratory biomarker analysis

National Cancer Institute (NCI) - Recruiting 18 years or older.
- Prospective Randomized Phase II Trial of Pazopanib (NSC # 737754, IND 75648) Versus Placebo in Patients With Progressive Carcinoid Tumors.
pazopanib hydrochloride; placebo; quality-of-life assessment; laboratory biomarker analysis

Advanced Solid Tumor Diseases Clinical Trial using Individual Meaning-Centered Psychotherapy (IMCP); standard Individual Supportive Psychotherapy (ISP); enhanced usual care (EUC)

Memorial Sloan-Kettering Cancer Center - Recruiting 21 years or older.
- A Randomized Controlled Trial of Individual Psychosocial Interventions for Cancer Patients.
Individual Meaning-Centered Psychotherapy (IMCP); standard Individual Supportive Psychotherapy (ISP); enhanced usual care (EUC)

Sarcoma, Wilm's Tumor, Lymphoma, or Neuroblastoma Clinical Trial using Ipilimumab(anti-CTLA-4 antibody)

National Institutes of Health Clinical Center (CC) - Recruiting 1 year to 21 years.
- A Phase I Study of Ipilimumab (Anti-CTLA-4) in Children, Adolescents, and Young Adults With Treatment Refractory Cancer.
Ipilimumab(anti-CTLA-4 antibody)

Solid Tumor, Malignant Hematological Tumor, or Primary or Seconda Clinical Trial

Hospira, Inc. - Recruiting N/A or older.
- The Compatibility of Nivestim(TM) Under Cytotoxic Chemotherapy in the Treatment of Malignant Diseases.

Tumor, Solid Clinical Trial using MK-8353

Merck Sharp & Dohme Corp. - Recruiting 18 years or older.
- A Phase 1 Study to Evaluate the Safety, Tolerability and Efficacy of MK-8353 (Formerly SCH 900353) in Subjects With Advanced Solid Tumors (Protocol No. 001 (Formerly P06203)).
MK-8353

Brain Tumor Clinical Trial using everolimus; immunohistochemistry staining method; laboratory biomarker analysis

University of California, San Francisco - Recruiting 18 years or older.
- Phase II Trial of RAD001 in Patients With Recurrent Low Grade Glioma.
everolimus; immunohistochemistry staining method; laboratory biomarker analysis

Cancer, Solid Tumor, or Hematologic Malignancy Clinical Trial

City of Hope Medical Center - Recruiting 65 years or older.
- Delivering the Geriatric Assessment Tool to Older Adults With Cancer Using Computer Survey Methodologies: Testing Feasibility, Reliability, and Validity of Research Electronic Data Capture (REDCap) and Support Screen (Touchscreen) Technologies.

Nausea, or Vomiting Clinical Trial using Aprepitant; Aprepitant Placebo; Ondansetron; Dexamethasone; Ondansetron Placebo; Rescue Therapy (granisetron, dolasetron, tropisetron or ondansetron; metoclopramide or alizapride).

Merck Sharp & Dohme Corp. - Recruiting 21 years or older.
- A Korean Multicenter, Randomized, Double-Blind, Clinical Trial to Evaluate the Efficacy and Tolerability of Aprepitant for the Prevention of Chemotherapy-Induced Nausea and Vomiting in the First Cycle of Moderately Emetogenic Chemotherapies (MEC, Non-AC Regimes) With Broad Range of Tumor Types (KMEC Study).
Aprepitant; Aprepitant Placebo; Ondansetron; Dexamethasone; Ondansetron Placebo; Rescue Therapy (granisetron, dolasetron, tropisetron or ondansetron; metoclopramide or alizapride).

Gastrointestinal Stromal Tumors Clinical Trial using Regorafenib (Stivarga, BAY73-4506)

Bayer - Recruiting N/A or older.
- Drug Use Investigation of Regorafenib/ STIVARGA for Gastrointestinal Stromal Tumor Progressed After Cancer Chemotherapy.
Regorafenib (Stivarga, BAY73-4506)

CNS Tumor, Adult Clinical Trial using temozolomide

University of California, San Francisco - Recruiting 18 years or older.
- A Phase II Study of Temozolomide (TEMODAR) in the Treatment of Adult Patients With Supratentorial Low Grade Glioma.
temozolomide

Solid Tumor, or Anaplastic Thyroid Cancer Clinical Trial using Cisplatin and Crolibulin; Cisplatin

National Institutes of Health Clinical Center (CC) - Recruiting 18 years to 90 years.
- A Phase I/II Trial of Crolibulin (EPC2407) Plus Cisplatin in Adults With Solid Tumors With a Focus on Anaplastic Thyroid Cancer (ATC).
Cisplatin and Crolibulin; Cisplatin

Breast Cancer, or Unspecified Adult Solid Tumor, Protocol Specifi Clinical Trial using positron emission tomography/computed tomography; fludeoxyglucose F 18; PET/MRI; gadopentetate dimeglumine; questionnaire administration

Case Comprehensive Cancer Center - Recruiting 18 years or older.
- Positron Mammographic Imaging (PMI).
positron emission tomography/computed tomography; fludeoxyglucose F 18; PET/MRI; gadopentetate dimeglumine; questionnaire administration

Breast Tumor, Breast Cysts, or Breast Abnormalities Clinical Trial using Experimental 3D Breast Ultrasound imaging; Experimental Photoacoustic Imaging

University of Michigan - Recruiting 30 years to 80 years.
- 2D Silicon Transducer-Compression Plates for Breast Ultrasound.
Experimental 3D Breast Ultrasound imaging; Experimental Photoacoustic Imaging

Tumors Metastatic to Brain, or Unspecified Adult Solid Tumor Clinical Trial using stereotactic radiosurgery; quality-of-life assessment; cognitive assessment

Case Comprehensive Cancer Center - Recruiting 18 years or older.
- Dose Escalation for Larger Brain Metastases: Phase I/II Study.
stereotactic radiosurgery; quality-of-life assessment; cognitive assessment

Advanced Solid Tumor Clinical Trial using INC280

Novartis - Recruiting 18 years or older.
- A Phase I Study of INC280 in Japanese Patients With Advanced Solid Tumors.
INC280

Patients That Have Been Diagnosed With Cancer, or Patients Eligib Clinical Trial

NovellusDx - Recruiting 18 years to 85 years.
- An Observational Study to Assess the Oncogenic Status of Colorectal Cancer Patients That Have Undergone Surgery.

Recurrent Melanoma, Recurrent Thyroid Cancer, Thyroid Gland Medul Clinical Trial using cabozantinib-s-malate; pharmacological study; laboratory biomarker analysis

National Cancer Institute (NCI) - Recruiting 2 years to 18 years.
- A Phase 1 Study of XL184 (Cabozantinib, IND# 116059) in Children and Adolescents With Recurrent or Refractory Solid Tumors, Including CNS Tumors.
cabozantinib-s-malate; pharmacological study; laboratory biomarker analysis

NSCLC Clinical Trial using Radiotherapy

The Netherlands Cancer Institute - Recruiting 18 years or older.
- Dose Escalation by Boosting Radiation Dose Within the Primary Tumor on the Basis of a Pre-treatment FDG-PET-CT Scan in Stage IB, II and III NSCLC: a Randomized Phase II Trial.
Radiotherapy

Estrogen Receptor-positive Breast Cancer, HER2-negative Breast Ca Clinical Trial using systemic chemotherapy; tamoxifen citrate; anastrozole; exemestane; letrozole

National Cancer Institute (NCI) - Recruiting 18 years or older.
- A PHASE III, RANDOMIZED CLINICAL TRIAL OF STANDARD ADJUVANT ENDOCRINE THERAPY +/-CHEMOTHERAPY IN PATIENTS WITH 1-3 POSITIVE NODES, HORMONE RECEPTOR-POSITIVE AND HER2-NEGATIVE BREAST CANCER WITH RECURRENCE SCORE (RS) OF 25 OR LESS. RXPONDER: A CLINICAL TRIAL RX FOR POSITIVE NODE, ENDOCRINE RESPONSIVE BREAST CANCER.
systemic chemotherapy; tamoxifen citrate; anastrozole; exemestane; letrozole

Transitional Cell Carcinoma of Bladder, Urethra Cancer, Ureter Ca Clinical Trial using Cisplatin; Gemcitabine; ALT-801

Altor Bioscience Corporation - Recruiting 18 years or older.
- A Phase Ib/II Trial of ALT-801 in Combination With Cisplatin and Gemcitabine in Muscle Invasive or Metastatic Urothelial Cancer.
Cisplatin; Gemcitabine; ALT-801

Neoplasm Clinical Trial

National Institutes of Health Clinical Center (CC) - Recruiting 18 years or older.
- Collection of Blood, Bone Marrow, Tumor, or Tissue Samples From Patients With Cancer or Normal Volunteers.

Mesolthelioma, Esophageal Cancer, or Lung Cancer Clinical Trial using Celecoxib; ISCOMATRIX (TM) Adjuvant; Autologous Tumor Cell Vaccine

National Institutes of Health Clinical Center (CC) - Recruiting 18 years or older.
- Epigenetically-Modified Autologous Tumor Cell Vaccines With ISCOMATRIX(TM) Adjuvant and Oral Celecoxib in Patients Undergoing Resection of Lung and Esophageal Cancers, Thoracic Sarcomas, and Malignant Pleural Mesotheliomas.
Celecoxib; ISCOMATRIX (TM) Adjuvant; Autologous Tumor Cell Vaccine

Advanced Solid Tumor Clinical Trial using LDE225; Wafarin; Bupropion

Novartis - Recruiting 18 years or older.
- A Phase Ib, Multi-center, Two Parallel Group, Open-label, Drug-drug Interaction Study to Assess the Effect of LDE225 on the Pharmacokinetics of Bupropion and Warfarin in Patients With Advanced Solid Tumors.
LDE225; Wafarin; Bupropion

Sarcoma, Melanoma, Epithelial Malignancies, or Pleural Malignanci Clinical Trial using Allogenic Tumor Cell Vaccine (K562)

National Institutes of Health Clinical Center (CC) - Recruiting 18 years or older.
- Adjuvant Allogeneic Tumor Cell Vaccine With Metronomic Oral Cyclophosphamide and Celecoxib in Patients Undergoing Resection of Sarcomas, Melanomas, Germ Cell Tumors, or Epithelial Malignancies Metastatic to Lungs, Pleura, or Mediastinum.
Allogenic Tumor Cell Vaccine (K562)

Carcinoma Hepatocellular Clinical Trial using RT and hyperthermia after TACE

Samsung Medical Center - Recruiting 20 years or older.
- Effectiveness and Safety of the Simultaneous Radiotherapy and Hyperthermia After Transarterial Chemoembolization in Hepatocellular Carcinoma Patients Combined With Portal Vein Tumor Thrombosis: Prospective Phase II Trial.
RT and hyperthermia after TACE

HER2-negative Und Hormone-receptor Positive Metastatic Breast Can Clinical Trial using Everolimus in combination with standard endocrine therapy

University of Ulm - Recruiting 18 years or older.
- DETECT IV - A Multicenter Single Arm Phase II Study to Investigate the Clinical Efficacy of Everolimus in Combination With Endocrine Therapy in Postmenopausal Patients With Hormone-receptor Positive, HER2-negative Metastatic Breast Cancer and Persisting HER2-negative Circulating Tumor Cells..
Everolimus in combination with standard endocrine therapy

Malignant Solid Tumor - Malignant Nervous System Neoplasm Clinical Trial using Cabazitaxel (XRP6258)

Sanofi - Recruiting 2 years to 18 years.
- A Phase 1-2 Dose Finding, Safety and Efficacy Study of Cabazitaxel in Pediatric Patients With Refractory Solid Tumors Including Tumors of the Central Nervous System.
Cabazitaxel (XRP6258)

Hepatocellular Carcinoma Clinical Trial

Peking Union Medical College Hospital - Recruiting 18 years to 80 years.
- Detected the Valuable Characteristic Changes Both in Circulating Cell-free DNA and Primary Tumor in the Patients With Hepatocelluar Carcinoma..

Neoplasm Clinical Trial using PF-05212384; Docetaxel; Cisplatin; Dacomitinib

Pfizer - Recruiting 18 years or older.
- A Phase 1B Open-Label Three-Arm Multi-Center Study To Assess The Safety And Tolerability Of PF-05212384 (PI3K/MTor Inhibitor) In Combination With Other Anti-Tumor Agents.
PF-05212384; Docetaxel; Cisplatin; Dacomitinib

Brain Tumor Clinical Trial using MRI

University of Texas Southwestern Medical Center - Recruiting 18 years or older.
- High Resolution Magnetic Resonance Imaging in Patients With Brain Tumors.
MRI

Advanced Solid Tumor and Lymphoma Malignancies Clinical Trial using TAK-659

Millennium Pharmaceuticals, Inc. - Recruiting 18 years or older.
- An Open-Label, Dose Escalation, Phase 1, First-in-Human Study of TAK-659 in Adult Patients With Advanced Solid Tumor and Lymphoma Malignancies.
TAK-659

Solid Tumor Clinical Trial using MSC2363318A

EMD Serono - Recruiting 18 years or older.
- A Phase I, First-in-Human, Dose Escalation Trial of MSC2363318A, a Dual p70S6K/Akt Inhibitor, in Subjects With Advanced Malignancies.
MSC2363318A

Glioblastoma Multiforme, Anaplastic Astrocytoma, Anaplastic Oligo Clinical Trial using Toca 511

Tocagen Inc. - Recruiting 18 years to 80 years.
- A P1 Ascending Dose Trial of the Safety and Tolerability of Toca 511, a Retroviral Replicating Vector, Administered Intravenously Prior to, and Intracranially at the Time of, Subsequent Resection for Recurrent HGG & Followed by Treatment With Extended-Release 5-FC.
Toca 511

Solid Tumor Malignancies Clinical Trial using Clostridium novyi-NT spores

BioMed Valley Discoveries, Inc - Recruiting 18 years or older.
- Phase I Safety Study of Intratumoral Injection of Clostridium Novyi-NT Spores in Patients With Treatment-refractory Solid Tumor Malignancies.
Clostridium novyi-NT spores

Prostate Cancer Clinical Trial using Abiraterone; Prednisone

Massachusetts General Hospital - Recruiting 18 years or older.
- Investigator-Initiated, Pilot Translational Study of Circulating Tumor Cells to Identify Predictive Factors of Response to Abiraterone Acetate in Men With Castration-Resistant Prostate Cancer.
Abiraterone; Prednisone

Kidney Cancer Clinical Trial using sunitinib malate; gene expression analysis; reverse transcriptase-polymerase chain reaction; western blotting; immunohistochemistry staining method; laboratory biomarker analysis; adjuvant therapy; neoadjuvant therapy; therapeutic conventional surgery

National Cancer Institute (NCI) - Recruiting 18 years or older.
- Biomarkers of Tumor Angiogenesis and Response to Sunitinib Maleate in Renal Cell Carcinoma.
sunitinib malate; gene expression analysis; reverse transcriptase-polymerase chain reaction; western blotting; immunohistochemistry staining method; laboratory biomarker analysis; adjuvant therapy; neoadjuvant therapy; therapeutic conventional surgery

Metastatic Cancer Clinical Trial using conventional surgery; intraoperative radiation therapy

National Cancer Institute (NCI) - Recruiting 18 years or older.
- A Phase I/II Study Utilizing the Zeiss INTRABEAM System for the Treatment of a Resected Solitary Brain Metastasis.
conventional surgery; intraoperative radiation therapy

Central Nervous System Tumor, Pediatric, Chemotherapy-induced Nau Clinical Trial using Real Acupressure Band; Placebo Acupressure Band

University of South Florida - Recruiting 4 years to 18 years.
- Randomized Controlled Trial of Acupressure to Control Chemotherapy-Induced Nausea (CIN) in Children Receiving Highly Emetogenic Chemotherapy.
Real Acupressure Band; Placebo Acupressure Band

Breast Cancer Clinical Trial using allogeneic GM-CSF-secreting breast cancer vaccine; trastuzumab; cyclophosphamide

Sidney Kimmel Comprehensive Cancer Center - Recruiting 18 years or older.
- A Randomized, Open-Label Comparative Study of Combination Therapy With Cyclophosphamide and an Allogeneic GM-CSF-secreting Breast Tumor Vaccine With or Without Trastuzumab for the Treatment of Metastatic Breast Cancer That Does NOT Over-express HER-2/Neu.
allogeneic GM-CSF-secreting breast cancer vaccine; trastuzumab; cyclophosphamide

Tumor, or Cancer Clinical Trial

National University Hospital, Singapore - Recruiting 21 years or older.
- Transcriptomal and Molecular Characterization of Tumor Associated Monocytes / Macrophages in Human Cancers.

Solid Tumor Clinical Trial using RX-3117

Rexahn Pharmaceuticals, Inc. - Recruiting 18 years or older.
- A Phase 1, Open-Label, Dose-Ranging, Safety and Pharmacokinetic Study to Determine the Maximum Tolerated Dose of RX-3117 Administered Orally as a Single-Agent to Subjects With Advanced Malignancies.
RX-3117

Recurrent Childhood Anaplastic Astrocytoma, Recurrent Childhood A Clinical Trial using oncolytic HSV-1716; dexamethasone; therapeutic conventional surgery; laboratory biomarker analysis

Pediatric Brain Tumor Consortium - Recruiting 16 years to 21 years.
- A Phase I Study of Intratumoral/Peritumoral Herpes Simplex Virus-1 Mutant HSV1716 in Patients With Refractory or Recurrent High Grade Gliomas (HGG).
oncolytic HSV-1716; dexamethasone; therapeutic conventional surgery; laboratory biomarker analysis

Metastatic Melanoma and Merkel Cell Carcinoma Clinical Trial using Pasireotide sub-cutaneous formulation

Novartis - Recruiting 18 years or older.
- A Phase I, Exploratory, Intra-patient Dose Escalation Study to Investigate the Preliminary Safety, Pharmacokinetics, and Anti-tumor Activity of Pasireotide (SOM230) s.c. in Patients With Metastatic Melanoma or Metastatic Merkel Cell Carcinoma.
Pasireotide sub-cutaneous formulation

Brain Metastases Clinical Trial using Single Fraction Stereotactic Radiosurgery (SRS); Fractionated Whole Brain Radiation Therapy (WBRT); Fractionated Stereotactic Radiation Therapy (FSRT); Magnetic Resonance Imaging (MRI) Assessments

University of Michigan Cancer Center - Recruiting 18 years or older.
- MRI Study of Changes in Blood-Brain/Tumor-Barrier Permeability in Patients With Brain Metastases During and After Radiotherapy.
Single Fraction Stereotactic Radiosurgery (SRS); Fractionated Whole Brain Radiation Therapy (WBRT); Fractionated Stereotactic Radiation Therapy (FSRT); Magnetic Resonance Imaging (MRI) Assessments

Gastrointestinal Tumor Clinical Trial using SOM230C LAR; FOLFIRI Infusion

H. Lee Moffitt Cancer Center and Research Institute - Recruiting 18 years or older.
- Phase I Trial of Combination of FOLFIRI and SOM 230 in Advanced Gastrointestinal Malignancies.
SOM230C LAR; FOLFIRI Infusion

Cancer, Infection, Inflammation, Tumor, Sarcoid, or Lymphadenopat Clinical Trial

University of Minnesota - Clinical and Translational Science Institute - Recruiting 18 years or older.
- Comparison of 'Wet Suction' Technique to Contemporary 'Dry Suction' Technique Using a 22 Gauge Needle for EUS FNA of Solid Lesions. A Randomized, Prospective, Blinded, and Controlled Trial.

Adult Spinal Cord Neoplasm, Recurrent Adult Spinal Cord Neoplasm, Clinical Trial using therapeutic conventional surgery; quality-of-life assessment

City of Hope Medical Center - Recruiting 18 years or older.
- Comparison of Minimally Invasive Approaches of Spine Tumor Surgery.
therapeutic conventional surgery; quality-of-life assessment

Hematopoietic/Lymphoid Cancer, or Unspecified Adult Solid Tumor, Clinical Trial using questionnaire administration; quality-of-life assessment

City of Hope Medical Center - Recruiting 18 years or older.
- Physical, Emotional and Social Stressors and Their Impact on Quality of Life of Caregivers of Hospitalized Older Adults With Cancer.
questionnaire administration; quality-of-life assessment

Non-small Cell Lung Cancer Clinical Trial using Anlotinib hydrochloric capsule; Placebo Capsule

Jiangsu Chia-tai Tianqing Pharmaceutical Co.,Ltd - Recruiting 18 years to 70 years.
- .
Anlotinib hydrochloric capsule; Placebo Capsule

Patients With Prostate Cancer Clinical Trial using Volumetric Modulated Arc Therapy (VMAT) and High-Dose Rate (HDR) Radiotherapy; No Active Treatment - completed Prior Radiation

University Health Network, Toronto - Recruiting 18 years or older.
- Tumor Targeted Radiotherapy for Patients With Localized Prostate Cancer.
Volumetric Modulated Arc Therapy (VMAT) and High-Dose Rate (HDR) Radiotherapy; No Active Treatment - completed Prior Radiation

Colorectal Cancer Clinical Trial

Milton S. Hershey Medical Center - Recruiting 18 years or older.
- Prevalence of Stem Cell and Prognostic Markers in Circulating Tumor Cells of Patients With Metastatic Colorectal Cancer Undergoing Chemotherapy.

Prostate Cancer Clinical Trial using whole-mount sectioning of the prostate

University Health Network, Toronto - Recruiting 18 years or older.
- Salvage Prostatectomy After Radiotherapy: Whole-Mount Histopathological Validation for Tumor-Targeted Salvage HDR Brachytherapy.
whole-mount sectioning of the prostate

Cancer Clinical Trial using GSK1120212B (Standard DMSO content); GSK1120212B (Lower DMSO content)

GlaxoSmithKline - Recruiting 18 years or older.
- An Open-label, Randomized, 2-treatment, 2-period, 2-way Crossover, Single-dose Study to Determine the Relative Bioavailability of the MEK Inhibitor, Trametinib, in Subjects With Solid Tumor Malignancies.
GSK1120212B (Standard DMSO content); GSK1120212B (Lower DMSO content)

Pancreatic Ductal Adenocarcinoma Clinical Trial using The risk assessment questionnaire; Blood specimens; tumor tissue samples will be requested

Memorial Sloan-Kettering Cancer Center - Recruiting 21 years or older.
- A Registry for BRCA Mutation Carriers With Pancreatic Ductal Adenocarcinoma.
The risk assessment questionnaire; Blood specimens; tumor tissue samples will be requested

Melanoma Clinical Trial using Paclitaxel; Carboplatin; Bevacizumab

Beijing Cancer Hospital - Recruiting 18 years to 70 years.
- A Randomized Phase II Study Evaluating the Activity of Bevacizumab in Combination With Carboplatin Plus Paclitaxel in Patients With Previously Untreated Advanced Mucosal Melanoma.
Paclitaxel; Carboplatin; Bevacizumab

Breast Neoplasms Clinical Trial using Doxorubicin; Trastuzumab; Cyclophosphamide; Paclitaxel

Washington University School of Medicine - Recruiting 18 years or older.
- A Phase II Randomized Trial Evaluating the Effect of Trastuzumab on Disease Free Survival in Early Stage HER2-Negative Breast Cancer Patients With ERBB2 Expressing Bone Marrow Disseminated Tumor Cells.
Doxorubicin; Trastuzumab; Cyclophosphamide; Paclitaxel

Metastatic Squamous Neck Cancer With Occult Primary Squamous Cell Clinical Trial using docetaxel; cisplatin; carboplatin; fluorouracil; bevacizumab

National Cancer Institute (NCI) - Recruiting 18 years or older.
- A Phase III Randomized Trial of Chemotherapy With or Without Bevacizumab in Patients With Recurrent or Metastatic Head and Neck Cancer.
docetaxel; cisplatin; carboplatin; fluorouracil; bevacizumab

Colorectal Neoplasms Clinical Trial using Eflornithine placebo & sulindac placebo; eflornithine & sulindac placebo; Eflornithine placebo & sulindac; Eflornithine plus sulindac

Southwest Oncology Group - Recruiting 18 years or older.
- A Double Blind Placebo-Controlled Trial of Eflornithine and Sulindac to Prevent Recurrence of High Risk Adenomas and Second Primary Colorectal Cancers in Patients With Stage 0-III Colon Cancer, Phase III - Preventing Adenomas of the Colon With Eflornithine and Sulindac (PACES).
Eflornithine placebo & sulindac placebo; eflornithine & sulindac placebo; Eflornithine placebo & sulindac; Eflornithine plus sulindac

Lung Cancer, or Solid Tumor (Not Breast or Prostate Cancers) Clinical Trial using Cabozantinib

Massachusetts General Hospital - Recruiting 18 years or older.
- Phase II Trial of Cabozantinib (XL184) in Patients With Advanced Solid (Non-breast, Non-prostate) Malignancies and Bony Metastases.
Cabozantinib

Unspecified Adult Solid Tumor, Protocol Specific Clinical Trial using methoxyamine; temozolomide; DNA analysis; laboratory biomarker analysis; pharmacological study

Case Comprehensive Cancer Center - Recruiting 18 years or older.
- A Phase I Study of Methoxyamine and Temozolomide in Patients With Advanced Solid Tumors.
methoxyamine; temozolomide; DNA analysis; laboratory biomarker analysis; pharmacological study

Prostate Cancer Clinical Trial using bicalutamide; flutamide; radiation therapy

Radiation Therapy Oncology Group - Recruiting 18 years or older.
- A Phase III Trial of Short Term Androgen Deprivation With Pelvic Lymph Node or Prostate Bed Only Radiotherapy (SPPORT) in Prostate Cancer Patients With a Rising PSA After Radical Prostatectomy.
bicalutamide; flutamide; radiation therapy

Cervical Cancer Clinical Trial using DCE-MRI and 18F-FMISO PET

Memorial Sloan-Kettering Cancer Center - Recruiting 18 years or older.
- Tumor Perfusion and Hypoxia Assessed by DCE-MRI and 18F-FMISO PET as Biomarkers of Treatment Response in Cervical Cancer.
DCE-MRI and 18F-FMISO PET

Adult Acute Erythroid Leukemia (M6), Adult Acute Megakaryoblastic Clinical Trial using asparaginase; daunorubicin hydrochloride; mitoxantrone hydrochloride; sorafenib tosylate; cytarabine; etoposide; bortezomib; pharmacological study; laboratory biomarker analysis; questionnaire administration; quality-of-life assessment

National Cancer Institute (NCI) - Recruiting N/A to 29 years.
- A Phase III Randomized Trial for Patients With de Novo AML Using Bortezomib and Sorafenib (IND#114480; NSC# 681239, NSC# 724772) for Patients With High Allelic Ratio FLT3/ITD.
asparaginase; daunorubicin hydrochloride; mitoxantrone hydrochloride; sorafenib tosylate; cytarabine; etoposide; bortezomib; pharmacological study; laboratory biomarker analysis; questionnaire administration; quality-of-life assessment

Lung Cancer, Non-Small Cell Clinical Trial using Collection of tumor and blood samples

GlaxoSmithKline - Recruiting 18 years or older.
- Analysis of the Expression of a Specific Set of Genes and Tumor Antigens in Patients With Non-small Cell Lung Cancer or Melanoma.
Collection of tumor and blood samples

Carcinoma Clinical Trial

Onkovis GmbH - Recruiting N/A or older.
- Open, Multicenter Observational Study of Oxaliplatin Utilized in Combination Therapy for Adjuvant Treatment of Colon Carcinoma of Stage III After Complete Removal of the Primary Tumor and for Treatment of Metastasizing Colorectal Carcinoma..

Germ Cell Cancer Clinical Trial using Endo-PAT2000 testing

Memorial Sloan-Kettering Cancer Center - Recruiting 18 years or older.
- A Pilot Study Measuring Acute Changes in Endothelial Function in Germ Cell Tumor Patients Treated With Cisplatin and Untreated Germ Cell Tumor Controls.
Endo-PAT2000 testing

Childhood Hepatocellular Carcinoma, Papillary Thyroid Cancer, Pre Clinical Trial using sorafenib tosylate; pharmacological study; laboratory biomarker analysis

National Cancer Institute (NCI) - Recruiting 2 years to 30 years.
- A Phase II Study of the Raf Kinase and Receptor Tyrosine Kinase Inhibitor Sorafenib (IND# 69896) in Children and Young Adults With Relapsed/Refractory Rhabdomyosarcoma, Wilms Tumor, Hepatocellular Carcinoma, and Papillary Thyroid Carcinoma.
sorafenib tosylate; pharmacological study; laboratory biomarker analysis

Brenner Tumor, Ovarian Carcinosarcoma, Ovarian Clear Cell Cystade Clinical Trial using paclitaxel; carboplatin; bevacizumab; veliparib; laboratory biomarker analysis

National Cancer Institute (NCI) - Recruiting 18 years or older.
- A PHASE I STUDY OF INTRAVENOUS CARBOPLATIN/PACLITAXEL OR INTRAVENOUS AND INTRAPERITONEAL PACLITAXEL/CISPLATIN IN COMBINATION WITH CONTINUOUS OR INTERMITTENT/ CTEP-SUPPLIED AGENT ABT-888 (NSC #737664) AND CTEP-SUPPLIED AGENT BEVACIZUMAB (NSC #704865) IN NEWLY DIAGNOSED PATIENTS WITH PREVIOUSLY UNTREATED EPITHELIAL OVARIAN, FALLOPIAN TUBE OR PRIMARY PERITONEAL CANCER.
paclitaxel; carboplatin; bevacizumab; veliparib; laboratory biomarker analysis

Distal Urethral Cancer, Metastatic Transitional Cell Cancer of th Clinical Trial using gemcitabine hydrochloride; cisplatin; placebo; bevacizumab; laboratory biomarker analysis

National Cancer Institute (NCI) - Recruiting 18 years or older.
- A Randomized Double-Blinded Phase III Study Comparing Gemcitabine, Cisplatin, and Bevacizumab to Gemcitabine, Cisplatin, and Placebo in Patients With Advanced Transitional Cell Carcinoma.
gemcitabine hydrochloride; cisplatin; placebo; bevacizumab; laboratory biomarker analysis

Cancer Clinical Trial

University of Miami Sylvester Comprehensive Cancer Center - Recruiting 18 years or older.
- Interrogation of Wnt, Notch and Hedgehog Activity in Primary Tumor Samples.

Ewing's Sarcoma, or Ovarian Cancer Clinical Trial using FANG

Gradalis, Inc. - Recruiting 12 years or older.
- Phase I Trial of Bi-shRNAfurin and GMCSF Augmented Autologous Tumor Cell Vaccine for Advanced Cancer.
FANG

Chronic Lymphocytic Leukemia (CLL) Clinical Trial using Autologous tumor cell extract vaccine

Xeme Biopharma Inc. - Recruiting 18 years or older.
- A Phase Ib Trial of Oncoquest-CLL Vaccine for Treatment-Naive Patients With Chronic Lymphocytic Leukemia.
Autologous tumor cell extract vaccine

Ovarian Cancer, Peritoneal Cavity Cancer, or Unspecified Adult So Clinical Trial using paclitaxel albumin-stabilized nanoparticle formulation; liquid chromatography; mass spectrometry; pharmacological study; laboratory biomarker analysis

City of Hope Medical Center - Recruiting 19 years or older.
- Phase I Trial of Intraperitoneal Nab-Paclitaxel (Abraxane) in the Treatment of Advanced Malignancies Primarily Confined to the Peritoneal Cavity.
paclitaxel albumin-stabilized nanoparticle formulation; liquid chromatography; mass spectrometry; pharmacological study; laboratory biomarker analysis

Pancreatic Cancer Clinical Trial using Gadobutrol; [F-18]HX4; Gemcitabine; Radiotherapy; Pancreaticoduodenectomy

Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) - Recruiting 18 years or older.
- The Role of the Tumor Microenvironment of Pancreatic Cancer to Predict Treatment Outcome.
Gadobutrol; [F-18]HX4; Gemcitabine; Radiotherapy; Pancreaticoduodenectomy

Sarcoma, Leiomyosarcoma, Malignant Peripheral Nerve Sheath Tumor, Clinical Trial using Gemcitabine and Docetaxel in Combination with Pazopanib

Memorial Sloan-Kettering Cancer Center - Recruiting 18 years or older.
- A Phase IB/II Study of Gemcitabine and Docetaxel in Combination With Pazopanib (Gem/Doce/Pzb) for the Neoadjuvant Treatment of Soft Tissue Sarcoma (STS).
Gemcitabine and Docetaxel in Combination with Pazopanib

Benign Neoplasms, Brain, Brain Cancer, Brain Neoplasms, Benign, B Clinical Trial using 5-ALA (Gliolan)

Emory University - Recruiting 18 years or older.
- WCI1999-11: A Phase II Study of 5-Aminolevulinic Acid (ALA) to Enhance Visualization and Resection of Newly Diagnosed or Recurrent Malignant Gliomas.
5-ALA (Gliolan)

Rectal Cancer Clinical Trial using Radiation

AHS Cancer Control Alberta - Recruiting 18 years or older.
- A Feasibility Study to Compare the Benefits of Endoscopic Tumor Clip Placement and 3T-MRI Simulation for Accurate Target Volume Definition for Rectal Cancer Patients Undergoing Pre-operative Chemoradiation.
Radiation

Non Small Cell Lung Cancer, or Chronic Obstructive Pulmonary Dise Clinical Trial

University of Virginia - Recruiting 18 years or older.
- The Use of Circulating Tumor Cells in Non-Small Cell Lung Cancer: Novel Isolation Methods and Clinical Applications.

Lung Cancer Clinical Trial using DNA/RNA sequencing and expression levels; Protein expression analysis; Lung tumor biopsy; Blood sample

Vanderbilt-Ingram Cancer Center - Recruiting N/A or older.
- Molecular Fingerprints in Lung Cancer: Predicting Tumor Response to Therapy.
DNA/RNA sequencing and expression levels; Protein expression analysis; Lung tumor biopsy; Blood sample

Brenner Tumor, Ovarian Clear Cell Cystadenocarcinoma, Ovarian End Clinical Trial using paclitaxel poliglumex; clinical observation; paclitaxel

Gynecologic Oncology Group - Recruiting N/A or older.
- A Randomized Phase III Trial of Maintenance Chemotherapy Comparing 12, Monthly Cycles of Single Agent Paclitaxel or CT-2103 (IND #70177), Versus No Treatment Until Documented Relapse in Women With Advanced Ovarian, Primary Peritoneal or Fallopian Tube Cancer Who Achieve a Complete Clinical Response to Primary Platinum/Taxane Chemotherapy.
paclitaxel poliglumex; clinical observation; paclitaxel

Metastatic Cancer, or Unspecified Adult Solid Tumor, Protocol Spe Clinical Trial using bevacizumab; quality-of-life assessment

Northwestern University - Recruiting 18 years or older.
- A Phase II Trial of Bevacizumab in Patients With Recurrent Solid Tumor Brain Metastases Who Have Failed Whole Brain Radiation Therapy.
bevacizumab; quality-of-life assessment

Ovarian Cancer Clinical Trial using FANG; standard of care observational follow-up

Gradalis, Inc. - Recruiting 18 years or older.
- Randomized Phase II Trial of Adjuvant Bi-shRNAfurin and GMCSF Augmented Autologous Tumor Cell Vaccine (FANGT) for High Risk Stage III/IV Ovarian Cancer.
FANG; standard of care observational follow-up

Stomach Cancer, Gastro-Esophageal(GE) Junction Cancer, Gastric (S Clinical Trial using Blood draw; Tissue tumor biopsy

Stanford University - Recruiting 18 years or older.
- Clinical & Pathological Studies of Upper Gastrointestinal Carcinoma.
Blood draw; Tissue tumor biopsy

Malignant Glioma (WHO Grade III or IV) Clinical Trial using CTO and Bevacizumab; CTO alone

Duke University - Recruiting 18 years or older.
- A Phase 1/2 Trial of Carboxyamidotriazole Orotate (CTO) Alone or in Combination With Bevacizumab for Adult Patients With Recurrent Malignant Glioma Post-Bevacizumab Failure.
CTO and Bevacizumab; CTO alone

Pancreatic Tumor, or Bile Duct Tumor Clinical Trial using Oral IMPACT

Chiba University - Recruiting 18 years to 80 years.
- Additional Effects of Perioperative Immunonutrition on Th1/Th2 Differentiation in Patients Undergoing Pancreaticoduodenectomy.
Oral IMPACT

Brain Tumor, or Malignant Neoplasm of Fourth Ventricle of Brain Clinical Trial using Ommaya Reservoir; Methotrexate; Leucovorin

M.D. Anderson Cancer Center - Recruiting N/A to 22 years.
- Methotrexate Infusion Into the Fourth Ventricle in Children With Malignant Fourth Ventricular Brain Tumors: A Pilot Study.
Ommaya Reservoir; Methotrexate; Leucovorin

Unspecified Childhood Solid Tumor, Protocol Specific Clinical Trial using tivantinib; pharmacological study; laboratory biomarker analysis

National Cancer Institute (NCI) - Recruiting 13 Months to 21 years.
- A Phase 1 Study of the c-Met Inhibitor, Tivantinib (ARQ 197, IND# 112603) in Children With Relapsed or Refractory Solid Tumors.
tivantinib; pharmacological study; laboratory biomarker analysis

Pigmented Villonodular Synovitis, or PVNS Clinical Trial using MCS110; Placebo

Novartis - Recruiting 18 years or older.
- A Phase II Randomized, Double -Blind, Placebo Controlled Study to Assess Safety, Tolerability and Effect on Tumor Size of MCS110 in Patients With Pigmented Villonodular Synovitis (PVNS).
MCS110; Placebo

Non-Small Cell Lung Cancer Clinical Trial using Peripherally located lung tumor; Centrally located lung tumor

University of Florida - Recruiting 18 years or older.
- Hypofractionated, Image-Guided Radiation Therapy With Proton Therapy for Stage I Non-Small Cell Lung Cancer.
Peripherally located lung tumor; Centrally located lung tumor

Brenner Tumor, Ovarian Clear Cell Cystadenocarcinoma, Ovarian End Clinical Trial using bortezomib; carboplatin; pharmacological study

National Cancer Institute (NCI) - Recruiting 18 years or older.
- A PHASE I PHARMACOKINETIC STUDY OF INTRAPERITONEAL CTEP-SUPPLIED AGENT BORTEZOMIB (PS-341, NSC 681239, IND# 58443) AND CARBOPLATIN (NSC# 241240) IN PATIENTS WITH PERSISTENT OR RECURRENT OVARIAN, FALLOPIAN TUBE, OR PRIMARY PERITONEAL CANCER.
bortezomib; carboplatin; pharmacological study

Contiguous Stage II Adult Lymphoblastic Lymphoma, Noncontiguous S Clinical Trial using doxorubicin hydrochloride; cytarabine; daunorubicin hydrochloride; prednisone; pegaspargase; methotrexate; leucovorin calcium; cyclophosphamide; mercaptopurine; nelarabine; asparaginase; dexamethasone; thioguanine; vincristine sulfate; radiation therapy; laboratory biomarker analysis

National Cancer Institute (NCI) - Recruiting 1 year to 30 years.
- Intensified Methotrexate, Nelarabine (Compound 506U78; IND #52611) and Augmented BFM Therapy for Children and Young Adults With Newly Diagnosed T-Cell Acute Lymphoblastic Leukemia (ALL) or T-cell Lymphoblastic Lymphoma.
doxorubicin hydrochloride; cytarabine; daunorubicin hydrochloride; prednisone; pegaspargase; methotrexate; leucovorin calcium; cyclophosphamide; mercaptopurine; nelarabine; asparaginase; dexamethasone; thioguanine; vincristine sulfate; radiation therapy; laboratory biomarker analysis

Advanced Solid Tumor Clinical Trial using BYL719

Novartis - Recruiting 18 years or older.
- A Study of BYL719 in Adult Patients With Advanced Solid Malignancies.
BYL719

Radiation Induced Sarcoma Clinical Trial using tumor genetic predisposition to develop sarcoma assessment

Centre Georges Francois Leclerc - Recruiting 18 years or older.
- Predictive Study of Radiation Induced Sarcoma From the GSF-GETO Data Base..
tumor genetic predisposition to develop sarcoma assessment

Lung Cancer Clinical Trial using computed tomography; 4-dimensional computed tomography; radiation therapy

Virginia Commonwealth University - Recruiting 18 years or older.
- Pulmonary Tumor Motion Reduction and Improved Breathing Reproducibility by Prone Patient Positioning in Radiation Therapy.
computed tomography; 4-dimensional computed tomography; radiation therapy

Recurrent Melanoma, Stage IIIA Melanoma, Stage IIIB Melanoma, Sta Clinical Trial using riluzole; sorafenib tosylate; diagnostic laboratory biomarker analysis; pharmacological study

National Cancer Institute (NCI) - Recruiting 18 years or older.
- A Phase I Trial of Riluzole and Sorafenib in Patients With Advanced Solid Tumors and Melanoma.
riluzole; sorafenib tosylate; diagnostic laboratory biomarker analysis; pharmacological study

Breast Cancer, Prostate Cancer, or Colorectal Cancer Clinical Trial

Viatar LLC - Recruiting 18 years or older.
- Collection of Blood Specimens for Circulating Tumor Cell Analysis.

Oral Cancer Clinical Trial

Roswell Park Cancer Institute - Recruiting 21 years or older.
- Autofluorescence Detection of Oral Malignancies and Database and Biospecimen Collection to Identify Biomarkers of Head and Neck Tumor Progression.

Brain Tumor Clinical Trial using Exercise Program

The Hospital for Sick Children - Recruiting 9 years to 14 years.
- The Neuro-protective Effects of Exercise in Children With Brain Tumors.
Exercise Program

Advanced Melanoma Clinical Trial using FANGT Autologous Tumor Cell Vaccine in Advanced Melanoma

Gradalis, Inc. - Recruiting 18 years or older.
- Phase II Trial of FANGT Autologous Tumor Cell Vaccine in Advanced Melanoma.
FANGT Autologous Tumor Cell Vaccine in Advanced Melanoma

Cancer Clinical Trial

Scripps Translational Science Institute - Recruiting 18 years or older.
- Human Tumor Sequencing Project.

Oral Tumors Clinical Trial using FastEEM4 System; Multispectral Digital Microscope

M.D. Anderson Cancer Center - Recruiting 18 years or older.
- Oral Tumor Margin Detection Using Optical Spectroscopy.
FastEEM4 System; Multispectral Digital Microscope

Actinic Keratoses Clinical Trial using 3% diclofenac in 2.5% hyaluronic acid gel

University Hospital Regensburg - Recruiting 18 years or older.
- Prospective, Controlled and Monocentric Study to Evaluate the Effects of Topical 3% Diclofenac in 2.5% Hyaluronic Acid Gel on Tumor Metabolism in the Treatment of Actinic Keratoses in Immunocompetent and Immunocompromised Patients.
3% diclofenac in 2.5% hyaluronic acid gel